CBL (Cbl proto-oncogene) - Rat Genome Database

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Gene: CBL (Cbl proto-oncogene) Canis lupus familiaris
Analyze
Symbol: CBL
Name: Cbl proto-oncogene
RGD ID: 12220334
Description: ENCODES a protein that exhibits ephrin receptor binding (ortholog); phosphatidylinositol 3-kinase regulatory subunit binding (ortholog); protein kinase binding (ortholog); INVOLVED IN cellular response to DNA damage stimulus (ortholog); cellular response to nerve growth factor stimulus (ortholog); cellular response to oxygen-glucose deprivation (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); B-lymphoblastic leukemia/lymphoma with hyperdiploidy (ortholog); FOUND IN axon (ortholog); cilium (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cas-Br-M (murine) ecotropic retroviral transforming sequence; E3 ubiquitin-protein ligase CBL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,600,409 - 14,676,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,607,013 - 14,676,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,653,516 - 14,730,936 (-)NCBI
ROS_Cfam_1.0514,543,644 - 14,621,193 (-)NCBI
ROS_Cfam_1.0 Ensembl514,549,582 - 14,620,322 (-)Ensembl
UMICH_Zoey_3.1514,681,808 - 14,759,290 (-)NCBI
UNSW_CanFamBas_1.0514,585,944 - 14,663,491 (-)NCBI
UU_Cfam_GSD_1.0514,626,100 - 14,703,693 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
CBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,600,409 - 14,676,974 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,607,013 - 14,676,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha514,653,516 - 14,730,936 (-)NCBI
ROS_Cfam_1.0514,543,644 - 14,621,193 (-)NCBI
ROS_Cfam_1.0 Ensembl514,549,582 - 14,620,322 (-)Ensembl
UMICH_Zoey_3.1514,681,808 - 14,759,290 (-)NCBI
UNSW_CanFamBas_1.0514,585,944 - 14,663,491 (-)NCBI
UU_Cfam_GSD_1.0514,626,100 - 14,703,693 (-)NCBI
CBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,206,339 - 119,308,149 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11119,206,298 - 119,313,926 (+)EnsemblGRCh38hg38GRCh38
GRCh3711119,077,049 - 119,178,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,582,200 - 118,684,069 (+)NCBINCBI36hg18NCBI36
Build 3411118,582,199 - 118,684,068NCBI
Celera11116,236,024 - 116,339,059 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11115,017,373 - 115,119,562 (+)NCBIHuRef
CHM1_111118,963,252 - 119,065,411 (+)NCBICHM1_1
T2T-CHM13v2.011119,226,712 - 119,328,785 (+)NCBI
Cbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,054,273 - 44,145,556 (-)NCBIGRCm39mm39
GRCm39 Ensembl944,054,273 - 44,145,346 (-)Ensembl
GRCm38944,142,976 - 44,234,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,142,976 - 44,234,049 (-)EnsemblGRCm38mm10GRCm38
MGSCv37943,957,345 - 44,042,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv36943,900,257 - 43,985,041 (-)NCBImm8
Celera941,406,821 - 41,486,735 (-)NCBICelera
Cytogenetic Map9A5.1- A5.2NCBI
cM Map924.72NCBI
Cbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2844,487,824 - 44,571,620 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl844,489,410 - 44,571,176 (-)Ensembl
Rnor_6.0848,481,256 - 48,564,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,489,036 - 48,564,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,105,710 - 47,183,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,135,357 - 47,211,889 (-)NCBIRGSC3.4rn4RGSC3.4
Celera844,074,668 - 44,158,034 (-)NCBICelera
Cytogenetic Map8q22NCBI
Cbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,307,011 - 20,388,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,307,011 - 20,388,539 (+)NCBIChiLan1.0ChiLan1.0
CBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111117,973,187 - 118,076,459 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11117,973,187 - 118,074,671 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011114,044,996 - 114,149,204 (+)NCBIMhudiblu_PPA_v0panPan3
Cbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,214,875 - 101,314,342 (+)NCBI
SpeTri2.0NW_0049365424,136,389 - 4,235,746 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,404,999 - 46,512,834 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,416,937 - 46,512,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,452,262 - 51,549,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,581,049 - 110,679,284 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,581,143 - 110,674,481 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604315,352,300 - 15,453,239 (-)NCBIVero_WHO_p1.0
Cbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,577,515 - 14,667,575 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462478414,577,582 - 14,671,816 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 5 4 5 8 6 3
Low 5 5 16 6 1 6 2 6 7 4 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038474778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038474780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038535925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038600118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038600119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038600120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038664656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038664657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038664658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000019218   ⟹   ENSCAFP00000017824
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,676,908 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062927   ⟹   ENSCAFP00000048102
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,658,527 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063744   ⟹   ENSCAFP00000054189
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,658,539 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000078750   ⟹   ENSCAFP00000050698
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,676,908 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000087876   ⟹   ENSCAFP00000060853
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,676,956 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000092192   ⟹   ENSCAFP00000046273
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl514,607,013 - 14,658,536 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845000345   ⟹   ENSCAFP00845000244
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl514,549,582 - 14,620,322 (-)Ensembl
RefSeq Acc Id: XM_038474778   ⟹   XP_038330706
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1514,681,808 - 14,759,290 (-)NCBI
RefSeq Acc Id: XM_038474779   ⟹   XP_038330707
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1514,681,808 - 14,758,204 (-)NCBI
RefSeq Acc Id: XM_038474780   ⟹   XP_038330708
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1514,681,808 - 14,758,313 (-)NCBI
RefSeq Acc Id: XM_038508307   ⟹   XP_038364235
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha514,653,516 - 14,729,850 (-)NCBI
RefSeq Acc Id: XM_038508308   ⟹   XP_038364236
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha514,653,516 - 14,729,959 (-)NCBI
RefSeq Acc Id: XM_038535923   ⟹   XP_038391851
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0514,626,100 - 14,703,693 (-)NCBI
RefSeq Acc Id: XM_038535924   ⟹   XP_038391852
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0514,626,100 - 14,702,606 (-)NCBI
RefSeq Acc Id: XM_038535925   ⟹   XP_038391853
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0514,626,100 - 14,702,715 (-)NCBI
RefSeq Acc Id: XM_038600118   ⟹   XP_038456046
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0514,585,944 - 14,663,491 (-)NCBI
RefSeq Acc Id: XM_038600119   ⟹   XP_038456047
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0514,585,944 - 14,662,405 (-)NCBI
RefSeq Acc Id: XM_038600120   ⟹   XP_038456048
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0514,585,944 - 14,662,514 (-)NCBI
RefSeq Acc Id: XM_038664656   ⟹   XP_038520584
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0514,543,644 - 14,621,193 (-)NCBI
RefSeq Acc Id: XM_038664657   ⟹   XP_038520585
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0514,543,644 - 14,620,107 (-)NCBI
RefSeq Acc Id: XM_038664658   ⟹   XP_038520586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0514,543,644 - 14,620,216 (-)NCBI
RefSeq Acc Id: XM_546487   ⟹   XP_546487
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1514,600,409 - 14,676,974 (-)NCBI
Dog10K_Boxer_Tasha514,653,516 - 14,730,936 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_546487   ⟸   XM_546487
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000050698   ⟸   ENSCAFT00000078750
RefSeq Acc Id: ENSCAFP00000060853   ⟸   ENSCAFT00000087876
RefSeq Acc Id: ENSCAFP00000054189   ⟸   ENSCAFT00000063744
RefSeq Acc Id: ENSCAFP00000017824   ⟸   ENSCAFT00000019218
RefSeq Acc Id: ENSCAFP00000048102   ⟸   ENSCAFT00000062927
RefSeq Acc Id: ENSCAFP00000046273   ⟸   ENSCAFT00000092192
RefSeq Acc Id: XP_038330706   ⟸   XM_038474778
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038330708   ⟸   XM_038474780
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038330707   ⟸   XM_038474779
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038456046   ⟸   XM_038600118
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038456048   ⟸   XM_038600120
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038456047   ⟸   XM_038600119
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038520584   ⟸   XM_038664656
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038520586   ⟸   XM_038664658
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038520585   ⟸   XM_038664657
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038364236   ⟸   XM_038508308
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038364235   ⟸   XM_038508307
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038391851   ⟸   XM_038535923
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038391853   ⟸   XM_038535925
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038391852   ⟸   XM_038535924
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845000244   ⟸   ENSCAFT00845000345
Protein Domains
Cbl-PTB   RING-type   UBA

Promoters
RGD ID:13683119
Promoter ID:EPDNEW_C1188
Type:single initiation site
Name:CBL_1
Description:Cbl proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1514,676,973 - 14,677,033EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012100 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845000222 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000017824 UniProtKB/TrEMBL
  ENSCAFP00000046273 UniProtKB/TrEMBL
  ENSCAFP00000048102 UniProtKB/TrEMBL
  ENSCAFP00000050698 UniProtKB/TrEMBL
  ENSCAFP00000054189 UniProtKB/TrEMBL
  ENSCAFP00000060853 UniProtKB/TrEMBL
  ENSCAFP00845000244 ENTREZGENE
Ensembl Transcript ENSCAFT00000019218 UniProtKB/TrEMBL
  ENSCAFT00000062927 UniProtKB/TrEMBL
  ENSCAFT00000063744 UniProtKB/TrEMBL
  ENSCAFT00000078750 UniProtKB/TrEMBL
  ENSCAFT00000087876 UniProtKB/TrEMBL
  ENSCAFT00000092192 UniProtKB/TrEMBL
  ENSCAFT00845000345 ENTREZGENE
Gene3D-CATH 1.20.930.20 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Adaptor_Cbl UniProtKB/TrEMBL
  Adaptor_Cbl_EF_hand-like UniProtKB/TrEMBL
  Adaptor_Cbl_N_dom_sf UniProtKB/TrEMBL
  Adaptor_Cbl_N_hlx UniProtKB/TrEMBL
  Adaptor_Cbl_SH2-like UniProtKB/TrEMBL
  CBL-B_RING-HC UniProtKB/TrEMBL
  Cbl_PTB UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene CBL ENTREZGENE
PANTHER PTHR23007 UniProtKB/TrEMBL
Pfam Cbl_N UniProtKB/TrEMBL
  Cbl_N2 UniProtKB/TrEMBL
  Cbl_N3 UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
PROSITE CBL_PTB UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF47668 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A5F4BWJ2_CANLF UniProtKB/TrEMBL
  A0A5F4C1S8_CANLF UniProtKB/TrEMBL
  A0A5F4CCU1_CANLF UniProtKB/TrEMBL
  A0A5F4CN18_CANLF UniProtKB/TrEMBL
  A0A5F4D2X8_CANLF UniProtKB/TrEMBL
  F1P861_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38758 ENTREZGENE