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Gene: ALDH2 (aldehyde dehydrogenase 2 family member) Homo sapiens
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Symbol: ALDH2
Name: aldehyde dehydrogenase 2 family member
Description: Exhibits aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in carbohydrate metabolic process and ethanol oxidation. Localizes to the extracellular exosome. Implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetaldehyde dehydrogenase 2; aldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; ALDM; liver mitochondrial ALDH; MGC1806; nucleus-encoded mitochondrial aldehyde dehydrogenase 2
Orthologs:
Mus musculus (house mouse) : Aldh2 (aldehyde dehydrogenase 2, mitochondrial)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aldh2 (aldehyde dehydrogenase 2 family member)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh2 (aldehyde dehydrogenase 2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH2 (aldehyde dehydrogenase 2 family member)
Canis lupus familiaris (dog) : ALDH2 (aldehyde dehydrogenase 2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh2 (aldehyde dehydrogenase 2 family member)
Sus scrofa (pig) : ALDH2 (aldehyde dehydrogenase 2 family member)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl12111,766,887 - 111,817,532 (+)Ensembl
GRCh3812111,766,933 - 111,817,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,204,691 - 112,247,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,688,729 - 110,732,167 (+)NCBINCBI36hg18NCBI36
Build 3412110,667,065 - 110,710,502NCBI
Celera12111,829,810 - 111,873,247 (+)NCBI
Cytogenetic Map12q24.12NCBI
HuRef12109,218,289 - 109,261,129 (+)NCBIHuRef
CHM1_112112,172,628 - 112,215,725 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ALDH2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69220
Created: 2001-11-14
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.