Recql4 (RecQ like helicase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Recql4 (RecQ like helicase 4) Heterocephalus glaber
Analyze
Symbol: Recql4
Name: RecQ like helicase 4
RGD ID: 18918345
Description: ENCODES a protein that exhibits 3'-5' DNA helicase activity (ortholog); bubble DNA binding (ortholog); DNA/DNA annealing activity (ortholog); INVOLVED IN DNA duplex unwinding (ortholog); negative regulation of sister chromatid cohesion (ortholog); pigmentation (ortholog); ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1 (ortholog); Baller-Gerold syndrome (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-dependent DNA helicase Q4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,345,844 - 12,351,637 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,345,326 - 12,351,783 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Recql4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,345,844 - 12,351,637 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,345,326 - 12,351,783 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RECQL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,511,288 - 144,517,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,511,288 - 144,517,845 (-)EnsemblGRCh38hg38GRCh38
GRCh378145,736,671 - 145,743,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,707,479 - 145,714,008 (-)NCBINCBI36Build 36hg18NCBI36
Build 348145,707,621 - 145,713,976NCBI
Celera8141,912,140 - 141,918,890 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,849,825 - 140,856,695 (-)NCBIHuRef
CHM1_18145,774,859 - 145,781,399 (-)NCBICHM1_1
T2T-CHM13v2.08145,681,054 - 145,688,017 (-)NCBIT2T-CHM13v2.0
Recql4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,587,753 - 76,594,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,587,753 - 76,594,748 (-)EnsemblGRCm39 Ensembl
GRCm381576,703,553 - 76,710,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,703,553 - 76,710,548 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,534,171 - 76,540,906 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,530,996 - 76,537,731 (-)NCBIMGSCv36mm8
Celera1578,197,351 - 78,204,086 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.28NCBI
Recql4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,304,092 - 110,311,426 (-)NCBIGRCr8
mRatBN7.27108,423,453 - 108,430,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,423,455 - 108,430,619 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7110,165,377 - 110,172,538 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,388,951 - 112,396,112 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,349,701 - 112,356,865 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,765,892 - 117,773,128 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,763,783 - 117,773,134 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,753,871 - 117,761,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,752,863 - 114,760,027 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,787,094 - 114,794,223 (-)NCBI
Celera7104,773,347 - 104,780,504 (-)NCBICelera
Cytogenetic Map7q34NCBI
Recql4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554543,136,216 - 3,142,422 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554543,136,097 - 3,142,525 (-)NCBIChiLan1.0ChiLan1.0
RECQL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27162,002,577 - 162,011,841 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,531,815 - 137,541,127 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl8144,267,101 - 144,276,985 (-)Ensemblpanpan1.1panPan2
RECQL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,930,906 - 37,936,653 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,930,621 - 37,936,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,891,440 - 37,897,555 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,404,421 - 38,410,540 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,404,634 - 38,410,081 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,096,373 - 38,102,486 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,204,789 - 38,210,471 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,681,262 - 38,687,377 (-)NCBIUU_Cfam_GSD_1.0
Recql4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303329,124 - 335,703 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364707,755,253 - 7,761,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RECQL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4287,214 - 293,913 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14287,206 - 293,629 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24378,111 - 384,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RECQL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,725,494 - 138,732,286 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,725,633 - 138,732,096 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,122,625 - 1,129,469 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000022544   ⟹   ENSHGLP00000022333
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473512,345,844 - 12,351,637 (+)Ensembl
RefSeq Acc Id: XM_004837684   ⟹   XP_004837741
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473512,345,328 - 12,351,783 (+)NCBI
RefSeq Acc Id: XM_021250063   ⟹   XP_021105722
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473512,345,327 - 12,351,711 (+)NCBI
RefSeq Acc Id: XM_021250069   ⟹   XP_021105728
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473512,345,328 - 12,351,783 (+)NCBI
RefSeq Acc Id: XR_002391555
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473512,345,326 - 12,351,135 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004837741 (Get FASTA)   NCBI Sequence Viewer  
  XP_021105722 (Get FASTA)   NCBI Sequence Viewer  
  XP_021105728 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB16877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022333
Reference Protein Sequences
RefSeq Acc Id: XP_021105722   ⟸   XM_021250063
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004837741   ⟸   XM_004837684
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021105728   ⟸   XM_021250069
- Peptide Label: isoform X3
- UniProtKB: G5C5R6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000022333   ⟸   ENSHGLT00000022544


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015925 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022544 ENTREZGENE
Gene3D-CATH 1.10.10.1460 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  Zinc finger, CCHC-type UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_RecQ UniProtKB/TrEMBL
  DNA_rep_checkpnt_protein UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Znf_CCHC UniProtKB/TrEMBL
  Znf_CCHC_sf UniProtKB/TrEMBL
NCBI Gene Recql4 ENTREZGENE
PANTHER ATP-DEPENDENT DNA HELICASE Q4 UniProtKB/TrEMBL
  DNA HELICASE RECQ FAMILY MEMBER UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  Drc1-Sld2 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  zf-CCHC UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
  ZF_CCHC UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
  ZnF_C2HC UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  SSF57756 UniProtKB/TrEMBL
UniProt G5C5R6 ENTREZGENE, UniProtKB/TrEMBL