Aldh2 (aldehyde dehydrogenase 2 family member) - Rat Genome Database

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Gene: Aldh2 (aldehyde dehydrogenase 2 family member) Heterocephalus glaber
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Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
RGD ID: 18933085
Description: ENCODES a protein that exhibits aldehyde dehydrogenase (NAD+) activity (ortholog); carboxylesterase activity (ortholog); identical protein binding (ortholog); INVOLVED IN acetaldehyde metabolic process (ortholog); aldehyde catabolic process (ortholog); apoptotic mitochondrial changes (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH Acute Alcohol Sensitivity (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aldehyde dehydrogenase 2 family (mitochondrial); Aldehyde dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Aldh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ALDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,766,933 - 111,817,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,766,887 - 111,817,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,204,737 - 112,255,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,688,729 - 110,732,167 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,667,065 - 110,710,502NCBI
Celera12111,829,810 - 111,873,247 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12109,218,289 - 109,261,129 (+)NCBIHuRef
CHM1_112112,172,628 - 112,215,725 (+)NCBICHM1_1
T2T-CHM13v2.012111,743,846 - 111,794,443 (+)NCBIT2T-CHM13v2.0
Aldh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,704,090 - 121,731,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)EnsemblGRCm39 Ensembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBIMGSCv36mm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.86NCBI
Aldh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,610,244 - 40,643,220 (+)NCBIGRCr8
mRatBN7.21234,949,549 - 34,982,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,122,427 - 36,155,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,733,638 - 36,766,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,786,091 - 35,818,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
Aldh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,352,569 - 8,384,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,352,569 - 8,383,097 (+)NCBIChiLan1.0ChiLan1.0
ALDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,734,243 - 112,776,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensemblpanpan1.1panPan2
ALDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,319,109 - 9,361,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,407 - 9,518,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,578,697 - 9,616,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,578,446 - 9,619,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,534,133 - 9,571,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,596,947 - 9,634,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,550,188 - 9,587,685 (+)NCBIUU_Cfam_GSD_1.0
Aldh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,091,721 - 155,116,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,362,654 - 4,390,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,362,693 - 4,387,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,896,565 - 39,933,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,902,317 - 39,933,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,378,891 - 42,409,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,019,015 - 107,060,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,019,111 - 107,060,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,033,968 - 138,076,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015273   ⟹   ENSHGLP00000015119
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000015274   ⟹   ENSHGLP00000015120
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474720,407,633 - 20,423,465 (-)Ensembl
RefSeq Acc Id: XM_004843781   ⟹   XP_004843838
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004843838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHA97640 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015119
GenBank Protein JAN96297 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004843838   ⟸   XM_004843781
- UniProtKB: G5AKU7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000015120   ⟸   ENSHGLT00000015274
Ensembl Acc Id: ENSHGLP00000015119   ⟸   ENSHGLT00000015273


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010830 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015273 ENTREZGENE
InterPro Ald_DH/histidinol_DH UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/TrEMBL
KEGG Report hgl:101706449 UniProtKB/TrEMBL
NCBI Gene Aldh2 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/TrEMBL
  ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/TrEMBL
UniProt G5AKU7 ENTREZGENE, UniProtKB/TrEMBL