Nras (NRAS proto-oncogene, GTPase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nras (NRAS proto-oncogene, GTPase) Heterocephalus glaber
Analyze
Symbol: Nras
Name: NRAS proto-oncogene, GTPase
RGD ID: 18922743
Description: ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); protein-containing complex binding (inferred); INVOLVED IN defense response to protozoan (ortholog); myoblast differentiation (ortholog); negative regulation of skeletal muscle tissue development (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN endomembrane system (inferred); Golgi apparatus (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTPase NRas; neuroblastoma RAS viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
anemia  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-cell lymphoma  (ISO)
Brain Neoplasms  (ISO)
cervical cancer  (ISO)
cholangitis  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myelomonocytic leukemia  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
epidermal nevus  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
focal epilepsy  (ISO)
Follicular Thyroid Cancer  (ISO)
follicular thyroid carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 47  (ISO)
juvenile myelomonocytic leukemia  (ISO)
large congenital melanocytic nevus  (ISO)
leukemia  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver carcinoma  (ISO)
Liver Metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
neuroblastoma  (ISO)
Neurocutaneous Melanosis  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibrosarcoma  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 6  (ISO)
Pigmented Nevus  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Pyogenic Granuloma  (ISO)
RASopathy  (ISO)
rectal benign neoplasm  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
Splenomegaly  (ISO)
transitional cell carcinoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,704,469 - 114,716,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,704,469 - 114,716,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,247,090 - 115,259,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,051,108 - 115,061,038 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,961,626 - 114,971,557NCBI
Celera1113,476,335 - 113,488,757 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1113,105,559 - 113,117,974 (-)NCBIHuRef
CHM1_11115,361,892 - 115,374,317 (-)NCBICHM1_1
T2T-CHM13v2.01114,715,929 - 114,728,216 (-)NCBIT2T-CHM13v2.0
Nras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,965,643 - 102,975,230 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3102,965,601 - 102,975,230 (+)EnsemblGRCm39 Ensembl
GRCm383103,058,285 - 103,067,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3103,058,285 - 103,067,914 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,862,208 - 102,871,837 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363103,187,290 - 103,197,396 (+)NCBIMGSCv36mm8
Celera3105,263,160 - 105,272,744 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Nras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82193,271,399 - 193,282,023 (+)NCBIGRCr8
mRatBN7.22190,582,885 - 190,593,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2190,582,918 - 190,591,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2198,180,438 - 198,188,074 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02196,052,865 - 196,060,501 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02190,870,131 - 190,877,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02205,553,119 - 205,563,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2205,553,163 - 205,560,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,983,707 - 224,994,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42198,292,650 - 198,300,286 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12198,255,369 - 198,265,062 (+)NCBI
Celera2183,056,304 - 183,063,940 (+)NCBICelera
Cytogenetic Map2q34NCBI
Nras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,001,517 - 18,009,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,001,517 - 18,009,105 (-)NCBIChiLan1.0ChiLan1.0
NRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21107,366,720 - 107,378,995 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11106,960,899 - 106,973,178 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0187,837,146 - 87,850,013 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,890,505 - 122,903,585 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,890,505 - 122,903,585 (+)Ensemblpanpan1.1panPan2
NRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,411,733 - 52,418,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,411,733 - 52,418,788 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,062,320 - 52,069,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01753,289,080 - 53,296,149 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1753,286,139 - 53,296,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11752,323,232 - 52,330,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01752,365,409 - 52,372,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01752,938,741 - 52,945,813 (-)NCBIUU_Cfam_GSD_1.0
Nras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505814,406,378 - 14,416,046 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493662773,413 - 82,590 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493662773,413 - 82,590 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,845,872 - 105,858,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,845,913 - 105,853,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24116,034,666 - 116,042,522 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,953,273 - 18,966,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,953,883 - 18,961,931 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603821,707,389 - 21,720,123 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004853781   ⟹   XP_004853838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462477210,358,554 - 10,369,371 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004853838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000013133
RefSeq Acc Id: XP_004853838   ⟸   XM_004853781
- UniProtKB: G5ATE8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009388 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000013271 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
KEGG Report hgl:101719269 UniProtKB/TrEMBL
NCBI Gene Nras ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt G5ATE8 ENTREZGENE, UniProtKB/TrEMBL