Trio (trio Rho guanine nucleotide exchange factor) - Rat Genome Database

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Gene: Trio (trio Rho guanine nucleotide exchange factor) Heterocephalus glaber
Analyze
Symbol: Trio
Name: trio Rho guanine nucleotide exchange factor
RGD ID: 18932397
Description: ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); negative regulation of fat cell differentiation (ortholog); neuron projection morphogenesis (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynapse (ortholog); presynaptic active zone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Triple functional domain protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475111,362,844 - 11,565,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475111,252,934 - 11,566,190 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Trio
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475111,362,844 - 11,565,269 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475111,252,934 - 11,566,190 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TRIO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38514,143,342 - 14,510,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl514,143,342 - 14,532,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37514,143,451 - 14,510,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36514,196,829 - 14,562,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 34514,196,828 - 14,562,457NCBI
Celera514,168,142 - 14,532,209 (+)NCBICelera
Cytogenetic Map5p15.2NCBI
HuRef514,242,473 - 14,481,695 (+)NCBIHuRef
CHM1_1514,143,936 - 14,509,323 (+)NCBICHM1_1
T2T-CHM13v2.0514,080,499 - 14,449,245 (+)NCBIT2T-CHM13v2.0
Trio
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391527,730,735 - 28,025,954 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1527,730,737 - 28,025,934 (-)EnsemblGRCm39 Ensembl
GRCm381527,730,649 - 28,025,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1527,730,651 - 28,025,848 (-)EnsemblGRCm38mm10GRCm38
MGSCv371527,660,404 - 27,955,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361527,675,376 - 27,970,437 (-)NCBIMGSCv36mm8
Celera1528,478,779 - 28,774,257 (-)NCBICelera
Cytogenetic Map15B1NCBI
cM Map1510.4NCBI
Trio
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8280,235,485 - 80,531,824 (-)NCBIGRCr8
mRatBN7.2278,505,069 - 78,801,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl278,505,070 - 78,803,135 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx285,573,060 - 85,868,316 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0283,694,791 - 83,990,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0278,761,319 - 79,056,786 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0280,471,398 - 80,769,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,473,202 - 80,667,481 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02100,137,355 - 100,437,964 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4279,634,843 - 79,832,549 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1279,581,604 - 79,878,530 (-)NCBI
Celera274,141,588 - 74,436,556 (-)NCBICelera
Cytogenetic Map2q22NCBI
Trio
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554263,646,728 - 3,846,988 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554263,647,273 - 3,846,916 (+)NCBIChiLan1.0ChiLan1.0
TRIO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2414,378,176 - 14,744,826 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1512,531,783 - 12,898,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0514,448,259 - 14,814,875 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1514,417,910 - 14,655,906 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl514,423,780 - 14,654,124 (+)Ensemblpanpan1.1panPan2
TRIO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.134271,572 - 505,656 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl34272,290 - 505,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha344,764,923 - 5,120,561 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.034182,486 - 534,192 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl34220,773 - 415,767 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.134194,569 - 548,163 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.034194,407 - 546,539 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.034437,086 - 788,757 (-)NCBIUU_Cfam_GSD_1.0
Trio
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213233,228,026 - 233,436,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366651,821,583 - 2,030,371 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366651,821,580 - 2,029,839 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,564,171 - 3,921,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,690,831 - 3,921,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,216,390 - 4,261,443 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1413,846,753 - 14,214,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl413,847,936 - 14,215,164 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606414,316,908 - 14,686,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000006027   ⟹   ENSHGLP00000005953
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475111,362,844 - 11,565,269 (+)Ensembl
RefSeq Acc Id: XM_004845191   ⟹   XP_004845248
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,253,676 - 11,566,190 (+)NCBI
RefSeq Acc Id: XM_004845192   ⟹   XP_004845249
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,252,934 - 11,565,269 (+)NCBI
RefSeq Acc Id: XM_013072374   ⟹   XP_012927828
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,253,671 - 11,523,339 (+)NCBI
RefSeq Acc Id: XM_021258624   ⟹   XP_021114283
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,253,673 - 11,553,911 (+)NCBI
RefSeq Acc Id: XM_021258625   ⟹   XP_021114284
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,253,674 - 11,554,106 (+)NCBI
RefSeq Acc Id: XM_021258626   ⟹   XP_021114285
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475111,253,671 - 11,531,138 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004845249   ⟸   XM_004845192
- Peptide Label: isoform X2
- UniProtKB: G5AZ97 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021114285   ⟸   XM_021258626
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012927828   ⟸   XM_013072374
- Peptide Label: isoform X6
RefSeq Acc Id: XP_021114283   ⟸   XM_021258624
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021114284   ⟸   XM_021258625
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004845248   ⟸   XM_004845191
- Peptide Label: isoform X1
- UniProtKB: G5AZ97 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005953   ⟸   ENSHGLT00000006027


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004346 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006027 ENTREZGENE
Gene3D-CATH 1.20.58.60 UniProtKB/TrEMBL
  CRAL-TRIO lipid binding domain UniProtKB/TrEMBL
  Dbl homology (DH) domain UniProtKB/TrEMBL
  Immunoglobulins UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CRAL-TRIO_dom UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kalirin_TRIO_PH_1 UniProtKB/TrEMBL
  Kalirin_TRIO_SH3_1 UniProtKB/TrEMBL
  Kalirin_TRIO_SH3_2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
NCBI Gene Trio ENTREZGENE
PANTHER RHO GUANINE EXCHANGE FACTOR-RELATED UniProtKB/TrEMBL
  TRIPLE FUNCTIONAL DOMAIN PROTEIN UniProtKB/TrEMBL
Pfam CRAL_TRIO_2 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH3-RhoG_link UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PROSITE CRAL_TRIO UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SEC14 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP CRAL/TRIO domain UniProtKB/TrEMBL
  DBL homology domain (DH-domain) UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  SH3-domain UniProtKB/TrEMBL
  Spectrin repeat UniProtKB/TrEMBL
UniProt G5AZ97 ENTREZGENE, UniProtKB/TrEMBL