Acly (ATP citrate lyase) - Rat Genome Database

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Gene: Acly (ATP citrate lyase) Heterocephalus glaber
Analyze
Symbol: Acly
Name: ATP citrate lyase
RGD ID: 18914289
Description: ENCODES a protein that exhibits ATP citrate synthase activity (ortholog); INVOLVED IN acetyl-CoA metabolic process (ortholog); citrate metabolic process (ortholog); fatty acid biosynthetic process (ortholog); PARTICIPATES IN fatty acid biosynthetic pathway; ASSOCIATED WITH congestive heart failure (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-citrate synthase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,872,454 - 1,911,004 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,872,413 - 1,910,495 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Acly
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,872,454 - 1,911,004 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,872,413 - 1,910,495 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ACLY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,866,917 - 41,930,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,866,917 - 41,930,542 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,023,170 - 40,075,275 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,276,705 - 37,328,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,276,706 - 37,328,798NCBI
Celera1736,674,340 - 36,725,809 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,785,140 - 35,836,956 (-)NCBIHuRef
CHM1_11740,258,594 - 40,311,000 (-)NCBICHM1_1
T2T-CHM13v2.01742,723,421 - 42,775,531 (-)NCBIT2T-CHM13v2.0
Acly
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,367,178 - 100,418,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,367,179 - 100,418,826 (-)EnsemblGRCm39 Ensembl
GRCm3811100,476,352 - 100,528,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,476,353 - 100,528,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,337,670 - 100,389,215 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,292,446 - 100,343,991 (-)NCBIMGSCv36mm8
Celera11111,095,710 - 111,147,350 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Acly
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,912,402 - 85,964,605 (-)NCBIGRCr8
mRatBN7.21085,412,045 - 85,464,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,448,266 - 90,499,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,927,528 - 89,978,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,320,315 - 85,371,541 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,392,248 - 88,442,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,185,495 - 88,237,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,420,934 - 89,471,398 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,435,312 - 89,485,719 (-)NCBI
Celera1084,129,399 - 84,179,946 (-)NCBICelera
Cytogenetic Map10q31NCBI
Acly
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,058,727 - 16,092,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,058,916 - 16,091,831 (-)NCBIChiLan1.0ChiLan1.0
ACLY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,053,400 - 23,115,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,943,541 - 25,005,482 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,385,335 - 15,447,269 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,615,957 - 15,665,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,615,994 - 15,664,800 (+)Ensemblpanpan1.1panPan2
ACLY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,929,530 - 20,974,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,929,614 - 20,973,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,390,153 - 20,434,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,648,350 - 21,693,226 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,648,295 - 21,693,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,433,791 - 20,478,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,700,516 - 20,745,189 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,803,776 - 20,849,064 (+)NCBIUU_Cfam_GSD_1.0
Acly
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,276,950 - 20,317,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,757,985 - 16,798,237 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,758,001 - 16,798,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACLY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,796,749 - 20,841,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,796,678 - 20,841,301 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,082,937 - 21,106,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACLY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,343,175 - 64,392,011 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607735,156,831 - 35,219,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000020076   ⟹   ENSHGLP00000019877
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,872,454 - 1,911,004 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000020077   ⟹   ENSHGLP00000019878
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247951,875,700 - 1,911,004 (+)Ensembl
RefSeq Acc Id: XM_004859371   ⟹   XP_004859428
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,881,077 - 1,910,495 (+)NCBI
RefSeq Acc Id: XM_004859372   ⟹   XP_004859429
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,872,413 - 1,910,495 (+)NCBI
RefSeq Acc Id: XM_004859373   ⟹   XP_004859430
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,881,078 - 1,910,495 (+)NCBI
RefSeq Acc Id: XM_013077680   ⟹   XP_012933134
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247951,875,700 - 1,910,495 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004859428 (Get FASTA)   NCBI Sequence Viewer  
  XP_004859429 (Get FASTA)   NCBI Sequence Viewer  
  XP_004859430 (Get FASTA)   NCBI Sequence Viewer  
  XP_012933134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019877
  ENSHGLP00000019878
  ENSHGLP00100020479
GenBank Protein JAO02456 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004859429   ⟸   XM_004859372
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JY01 (UniProtKB/TrEMBL),   G5B0L4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933134   ⟸   XM_013077680
- Peptide Label: isoform X2
- UniProtKB: G5B0L4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859428   ⟸   XM_004859371
- Peptide Label: isoform X2
- UniProtKB: G5B0L4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004859430   ⟸   XM_004859373
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JY01 (UniProtKB/TrEMBL),   G5B0L4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000019878   ⟸   ENSHGLT00000020077
RefSeq Acc Id: ENSHGLP00000019877   ⟸   ENSHGLT00000020076


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014233 Ensembl, ENTREZGENE
  ENSHGLG00100015087 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000020076 ENTREZGENE
  ENSHGLT00000020077 ENTREZGENE
  ENSHGLT00100020694 UniProtKB/TrEMBL
Gene3D-CATH 1.10.230.10 UniProtKB/TrEMBL
  3.30.470.110 UniProtKB/TrEMBL
  3.40.50.261 UniProtKB/TrEMBL
  Citrate Synthase, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro ATP-citrate_synthase UniProtKB/TrEMBL
  Cit_synth/succinyl-CoA_lig_AS UniProtKB/TrEMBL
  Citrate-bd UniProtKB/TrEMBL
  Citrate_synth-like_lrg_a-sub UniProtKB/TrEMBL
  Citrate_synth-like_sm_a-sub UniProtKB/TrEMBL
  Citrate_synthase UniProtKB/TrEMBL
  Citrate_synthase_sf UniProtKB/TrEMBL
  Citrt_syn/SCS-alpha_CS UniProtKB/TrEMBL
  CoA-bd UniProtKB/TrEMBL
  CoA_ligase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Succ-CoA_synthase_bsu_CS UniProtKB/TrEMBL
  Succinyl-CoA_synth-like UniProtKB/TrEMBL
NCBI Gene Acly ENTREZGENE
PANTHER ATP-CITRATE SYNTHASE UniProtKB/TrEMBL
  ATP-CITRATE SYNTHASE UniProtKB/TrEMBL
Pfam Citrate_bind UniProtKB/TrEMBL
  Citrate_synt UniProtKB/TrEMBL
  CoA_binding UniProtKB/TrEMBL
  Ligase_CoA UniProtKB/TrEMBL
PIRSF ATP_citrt_syn UniProtKB/TrEMBL
PROSITE SUCCINYL_COA_LIG_1 UniProtKB/TrEMBL
  SUCCINYL_COA_LIG_2 UniProtKB/TrEMBL
  SUCCINYL_COA_LIG_3 UniProtKB/TrEMBL
SMART CoA_binding UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
  SSF48256 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF52210 UniProtKB/TrEMBL
UniProt A0A0P6JY01 ENTREZGENE, UniProtKB/TrEMBL
  G5B0L4 ENTREZGENE, UniProtKB/TrEMBL