Dnase1l3 (deoxyribonuclease 1L3) - Rat Genome Database

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Gene: Dnase1l3 (deoxyribonuclease 1L3) Heterocephalus glaber
Analyze
Symbol: Dnase1l3
Name: deoxyribonuclease 1L3 (Ensembl:deoxyribonuclease 1 like 3)
RGD ID: 18910706
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); neutrophil activation involved in immune response (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: deoxyribonuclease 1 like 3; Deoxyribonuclease gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821849,434 - 871,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821845,631 - 871,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dnase1l3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821849,434 - 871,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821845,631 - 871,156 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DNASE1L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,192,257 - 58,210,972 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,192,257 - 58,214,697 (-)EnsemblGRCh38hg38GRCh38
GRCh37358,177,984 - 58,196,699 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,153,394 - 58,175,438 (-)NCBINCBI36Build 36hg18NCBI36
Build 34358,153,393 - 58,175,438NCBI
Celera358,192,880 - 58,214,912 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,275,239 - 58,293,591 (-)NCBIHuRef
CHM1_1358,128,540 - 58,147,077 (-)NCBICHM1_1
T2T-CHM13v2.0358,232,673 - 58,251,379 (-)NCBIT2T-CHM13v2.0
Dnase1l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,475,014 - 14,504,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,475,200 - 14,505,240 (+)EnsemblGRCm39 Ensembl
GRCm38147,965,187 - 7,994,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,964,533 - 7,994,573 (-)EnsemblGRCm38mm10GRCm38
MGSCv37148,797,701 - 8,826,696 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,757,066 - 6,786,061 (-)NCBIMGSCv36mm8
Celera143,588,560 - 3,617,542 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.67NCBI
Dnase1l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,351,683 - 19,378,536 (+)NCBIGRCr8
mRatBN7.21516,922,335 - 16,948,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,922,335 - 16,948,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,097,088 - 19,122,996 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,055,563 - 20,081,473 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,310,474 - 18,336,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,710,492 - 18,736,476 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,710,492 - 18,736,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01521,913,671 - 21,925,373 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01522,676,702 - 22,702,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,909,363 - 18,935,347 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,909,362 - 18,935,344 (+)NCBI
Celera1516,878,636 - 16,904,597 (+)NCBICelera
Cytogenetic Map15p14NCBI
Dnase1l3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,867,109 - 7,892,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554307,867,172 - 7,892,079 (-)NCBIChiLan1.0ChiLan1.0
DNASE1L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,162,226 - 58,181,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,167,000 - 58,186,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,127,491 - 58,146,177 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,542,243 - 59,560,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,542,243 - 59,560,363 (-)Ensemblpanpan1.1panPan2
DNASE1L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,350,138 - 32,379,240 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,358,110 - 32,379,245 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,279,076 - 32,308,726 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,622,923 - 32,652,898 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,631,042 - 32,653,137 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,078,710 - 32,108,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,434,957 - 32,464,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,607,074 - 32,636,716 (+)NCBIUU_Cfam_GSD_1.0
Dnase1l3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118175,291,652 - 175,356,649 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364738,430,231 - 8,457,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364738,430,235 - 8,495,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNASE1L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,958,387 - 39,975,946 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,958,384 - 39,976,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,927,674 - 43,932,404 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNASE1L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,487,767 - 19,496,019 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,487,596 - 19,496,129 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,331,166 - 147,373,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006750   ⟹   ENSHGLP00000006668
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624821849,434 - 871,609 (-)Ensembl
RefSeq Acc Id: XM_004864239   ⟹   XP_004864296
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624821845,631 - 871,156 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004864296 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB10483 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006668
  ENSHGLP00100035750
GenBank Protein JAO00655 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004864296   ⟸   XM_004864239
- UniProtKB: G5BMH2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006668   ⟸   ENSHGLT00000006750


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004869 Ensembl, ENTREZGENE
  ENSHGLG00100040090 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000006750 ENTREZGENE
  ENSHGLT00100086298 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro Deoxyribonuclease-1_AS UniProtKB/TrEMBL
  DNase_I UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
KEGG Report hgl:101715680 UniProtKB/TrEMBL
NCBI Gene Dnase1l3 ENTREZGENE
PANTHER DEOXYRIBONUCLEASE UniProtKB/TrEMBL
  DEOXYRIBONUCLEASE GAMMA UniProtKB/TrEMBL
Pfam Exo_endo_phos UniProtKB/TrEMBL
PIRSF DNase_I_euk UniProtKB/TrEMBL
PRINTS DNASEI UniProtKB/TrEMBL
PROSITE DNASE_I_1 UniProtKB/TrEMBL
  DNASE_I_2 UniProtKB/TrEMBL
SMART DNaseIc UniProtKB/TrEMBL
Superfamily-SCOP SSF56219 UniProtKB/TrEMBL
UniProt G5BMH2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-19 Dnase1l3  deoxyribonuclease 1L3  Dnase1l3  deoxyribonuclease 1 like 3  Symbol and/or name change 5135510 APPROVED