Hamp (hepcidin antimicrobial peptide) - Rat Genome Database

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Gene: Hamp (hepcidin antimicrobial peptide) Heterocephalus glaber
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Symbol: Hamp
Name: hepcidin antimicrobial peptide
RGD ID: 18907583
Description: ENCODES a protein that exhibits copper ion binding (ortholog); iron ion transmembrane transporter inhibitor activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN acute-phase response (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholog); PARTICIPATES IN iron efflux pathway; ASSOCIATED WITH Alcoholic Liver Diseases (ortholog); anemia (ortholog); atransferrinemia (ortholog); FOUND IN apical cortex (ortholog); extracellular space (ortholog); intercalated disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Hepcidin; hepcidin preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,257,760 - 8,259,264 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,257,760 - 8,259,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to bile acid  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
defense response to bacterium  (IEA,ISO)
defense response to fungus  (ISO)
establishment of localization in cell  (ISO)
inflammatory response  (ISO)
inorganic ion homeostasis  (IEA)
intracellular iron ion homeostasis  (IEA,ISO)
iron ion transmembrane transport  (ISO)
liver regeneration  (ISO)
macrophage activation  (ISO)
monoatomic cation homeostasis  (IEA)
multicellular organismal-level iron ion homeostasis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of bone resorption  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of intestinal absorption  (ISO)
negative regulation of iron export across plasma membrane  (ISO)
negative regulation of iron ion transmembrane transport  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein polyubiquitination  (ISO)
positive regulation of receptor catabolic process  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein catabolic process  (ISO)
response to erythropoietin  (ISO)
response to ethanol  (ISO)
response to iron ion  (ISO)
response to iron ion starvation  (ISO)
response to vitamin A  (ISO)
response to zinc ion  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:26763976   PMID:30032202  


Genomics

Comparative Map Data
Hamp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247948,257,760 - 8,259,264 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247948,257,760 - 8,259,243 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HAMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,282,528 - 35,285,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,280,716 - 35,285,143 (+)EnsemblGRCh38hg38GRCh38
GRCh371935,773,431 - 35,776,046 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,465,250 - 40,467,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 341940,465,249 - 40,467,883NCBI
Celera1932,486,848 - 32,489,484 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,282,038 - 32,284,542 (+)NCBIHuRef
CHM1_11935,775,030 - 35,777,667 (+)NCBICHM1_1
T2T-CHM13v2.01937,827,196 - 37,829,811 (+)NCBIT2T-CHM13v2.0
Hamp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,641,793 - 30,643,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,641,793 - 30,643,457 (-)EnsemblGRCm39 Ensembl
GRCm38730,942,368 - 30,944,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,942,368 - 30,944,032 (-)EnsemblGRCm38mm10GRCm38
MGSCv37731,727,387 - 31,729,036 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,651,128 - 30,652,777 (-)NCBIMGSCv36mm8
Celera725,508,433 - 25,510,082 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map719.27NCBI
Hamp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8195,298,332 - 95,300,271 (-)NCBIGRCr8
mRatBN7.2186,170,926 - 86,172,865 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,170,901 - 86,172,891 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,591,061 - 91,592,997 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01100,057,225 - 100,059,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0193,349,359 - 93,351,295 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,368,021 - 89,369,960 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,368,021 - 89,369,960 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,523,506 - 90,525,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,978,120 - 85,980,059 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,056,230 - 86,058,170 (-)NCBI
Celera180,539,771 - 80,541,710 (-)NCBICelera
Cytogenetic Map1q21NCBI
Hamp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554684,575,510 - 4,577,649 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554684,576,080 - 4,577,591 (+)NCBIChiLan1.0ChiLan1.0
HAMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,294,878 - 41,297,684 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,278,243 - 43,281,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,228,701 - 32,231,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11940,964,445 - 40,968,861 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1940,964,445 - 40,968,861 (+)Ensemblpanpan1.1panPan2
HAMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11117,305,531 - 117,306,587 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1117,305,411 - 117,306,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,708,503 - 116,709,559 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,905,446 - 117,906,502 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,905,326 - 117,906,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,468,198 - 117,469,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01117,094,052 - 117,095,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01118,149,597 - 118,150,653 (-)NCBIUU_Cfam_GSD_1.0
Hamp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934910,634,907 - 10,636,644 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365701,009,312 - 1,010,686 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365701,009,344 - 1,010,654 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl644,784,160 - 44,787,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1644,785,863 - 44,787,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,205,859 - 40,207,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAMP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,214,820 - 30,218,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,215,563 - 30,217,996 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660737,989,379 - 7,992,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011391   ⟹   ENSHGLP00000011266
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247948,257,760 - 8,259,264 (-)Ensembl
RefSeq Acc Id: XM_004858837   ⟹   XP_004858894
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247948,257,760 - 8,259,243 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004858894 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AIZ09002 (Get FASTA)   NCBI Sequence Viewer  
  EHB14005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011266
RefSeq Acc Id: XP_004858894   ⟸   XM_004858837
- UniProtKB: G5BXJ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011266   ⟸   ENSHGLT00000011391


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008083 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011391 ENTREZGENE, UniProtKB/TrEMBL
InterPro Hepcidin UniProtKB/TrEMBL
KEGG Report hgl:101700964 UniProtKB/TrEMBL
NCBI Gene Hamp ENTREZGENE
PANTHER HEPCIDIN UniProtKB/TrEMBL
  PTHR16877 UniProtKB/TrEMBL
Pfam Hepcidin UniProtKB/TrEMBL
UniProt G5BXJ4 ENTREZGENE, UniProtKB/TrEMBL