RGD Reference Report - Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification. - Rat Genome Database

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Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification.

Authors: Park, Hyun-Joo  Kim, Yeon  Kim, Mi-Kyoung  Hwang, Jae Joon  Kim, Hyung Joon  Bae, Soo-Kyung  Bae, Moon-Kyoung 
Citation: Park HJ, etal., Cells. 2020 Mar 17;9(3):737. doi: 10.3390/cells9030737.
RGD ID: 329961569
Pubmed: PMID:32192106   (View Abstract at PubMed)
PMCID: PMC7140688   (View Article at PubMed Central)
DOI: DOI:10.3390/cells9030737   (Journal Full-text)

Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle cells (VSMCs). This attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in VSMCs. Moreover, the treatment with RC-3095 effectively ameliorated phosphate-induced calcium deposition in rat aortas ex vivo and aortas of chronic kidney disease in mice in vivo. Therefore, the regulation of the GRP-GRP receptor axis may be a potential strategy for treatment of diseases associated with excessive vascular calcification.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRPHumanAortic Calcification treatmentISOGrp (Mus musculus)associated with chronic kidney diseaseRGD 
GrpRatAortic Calcification treatmentISOGrp (Mus musculus)associated with chronic kidney diseaseRGD 
GrpMouseAortic Calcification treatmentIEP associated with chronic kidney diseaseRGD 
GRPHumanchronic kidney disease  ISOGrp (Rattus norvegicus)mRNA more ...RGD 
GrpRatchronic kidney disease  IEP mRNA more ...RGD 
GrpMousechronic kidney disease  ISOGrp (Rattus norvegicus)mRNA more ...RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRPHumanadenine increases expression ISOGrp (Rattus norvegicus)Adenine increases expression of Grp mRNA in the aortaRGD 
GrpRatadenine increases expression EXP Adenine increases expression of Grp mRNA in the aortaRGD 
GrpMouseadenine increases expression ISOGrp (Rattus norvegicus)Adenine increases expression of Grp mRNA in the aortaRGD 
GRPHumanphosphate(3-) increases expression ISOGrp (Rattus norvegicus)Inorganic phosphate increases expression of Grp mRNA and protein in vascular smooth muscle cellsRGD 
GrpRatphosphate(3-) increases expression EXP Inorganic phosphate increases expression of Grp mRNA and protein in vascular smooth muscle cellsRGD 
GrpMousephosphate(3-) increases expression ISOGrp (Rattus norvegicus)Inorganic phosphate increases expression of Grp mRNA and protein in vascular smooth muscle cellsRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GrpRatcellular response to sodium phosphate  IEP  RGD 
GrpRatossification  IMP  RGD 
GrpRatpositive regulation of vascular associated smooth muscle cell apoptotic process  IMP  RGD 
GrpRatregulation of gene expression  IMP Runx2 and Cnn1RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GrpRatextracellular region  IDA  RGD 
GrpRatextracellular space  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grp  (gastrin releasing peptide)

Genes (Mus musculus)
Grp  (gastrin releasing peptide)

Genes (Homo sapiens)
GRP  (gastrin releasing peptide)


Additional Information