Cbl (Cbl proto-oncogene) - Rat Genome Database

Name: Cbl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cbl (Cbl proto-oncogene) Heterocephalus glaber

Analyze

Symbol:

Cbl

Name:

Cbl proto-oncogene

RGD ID:

18931090

Description:

ENCODES a protein that exhibits ephrin receptor binding (ortholog); phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); cellular response to nerve growth factor stimulus (ortholog); cellular response to platelet-derived growth factor stimulus (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); B-lymphoblastic leukemia/lymphoma with hyperdiploidy (ortholog); FOUND IN axon (ortholog); cilium (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase CBL

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CBL (Cbl proto-oncogene)	NCBI	Ortholog
Mus musculus (house mouse):	Cbl (Casitas B-lineage lymphoma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cbl (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cbl (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CBL (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CBL (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cbl (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CBL (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CBL (Cbl proto-oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	14,577,515 - 14,667,575 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	14,577,582 - 14,671,816 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

B-lymphoblastic leukemia/lymphoma with hyperdiploidy (ISO)

Carotid Artery Injuries (ISO)

CD3epsilon deficiency (ISO)

Chromosome 11, Partial Trisomy 11q (ISO)

colorectal cancer (ISO)

congenital diaphragmatic hernia (ISO)

congenital disorder of glycosylation Ij (ISO)

congenital myasthenic syndrome 13 (ISO)

congestive heart failure (ISO)

cryptorchidism (ISO)

Developmental Disabilities (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

Dwarfism (ISO)

Experimental Arthritis (ISO)

Experimental Leukemia (ISO)

genetic disease (ISO)

Growth Disorders (ISO)

hematologic cancer (ISO)

Hematologic Neoplasms (ISO)

hepatocellular carcinoma (ISO)

hyperglycemia (ISO)

immunodeficiency 17 (ISO)

immunodeficiency 18 (ISO)

immunodeficiency 19 (ISO)

inflammatory bowel disease 28 (ISO)

isolated microphthalmia 5 (ISO)

juvenile myelomonocytic leukemia (ISO)

long QT syndrome 10 (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

lymphopenia (ISO)

male infertility (ISO)

malignant ovarian germ cell neoplasm (ISO)

microcephaly (ISO)

multiple myeloma (ISO)

myeloid neoplasm (ISO)

Myocardial Reperfusion Injury (ISO)

Neurodevelopmental Disorders (ISO)

Noonan Like Syndrome (ISO)

Noonan syndrome (ISO)

Noonan syndrome 1 (ISO)

Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia (ISO)

osteosarcoma (ISO)

ovarian germ cell cancer (ISO)

Peripheral Nerve Injuries (ISO)

RASopathy (ISO)

rhabdomyosarcoma (ISO)

schizophrenia (ISO)

Stroke (ISO)

transient cerebral ischemia (ISO)

type 1 diabetes mellitus (ISO)

vasculitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IEA)

cellular response to hypoxia (ISO)

cellular response to nerve growth factor stimulus (ISO)

cellular response to platelet-derived growth factor stimulus (ISO)

DNA damage response (ISO)

male gonad development (ISO)

mast cell degranulation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of epidermal growth factor receptor signaling pathway (ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

positive regulation of receptor-mediated endocytosis (ISO)

protein autoubiquitination (ISO)

protein monoubiquitination (ISO)

protein polyubiquitination (ISO)

protein ubiquitination (IEA)

regulation of platelet-derived growth factor receptor-alpha signaling pathway (ISO)

regulation of Rap protein signal transduction (ISO)

regulation of signaling (IEA)

response to activity (ISO)

response to ethanol (ISO)

response to gamma radiation (ISO)

response to starvation (ISO)

response to testosterone (ISO)

signal transduction (IEA)

ubiquitin-dependent endocytosis (ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

axon (ISO)

cilium (ISO)

cytosol (ISO)

flotillin complex (ISO)

focal adhesion (ISO)

Golgi apparatus (ISO)

growth cone (ISO)

membrane raft (IEA)

perinuclear region of cytoplasm (ISO)

plasma membrane (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

ephrin receptor binding (ISO)

metal ion binding (IEA)

phosphatidylinositol 3-kinase regulatory subunit binding (ISO)

phosphotyrosine residue binding (IEA)

protein binding (ISO)

protein kinase binding (ISO)

protein tyrosine kinase binding (ISO)

receptor tyrosine kinase binding (IEA)

SH3 domain binding (IEA,ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IEA,ISO)

ubiquitin-protein transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cbl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	14,577,515 - 14,667,575 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624784	14,577,582 - 14,671,816 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

CBL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	119,206,339 - 119,308,149 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	119,206,298 - 119,313,926 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	119,077,049 - 119,178,859 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	118,582,200 - 118,684,069 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	118,582,199 - 118,684,068	NCBI
Celera	11	116,236,024 - 116,339,059 (+)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	115,017,373 - 115,119,562 (+)	NCBI		HuRef
CHM1_1	11	118,963,252 - 119,065,411 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	119,226,712 - 119,328,785 (+)	NCBI		T2T-CHM13v2.0

Cbl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	44,054,273 - 44,145,556 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	44,054,273 - 44,145,346 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	44,142,976 - 44,234,259 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	44,142,976 - 44,234,049 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	43,957,345 - 44,042,129 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	43,900,257 - 43,985,041 (-)	NCBI		MGSCv36	mm8
Celera	9	41,406,821 - 41,486,735 (-)	NCBI		Celera
Cytogenetic Map	9	A5.1- A5.2	NCBI
cM Map	9	24.72	NCBI

Cbl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	53,384,656 - 53,468,067 (-)	NCBI		GRCr8
mRatBN7.2	8	44,487,824 - 44,571,620 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	44,489,410 - 44,571,176 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	48,481,256 - 48,564,775 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	48,489,036 - 48,564,722 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	47,105,710 - 47,183,347 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	47,135,357 - 47,211,889 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	44,074,668 - 44,158,034 (-)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

Cbl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	20,307,011 - 20,388,539 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	20,307,011 - 20,388,539 (+)	NCBI	ChiLan1.0	ChiLan1.0

CBL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	119,911,371 - 120,015,890 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	121,015,030 - 121,119,390 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	114,044,996 - 114,149,204 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	117,973,187 - 118,076,459 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	117,973,187 - 118,074,671 (+)	Ensembl	panpan1.1		panPan2

CBL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	14,600,409 - 14,676,974 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	14,607,013 - 14,676,956 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	14,653,516 - 14,730,936 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	14,543,644 - 14,621,193 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	14,549,582 - 14,620,322 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	14,681,808 - 14,759,290 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	14,585,944 - 14,663,491 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	14,626,100 - 14,703,693 (-)	NCBI		UU_Cfam_GSD_1.0

Cbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	101,214,875 - 101,314,342 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936542	4,136,511 - 4,228,288 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936542	4,136,389 - 4,235,746 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CBL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	46,416,938 - 46,512,834 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	46,416,937 - 46,512,855 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	51,452,262 - 51,549,181 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CBL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	110,581,049 - 110,679,284 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	110,581,143 - 110,674,481 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	15,352,300 - 15,453,239 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004856793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021237656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01061154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01061155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01061156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000023299 ⟹ ENSHGLP00000023084

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624784	14,577,515 - 14,667,575 (+)	Ensembl

RefSeq Acc Id:

ENSHGLT00000023300 ⟹ ENSHGLP00000023085

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624784	14,577,515 - 14,662,783 (+)	Ensembl

RefSeq Acc Id:

XM_004856793 ⟹ XP_004856850

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624784	14,577,584 - 14,671,816 (+)	NCBI

RefSeq Acc Id:

XM_021237656 ⟹ XP_021093315

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624784	14,577,582 - 14,662,648 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004856850	(Get FASTA)	NCBI Sequence Viewer
	XP_021093315	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000023084
	ENSHGLP00000023085

RefSeq Acc Id:	XP_021093315 ⟸ XM_021237656
- Peptide Label:	isoform X2
- UniProtKB:	G5BHP2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_004856850 ⟸ XM_004856793
- Peptide Label:	isoform X1
- UniProtKB:	G5BHP2 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSHGLP00000023085 ⟸ ENSHGLT00000023300

RefSeq Acc Id:

ENSHGLP00000023084 ⟸ ENSHGLT00000023299

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000016461	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000023299	ENTREZGENE
	ENSHGLT00000023300	ENTREZGENE
Gene3D-CATH	Adaptor protein Cbl, N-terminal domain	UniProtKB/TrEMBL
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	SH2 domain	UniProtKB/TrEMBL
	Zinc/RING finger domain, C3HC4 (zinc finger)	UniProtKB/TrEMBL
InterPro	Adaptor_Cbl	UniProtKB/TrEMBL
	Adaptor_Cbl_EF_hand-like	UniProtKB/TrEMBL
	Adaptor_Cbl_N_dom_sf	UniProtKB/TrEMBL
	Adaptor_Cbl_N_hlx	UniProtKB/TrEMBL
	Adaptor_Cbl_SH2-like	UniProtKB/TrEMBL
	Cbl_PTB	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
	UBA-like_sf	UniProtKB/TrEMBL
	Znf_C3HC4_RING-type	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
NCBI Gene	Cbl	ENTREZGENE
PANTHER	CBL	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE CBL	UniProtKB/TrEMBL
Pfam	Cbl_N	UniProtKB/TrEMBL
	Cbl_N2	UniProtKB/TrEMBL
	Cbl_N3	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
	zf-C3HC4	UniProtKB/TrEMBL
PROSITE	CBL_PTB	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	RING	UniProtKB/TrEMBL
	UBA	UniProtKB/TrEMBL
Superfamily-SCOP	EF-hand	UniProtKB/TrEMBL
	N-terminal domain of cbl (N-cbl)	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
	SH2 domain	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
UniProt	G5BHP2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)