Grp (gastrin releasing peptide) - Rat Genome Database

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Gene: Grp (gastrin releasing peptide) Heterocephalus glaber
Analyze
Symbol: Grp
Name: gastrin releasing peptide
RGD ID: 18923939
Description: ENCODES a protein that exhibits neuropeptide hormone activity (inferred); INVOLVED IN cellular response to sodium phosphate (ortholog); negative regulation of voltage-gated potassium channel activity (ortholog); negative regulation of voltage-gated sodium channel activity (ortholog); ASSOCIATED WITH amnestic disorder (ortholog); Aortic Calcification (ortholog); cerebrovascular disease (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); neuron projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gastrin-releasing peptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,623,097 - 4,633,570 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247924,623,082 - 4,633,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-RatAortic Calcification treatmentISOGrp (Mus musculus)9068941associated with chronic kidney diseaseRGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratcerebrovascular disease  ISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratchronic kidney disease  ISOGrp (Rattus norvegicus)9068941mRNA more ...RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratcolorectal cancer  ISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratcongestive heart failure  ISOGRP (Homo sapiens)9068941protein:decreased expression:plasma (human)RGDPMID:1396815 and REF_RGD_ID:401700398
GrpNaked Mole-Ratcongestive heart failure exacerbatesISOGRP (Homo sapiens)9068941protein:increased expression:plasma (human)RGDPMID:30145817 and REF_RGD_ID:329961562
GrpNaked Mole-Ratkidney failure  ISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratlung non-small cell carcinoma disease_progressionISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratlung small cell carcinoma disease_progressionISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratpneumonia  ISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
GrpNaked Mole-Ratprostate cancer  ISOGRP (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:30146822 and REF_RGD_ID:401700396
1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-Ratimmunodeficiency 12  ISOGRP (Homo sapiens)8554872ClinVar Annotator: match by term: Combined immunodeficiency due to MALT1 deficiencyClinVarPMID:28492532
GrpNaked Mole-Ratisolated microphthalmia 3  ISOGRP (Homo sapiens)8554872ClinVar Annotator: match by term: Isolated microphthalmia 3ClinVarPMID:14662654 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-Ratamnestic disorder  ISOGRP (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:11564462
GrpNaked Mole-RatExperimental Liver Neoplasms  ISOGRP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:2910524
GrpNaked Mole-RatHead and Neck Neoplasms  ISOGRP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15342401
GrpNaked Mole-RatPruritus  ISOGRP (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29669290


Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-Ratcellular response to sodium phosphate  ISOGrp (Rattus norvegicus)9068941 RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratmast cell degranulation involved_inIEAUniProtKB-KW:KW-0467150520179 UniProtGO_REF:0000043
GrpNaked Mole-Ratnegative regulation of voltage-gated potassium channel activity involved_inISOGrp (Rattus norvegicus)9068941PMID:33059246UniProtPMID:33059246 and REF_RGD_ID:151356648
GrpNaked Mole-Ratnegative regulation of voltage-gated sodium channel activity involved_inISOGrp (Rattus norvegicus)9068941PMID:33059246UniProtPMID:33059246 and REF_RGD_ID:151356648
GrpNaked Mole-Ratneuropeptide signaling pathway involved_inIEAPANTHER:PTN000423941150520179 TreeGrafterGO_REF:0000118
GrpNaked Mole-Ratneuropeptide signaling pathway involved_inIEAInterPro:IPR000874150520179 InterProGO_REF:0000002
GrpNaked Mole-Ratneuropeptide signaling pathway acts_upstream_of_or_withinISOGRP (Homo sapiens)9068941 PMID:8756537MGIPMID:8756537
GrpNaked Mole-Ratneuropeptide signaling pathway  ISOGrp (Rattus norvegicus)9068941 RGDPMID:12419521 and REF_RGD_ID:728702
GrpNaked Mole-Ratossification  ISOGrp (Rattus norvegicus)9068941 RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratpositive regulation of behavioral fear response involved_inISOGrp (Mus musculus)9068941 PMID:34610277UniProtPMID:34610277
GrpNaked Mole-Ratpositive regulation of peptide hormone secretion involved_inISOGRP (Sus scrofa)9068941 PMID:496973UniProtPMID:496973
GrpNaked Mole-Ratpositive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway involved_inISOGrp (Mus musculus)9068941 PMID:26658875UniProtPMID:26658875
GrpNaked Mole-Ratpositive regulation of respiratory gaseous exchange involved_inISOGrp (Mus musculus)9068941 PMID:26855425UniProtPMID:26855425
GrpNaked Mole-Ratpositive regulation of vascular associated smooth muscle cell apoptotic process  ISOGrp (Rattus norvegicus)9068941 RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratpsychomotor behavior involved_inISOGrp (Mus musculus)9068941 PMID:28280205UniProtPMID:28280205
GrpNaked Mole-Ratregulation of gene expression  ISOGrp (Rattus norvegicus)9068941Runx2 and Cnn1RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratresponse to external biotic stimulus involved_inISOGrp (Mus musculus)9068941 PMID:28280205UniProtPMID:28280205
GrpNaked Mole-Ratsocial behavior involved_inISOGrp (Mus musculus)9068941 PMID:28280205UniProtPMID:28280205
1 to 18 of 18 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-0968150520179 UniProtGO_REF:0000043
GrpNaked Mole-Ratextracellular region  ISOGrp (Rattus norvegicus)9068941 RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
GrpNaked Mole-Ratextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
GrpNaked Mole-Ratextracellular space located_inIEAPANTHER:PTN000423941150520179 TreeGrafterGO_REF:0000118
GrpNaked Mole-Ratextracellular space  ISOGrp (Rattus norvegicus)9068941 RGDPMID:32192106 and REF_RGD_ID:329961569
GrpNaked Mole-Ratneuron projection located_inISOGrp (Mus musculus)9068941 PMID:26855425UniProtPMID:26855425
GrpNaked Mole-Ratneuronal dense core vesicle is_active_inISOGrp (Rattus norvegicus)9068941PMID:2422591SynGOPMID:2422591 and REF_RGD_ID:155230719

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GrpNaked Mole-Ratneuropeptide hormone activity enablesIEAPANTHER:PTN000423941150520179 TreeGrafterGO_REF:0000118
GrpNaked Mole-Ratprotein binding enablesISOUniProtKB:Q156999068941 PMID:32296183IntActPMID:32296183

PMID:22301074   PMID:30032202  



Grp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247924,623,097 - 4,633,570 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247924,623,082 - 4,633,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
GRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,219,189 - 59,230,771 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,220,158 - 59,230,774 (+)EnsemblGRCh38hg38GRCh38
GRCh371856,887,390 - 56,898,003 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,038,380 - 55,048,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 341855,038,379 - 55,048,980NCBI
Celera1853,605,282 - 53,615,885 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1853,595,537 - 53,606,136 (+)NCBIHuRef
CHM1_11856,882,622 - 56,893,227 (+)NCBICHM1_1
T2T-CHM13v2.01859,420,451 - 59,432,025 (+)NCBIT2T-CHM13v2.0
Grp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,005,826 - 66,019,670 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,005,891 - 66,019,667 (+)EnsemblGRCm39 Ensembl
GRCm381865,872,751 - 65,886,599 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1865,872,820 - 65,886,596 (+)EnsemblGRCm38mm10GRCm38
MGSCv371866,033,148 - 66,046,233 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361865,998,863 - 66,011,948 (+)NCBIMGSCv36mm8
Celera1867,148,374 - 67,161,630 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1838.98NCBI
Grp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81861,658,655 - 61,672,037 (+)NCBIGRCr8
mRatBN7.21859,388,679 - 59,402,061 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,388,274 - 59,402,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1861,481,572 - 61,495,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,180,256 - 62,193,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,008,373 - 60,021,747 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01861,563,458 - 61,576,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1861,563,053 - 61,576,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01860,759,485 - 60,772,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,162,526 - 62,176,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,236,136 - 62,249,529 (+)NCBI
Celera1857,511,148 - 57,523,903 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Grp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540243,382,552 - 43,393,463 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540243,382,608 - 43,393,452 (+)NCBIChiLan1.0ChiLan1.0
GRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21776,763,081 - 76,776,923 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11862,455,695 - 62,469,561 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01852,614,169 - 52,626,427 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11855,941,405 - 55,953,188 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1855,942,263 - 55,953,188 (+)Ensemblpanpan1.1panPan2
GRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,974,818 - 16,987,578 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,975,113 - 16,987,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,949,830 - 17,962,541 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,851,713 - 16,864,426 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,851,715 - 16,864,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,887,063 - 16,899,774 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,807,873 - 16,820,608 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0117,069,404 - 17,082,115 (-)NCBIUU_Cfam_GSD_1.0
Grp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494430,237,465 - 30,248,354 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364975,476,800 - 5,487,358 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364975,473,293 - 5,487,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,708,812 - 161,721,782 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11161,708,815 - 161,721,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21179,286,730 - 179,292,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11820,496,201 - 20,508,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1820,496,516 - 20,507,153 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660605,077,640 - 5,091,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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RefSeq Transcripts XM_004858422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021239286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01066008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000003462   ⟹   ENSHGLP00000003407
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247924,623,097 - 4,633,570 (+)Ensembl
RefSeq Acc Id: XM_004858422   ⟹   XP_004858479
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247924,623,082 - 4,633,545 (+)NCBI
RefSeq Acc Id: XM_021239286   ⟹   XP_021094945
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247924,623,082 - 4,633,545 (+)NCBI
Protein RefSeqs XP_004858479 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094945 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000003407
RefSeq Acc Id: XP_021094945   ⟸   XM_021239286
- Peptide Label: isoform X1
- UniProtKB: G5AYY6 (UniProtKB/TrEMBL),   A0AAX6RHW0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004858479   ⟸   XM_004858422
- Peptide Label: isoform X2
- UniProtKB: G5AYY6 (UniProtKB/TrEMBL),   A0AAX6PS28 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000003407   ⟸   ENSHGLT00000003462



1 to 11 of 11 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000002520 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003462 ENTREZGENE
InterPro Bombesin UniProtKB/TrEMBL
NCBI Gene Grp ENTREZGENE
PANTHER GASTRIN-RELEASING PEPTIDE UniProtKB/TrEMBL
  GASTRIN-RELEASING PEPTIDE UniProtKB/TrEMBL
Pfam Bombesin UniProtKB/TrEMBL
PROSITE BOMBESIN UniProtKB/TrEMBL
UniProt A0AAX6PS28 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RHW0 ENTREZGENE, UniProtKB/TrEMBL
  G5AYY6 ENTREZGENE, UniProtKB/TrEMBL
1 to 11 of 11 rows