RGD Reference Report - Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis. - Rat Genome Database

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Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis.

Authors: Wu, CG  Groenink, M  Bosma, A  Reitsma, PH  Van Deventer, SJ  Chamuleau, RA 
Citation: Wu CG, etal., Carcinogenesis 1997 Jan;18(1):47-52.
RGD ID: 632698
Pubmed: PMID:9054589   (View Abstract at PubMed)

Elevated serum ferritin levels, especially of the H subunit, accompany many clinical malignancies. By using the subtraction-enhanced display technique, we have recently isolated several cDNA clones which are over-expressed in rat hepatocellular carcinoma induced by diethylnitrosamine. One 830-base-pair clone was 88% similar to human ferritin-H cDNA and encoded a 182 amino acid protein which is 97% homologous to human ferritin-H chain. Hepatic mRNA levels of ferritin-H were increased markedly at the early stage of diethylnitrosamine-induced hepatocarcinogenesis in the rat (6 weeks) and appeared more than 10-fold overexpressed as the tumour progressed. In contrast, hepatic ferritin-H mRNA remained constant during liver regeneration after a 70% partial hepatectomy. In situ hybridization showed that over-expression of ferritin-H was exclusively localized to preneoplastic foci, to tumour nodules and to tumour cells invading blood vessels. These findings suggest that ferritin-H is a highly conserved protein, its over-expression during tumour development is phenotypically correlated with tumour initiation and/or progression, and it is useful as an early marker for hepatocellular carcinoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma  ISOFth1 (Rattus norvegicus)632698; 632698mRNA:increased expression:liver (rat)RGD 
hepatocellular carcinoma  IEP 632698mRNA:increased expression:liver (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fth1  (ferritin heavy chain 1)

Genes (Mus musculus)
Fth1  (ferritin heavy polypeptide 1)

Genes (Homo sapiens)
FTH1  (ferritin heavy chain 1)


Additional Information