|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Benzophenones inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:18324785 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity |
EXP |
Benzophenones results in increased activity of ESR1 protein |
CTD |
PMID:12504345 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases expression |
ISO |
Benzophenones results in decreased expression of NQO1 mRNA; Benzophenones results in decreased expression of NQO1 protein |
CTD |
PMID:22021338 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein] |
CTD |
PMID:32407875 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
dioxybenzone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
dioxybenzone binds to and results in increased activity of ESR1 protein |
CTD |
PMID:16079615 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
dioxybenzone binds to and results in increased activity of ESR2 protein |
CTD |
PMID:16079615 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] |
CTD |
PMID:32407875 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
dioxybenzone results in increased expression of HMGCR mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
dioxybenzone results in increased expression of HMGCS1 mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases activity |
ISO |
dioxybenzone results in decreased activity of HSD3B1 protein |
CTD |
PMID:37217011 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] |
CTD |
PMID:32407875 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
dioxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] |
CTD |
PMID:32407875 |
|
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
dioxybenzone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression |
ISO |
dioxybenzone results in increased expression of PPARA mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression multiple interactions affects binding |
ISO |
dioxybenzone results in increased expression of PPARG mRNA dioxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; dioxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] dioxybenzone binds to PPARG protein |
CTD |
PMID:32407875 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
dioxybenzone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
|
G |
Ar |
androgen receptor |
affects binding multiple interactions |
EXP ISO |
2,4-dihydroxybenzophenone binds to AR protein 2,4-dihydroxybenzophenone analog binds to and results in decreased activity of AR protein; 2,4-dihydroxybenzophenone binds to and results in decreased activity of AR protein |
CTD |
PMID:14565775 PMID:33684284 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in increased expression of CCND1 mRNA; 2,4-dihydroxybenzophenone results in increased expression of CCND1 protein fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 mRNA]; fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CCND1 protein] |
CTD |
PMID:23328252 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cdh1 |
cadherin 1 |
decreases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in decreased expression of CDH1 protein] |
CTD |
PMID:27145024 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G |
Cdh2 |
cadherin 2 |
increases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in increased expression of CDH2 protein fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of CDH2 protein] |
CTD |
PMID:27145024 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
2,4-dihydroxybenzophenone results in decreased expression of CDKN1A protein |
CTD |
PMID:23328252 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Esr1 |
estrogen receptor 1 |
increases expression multiple interactions affects binding |
ISO |
2,4-dihydroxybenzophenone analog results in increased expression of ESR1 mRNA 2,4-dihydroxybenzophenone binds to and results in increased activity of ESR1 protein; 2,4-dihydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein] 2,4-dihydroxybenzophenone binds to ESR1 protein |
CTD |
PMID:11823001 PMID:16079615 PMID:18973785 PMID:19913605 PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
increases expression affects binding multiple interactions |
ISO |
2,4-dihydroxybenzophenone analog results in increased expression of ESR2 mRNA 2,4-dihydroxybenzophenone binds to ESR2 protein 2,4-dihydroxybenzophenone binds to and results in increased activity of ESR2 protein |
CTD |
PMID:16079615 PMID:18973785 PMID:19913605 PMID:33049310 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Flg |
filaggrin |
multiple interactions affects response to substance |
ISO |
[FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Testosterone |
CTD |
PMID:30245359 |
|
NCBI chr 2:178,884,793...178,912,986
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
[FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in decreased secretion of FSHB protein |
CTD |
PMID:30245359 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases activity |
ISO |
2,4-dihydroxybenzophenone results in decreased activity of HSD3B1 protein |
CTD |
PMID:37217011 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
|
|
G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
decreases activity |
EXP |
2,4-dihydroxybenzophenone results in decreased activity of HSD3B2 protein |
CTD |
PMID:37217011 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
|
|
G |
Klk1c10 |
kallikrein 1-related peptidase C10 |
decreases expression |
ISO |
2,4-dihydroxybenzophenone analog results in decreased expression of KLK3 mRNA |
CTD |
PMID:33684284 |
|
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
|
|
G |
Nkx3-1 |
NK3 homeobox 1 |
decreases expression |
ISO |
2,4-dihydroxybenzophenone analog results in decreased expression of NKX3-1 mRNA |
CTD |
PMID:33684284 |
|
NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
2,4-dihydroxybenzophenone binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
2,4-dihydroxybenzophenone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
|
|
G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
2,4-dihydroxybenzophenone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
increases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein] |
CTD |
PMID:27145024 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Snai2 |
snail family transcriptional repressor 2 |
increases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI2 protein] |
CTD |
PMID:27145024 |
|
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
|
|
G |
Tff1 |
trefoil factor 1 |
increases expression multiple interactions |
ISO |
2,4-dihydroxybenzophenone results in increased expression of TFF1 mRNA [oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA |
CTD |
PMID:16183391 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
|
|
G |
Tpo |
thyroid peroxidase |
decreases activity |
EXP |
2,4-dihydroxybenzophenone results in decreased activity of TPO protein |
CTD |
PMID:26884060 |
|
NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
|
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
4,4'-dichlorobenzophenone inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] |
CTD |
PMID:21291947 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Clu |
clusterin |
multiple interactions |
ISO |
4,4'-dichlorobenzophenone inhibits the reaction [Dihydrotestosterone results in decreased expression of CLU mRNA] |
CTD |
PMID:21291947 |
|
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
|
|
|
G |
Adm2 |
adrenomedullin 2 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of ADM2 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
|
|
G |
Akr1b7 |
aldo-keto reductase family 1, member B7 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of AKR1B7 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
|
|
G |
Ar |
androgen receptor |
affects binding |
EXP |
4-hydroxybenzophenone binds to AR protein |
CTD |
PMID:14565775 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Atf4 |
activating transcription factor 4 |
increases expression multiple interactions |
ISO |
4-hydroxybenzophenone results in increased expression of ATF4 protein CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF4 protein] |
CTD |
PMID:35476924 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
|
|
G |
Atf6 |
activating transcription factor 6 |
increases expression multiple interactions |
ISO |
4-hydroxybenzophenone results in increased expression of ATF6 protein CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF6 protein] |
CTD |
PMID:35476924 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
|
|
G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of ATP2A3 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
|
|
G |
Casp3 |
caspase 3 |
multiple interactions increases expression |
ISO |
CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of CASP3 protein modified form] |
CTD |
PMID:35476924 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of CCL2 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cdsn |
corneodesmosin |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of CDSN mRNA |
CTD |
PMID:35476924 |
|
NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250
|
|
G |
Cntnap3 |
contactin associated protein family member 3 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of CNTNAP3 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr17:267,379...455,478
Ensembl chr17:267,508...454,102
|
|
G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of CXCL10 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression multiple interactions |
ISO |
4-hydroxybenzophenone results in increased expression of CXCL1 mRNA; 4-hydroxybenzophenone results in increased expression of CXCL1 protein CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in decreased expression of MKI67 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF4 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of ATF6 protein]; CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in increased expression of CASP3 protein modified form] |
CTD |
PMID:35476924 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Cyb5r1 |
cytochrome b5 reductase 1 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of CYB5R1 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity multiple interactions affects binding |
EXP ISO |
4-hydroxybenzophenone results in increased activity of ESR1 protein 4-hydroxybenzophenone binds to and results in increased activity of ESR1 protein; 4-hydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein] 4-hydroxybenzophenone binds to ESR1 protein |
CTD |
PMID:11354909 PMID:12504345 PMID:12765246 PMID:16079615 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
ISO |
4-hydroxybenzophenone binds to and results in increased activity of ESR2 protein |
CTD |
PMID:16079615 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
|
|
G |
Fbln5 |
fibulin 5 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of FBLN5 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
|
|
G |
Fibin |
fin bud initiation factor homolog |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of FIBIN mRNA |
CTD |
PMID:35476924 |
|
NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676
|
|
G |
Flg |
filaggrin |
multiple interactions affects response to substance |
ISO |
[FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in increased secretion of Estradiol |
CTD |
PMID:30245359 |
|
NCBI chr 2:178,884,793...178,912,986
|
|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
[FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein |
CTD |
PMID:30245359 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of GDF15 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Kcnt2 |
potassium sodium-activated channel subfamily T member 2 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of KCNT2 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr13:51,664,129...52,059,209
Ensembl chr13:51,664,686...52,056,987
|
|
G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions decreases expression |
ISO |
CXCL1 protein promotes the reaction [4-hydroxybenzophenone results in decreased expression of MKI67 protein] |
CTD |
PMID:35476924 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
|
|
G |
Mylk2 |
myosin light chain kinase 2 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of MYLK2 mRNA |
CTD |
PMID:35476924 |
|
NCBI chr 3:141,376,450...141,388,357
Ensembl chr 3:141,376,691...141,387,728
|
|
G |
Ostn |
osteocrin |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of OSTN mRNA |
CTD |
PMID:35476924 |
|
NCBI chr11:73,442,167...73,478,498
Ensembl chr11:73,442,487...73,468,603
|
|
G |
P2rx3 |
purinergic receptor P2X 3 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of P2RX3 mRNA |
CTD |
PMID:35476924 |
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NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
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Slc7a3 |
solute carrier family 7 member 3 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of SLC7A3 mRNA |
CTD |
PMID:35476924 |
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NCBI chr X:66,210,071...66,216,482
Ensembl chr X:66,210,081...66,215,708
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G |
Soat2 |
sterol O-acyltransferase 2 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of SOAT2 mRNA |
CTD |
PMID:35476924 |
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NCBI chr 7:133,281,818...133,294,915
Ensembl chr 7:133,281,818...133,294,915
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G |
Tgm1 |
transglutaminase 1 |
increases expression |
ISO |
4-hydroxybenzophenone results in increased expression of TGM1 mRNA |
CTD |
PMID:35476924 |
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NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
benzophenone results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Anapc11 |
anaphase promoting complex subunit 11 |
decreases expression |
EXP |
benzophenone results in decreased expression of ANAPC11 mRNA |
CTD |
PMID:22584684 |
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NCBI chr10:105,875,209...105,886,307
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Ar |
androgen receptor |
affects binding |
EXP |
benzophenone binds to AR protein |
CTD |
PMID:14565775 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Ccnb1 |
cyclin B1 |
increases expression |
EXP |
benzophenone results in increased expression of CCNB1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
EXP |
benzophenone results in increased expression of CDK1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
benzophenone results in increased expression of CYP2B1; benzophenone results in increased expression of CYP2B1 mRNA |
CTD |
PMID:14613717 PMID:22584684 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases expression |
EXP |
benzophenone results in increased expression of CYP2B2 mRNA |
CTD |
PMID:14613717 |
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NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
increases expression |
EXP |
benzophenone results in increased expression of CYP2C11 mRNA |
CTD |
PMID:14613717 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
increases expression |
EXP |
benzophenone results in increased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:14613717 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
benzophenone binds to and results in increased activity of ESR1 protein |
CTD |
PMID:16079615 PMID:27633901 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
benzophenone binds to and results in increased activity of ESR2 protein benzophenone binds to ESR2 protein |
CTD |
PMID:12224631 PMID:16079615 PMID:27633901 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
benzophenone results in increased expression of FOS mRNA; benzophenone results in increased expression of FOS protein |
CTD |
PMID:24308608 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases activity |
ISO |
benzophenone results in decreased activity of HSD3B1 protein |
CTD |
PMID:37217011 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Mir200a |
microRNA 200a |
increases expression |
EXP |
benzophenone results in increased expression of MIR200A mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:166,648,494...166,648,582
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G |
Mir200b |
microRNA 200b |
increases expression |
EXP |
benzophenone results in increased expression of MIR200B mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
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G |
Mir221 |
microRNA 221 |
decreases expression |
EXP |
benzophenone results in decreased expression of MIR221 mRNA |
CTD |
PMID:22584684 |
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NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573
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G |
Mir429 |
microRNA 429 |
increases expression |
EXP |
benzophenone results in increased expression of MIR429 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543
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G |
Mir96 |
microRNA 96 |
increases expression |
EXP |
benzophenone results in increased expression of MIR96 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
EXP |
benzophenone binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:14613717 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
benzophenone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nusap1 |
nucleolar and spindle associated protein 1 |
increases expression |
EXP |
benzophenone results in increased expression of NUSAP1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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G |
Smad3 |
SMAD family member 3 |
decreases phosphorylation multiple interactions |
ISO |
benzophenone results in decreased phosphorylation of SMAD3 protein fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein] |
CTD |
PMID:24308608 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Steap3 |
STEAP3 metalloreductase |
decreases expression |
EXP |
benzophenone results in decreased expression of STEAP3 mRNA |
CTD |
PMID:22584684 |
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NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
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G |
Stmn1 |
stathmin 1 |
increases expression |
EXP |
benzophenone results in increased expression of STMN1 mRNA |
CTD |
PMID:22584684 |
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NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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G |
Tpo |
thyroid peroxidase |
decreases activity |
ISO |
benzophenone results in decreased activity of TPO protein |
CTD |
PMID:21809831 |
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NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
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G |
Txnl4b |
thioredoxin-like 4B |
increases expression |
EXP |
benzophenone results in increased expression of TXNL4B mRNA |
CTD |
PMID:22584684 |
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NCBI chr19:37,530,157...37,539,827
Ensembl chr19:37,530,152...37,538,521
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
bromfenac results in decreased activity of ABCB11 protein |
CTD |
PMID:22646477 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity |
ISO |
bromfenac results in decreased activity of ABCC2 protein |
CTD |
PMID:22646477 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
bromfenac results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of bromfenac metabolite |
CTD |
PMID:31815452 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases hydroxylation |
ISO |
CYP2C19 protein results in increased hydroxylation of bromfenac |
CTD |
PMID:31815452 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
increases hydroxylation |
ISO |
CYP2C8 protein results in increased hydroxylation of bromfenac |
CTD |
PMID:31815452 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP3A4 protein results in increased metabolism of bromfenac metabolite |
CTD |
PMID:31815452 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Ereg |
epiregulin |
increases expression |
ISO |
bromfenac results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
bromfenac results in increased expression of IL1A mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
bromfenac results in increased expression of IL1B mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
bromfenac results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
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NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
bromfenac results in increased expression of PTGS2 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Slc7a11 |
solute carrier family 7 member 11 |
decreases expression |
ISO |
bromfenac results in decreased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
bromfenac results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases metabolic processing multiple interactions |
ISO |
UGT2B7 protein results in increased metabolism of bromfenac Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased metabolism of bromfenac] |
CTD |
PMID:31815452 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
A1bg |
alpha-1-B glycoprotein |
decreases expression |
EXP |
Fenofibrate results in decreased expression of A1BG protein |
CTD |
PMID:20118634 |
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NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097
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G |
Aadac |
arylacetamide deacetylase |
increases expression |
ISO |
Fenofibrate results in increased expression of AADAC mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of AARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of ABCA1 mRNA; Fenofibrate results in increased expression of ABCA1 protein |
CTD |
PMID:19201410 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases expression decreases activity |
ISO EXP |
Fenofibrate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Fenofibrate results in decreased expression of ABCB11 mRNA Fenofibrate results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [ABCB1 protein results in increased transport of Vincristine] |
CTD |
PMID:16316932 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of ABCB4 mRNA |
CTD |
PMID:17118139 PMID:19118567 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcb6 |
ATP binding cassette subfamily B member 6 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ABCB6 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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G |
Abcb9 |
ATP binding cassette subfamily B member 9 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCB9 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCC2 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ABCC3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCC4 mRNA |
CTD |
PMID:27765674 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcd3 |
ATP binding cassette subfamily D member 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of ABCD3 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCG1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCG5 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
increases expression |
EXP |
Fenofibrate results in increased expression of ABCG8 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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G |
Abhd4 |
abhydrolase domain containing 4, N-acyl phospholipase B |
increases expression |
EXP |
Fenofibrate results in increased expression of ABHD4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
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G |
Abi3bp |
ABI family member 3 binding protein |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ABI3BP mRNA |
CTD |
PMID:25572481 |
|
NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929
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G |
Acaa1a |
acetyl-CoA acyltransferase 1A |
increases expression multiple interactions affects expression |
ISO EXP |
Fenofibrate results in increased expression of ACAA1A mRNA Fenofibrate results in increased expression of ACAA1 mRNA Fenofibrate results in increased expression of ACAA1 mRNA; Fenofibrate results in increased expression of ACAA1A mRNA Fenofibrate promotes the reaction [Pyrazinamide results in increased expression of ACAA1 mRNA]; Pyrazinamide promotes the reaction [Fenofibrate results in increased expression of ACAA1 mRNA] Fenofibrate affects the expression of ACAA1A mRNA |
CTD |
PMID:11798191 PMID:20801182 PMID:24752549 PMID:27071702 PMID:32741897 |
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NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
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G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of ACAA2 mRNA Fenofibrate results in increased expression of ACAA2 mRNA Fenofibrate results in increased expression of ACAA2 mRNA; Fenofibrate results in increased expression of ACAA2 protein |
CTD |
PMID:20118634 PMID:20801182 PMID:25572481 PMID:27665778 PMID:32741897 |
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NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions decreases expression increases expression |
ISO EXP |
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA] Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA] Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein] Fenofibrate results in decreased expression of ACACA protein |
CTD |
PMID:23063693 PMID:24752549 PMID:32730863 PMID:38216941 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
multiple interactions increases expression |
ISO |
NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACB mRNA] |
CTD |
PMID:17118139 PMID:23063693 |
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NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acadl |
acyl-CoA dehydrogenase, long chain |
increases expression |
ISO |
Fenofibrate results in increased expression of ACADL mRNA |
CTD |
PMID:17690133 |
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NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ACADM mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of ACADM mRNA] |
CTD |
PMID:11798191 PMID:17690133 PMID:19124612 PMID:24752549 PMID:25572481 PMID:33408297 More...
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NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [ACADS protein affects the cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein] |
CTD |
PMID:26989860 |
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NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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G |
Acadvl |
acyl-CoA dehydrogenase, very long chain |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of ACADVL mRNA |
CTD |
PMID:17118139 PMID:24752549 PMID:27665778 |
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NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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G |
Acat1 |
acetyl-CoA acetyltransferase 1 |
multiple interactions increases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACAT1 mRNA Fenofibrate results in increased expression of ACAT1 mRNA |
CTD |
PMID:18253720 PMID:24752549 |
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NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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G |
Acly |
ATP citrate lyase |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ACLY mRNA PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACLY mRNA] |
CTD |
PMID:23063693 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Aco1 |
aconitase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACO1 mRNA |
CTD |
PMID:17264098 |
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NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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G |
Aco2 |
aconitase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ACO2 mRNA |
CTD |
PMID:24752549 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acot1 |
acyl-CoA thioesterase 1 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of ACOT1 mRNA |
CTD |
PMID:11798191 PMID:17690133 PMID:27665778 PMID:32741897 |
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NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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G |
Acot2 |
acyl-CoA thioesterase 2 |
affects expression multiple interactions increases expression |
EXP |
Fenofibrate affects the expression of ACOT2 mRNA Fenofibrate results in increased expression of and results in increased activity of ACOT2 protein Fenofibrate results in increased expression of ACOT2 mRNA |
CTD |
PMID:16595124 PMID:20801182 PMID:27665778 PMID:32741897 |
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NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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G |
Acot3 |
acyl-CoA thioesterase 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACOT3 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427 Ensembl chr 6:103,682,596...103,688,427
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G |
Acot4 |
acyl-CoA thioesterase 4 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACOT4 mRNA |
CTD |
PMID:27665778 PMID:32741897 |
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NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
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G |
Acot7 |
acyl-CoA thioesterase 7 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACOT7 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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G |
Acox1 |
acyl-CoA oxidase 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Fenofibrate affects the expression of ACOX1 mRNA [Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of ACOX1 protein; [Fenofibrate co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein] Fenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 protein Fenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein] [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNA |
CTD |
PMID:16707586 PMID:17118139 PMID:17690133 PMID:18253720 PMID:18775883 PMID:19395589 PMID:20801182 PMID:22301950 PMID:23063693 PMID:24534255 PMID:24735863 PMID:24752549 PMID:24986865 PMID:25572481 PMID:28871336 PMID:30611848 PMID:32741897 More...
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acox2 |
acyl-CoA oxidase 2 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of ACOX2 mRNA] |
CTD |
PMID:28871336 |
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NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
increases expression multiple interactions affects expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of ACSL1 mRNA; Fenofibrate results in increased expression of ACSL1 protein PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACSL1 protein] PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 protein] Fenofibrate affects the expression of ACSL1 mRNA Fenofibrate results in decreased expression of ACSL1 protein |
CTD |
PMID:10600944 PMID:17118139 PMID:20118634 PMID:20801182 PMID:24752549 PMID:25596134 PMID:32741897 More...
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NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACSL3 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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G |
Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of ACSL4 mRNA |
CTD |
PMID:17118139 |
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NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
increases expression |
ISO |
Fenofibrate results in increased expression of ACSL5 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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G |
Acsl6 |
acyl-CoA synthetase long-chain family member 6 |
increases expression |
EXP |
Fenofibrate results in increased expression of ACSL6 mRNA |
CTD |
PMID:16595124 |
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NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
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G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ACSS2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein] Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] |
CTD |
PMID:28871336 PMID:32613381 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adam22 |
ADAM metallopeptidase domain 22 |
increases expression |
EXP |
Fenofibrate results in increased expression of ADAM22 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962
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G |
Adcy1 |
adenylate cyclase 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ADCY1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
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G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ADH1C mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ADH4 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ADIPOQ protein [candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ADIPOQ protein] |
CTD |
PMID:16443859 PMID:24735863 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:16306350 |
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NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Agrn |
agrin |
decreases expression |
EXP |
Fenofibrate results in decreased expression of AGRN mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]] |
CTD |
PMID:31016362 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agxt2 |
alanine-glyoxylate aminotransferase 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of AGXT2 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
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G |
Ahr |
aryl hydrocarbon receptor |
affects activity multiple interactions |
ISO EXP |
Fenofibrate affects the activity of AHR protein Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]] |
CTD |
PMID:25596134 PMID:31016362 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aifm2 |
apoptosis inducing factor, mitochondria associated 2 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of AIFM2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
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G |
Aig1 |
androgen-induced 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of AIG1 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084
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G |
Ak4 |
adenylate kinase 4 |
affects expression |
EXP |
Fenofibrate affects the expression of AK4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
multiple interactions decreases activity |
ISO |
Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] Fenofibrate results in decreased activity of AKR1B10 protein; Fenofibrate results in decreased activity of AKR1B10 protein mutant form |
CTD |
PMID:18325492 PMID:19028477 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
increases expression |
ISO |
Fenofibrate results in increased expression of AKR1C2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Alb |
albumin |
multiple interactions |
ISO |
dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]]; dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]]; dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased degradation of NFKBIA protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of NFKB1 protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]; PRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form] Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA] |
CTD |
PMID:20580385 PMID:37076581 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ALDH1A2 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aldh6a1 |
aldehyde dehydrogenase 6 family, member A1 |
increases expression |
ISO |
Fenofibrate results in increased expression of ALDH6A1 mRNA |
CTD |
PMID:24752549 |
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NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
Fenofibrate results in increased expression of ALDOA mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression |
ISO |
Fenofibrate results in increased expression of ALOX12 mRNA |
CTD |
PMID:12759900 |
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NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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G |
Alpk2 |
alpha-kinase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ALPK2 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr18:58,775,603...58,906,150
Ensembl chr18:58,775,605...58,906,258
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ALPL mRNA |
CTD |
PMID:25572481 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Anapc11 |
anaphase promoting complex subunit 11 |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of ANAPC11 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:105,875,209...105,886,307
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G |
Angptl4 |
angiopoietin-like 4 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:17118139 PMID:25572481 PMID:25596134 PMID:27665778 PMID:32741897 |
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NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Ankra2 |
ankyrin repeat family A member 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ANKRA2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:29,612,867...29,623,748
Ensembl chr 2:29,612,925...29,623,730
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G |
Anxa3 |
annexin A3 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ANXA3 protein |
CTD |
PMID:20118634 |
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NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA Fenofibrate results in increased expression of APEX1 mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Apoa1 |
apolipoprotein A1 |
decreases expression multiple interactions |
ISO EXP |
Fenofibrate results in decreased expression of APOA1 mRNA; Fenofibrate results in decreased expression of APOA1 protein [Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNA Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein affects the reaction [Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]] Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein inhibits the reaction [Fenofibrate results in decreased expression of APOA1 mRNA] |
CTD |
PMID:7983038 PMID:19201410 PMID:19445040 PMID:27071702 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoa4 |
apolipoprotein A4 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of APOA4 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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G |
Apob |
apolipoprotein B |
decreases expression |
ISO |
Fenofibrate results in decreased expression of APOB protein |
CTD |
PMID:21411093 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc3 |
apolipoprotein C3 |
affects expression decreases expression |
EXP ISO |
Fenofibrate affects the expression of APOC3 mRNA Fenofibrate results in decreased expression of APOC3 mRNA; Fenofibrate results in decreased expression of APOC3 protein |
CTD |
PMID:8847480 PMID:10799317 PMID:20801182 PMID:24752549 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein] |
CTD |
PMID:17962197 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqp3 |
aquaporin 3 (Gill blood group) |
increases expression |
EXP |
Fenofibrate results in increased expression of AQP3 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
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G |
Aqp7 |
aquaporin 7 |
increases expression |
EXP |
Fenofibrate results in increased expression of AQP7 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
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G |
Aqp9 |
aquaporin 9 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of AQP9 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Arfgef2 |
ADP ribosylation factor guanine nucleotide exchange factor 2 |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of ARFGEF2 mRNA Fenofibrate results in decreased expression of ARFGEF2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
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G |
Arhgef10 |
Rho guanine nucleotide exchange factor 10 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ARHGEF10 mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
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G |
Arih1 |
ariadne RBR E3 ubiquitin protein ligase 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ARIH1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of ARIH1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
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G |
Arl1 |
ADP-ribosylation factor like GTPase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ARL1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Asb6 |
ankyrin repeat and SOCS box-containing 6 |
multiple interactions increases expression |
ISO |
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of ASB6 mRNA Fenofibrate results in increased expression of ASB6 mRNA |
CTD |
PMID:21318169 |
|
NCBI chr 3:14,110,628...14,115,274
Ensembl chr 3:14,110,628...14,115,242
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of ASNS mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Ate1 |
arginyltransferase 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ATE1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of ATE1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 1:184,961,548...185,081,112
Ensembl chr 1:184,963,562...185,080,908
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions increases expression |
ISO EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ATF3 mRNA Fenofibrate results in increased expression of ATF3 mRNA |
CTD |
PMID:18978307 PMID:25596134 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
affects activity multiple interactions |
ISO EXP |
Fenofibrate affects the activity of ATF4 protein Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF4 mRNA]; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF4 protein] |
CTD |
PMID:25596134 PMID:38216941 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF6 mRNA]; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF6 protein] |
CTD |
PMID:38216941 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg12 |
autophagy related 12 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ATG12 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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G |
Atg7 |
autophagy related 7 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ATG7 mRNA Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG7 mRNA] |
CTD |
PMID:21318169 PMID:36905866 |
|
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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G |
Atosa |
atos homolog A |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ATOSA mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ATP2A2 protein |
CTD |
PMID:20118634 |
|
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp2b4 |
ATPase plasma membrane Ca2+ transporting 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of ATP2B4 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein] |
CTD |
PMID:26989860 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcar3 |
BCAR3 adaptor protein, NSP family member |
decreases expression |
EXP |
Fenofibrate results in decreased expression of BCAR3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of BCAT1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcat2 |
branched chain amino acid transaminase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of BCAT2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
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G |
Bckdk |
branched chain ketoacid dehydrogenase kinase |
decreases activity |
EXP |
Fenofibrate results in decreased activity of BCKDK protein |
CTD |
PMID:19819289 |
|
NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Fenofibrate results in decreased expression of BCL2 mRNA Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein] |
CTD |
PMID:15843896 PMID:26989860 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2a1 |
BCL2-related protein A1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of BCL2A1 mRNA |
CTD |
PMID:20520642 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:20520642 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl3 |
BCL3, transcription coactivator |
decreases expression |
ISO |
Fenofibrate results in decreased expression of BCL3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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G |
Bcr |
BCR activator of RhoGEF and GTPase |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of BCR mRNA |
CTD |
PMID:18253720 |
|
NCBI chr20:13,469,325...13,596,942
Ensembl chr20:13,471,668...13,597,016
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G |
Bdh1 |
3-hydroxybutyrate dehydrogenase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of BDH1 protein |
CTD |
PMID:20118634 |
|
NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
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G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein] |
CTD |
PMID:36905866 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of BHLHE40 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of BIRC3 mRNA |
CTD |
PMID:20520642 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Bmf |
Bcl2 modifying factor |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of BMF mRNA Fenofibrate results in decreased expression of BMF mRNA |
CTD |
PMID:25572481 PMID:25596134 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of BNIP3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Brap |
BRCA1 associated protein |
affects expression multiple interactions |
ISO |
Fenofibrate affects the expression of BRAP mRNA PPARA protein affects the reaction [Fenofibrate affects the expression of BRAP mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr12:34,874,533...34,901,030
Ensembl chr12:34,874,533...34,901,030
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G |
Brcc3 |
BRCA1/BRCA2-containing complex subunit 3 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of BRCC3 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of BRCC3 mRNA |
CTD |
PMID:21318169 |
|
NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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|
G |
Brd2 |
bromodomain containing 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of BRD2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
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G |
Btg2 |
BTG anti-proliferation factor 2 |
affects expression |
EXP |
Fenofibrate affects the expression of BTG2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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|
G |
C1h19orf12 |
similar to human chromosome 19 open reading frame 12 |
increases expression |
ISO |
Fenofibrate results in increased expression of C19ORF12 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 1:90,873,578...90,887,205
Ensembl chr 1:90,873,549...90,886,208
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G |
C9 |
complement C9 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of C9 mRNA |
CTD |
PMID:11798191 |
|
NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
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G |
Cacna2d3 |
calcium voltage-gated channel auxiliary subunit alpha2delta 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of CACNA2D3 mRNA |
CTD |
PMID:32741897 |
|
NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351
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G |
Calm1 |
calmodulin 1 |
affects expression |
EXP |
Fenofibrate affects the expression of CALM1 mRNA |
CTD |
PMID:20801182 |
|
NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Canx |
calnexin |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of CANX mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Car9 |
carbonic anhydrase 9 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein] |
CTD |
PMID:34520103 |
|
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
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G |
Casp3 |
caspase 3 |
increases cleavage decreases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased cleavage of CASP3 protein Fenofibrate results in decreased expression of CASP3 protein [ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein] [Fenofibrate co-treated with Pioglitazone] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Fenofibrate inhibits the reaction [ACADS protein affects the cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein] |
CTD |
PMID:20520642 PMID:26989860 PMID:29134746 PMID:32730863 PMID:36988379 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
EXP |
Fenofibrate results in increased expression of CASP4 mRNA |
CTD |
PMID:17264098 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Cat |
catalase |
multiple interactions increases expression increases activity |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased activity of CAT protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CAT mRNA Fenofibrate results in increased expression of CAT mRNA Fenofibrate results in increased activity of CAT protein |
CTD |
PMID:17264098 PMID:18253720 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of CAV1 mRNA |
CTD |
PMID:15314095 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Cblb |
Cbl proto-oncogene B |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of CBLB mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of CBLB mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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G |
Ccdc34 |
coiled-coil domain containing 34 |
increases expression |
EXP |
Fenofibrate results in increased expression of CCDC34 mRNA |
CTD |
PMID:32741897 |
|
NCBI chr 3:96,553,074...96,588,310
Ensembl chr 3:96,552,992...96,588,146
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G |
Ccdc90b |
coiled-coil domain containing 90B |
increases expression |
EXP |
Fenofibrate results in increased expression of CCDC90B mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
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G |
Ccl12 |
C-C motif chemokine ligand 12 |
increases expression |
ISO |
Fenofibrate results in increased expression of CCL13 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression |
ISO |
Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein] Fenofibrate results in decreased expression of CCL2 mRNA; Fenofibrate results in decreased expression of CCL2 protein Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] |
CTD |
PMID:15968640 PMID:16306350 PMID:16600694 PMID:18356826 PMID:19132243 PMID:32613381 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein] |
CTD |
PMID:12126966 PMID:12586603 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccn1 |
cellular communication network factor 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of CCN1 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccnd1 |
cyclin D1 |
decreases expression increases expression multiple interactions |
ISO EXP |
Fenofibrate results in decreased expression of CCND1 mRNA; Fenofibrate results in decreased expression of CCND1 protein Fenofibrate results in increased expression of CCND1 protein ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein]; Estradiol inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein] Fenofibrate results in increased expression of CCND1 mRNA [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA |
CTD |
PMID:16569247 PMID:17264098 PMID:18253720 PMID:18978307 PMID:20520642 PMID:29134746 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnf |
cyclin F |
increases expression |
EXP |
Fenofibrate results in increased expression of CCNF mRNA |
CTD |
PMID:32741897 |
|
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Ccng2 |
cyclin G2 |
decreases expression increases expression |
ISO EXP |
Fenofibrate results in decreased expression of CCNG2 mRNA Fenofibrate results in increased expression of CCNG2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccnt1 |
cyclin T1 |
multiple interactions |
EXP |
Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] |
CTD |
PMID:20828602 |
|
NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
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G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
Fenofibrate results in increased expression of CD14 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd36 |
CD36 molecule |
increases expression multiple interactions |
EXP ISO |
Fenofibrate results in increased expression of CD36 mRNA Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA] |
CTD |
PMID:16707586 PMID:17118139 PMID:25572481 PMID:32613381 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40 |
CD40 molecule |
decreases expression |
ISO |
Fenofibrate results in decreased expression of CD40 mRNA |
CTD |
PMID:20520642 |
|
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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G |
Cd40lg |
CD40 ligand |
multiple interactions decreases expression |
ISO |
candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein] |
CTD |
PMID:16443859 |
|
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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|
G |
Cdc25a |
cell division cycle 25A |
increases expression |
EXP |
Fenofibrate results in increased expression of CDC25A mRNA |
CTD |
PMID:17264098 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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|
G |
Cdk20 |
cyclin-dependent kinase 20 |
increases expression |
ISO |
Fenofibrate results in increased expression of CDK20 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr17:701,122...707,869
Ensembl chr17:701,124...707,826
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|
G |
Cdk9 |
cyclin-dependent kinase 9 |
multiple interactions |
EXP |
Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] |
CTD |
PMID:20828602 |
|
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions decreases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1A mRNA Fenofibrate results in decreased expression of CDKN1A mRNA |
CTD |
PMID:18253720 PMID:25596134 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions decreases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA ESR1 protein inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; Estradiol inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein] |
CTD |
PMID:18253720 PMID:29134746 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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|
G |
Cep128 |
centrosomal protein 128 |
increases expression |
EXP |
Fenofibrate results in increased expression of CEP128 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 6:109,951,009...110,328,686
Ensembl chr 6:109,951,061...110,328,713
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G |
Cers5 |
ceramide synthase 5 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of CERS5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Chek1 |
checkpoint kinase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of CHEK1 mRNA |
CTD |
PMID:17264098 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CHEK2 mRNA |
CTD |
PMID:18253720 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chid1 |
chitinase domain containing 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of CHID1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606
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G |
Chrna2 |
cholinergic receptor nicotinic alpha 2 subunit |
increases expression |
EXP |
Fenofibrate results in increased expression of CHRNA2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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G |
Chst8 |
carbohydrate sulfotransferase 8 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CHST8 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900
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G |
Cish |
cytokine inducible SH2-containing protein |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of CISH mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of CISH mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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G |
Cmbl |
carboxymethylenebutenolidase homolog |
increases expression |
EXP |
Fenofibrate results in increased expression of CMBL mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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G |
Cnot4 |
CCR4-NOT transcription complex, subunit 4 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in increased expression of CNOT4 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 4:63,712,770...63,814,355
Ensembl chr 4:63,712,770...63,814,360
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of COL1A1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]] |
CTD |
PMID:19593819 PMID:28871336 PMID:31016362 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of COL3A1 mRNA] |
CTD |
PMID:28871336 PMID:31016362 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA] |
CTD |
PMID:28871336 |
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NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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G |
Colq |
collagen like tail subunit of asymmetric acetylcholinesterase |
increases expression |
EXP |
Fenofibrate results in increased expression of COLQ mRNA |
CTD |
PMID:27665778 PMID:32741897 |
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NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107
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G |
Coq7 |
coenzyme Q7, hydroxylase |
increases expression |
EXP |
Fenofibrate results in increased expression of COQ7 mRNA |
CTD |
PMID:16595124 |
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NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158
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G |
Cox6b2 |
cytochrome c oxidase subunit 6B2 |
increases expression |
ISO |
Fenofibrate results in increased expression of COX6B2 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 1:69,094,009...69,095,312
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of CPT1A mRNA Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA] Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of CPT1A mRNA]; Fenofibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA] |
CTD |
PMID:16595124 PMID:17070643 PMID:17118139 PMID:19124612 PMID:24534255 PMID:24735863 PMID:25572481 PMID:27665778 PMID:28871336 PMID:30611848 PMID:32613381 PMID:32741897 More...
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
affects expression multiple interactions increases expression |
EXP |
Fenofibrate affects the expression of CPT1B mRNA Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of CPT1B mRNA] Fenofibrate results in increased expression of CPT1B mRNA |
CTD |
PMID:16595124 PMID:19395589 PMID:20801182 PMID:27071702 PMID:32741897 |
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NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
decreases expression multiple interactions increases expression |
EXP ISO |
Fenofibrate results in decreased expression of CPT2 protein Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT2 mRNA] Fenofibrate results in increased expression of CPT2 mRNA [Oleic Acid co-treated with Fenofibrate] results in increased expression of CPT2 mRNA |
CTD |
PMID:16595124 PMID:16707586 PMID:19395589 PMID:20118634 PMID:24534255 PMID:25572481 PMID:27665778 PMID:28871336 PMID:32741897 More...
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NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Crat |
carnitine O-acetyltransferase |
increases expression increases activity multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of CRAT mRNA Fenofibrate results in increased activity of CRAT protein [Fenofibrate co-treated with Diethylnitrosamine] results in increased activity of CRAT protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CRAT mRNA |
CTD |
PMID:11798191 PMID:17264098 PMID:18253720 PMID:27665778 PMID:32741897 |
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NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Creb3l3 |
cAMP responsive element binding protein 3-like 3 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of CREB3L3 mRNA |
CTD |
PMID:25572481 PMID:32741897 |
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NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
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G |
Crot |
carnitine O-octanoyltransferase |
increases expression |
EXP |
Fenofibrate results in increased expression of CROT mRNA |
CTD |
PMID:32741897 |
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NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
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G |
Crp |
C-reactive protein |
multiple interactions decreases expression |
ISO |
candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein] |
CTD |
PMID:16123850 PMID:16443859 |
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NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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G |
Csf1r |
colony stimulating factor 1 receptor |
decreases expression |
EXP |
Fenofibrate results in decreased expression of CSF1R mRNA |
CTD |
PMID:16707586 |
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NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CSF2 mRNA |
CTD |
PMID:18253720 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cth |
cystathionine gamma-lyase |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of CTH mRNA Fenofibrate results in decreased expression of CTH mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Ctsc |
cathepsin C |
decreases expression |
EXP |
Fenofibrate results in decreased expression of CTSC mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein] |
CTD |
PMID:19132243 |
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NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein] |
CTD |
PMID:32730863 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyld |
CYLD lysine 63 deubiquitinase |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of CYLD mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of CYLD mRNA] |
CTD |
PMID:21318169 |
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NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases activity |
EXP ISO |
Fenofibrate results in increased expression of CYP1A1 mRNA Fenofibrate results in decreased activity of CYP1A1 protein |
CTD |
PMID:19118567 PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions affects expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP1A2 mRNA Fenofibrate affects the expression of CYP1A2 mRNA |
CTD |
PMID:18253720 PMID:20801182 PMID:25596134 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Fenofibrate results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP2A3 mRNA |
CTD |
PMID:18253720 |
|
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of CYP2B1 mRNA |
CTD |
PMID:19118567 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b15 |
cytochrome P450, family 2, subfamily b, polypeptide 15 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP2B15 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of CYP2B10 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases expression |
ISO |
Fenofibrate results in increased expression of CYP2C19 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c7 |
cytochrome P450, family 2, subfamily c, polypeptide 7 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2C7 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity affects expression increases expression |
ISO |
Fenofibrate results in decreased activity of CYP2C8 protein Fenofibrate affects the expression of CYP2C8 protein Fenofibrate results in increased expression of CYP2C8 mRNA |
CTD |
PMID:15601807 PMID:25572481 PMID:29960002 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of CYP2E1 mRNA |
CTD |
PMID:19118567 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2f4 |
cytochrome P450, family 2, subfamily f, polypeptide 4 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2F2 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
affects expression |
ISO |
Fenofibrate affects the expression of CYP2J2 protein |
CTD |
PMID:29960002 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP3A23-3A1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP3A13 mRNA |
CTD |
PMID:18253720 |
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
affects expression increases expression multiple interactions |
EXP ISO |
Fenofibrate affects the expression of CYP4A1 mRNA Fenofibrate results in increased expression of CYP4A22 mRNA Fenofibrate results in increased expression of CYP4A1 mRNA [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP4A1 mRNA |
CTD |
PMID:17264098 PMID:18775883 PMID:20801182 PMID:25572481 PMID:27665778 PMID:32741897 More...
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NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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G |
Cyp4a2 |
cytochrome P450, family 4, subfamily a, polypeptide 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of CYP4A2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
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G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of CYP4A3 mRNA |
CTD |
PMID:27665778 PMID:32741897 |
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NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyp4a8 |
cytochrome P450, family 4, subfamily a, polypeptide 8 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4A8 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
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G |
Cyp4b1 |
cytochrome P450, family 4, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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G |
Cyp4x1 |
cytochrome P450, family 4, subfamily x, polypeptide 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of CYP4X1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 5:128,651,681...128,683,338
Ensembl chr 5:128,651,776...128,682,779
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions decreases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA Fenofibrate results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:14685799 PMID:18253720 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7B1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA Fenofibrate results in increased expression of CYP8B1 mRNA |
CTD |
PMID:18253720 PMID:32741897 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dact2 |
dishevelled-binding antagonist of beta-catenin 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of DACT2 mRNA |
CTD |
PMID:27665778 |
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NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
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G |
Dbi |
diazepam binding inhibitor |
increases expression |
ISO |
Fenofibrate results in increased expression of DBI mRNA |
CTD |
PMID:17118139 |
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NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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G |
Dcun1d1 |
defective in cullin neddylation 1 domain containing 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of DCUN1D1 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 2:118,721,275...118,772,606
Ensembl chr 2:118,721,822...118,772,602
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of DDIT3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
decreases expression increases expression |
ISO EXP |
Fenofibrate results in decreased expression of DDIT4 mRNA Fenofibrate results in increased expression of DDIT4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Ddx24 |
DEAD-box helicase 24 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of DDX24 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927
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Decr1 |
2,4-dienoyl-CoA reductase 1 |
increases expression affects expression |
ISO EXP |
Fenofibrate results in increased expression of DECR1 mRNA Fenofibrate results in increased expression of DECR1 mRNA; Fenofibrate results in increased expression of DECR1 protein Fenofibrate affects the expression of DECR1 mRNA |
CTD |
PMID:11798191 PMID:20118634 PMID:20801182 PMID:27665778 PMID:32741897 |
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NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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G |
Decr2 |
2,4-dienoyl-CoA reductase 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of DECR2 mRNA |
CTD |
PMID:27665778 |
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NCBI chr10:15,104,907...15,113,281
Ensembl chr10:15,002,926...15,118,479
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Dhx37 |
DEAH-box helicase 37 |
increases expression |
ISO |
Fenofibrate results in increased expression of DHX37 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
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Dmd |
dystrophin |
decreases expression |
ISO |
Fenofibrate results in decreased expression of DMD mRNA |
CTD |
PMID:11798191 |
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NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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G |
Dnaja2 |
DnaJ heat shock protein family (Hsp40) member A2 |
multiple interactions increases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNA Fenofibrate results in increased expression of DNAJA2 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJA2 mRNA] |
CTD |
PMID:18253720 PMID:21318169 |
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NCBI chr19:21,497,792...21,516,904
Ensembl chr19:21,497,729...21,516,901
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
increases expression |
ISO |
Fenofibrate results in increased expression of DNAJA3 mRNA |
CTD |
PMID:21318169 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJB1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of DNAJB4 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of DNAJB4 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Dnajb6 |
DnaJ heat shock protein family (Hsp40) member B6 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of DNAJB6 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJB6 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of DNAJB9 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnajc14 |
DnaJ heat shock protein family (Hsp40) member C14 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of DNAJC14 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC14 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 7:1,233,856...1,247,349
Ensembl chr 7:1,235,162...1,248,645
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G |
Dnajc19 |
DnaJ heat shock protein family (Hsp40) member C19 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of DNAJC19 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC19 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 2:116,923,272...116,945,312
Ensembl chr 2:116,923,272...116,945,264
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G |
Dnajc2 |
DnaJ heat shock protein family (Hsp40) member C2 |
multiple interactions increases expression |
ISO |
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC2 mRNA Fenofibrate results in increased expression of DNAJC2 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 4:13,270,239...13,297,438
Ensembl chr 4:13,270,191...13,297,431
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G |
Dnajc27 |
DnaJ heat shock protein family (Hsp40) member C27 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of RBJ mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of RBJ mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 6:27,068,713...27,098,449
Ensembl chr 6:27,068,686...27,098,449
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G |
Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of DNAJC3 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC3 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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G |
Dnajc5 |
DnaJ heat shock protein family (Hsp40) member C5 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of DNAJC5 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC5 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935
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G |
Dnajc5b |
DnaJ heat shock protein family (Hsp40) member C5 beta |
increases expression |
EXP |
Fenofibrate results in increased expression of DNAJC5B mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:101,973,726...102,066,275
Ensembl chr 2:101,973,793...102,066,275
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein] |
CTD |
PMID:32730863 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmbp |
dynamin binding protein |
decreases expression |
EXP |
Fenofibrate results in decreased expression of DNMBP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
Fenofibrate results in increased expression of DUSP5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Ech1 |
enoyl-CoA hydratase 1 |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of ECH1 mRNA Fenofibrate results in increased expression of ECH1 mRNA; Fenofibrate results in increased expression of ECH1 protein |
CTD |
PMID:11798191 PMID:17118139 PMID:20118634 PMID:20801182 PMID:27665778 PMID:32741897 More...
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of ECHS1 mRNA |
CTD |
PMID:24752549 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Eci1 |
enoyl-CoA delta isomerase 1 |
increases expression affects expression |
ISO EXP |
Fenofibrate results in increased expression of ECI1 mRNA Fenofibrate affects the expression of ECI1 mRNA |
CTD |
PMID:11798191 PMID:20801182 PMID:27665778 PMID:32741897 |
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NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
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G |
Eci2 |
enoyl-CoA delta isomerase 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of ECI2 mRNA |
CTD |
PMID:16707586 |
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NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP ISO |
EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]] Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA] |
CTD |
PMID:22198280 PMID:31016362 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Egfr |
epidermal growth factor receptor |
decreases expression |
ISO |
Fenofibrate results in decreased expression of EGFR mRNA |
CTD |
PMID:11798191 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
increases expression affects expression |
ISO EXP |
Fenofibrate results in increased expression of EHHADH mRNA Fenofibrate affects the expression of EHHADH mRNA |
CTD |
PMID:11798191 PMID:17118139 PMID:20801182 PMID:27665778 PMID:32741897 |
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NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
decreases expression increases expression |
EXP ISO |
Fenofibrate results in decreased expression of EIF1 mRNA Fenofibrate results in increased expression of EIF1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:38216941 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
affects expression |
EXP |
Fenofibrate affects the expression of EIF2S2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif3c |
eukaryotic translation initiation factor 3, subunit C |
increases expression |
EXP |
Fenofibrate results in increased expression of EIF3C mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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G |
Elk4 |
ETS transcription factor ELK4 |
increases expression |
ISO |
Fenofibrate results in increased expression of ELK4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
multiple interactions increases expression |
ISO EXP |
[Oleic Acid co-treated with Fenofibrate] affects the expression of ELOVL6 mRNA Fenofibrate results in increased expression of ELOVL6 mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA] |
CTD |
PMID:23063693 PMID:24534255 PMID:27665778 |
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NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of ENC1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of ENC1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Eno1 |
enolase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of ENO1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ENPP2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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G |
Entpd7 |
ectonucleoside triphosphate diphosphohydrolase 7 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ENTPD7 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
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G |
Ep400 |
E1A binding protein p400 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of EP400 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
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G |
Ephx2 |
epoxide hydrolase 2 |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of EPHX2 mRNA Fenofibrate results in increased expression of EPHX2 mRNA Fenofibrate affects the expression of EPHX2 protein |
CTD |
PMID:20801182 PMID:29960002 PMID:32741897 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Eprs1 |
glutamyl-prolyl-tRNA synthetase 1 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of EPRS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
increases expression |
EXP |
Fenofibrate results in increased expression of ERO1A mRNA |
CTD |
PMID:25596134 |
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NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
[ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; ESR1 protein inhibits the reaction [Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; ESR1 protein inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein]; ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]; Estradiol inhibits the reaction [ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein] |
CTD |
PMID:29134746 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Etfa |
electron transfer flavoprotein subunit alpha |
increases expression |
ISO |
Fenofibrate results in increased expression of ETFA mRNA |
CTD |
PMID:25572481 |
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NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969
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G |
Etfdh |
electron transfer flavoprotein dehydrogenase |
decreases expression increases expression |
EXP ISO |
Fenofibrate results in decreased expression of ETFDH protein Fenofibrate results in increased expression of ETFDH mRNA |
CTD |
PMID:20118634 PMID:25572481 |
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NCBI chr 2:164,740,547...164,762,754
Ensembl chr 2:164,729,749...164,762,745
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G |
Etnk2 |
ethanolamine kinase 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ETNK2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037
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G |
F2 |
coagulation factor II, thrombin |
multiple interactions |
ISO |
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein] |
CTD |
PMID:9681093 |
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NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F7 |
coagulation factor VII |
multiple interactions |
ISO |
Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein] |
CTD |
PMID:9681093 |
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NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of FABP1 mRNA Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of FABP1 mRNA] |
CTD |
PMID:17118139 PMID:24752549 PMID:27071702 PMID:32741897 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fabp2 |
fatty acid binding protein 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of FABP2 mRNA |
CTD |
PMID:17118139 |
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NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fabp3 |
fatty acid binding protein 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of FABP3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of FABP4 mRNA |
CTD |
PMID:11798191 PMID:12759900 PMID:25572481 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fads1 |
fatty acid desaturase 1 |
multiple interactions increases expression |
ISO |
beta-hydroxy simvastatin acid promotes the reaction [Fenofibrate results in increased expression of FADS1 mRNA]; Fenofibrate promotes the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA] |
CTD |
PMID:17655842 |
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NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fah |
fumarylacetoacetate hydrolase |
increases expression |
ISO |
Fenofibrate results in increased expression of FAH mRNA |
CTD |
PMID:25572481 |
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NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
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G |
Fam210a |
family with sequence similarity 210, member A |
affects expression |
EXP |
Fenofibrate affects the expression of FAM210A mRNA |
CTD |
PMID:25596134 |
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NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
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G |
Fam222a |
family with sequence similarity 222, member A |
increases expression |
ISO |
Fenofibrate results in increased expression of FAM222A mRNA |
CTD |
PMID:25572481 |
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NCBI chr12:41,982,064...42,033,085
Ensembl chr12:41,986,780...42,033,682
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G |
Fam241a |
family with sequence similarity 241 member A |
increases expression |
ISO |
Fenofibrate results in increased expression of FAM241A mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:216,344,563...216,375,193
Ensembl chr 2:216,343,822...216,375,242
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G |
Fam89a |
family with sequence similarity 89, member A |
increases expression |
ISO |
Fenofibrate results in increased expression of FAM89A mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631
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G |
Fas |
Fas cell surface death receptor |
multiple interactions decreases expression |
ISO EXP |
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]] fenofibrate co-treated with fructose diet increases expression of Fas mRNA in liver Fenofibrate results in decreased expression of FAS mRNA |
CTD RGD |
PMID:19593819 PMID:25596134 PMID:11934685 |
RGD:628329 |
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
multiple interactions increases expression |
ISO EXP |
[Oleic Acid co-treated with Fenofibrate] affects the expression of FASN mRNA; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein] [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA] Fenofibrate results in increased expression of FASN mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA] |
CTD |
PMID:17118139 PMID:23063693 PMID:24534255 PMID:26973390 PMID:32730863 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbp2 |
fructose-bisphosphatase 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of FBP2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
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G |
Fbxo21 |
F-box protein 21 |
increases expression |
ISO |
Fenofibrate results in increased expression of FBXO21 mRNA |
CTD |
PMID:21318169 |
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NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
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G |
Fbxo22 |
F-box protein 22 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of FBXO22 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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G |
Fbxo3 |
F-box protein 3 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of FBXO3 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO3 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:90,417,262...90,449,557
Ensembl chr 3:90,417,297...90,449,557
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G |
Fbxo30 |
F-box protein 30 |
increases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of FBXO30 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO30 mRNA] |
CTD |
PMID:21318169 PMID:25596134 |
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NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions increases expression |
ISO |
Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO32 mRNA] Fenofibrate results in increased expression of FBXO32 mRNA; Fenofibrate results in increased expression of FBXO32 protein |
CTD |
PMID:33408297 |
|
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fbxo36 |
F-box protein 36 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of FBXO36 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 9:86,042,522...86,107,220
Ensembl chr 9:86,040,862...86,107,229
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G |
Fbxo9 |
f-box protein 9 |
increases expression |
ISO |
Fenofibrate results in increased expression of FBXO9 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of FDFT1 mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA] |
CTD |
PMID:23063693 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fga |
fibrinogen alpha chain |
multiple interactions decreases expression |
ISO EXP |
PPARA promotes the reaction [Fenofibrate results in decreased expression of FGA mRNA] |
CTD |
PMID:10216095 |
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NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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G |
Fgb |
fibrinogen beta chain |
decreases expression |
EXP |
Fenofibrate results in decreased expression of FGB mRNA |
CTD |
PMID:10216095 |
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NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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G |
Fgf21 |
fibroblast growth factor 21 |
increases expression |
ISO |
Fenofibrate results in increased expression of FGF21 mRNA; Fenofibrate results in increased expression of FGF21 protein |
CTD |
PMID:22338096 |
|
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
Fgg |
fibrinogen gamma chain |
decreases expression |
EXP |
Fenofibrate results in decreased expression of FGG mRNA |
CTD |
PMID:10216095 |
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NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
affects expression |
EXP |
Fenofibrate affects the expression of FGR mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein] |
CTD |
PMID:32730863 |
|
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Fkbp15 |
FKBP prolyl isomerase family member 15 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of FKBP15 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of FKBP15 mRNA |
CTD |
PMID:21318169 |
|
NCBI chr 5:75,750,786...75,815,038
Ensembl chr 5:75,750,787...75,814,990
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G |
Fkbp8 |
FKBP prolyl isomerase 8 |
increases expression |
ISO |
Fenofibrate results in increased expression of FKBP8 mRNA |
CTD |
PMID:21318169 |
|
NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA |
CTD |
PMID:18253720 |
|
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo5 |
flavin containing dimethylaniline monoxygenase 5 |
multiple interactions decreases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO5 mRNA Fenofibrate results in decreased expression of FMO5 mRNA |
CTD |
PMID:18253720 PMID:25572481 |
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NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
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G |
Fn1 |
fibronectin 1 |
affects expression multiple interactions |
EXP ISO |
Fenofibrate affects the expression of FN1 mRNA Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of FN1 protein] |
CTD |
PMID:20801182 PMID:28871336 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Foxo1 |
forkhead box O1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of FOXO1 mRNA; Fenofibrate results in increased expression of FOXO1 protein Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FOXO1 mRNA] |
CTD |
PMID:33408297 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxq1 |
forkhead box Q1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of FOXQ1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377 Ensembl chr17:32,912,744...32,915,377
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of G6PC1 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GADD45A mRNA Fenofibrate results in increased expression of GADD45A mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 PMID:25596134 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNA |
CTD |
PMID:18253720 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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G |
Galt |
galactose-1-phosphate uridylyltransferase |
increases expression |
ISO |
Fenofibrate results in increased expression of GALT mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 5:56,927,039...56,930,284
Ensembl chr 5:56,926,724...56,930,265
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G |
Gars1 |
glycyl-tRNA synthetase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of GARS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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G |
Gata4 |
GATA binding protein 4 |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]] |
CTD |
PMID:22198280 |
|
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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G |
Gbe1 |
1,4-alpha-glucan branching enzyme 1 |
decreases expression increases expression |
EXP ISO |
Fenofibrate results in decreased expression of GBE1 mRNA Fenofibrate results in increased expression of GBE1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
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G |
Gcat |
glycine C-acetyltransferase |
decreases expression |
ISO |
Fenofibrate results in decreased expression of GCAT mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
decreases expression multiple interactions |
EXP ISO |
Fenofibrate results in decreased expression of GCLC mRNA Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein] |
CTD |
PMID:25596134 PMID:36905866 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Fenofibrate results in increased expression of GCLM mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gcnt3 |
glucosaminyl (N-acetyl) transferase 3, mucin type |
increases expression |
ISO |
Fenofibrate results in increased expression of GCNT3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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G |
Gde1 |
glycerophosphodiester phosphodiesterase 1 |
affects expression |
EXP |
Fenofibrate affects the expression of GDE1 mRNA |
CTD |
PMID:20801182 |
|
NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of GDF15 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gk |
glycerol kinase |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of GK mRNA |
CTD |
PMID:25572481 PMID:32741897 |
|
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
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G |
Gmnn |
geminin, DNA replication inhibitor |
increases expression |
EXP |
Fenofibrate results in increased expression of GMNN mRNA |
CTD |
PMID:32741897 |
|
NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054
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G |
Gnmt |
glycine N-methyltransferase |
decreases expression |
ISO |
Fenofibrate results in decreased expression of GNMT mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression multiple interactions |
EXP |
Fenofibrate results in increased expression of GOT1 mRNA Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of GOT1 protein] |
CTD |
PMID:25596134 PMID:38216941 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of GOT2 mRNA |
CTD |
PMID:19652460 |
|
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
increases expression |
EXP |
Fenofibrate results in increased expression of GPAM mRNA |
CTD |
PMID:16707586 |
|
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gpat3 |
glycerol-3-phosphate acyltransferase 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of GPAT3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
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G |
Gphn |
gephyrin |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of GPHN mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in increased expression of GPT protein] Fenofibrate inhibits the reaction [tyloxapol results in increased expression of GPT protein] |
CTD |
PMID:27071702 PMID:36905866 PMID:38216941 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX1 mRNA] |
CTD |
PMID:31241159 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gpx2 |
glutathione peroxidase 2 |
multiple interactions increases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX2 mRNA] Fenofibrate results in increased expression of GPX2 mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 PMID:31241159 |
|
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX3 mRNA] |
CTD |
PMID:31241159 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA] |
CTD |
PMID:31241159 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Grm3 |
glutamate metabotropic receptor 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of GRM3 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
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G |
Grpel2 |
GrpE-like 2, mitochondrial |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of GRPEL2 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of GRPEL2 mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr18:55,167,831...55,180,073
Ensembl chr18:55,168,209...55,180,180
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G |
Gsr |
glutathione-disulfide reductase |
increases expression |
EXP |
Fenofibrate results in increased expression of GSR mRNA |
CTD |
PMID:25596134 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases expression multiple interactions |
EXP |
Fenofibrate results in decreased expression of GSTA2 mRNA [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTA2 mRNA |
CTD |
PMID:18253720 PMID:18775883 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta3 |
glutathione S-transferase alpha 3 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTA3 mRNA |
CTD |
PMID:18253720 |
|
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA Fenofibrate results in increased expression of GSTA5 mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions decreases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA Fenofibrate results in decreased expression of GSTM2 mRNA |
CTD |
PMID:18253720 PMID:18775883 |
|
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
multiple interactions decreases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA Fenofibrate results in decreased expression of GSTM3 mRNA |
CTD |
PMID:18253720 PMID:18775883 |
|
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gtse1 |
G-2 and S-phase expressed 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of GTSE1 mRNA |
CTD |
PMID:32741897 |
|
NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases expression |
ISO |
Fenofibrate results in decreased expression of H1-2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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G |
Hadh |
hydroxyacyl-CoA dehydrogenase |
increases expression |
ISO |
Fenofibrate results in increased expression of HADH mRNA |
CTD |
PMID:24752549 |
|
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of HADHA mRNA Fenofibrate results in decreased expression of HADHA protein |
CTD |
PMID:16707586 PMID:17118139 PMID:20118634 PMID:25572481 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression decreases expression affects expression |
ISO EXP |
Fenofibrate results in increased expression of HADHB mRNA Fenofibrate results in decreased expression of HADHB protein Fenofibrate affects the expression of HADHB mRNA |
CTD |
PMID:17118139 PMID:20118634 PMID:20801182 PMID:24752549 PMID:25572481 |
|
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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G |
Hal |
histidine ammonia lyase |
decreases expression |
EXP |
Fenofibrate results in decreased expression of HAL mRNA |
CTD |
PMID:32741898 |
|
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hdc |
histidine decarboxylase |
increases expression |
EXP |
Fenofibrate results in increased expression of HDC mRNA; Fenofibrate results in increased expression of HDC protein |
CTD |
PMID:32741897 PMID:32741898 |
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NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G |
Hdgfl3 |
HDGF like 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of HDGFL3 mRNA |
CTD |
PMID:17264098 |
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NCBI chr 1:135,822,600...135,876,719
Ensembl chr 1:135,827,549...135,876,719
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G |
Hectd1 |
HECT domain E3 ubiquitin protein ligase 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HECTD1 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HECTD1 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 6:69,181,429...69,268,045
Ensembl chr 6:69,181,436...69,268,053
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G |
Herc3 |
HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of HERC3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA] |
CTD |
PMID:31241159 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression multiple interactions affects activity |
ISO EXP |
Fenofibrate results in increased expression of HIF1A mRNA Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Fenofibrate results in decreased expression of and results in increased degradation of HIF1A protein Fenofibrate affects the activity of HIF1A protein |
CTD |
PMID:17118139 PMID:25596134 PMID:34520103 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hilpda |
hypoxia inducible lipid droplet-associated |
increases expression |
EXP |
Fenofibrate results in increased expression of HILPDA mRNA |
CTD |
PMID:32741897 |
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NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression decreases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of HMGCR mRNA Fenofibrate results in decreased expression of HMGCR mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA] |
CTD |
PMID:16595124 PMID:23063693 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of HMGCS1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of HMGCS2 mRNA |
CTD |
PMID:25572481 PMID:27665778 PMID:32741897 |
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NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
EXP ISO |
Fenofibrate results in increased expression of HMOX1 mRNA Fenofibrate results in increased expression of HMOX1 protein dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of HMOX1 protein] Fenofibrate results in increased expression of HMOX1 mRNA; Fenofibrate results in increased expression of HMOX1 protein |
CTD |
PMID:25596134 PMID:34520103 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hoga1 |
4-hydroxy-2-oxoglutarate aldolase 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of HOGA1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of HRAS mRNA |
CTD |
PMID:18978307 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of HSD11B1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of HSD17B4 mRNA |
CTD |
PMID:17118139 PMID:25572481 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsdl2 |
hydroxysteroid dehydrogenase like 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of HSDL2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
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G |
Hsf1 |
heat shock transcription factor 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HSP90AA1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AA1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AB1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of HSP90B1 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
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G |
Hspa13 |
heat shock protein family A (Hsp70) member 13 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of HSPA13 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of HSPA13 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr11:14,375,669...14,389,853
Ensembl chr11:14,373,275...14,389,895
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G |
Hspa4l |
heat shock protein family A (Hsp70) member 4 like |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HSPA4L mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA4L mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression multiple interactions |
EXP |
Fenofibrate results in decreased expression of HSPA5 mRNA Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein] |
CTD |
PMID:25596134 PMID:38216941 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HSPA8 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA8 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HSPA9 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA9 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
affects expression multiple interactions increases expression |
EXP ISO |
Fenofibrate affects the expression of HSPB1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPB1 mRNA] |
CTD |
PMID:20801182 PMID:21318169 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Hspb8 |
heat shock protein family B (small) member 8 |
multiple interactions increases expression |
ISO |
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HSPB8 mRNA Fenofibrate results in increased expression of HSPB8 mRNA |
CTD |
PMID:21318169 |
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NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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G |
Hspe1 |
heat shock protein family E (Hsp10) member 1 |
affects expression |
EXP |
Fenofibrate affects the expression of HSPE1 mRNA |
CTD |
PMID:20801182 |
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NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of HSPH1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPH1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Htatip2 |
HIV-1 Tat interactive protein 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of HTATIP2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
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G |
Iars1 |
isoleucyl-tRNA synthetase 1 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of IARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA] dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA] |
CTD |
PMID:20580385 PMID:21300114 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id2 |
inhibitor of DNA binding 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ID2 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Idh3b |
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta |
increases expression |
ISO |
Fenofibrate results in increased expression of IDH3B mRNA |
CTD |
PMID:24752549 |
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NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
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G |
Iffo1 |
intermediate filament family orphan 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of IFFO1 mRNA |
CTD |
PMID:16707586 |
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NCBI chr 4:157,945,075...157,962,302
Ensembl chr 4:157,945,107...157,962,302
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G |
Ifng |
interferon gamma |
multiple interactions |
EXP |
Fenofibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] |
CTD |
PMID:20631892 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf2r |
insulin-like growth factor 2 receptor |
decreases expression |
EXP |
Fenofibrate results in decreased expression of IGF2R mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] |
CTD |
PMID:15968640 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il17rb |
interleukin 17 receptor B |
decreases expression |
EXP |
Fenofibrate results in decreased expression of IL17RB mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
[Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL1B mRNA] Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein] Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]]; Fenofibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]] |
CTD |
PMID:15968640 PMID:20631892 PMID:21300114 PMID:31241159 PMID:32613381 PMID:36988379 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions affects response to substance |
ISO |
[Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; Fenofibrate promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]] IL6 promoter polymorphism affects the susceptibility to Fenofibrate |
CTD |
PMID:15968640 PMID:16607077 PMID:19593819 PMID:21300114 PMID:25035112 PMID:31241159 PMID:37076581 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [Fructose results in increased secretion of INS1 protein] |
CTD |
PMID:26973390 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein] |
CTD |
PMID:32613381 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig1 |
insulin induced gene 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of INSIG1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Insig2 |
insulin induced gene 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of INSIG2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of IRAK2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
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G |
Irf7 |
interferon regulatory factor 7 |
increases expression |
ISO |
Fenofibrate results in increased expression of IRF7 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Itch |
itchy E3 ubiquitin protein ligase |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of ITCH mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
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G |
Itfg2 |
integrin alpha FG-GAP repeat containing 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of ITFG2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:161,684,249...161,698,315
Ensembl chr 4:161,684,249...161,698,422
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G |
Itgb1 |
integrin subunit beta 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of ITGB1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb3 |
integrin subunit beta 3 |
affects expression |
EXP |
Fenofibrate affects the expression of ITGB3 mRNA |
CTD |
PMID:20801182 |
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Glucose results in increased expression of JUN protein] [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of JUN mRNA; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA] |
CTD |
PMID:16600694 PMID:18978307 PMID:31016362 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcnk13 |
potassium two pore domain channel subfamily K member 13 |
increases expression |
ISO |
Fenofibrate results in increased expression of KCNK13 mRNA |
CTD |
PMID:25572481 PMID:25596134 |
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NCBI chr 6:119,240,825...119,345,292
Ensembl chr 6:119,242,188...119,345,240
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein] |
CTD |
PMID:36905866 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kif22 |
kinesin family member 22 |
increases expression |
EXP |
Fenofibrate results in increased expression of KIF22 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
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G |
Kifc1 |
kinesin family member C1 |
increases expression |
EXP |
Fenofibrate results in increased expression of KIFC1 mRNA |
CTD |
PMID:32741897 |
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NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105
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G |
Klf10 |
KLF transcription factor 10 |
decreases expression increases expression |
ISO |
Fenofibrate results in decreased expression of KLF10 mRNA Fenofibrate results in increased expression of KLF10 mRNA |
CTD |
PMID:11798191 PMID:25572481 |
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NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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G |
Klf11 |
KLF transcription factor 11 |
increases expression |
ISO |
Fenofibrate results in increased expression of KLF11 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550
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G |
Krt18 |
keratin 18 |
multiple interactions |
ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein |
CTD |
PMID:18978307 |
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NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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G |
Krt23 |
keratin 23 |
increases expression |
EXP |
Fenofibrate results in increased expression of KRT23 mRNA |
CTD |
PMID:32741897 |
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NCBI chr10:84,434,445...84,450,773
Ensembl chr10:84,434,380...84,450,983
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G |
Krt8 |
keratin 8 |
multiple interactions |
ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT8 protein |
CTD |
PMID:18978307 |
|
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
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G |
Krtap1-1 |
keratin associated protein 1-1 |
increases expression |
EXP |
Fenofibrate results in increased expression of KRTAP1-5 mRNA |
CTD |
PMID:32741897 |
|
NCBI chr10:84,545,765...84,546,331
Ensembl chr10:84,545,580...84,546,354
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G |
Lama4 |
laminin subunit alpha 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of LAMA4 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
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|
G |
Lars1 |
leucyl-tRNA synthetase 1 |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of LARS1 mRNA Fenofibrate results in decreased expression of LARS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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G |
Lbh |
LBH regulator of WNT signaling pathway |
increases expression |
ISO |
Fenofibrate results in increased expression of LBH mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079
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G |
Ldhb |
lactate dehydrogenase B |
increases expression |
ISO |
Fenofibrate results in increased expression of LDHB mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
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G |
Lep |
leptin |
multiple interactions |
EXP ISO |
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] |
CTD |
PMID:26973390 PMID:32929351 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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|
G |
Lgals1 |
galectin 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of LGALS1 mRNA |
CTD |
PMID:11798191 |
|
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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|
G |
Lifr |
LIF receptor subunit alpha |
decreases expression |
ISO |
Fenofibrate results in decreased expression of LIFR mRNA |
CTD |
PMID:11798191 |
|
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
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G |
Lmcd1 |
LIM and cysteine-rich domains 1 |
affects expression |
EXP |
Fenofibrate affects the expression of LMCD1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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G |
Lnx1 |
ligand of numb-protein X 1 |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of LNX1 mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086
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|
G |
Lpcat2 |
lysophosphatidylcholine acyltransferase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of LPCAT2 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr19:14,088,389...14,152,742
Ensembl chr19:14,089,686...14,152,829
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G |
Lpcat3 |
lysophosphatidylcholine acyltransferase 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of LPCAT3 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
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G |
Lpl |
lipoprotein lipase |
increases expression multiple interactions increases activity |
ISO EXP |
Fenofibrate results in increased expression of LPL mRNA; Fenofibrate results in increased expression of LPL protein PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL protein] PPARA protein promotes the reaction [Fenofibrate results in increased expression of LPL protein] Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of LPL mRNA] Fenofibrate results in increased activity of LPL protein |
CTD |
PMID:8593127 PMID:11798191 PMID:16595124 PMID:24752549 PMID:27071702 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Lrrc31 |
leucine rich repeat containing 31 |
increases expression |
ISO |
Fenofibrate results in increased expression of LRRC31 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 2:112,702,844...112,725,431
Ensembl chr 2:112,700,136...112,724,322
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G |
Lrsam1 |
leucine rich repeat and sterile alpha motif containing 1 |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of LRSAM1 mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr 3:16,223,367...16,264,261
Ensembl chr 3:16,223,367...16,264,154
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G |
Lss |
lanosterol synthase |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of LSS mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA] |
CTD |
PMID:23063693 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Ltn1 |
listerin E3 ubiquitin protein ligase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of LTN1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
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G |
Ly6d |
lymphocyte antigen 6 family member D |
increases expression |
ISO |
Fenofibrate results in increased expression of LY6D mRNA |
CTD |
PMID:17118139 |
|
NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
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G |
Lyrm1 |
LYR motif containing 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of LYRM1 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 1:174,284,116...174,305,053
Ensembl chr 1:174,284,602...174,305,053
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|
G |
Lyz2 |
lysozyme 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of LYZ2 mRNA |
CTD |
PMID:11798191 |
|
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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G |
Mafg |
MAF bZIP transcription factor G |
decreases expression increases expression |
EXP ISO |
Fenofibrate results in decreased expression of MAFG mRNA Fenofibrate results in increased expression of MAFG mRNA |
CTD |
PMID:25596134 |
|
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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G |
Man1a1 |
mannosidase, alpha, class 1A, member 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of MAN1A mRNA |
CTD |
PMID:16707586 |
|
NCBI chr20:33,202,509...33,385,747
Ensembl chr20:33,202,517...33,385,824
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G |
Man1a2 |
mannosidase, alpha, class 1A, member 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of MAN1A2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
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G |
Maob |
monoamine oxidase B |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA |
CTD |
PMID:18253720 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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G |
Map1lc3a |
microtubule-associated protein 1 light chain 3 alpha |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of MAP1LC3A mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MAP1LC3A mRNA |
CTD |
PMID:21318169 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:36905866 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map3k13 |
mitogen-activated protein kinase kinase kinase 13 |
increases expression |
EXP |
Fenofibrate results in increased expression of MAP3K13 mRNA |
CTD |
PMID:32741897 |
|
NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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G |
Mat2a |
methionine adenosyltransferase 2A |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MAT2A mRNA |
CTD |
PMID:16569247 |
|
NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493
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G |
Mc1r |
melanocortin 1 receptor |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of MC1R mRNA [Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins |
CTD |
PMID:23872139 |
|
NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
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G |
Mdh2 |
malate dehydrogenase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of MDH mRNA |
CTD |
PMID:24752549 |
|
NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
EXP |
Fenofibrate results in decreased expression of MDM2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Me1 |
malic enzyme 1 |
affects expression increases expression multiple interactions |
EXP ISO |
Fenofibrate affects the expression of ME1 mRNA Fenofibrate results in increased expression of ME1 mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA] |
CTD |
PMID:20801182 PMID:23063693 PMID:25596134 PMID:27071702 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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G |
Mertk |
MER proto-oncogene, tyrosine kinase |
increases expression |
ISO |
Fenofibrate results in increased expression of MERTK mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
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G |
Mfn2 |
mitofusin 2 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein] |
CTD |
PMID:32730863 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mfsd2a |
MFSD2 lysolipid transporter A, lysophospholipid |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MFSD2A mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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G |
Mgll |
monoglyceride lipase |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of MGLL mRNA |
CTD |
PMID:11798191 PMID:17118139 PMID:27665778 |
|
NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA Fenofibrate results in increased expression of MGMT mRNA |
CTD |
PMID:17264098 PMID:18253720 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mgrn1 |
mahogunin ring finger 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of MGRN1 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MGRN1 mRNA |
CTD |
PMID:21318169 |
|
NCBI chr10:10,638,881...10,688,332
Ensembl chr10:10,638,880...10,688,315
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G |
Mgst3 |
microsomal glutathione S-transferase 3 |
increases expression |
ISO |
Fenofibrate results in increased expression of MGST3 mRNA |
CTD |
PMID:11798191 |
|
NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
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G |
Mitf |
melanocyte inducing transcription factor |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MITF mRNA; Fenofibrate results in decreased expression of MITF protein |
CTD |
PMID:23872139 |
|
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
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G |
Mki67 |
marker of proliferation Ki-67 |
increases expression |
EXP |
Fenofibrate results in increased expression of MKI67 mRNA; Fenofibrate results in increased expression of MKI67 protein |
CTD |
PMID:17264098 PMID:32741897 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlh1 |
mutL homolog 1 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNA Fenofibrate results in increased expression of MLH1 mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 |
|
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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G |
Mlycd |
malonyl-CoA decarboxylase |
multiple interactions |
EXP |
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA] |
CTD |
PMID:14641110 PMID:26973390 |
|
NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
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G |
Mmd |
monocyte to macrophage differentiation-associated |
increases expression |
ISO |
Fenofibrate results in increased expression of MMD mRNA |
CTD |
PMID:25572481 |
|
NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
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G |
Mmp1 |
matrix metallopeptidase 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MMP1 protein |
CTD |
PMID:25545733 |
|
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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G |
Mmp19 |
matrix metallopeptidase 19 |
increases expression |
EXP |
Fenofibrate results in increased expression of MMP19 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MMP2 protein |
CTD |
PMID:25545733 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MMP7 protein |
CTD |
PMID:25545733 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases expression |
ISO |
Fenofibrate inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; Fenofibrate inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein] Fenofibrate results in decreased expression of MMP9 protein |
CTD |
PMID:19880272 PMID:21075133 PMID:25545733 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mrap |
melanocortin 2 receptor accessory protein |
increases expression |
ISO |
Fenofibrate results in increased expression of MRAP mRNA |
CTD |
PMID:11798191 |
|
NCBI chr11:29,991,974...30,003,024
Ensembl chr11:29,992,034...30,003,024
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G |
Ms4a10 |
membrane spanning 4-domains A10 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MS4A10 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr 1:207,611,312...207,624,452
Ensembl chr 1:207,611,312...207,624,452
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G |
Msc |
musculin |
decreases expression |
EXP |
Fenofibrate results in decreased expression of MSC mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
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G |
Msmo1 |
methylsterol monooxygenase 1 |
affects expression |
EXP |
Fenofibrate affects the expression of MSMO1 mRNA |
CTD |
PMID:20801182 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Mttp |
microsomal triglyceride transfer protein |
increases expression |
EXP |
Fenofibrate results in increased expression of MTTP mRNA |
CTD |
PMID:32741897 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions increases expression |
ISO EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MYC mRNA Fenofibrate results in increased expression of MYC mRNA |
CTD |
PMID:18978307 PMID:32741897 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Mylk |
myosin light chain kinase |
decreases expression |
ISO |
Fenofibrate results in decreased expression of MYLK mRNA |
CTD |
PMID:25572481 |
|
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
N4bp2l1 |
NEDD4 binding protein 2-like 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of N4BP2L1 mRNA |
CTD |
PMID:25572481 |
|
NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257
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G |
Nacc1 |
nucleus accumbens associated 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of NACC1 mRNA |
CTD |
PMID:17264098 |
|
NCBI chr19:23,468,688...23,486,528
Ensembl chr19:23,468,419...23,486,528
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G |
Nampt |
nicotinamide phosphoribosyltransferase |
increases expression |
EXP |
Fenofibrate results in increased expression of NAMPT mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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G |
Nars1 |
asparaginyl-tRNA synthetase 1 |
affects expression |
EXP |
Fenofibrate affects the expression of NARS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
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G |
Nat8f3 |
N-acetyltransferase 8 (GCN5-related) family member 3 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NAT8F3 mRNA |
CTD |
PMID:18253720 |
|
NCBI chr 4:118,241,792...118,246,010
Ensembl chr 4:118,239,304...118,285,500
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|
G |
Nbn |
nibrin |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NBN mRNA Fenofibrate results in increased expression of NBN mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 |
|
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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G |
Nceh1 |
neutral cholesterol ester hydrolase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of NCEH1 mRNA |
CTD |
PMID:27665778 |
|
NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
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|
G |
Ndufab1 |
NADH:ubiquinone oxidoreductase subunit AB1 |
increases expression |
ISO |
Fenofibrate results in increased expression of NDUFAB1 mRNA |
CTD |
PMID:11798191 |
|
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
|
|
G |
Nedd4 |
NEDD4 E3 ubiquitin protein ligase |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of NEDD4 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of NEDD4 mRNA] |
CTD |
PMID:21318169 |
|
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
|
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G |
Nedd9 |
neural precursor cell expressed, developmentally down-regulated 9 |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of NEDD9 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
|
|
G |
Nfatc4 |
nuclear factor of activated T-cells 4 |
multiple interactions |
EXP |
EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]] |
CTD |
PMID:22198280 |
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NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity decreases expression affects activity |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein] Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 protein] Fenofibrate results in increased activity of NFE2L2 protein Fenofibrate results in decreased expression of NFE2L2 mRNA Fenofibrate affects the activity of NFE2L2 protein |
CTD |
PMID:18775883 PMID:25596134 PMID:30114225 PMID:30203046 PMID:31241159 PMID:32730863 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions affects localization |
ISO |
Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of NFKB1 protein] Fenofibrate affects the localization of NFKB1 protein |
CTD |
PMID:20580385 PMID:25545733 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases expression |
ISO |
Fenofibrate inhibits the reaction [ALB protein modified form results in increased degradation of NFKBIA protein] Fenofibrate results in decreased expression of NFKBIA protein modified form |
CTD |
PMID:20580385 PMID:25545733 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NFKBIB mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NFKBIB mRNA |
CTD |
PMID:18253720 PMID:21999347 |
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NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Nim1k |
NIM1 serine/threonine protein kinase |
increases expression |
EXP |
Fenofibrate results in increased expression of NIM1K mRNA |
CTD |
PMID:32741897 |
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NCBI chr 2:51,670,764...51,714,782
Ensembl chr 2:51,670,772...51,714,762
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G |
Ninj1 |
ninjurin 1 |
affects expression |
EXP |
Fenofibrate affects the expression of NINJ1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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G |
Nmur1 |
neuromedin U receptor 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of NMUR1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
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G |
Nnmt |
nicotinamide N-methyltransferase |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NNMT mRNA |
CTD |
PMID:18253720 |
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NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NOS2 mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NOS2 protein |
CTD |
PMID:21300114 PMID:21999347 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases phosphorylation increases activity |
ISO |
dorsomorphin inhibits the reaction [Fenofibrate results in increased activity of NOS3 protein]; Fenofibrate inhibits the reaction [Wortmannin results in decreased phosphorylation of NOS3 protein]; PRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein] Fenofibrate results in increased phosphorylation of NOS3 protein |
CTD |
PMID:16442496 PMID:20580385 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Notch1 |
notch receptor 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA] |
CTD |
PMID:31241159 |
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NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G |
Notch3 |
notch receptor 3 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein] |
CTD |
PMID:31241159 |
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NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Doxorubicin results in decreased expression of NPPA mRNA] |
CTD |
PMID:17531194 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
EXP |
Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]] |
CTD |
PMID:22198280 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions increases expression |
ISO EXP |
Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]; dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]; pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] [Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]] Fenofibrate results in increased expression of NR0B2 mRNA; Fenofibrate results in increased expression of NR0B2 protein |
CTD |
PMID:19593819 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of NR1H2 mRNA NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA] |
CTD |
PMID:19201410 PMID:23063693 |
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NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases expression multiple interactions affects response to substance |
ISO |
Fenofibrate results in increased expression of NR1H3 mRNA NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of NR1H3 mRNA] NR1H3 protein affects the susceptibility to Fenofibrate [Oleic Acid co-treated with Fenofibrate] affects the expression of NR1H3 mRNA; NR1H3 protein affects the reaction [Fenofibrate results in increased expression of PPARA mRNA] |
CTD |
PMID:19201410 PMID:23063693 PMID:24534255 PMID:25949234 |
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NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions increases expression |
ISO EXP |
[Oleic Acid co-treated with Fenofibrate] results in decreased expression of NR1H4 mRNA fenofibrate increases expression of Nr1h4 mRNA in steatotic liver |
CTD RGD |
PMID:24534255 PMID:30257410 |
RGD:15090799 |
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Fenofibrate binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:20024649 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
affects localization increases activity multiple interactions increases expression |
ISO EXP |
Fenofibrate affects the localization of NR1I3 protein Fenofibrate results in increased activity of NR1I3 protein [Oleic Acid co-treated with Fenofibrate] results in increased expression of NR1I3 mRNA; Fenofibrate binds to and results in increased activity of NR1I3 protein alternative form Fenofibrate results in increased expression of NR1I3 mRNA |
CTD |
PMID:17962186 PMID:19118567 PMID:24534255 PMID:30203046 PMID:31312845 PMID:32741897 More...
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]] |
CTD |
PMID:19593819 |
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NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nrep |
neuronal regeneration related protein |
decreases expression |
ISO |
Fenofibrate results in decreased expression of NREP mRNA |
CTD |
PMID:25596134 |
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NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
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G |
Nsdhl |
NAD(P) dependent steroid dehydrogenase-like |
increases expression |
ISO |
Fenofibrate results in increased expression of NSDHL mRNA |
CTD |
PMID:11798191 |
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NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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G |
Ntpcr |
nucleoside-triphosphatase, cancer-related |
affects expression |
EXP |
Fenofibrate affects the expression of NTPCR mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
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G |
Nuak1 |
NUAK family kinase 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of NUAK1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913
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G |
Oasl |
2'-5'-oligoadenylate synthetase-like |
increases expression |
ISO |
Fenofibrate results in increased expression of OASL mRNA |
CTD |
PMID:25572481 |
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NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein] |
CTD |
PMID:32730863 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Orai3 |
ORAI calcium release-activated calcium modulator 3 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ORAI3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
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G |
Osgin1 |
oxidative stress induced growth inhibitor 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of OSGIN1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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G |
P4ha1 |
prolyl 4-hydroxylase subunit alpha 1 |
affects expression |
EXP |
Fenofibrate affects the expression of P4HA1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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G |
P4hb |
prolyl 4-hydroxylase subunit beta |
affects expression |
EXP |
Fenofibrate affects the expression of P4HB mRNA |
CTD |
PMID:20801182 |
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NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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G |
Pank1 |
pantothenate kinase 1 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of PANK1 mRNA |
CTD |
PMID:16707586 PMID:25572481 PMID:25596134 |
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NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
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G |
Pbk |
PDZ binding kinase |
increases expression |
EXP |
Fenofibrate results in increased expression of PBK mRNA |
CTD |
PMID:32741897 |
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NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of PCK1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
increases expression |
ISO |
Fenofibrate results in increased expression of PCK2 mRNA |
CTD |
PMID:16569247 PMID:24752549 |
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NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions increases expression |
ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]; Estradiol inhibits the reaction [Fenofibrate results in increased expression of PCNA protein] |
CTD |
PMID:18978307 PMID:29134746 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
increases expression |
ISO |
Fenofibrate results in increased expression of PCSK9 protein |
CTD |
PMID:21411093 |
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NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Pdia5 |
protein disulfide isomerase family A, member 5 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PDIA5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PDK1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of PDK4 mRNA |
CTD |
PMID:17118139 PMID:19395589 PMID:25572481 PMID:25596134 PMID:27665778 PMID:32741897 More...
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NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Pdlim1 |
PDZ and LIM domain 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PDLIM1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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G |
Pdrg1 |
p53 and DNA damage regulated 1 |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of PDRG1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
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G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
increases expression |
ISO |
Fenofibrate results in increased expression of PEMT mRNA |
CTD |
PMID:25572481 |
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NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013
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G |
Pex11a |
peroxisomal biogenesis factor 11 alpha |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of PEX11A mRNA Fenofibrate results in increased expression of PEX11A mRNA |
CTD |
PMID:20801182 PMID:25572481 PMID:27665778 PMID:32741897 |
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NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
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G |
Pgm1 |
phosphoglucomutase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of PGM1 mRNA |
CTD |
PMID:24752549 |
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NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
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G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of PHGDH mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
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G |
Phlda1 |
pleckstrin homology-like domain, family A, member 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of PHLDA1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
affects expression |
EXP |
Fenofibrate affects the expression of PHLDA3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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G |
Pik3c2g |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PIK3C2G mRNA |
CTD |
PMID:16707586 |
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NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
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G |
Pir |
pirin |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PIR mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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G |
Pja2 |
praja ring finger ubiquitin ligase 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PJA2 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of PJA2 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
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G |
Pkib |
cAMP-dependent protein kinase inhibitor beta |
increases expression |
ISO |
Fenofibrate results in increased expression of PKIB mRNA |
CTD |
PMID:25572481 |
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NCBI chr20:36,965,172...37,062,190
Ensembl chr20:36,905,340...37,062,187
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G |
Pklr |
pyruvate kinase L/R |
decreases expression |
ISO |
Fenofibrate results in decreased expression of PKLR mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Pla1a |
phospholipase A1 member A |
increases expression |
ISO |
Fenofibrate results in increased expression of PLA1A mRNA |
CTD |
PMID:25572481 |
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NCBI chr11:62,320,112...62,357,779
Ensembl chr11:62,320,493...62,357,779
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G |
Pla2g7 |
phospholipase A2 group VII |
decreases activity multiple interactions |
ISO |
Fenofibrate results in decreased activity of PLA2G7 protein [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein |
CTD |
PMID:16911813 |
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NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
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G |
Plcxd3 |
phosphatidylinositol-specific phospholipase C, X domain containing 3 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of PLCXD3 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384
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G |
Plin1 |
perilipin 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of PLIN1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
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G |
Plin2 |
perilipin 2 |
increases expression multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of PLIN2 mRNA Fenofibrate promotes the reaction [Oleic Acid results in increased expression of PLIN2 mRNA] |
CTD |
PMID:24534255 PMID:25572481 PMID:25596134 PMID:27665778 |
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NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Plin4 |
perilipin 4 |
increases expression |
ISO |
Fenofibrate results in increased expression of PLIN4 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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G |
Plin5 |
perilipin 5 |
increases expression |
EXP |
Fenofibrate results in increased expression of PLIN5 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 9:939,745...946,188
Ensembl chr 9:939,747...946,120
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G |
Pltp |
phospholipid transfer protein |
increases expression |
ISO |
Fenofibrate results in increased expression of PLTP mRNA |
CTD |
PMID:11798191 |
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NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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G |
Pmepa1 |
prostate transmembrane protein, androgen induced 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PMEPA1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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G |
Pml |
PML nuclear body scaffold |
multiple interactions |
ISO |
Fenofibrate promotes the reaction [Arsenic Trioxide results in decreased expression of PML protein mutant form] |
CTD |
PMID:32929351 |
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NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G |
Podxl |
podocalyxin-like |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of PODXL mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
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G |
Pon1 |
paraoxonase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of PON1 protein |
CTD |
PMID:16123850 |
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NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Por |
cytochrome p450 oxidoreductase |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of POR mRNA |
CTD |
PMID:16707586 PMID:25572481 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppan |
peter pan homolog |
affects expression |
EXP |
Fenofibrate affects the expression of PPAN mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression multiple interactions increases response to substance increases activity decreases response to substance increases expression affects response to substance |
ISO EXP |
Fenofibrate results in decreased expression of PPARA mRNA fenofibrate co-treated with fructose diet decreases expression of ppara mRNA in liver PPARA protein results in increased susceptibility to Fenofibrate Fenofibrate results in increased activity of PPARA protein PPARA gene mutant form results in decreased susceptibility to Fenofibrate [Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of PPARA mRNA; ESR1 protein inhibits the reaction [Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Estradiol inhibits the reaction [ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA protein]; NR1H3 protein affects the reaction [Fenofibrate results in increased expression of PPARA mRNA]; PPARA protein inhibits the reaction [Fenofibrate results in decreased expression of APOA1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACSL1 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of LPL protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of SLC27A4 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of UCP2 protein] [Fenofibrate binds to and results in increased activity of PPARA protein] which affects the abundance of Fatty Acids, Nonesterified; [Fenofibrate binds to and results in increased activity of PPARA protein] which affects the abundance of Triglycerides; [Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate; [Fenofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of ASB6 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of BRCC3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC14 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC19 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC2 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of FKBP15 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HECTD1 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HSPB8 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MAP1LC3A mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MGRN1 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of PRKAB2 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SEC63 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SMPD3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of TOPORS mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of UBR2 mRNA; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of PPARA mRNA]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate results in increased expression of and results in increased activity of PPARA protein; Lipopolysaccharides inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACB mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACLY mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of NR1H3 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 protein]; PPARA promotes the reaction [Fenofibrate results in decreased expression of FGA mRNA]; PPARA protein affects the reaction [Fenofibrate affects the expression of BRAP mRNA]; PPARA protein affects the reaction [Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of ANAPC11 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of CISH mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of CYLD mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of DNAJB4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of HSPA13 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of ITCH mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of LNX1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of LRSAM1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PDRG1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PRKAB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of RBJ mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of RNF144B mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of UBE2R2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of URM1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of USP36 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of WSB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ACADM mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ARIH1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATE1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG7 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CBLB mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CNOT4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJA2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJB6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC3 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC5 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ENC1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO3 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO30 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO32 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FOXO1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of GRPEL2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AA1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA4L mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA8 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA9 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPH1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of NEDD4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PJA2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PPP1R15B mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMB2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMC6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMD4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of RABGEF1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of RNF14 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SENP2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SPOP mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR1B mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR3A mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIM63 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIP12 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE2Q2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE3A mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of URI1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP10 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP22 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP38 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP7 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP9X mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USPL1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of VCPIP1 mRNA] Fenofibrate results in increased expression of PPARA mRNA; Fenofibrate results in increased expression of PPARA protein PPARA protein results in increased susceptibility to Fenofibrate; PPARA results in increased susceptibility to Fenofibrate [Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA protein]; Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]; Fenofibrate promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]] |
CTD RGD |
PMID:7983038 PMID:10216095 PMID:11341955 PMID:11798191 PMID:11934685 PMID:12759900 PMID:14641110 PMID:15299082 PMID:15968640 PMID:16569247 PMID:17201732 PMID:17655842 PMID:18300857 PMID:18356826 PMID:18812576 PMID:19118567 PMID:19124612 PMID:19201410 PMID:19445040 PMID:19569716 PMID:19593819 PMID:20520642 PMID:21300114 PMID:21318169 PMID:22198280 PMID:23063693 PMID:24735863 PMID:24752549 PMID:24986865 PMID:25035112 PMID:25689681 PMID:25949234 PMID:26989860 PMID:27071702 PMID:28743512 PMID:28871336 PMID:29134746 PMID:30203046 PMID:30611848 PMID:33408297 PMID:11934685 More...
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RGD:628329 |
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases expression |
ISO |
Fenofibrate results in increased expression of PPARD mRNA |
CTD |
PMID:19201410 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression affects activity multiple interactions |
ISO EXP |
Fenofibrate results in increased expression of PPARG mRNA Fenofibrate affects the activity of PPARG protein [Oleic Acid co-treated with Fenofibrate] results in increased expression of PPARG mRNA |
CTD |
PMID:19201410 PMID:24534255 PMID:25596134 PMID:28034800 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA] Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein] |
CTD |
PMID:28871336 PMID:32730863 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppcs |
phosphopantothenoylcysteine synthetase |
increases expression |
EXP |
Fenofibrate results in increased expression of PPCS mRNA |
CTD |
PMID:27665778 |
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NCBI chr 5:133,023,077...133,026,899
Ensembl chr 5:133,023,121...133,026,933
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G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
decreases expression |
EXP |
Fenofibrate results in decreased expression of PPM1D mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of PPP1R15A mRNA Fenofibrate results in decreased expression of PPP1R15A mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp1r15b |
protein phosphatase 1, regulatory subunit 15B |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PPP1R15B mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of PPP1R15B mRNA] |
CTD |
PMID:21318169 |
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NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions decreases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions decreases response to substance |
ISO |
PRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form]; PRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]; PRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein] PRKAA1 gene mutant form results in decreased susceptibility to Fenofibrate |
CTD |
PMID:20580385 PMID:25545733 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkab1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
decreases expression increases phosphorylation multiple interactions |
ISO |
Fenofibrate results in decreased expression of PRKAB1 mRNA Fenofibrate results in increased phosphorylation of PRKAB1 protein PPARA protein affects the reaction [Fenofibrate results in decreased expression of PRKAB1 mRNA] |
CTD |
PMID:21318169 PMID:25545733 |
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NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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G |
Prkab2 |
protein kinase AMP-activated non-catalytic subunit beta 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PRKAB2 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of PRKAB2 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
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G |
Prkag1 |
protein kinase AMP-activated non-catalytic subunit gamma 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of PRKAG1 protein |
CTD |
PMID:25545733 |
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NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561
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G |
Prodh |
proline dehydrogenase |
decreases expression |
ISO |
Fenofibrate results in decreased expression of PRODH mRNA |
CTD |
PMID:25572481 |
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NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
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G |
Prrg4 |
proline rich and Gla domain 4 |
increases expression |
EXP |
Fenofibrate results in increased expression of PRRG4 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 3:91,214,646...91,243,347
Ensembl chr 3:91,214,653...91,243,273
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G |
Psen1 |
presenilin 1 |
multiple interactions |
ISO |
Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein] |
CTD |
PMID:17962197 |
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NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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G |
Psmb2 |
proteasome 20S subunit beta 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PSMB2 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMB2 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PSMC6 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMC6 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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G |
Psmd4 |
proteasome 26S subunit ubiquitin receptor, non-ATPase 4 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of PSMD4 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMD4 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21300114 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
affects expression |
EXP |
Fenofibrate affects the expression of PTPRF mRNA |
CTD |
PMID:20801182 |
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NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
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G |
Ptprq |
protein tyrosine phosphatase, receptor type, Q |
decreases expression |
ISO |
Fenofibrate results in decreased expression of PTPRQ mRNA |
CTD |
PMID:25572481 |
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NCBI chr 7:42,834,455...43,016,807
Ensembl chr 7:42,837,109...43,016,917
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G |
Pygl |
glycogen phosphorylase L |
increases expression |
EXP |
Fenofibrate results in increased expression of PYGL mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Qpct |
glutaminyl-peptide cyclotransferase |
increases expression |
EXP |
Fenofibrate results in increased expression of QPCT mRNA |
CTD |
PMID:27665778 PMID:32741897 |
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NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711
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G |
Rab30 |
RAB30, member RAS oncogene family |
increases expression |
EXP |
Fenofibrate results in increased expression of RAB30 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181
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G |
Rab31 |
RAB31, member RAS oncogene family |
decreases expression |
ISO |
Fenofibrate results in decreased expression of RAB31 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253
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G |
Rabgef1 |
RAB guanine nucleotide exchange factor 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of RABGEF1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of RABGEF1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
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G |
Rad50 |
RAD50 double strand break repair protein |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RAD50 mRNA |
CTD |
PMID:18253720 |
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NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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G |
Rad51b |
RAD51 paralog B |
increases expression |
ISO |
Fenofibrate results in increased expression of RAD51B mRNA |
CTD |
PMID:11798191 |
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NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979
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G |
Raet1e |
retinoic acid early transcript 1E |
increases expression |
ISO |
Fenofibrate results in increased expression of RAET1E mRNA |
CTD |
PMID:11798191 |
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NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755
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G |
Ramp2 |
receptor activity modifying protein 2 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of RAMP2 mRNA |
CTD |
PMID:11798191 |
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NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions decreases expression |
EXP ISO |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA Fenofibrate results in decreased expression of RARA mRNA |
CTD |
PMID:18253720 PMID:25596134 |
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA |
CTD |
PMID:18253720 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rbp2 |
retinol binding protein 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of RBP2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
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G |
Rbx1 |
ring-box 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of RBX1 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
Fenofibrate affects the localization of and results in decreased activity of RELA protein; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of RELA protein]; Fenofibrate results in decreased localization of and results in decreased activity of RELA protein [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of RELA protein; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] |
CTD |
PMID:16600694 PMID:20520642 PMID:20580385 PMID:21999347 PMID:25545733 PMID:36988379 PMID:38216941 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of RETN protein] |
CTD |
PMID:32929351 |
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NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Retsat |
retinol saturase |
increases expression |
ISO |
Fenofibrate results in increased expression of RETSAT mRNA |
CTD |
PMID:11798191 |
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NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
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G |
Rgs16 |
regulator of G-protein signaling 16 |
increases expression |
EXP |
Fenofibrate results in increased expression of RGS16 mRNA |
CTD |
PMID:32741897 |
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NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
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G |
Rhof |
ras homolog family member F, filopodia associated |
increases expression |
EXP |
Fenofibrate results in increased expression of RHOF mRNA |
CTD |
PMID:32741897 |
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NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703
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G |
Rlf |
RLF zinc finger |
increases expression |
EXP |
Fenofibrate results in increased expression of RLF mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257
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G |
Rnd1 |
Rho family GTPase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of RND1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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G |
Rnd3 |
Rho family GTPase 3 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of RND3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
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G |
Rnf125 |
ring finger protein 125 |
increases expression |
ISO |
Fenofibrate results in increased expression of RNF125 mRNA |
CTD |
PMID:21318169 |
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NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983
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G |
Rnf14 |
ring finger protein 14 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of RNF14 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of RNF14 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr18:30,131,627...30,155,686
Ensembl chr18:30,131,691...30,155,685
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G |
Rnf144b |
ring finger protein 144B |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of RNF144B mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of RNF144B mRNA] |
CTD |
PMID:21318169 |
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NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760
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G |
Rnf19a |
ring finger protein 19A, RBR E3 ubiquitin protein ligase |
increases expression |
ISO |
Fenofibrate results in increased expression of RNF19A mRNA |
CTD |
PMID:21318169 |
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NCBI chr 7:67,425,833...67,465,214
Ensembl chr 7:67,425,837...67,465,222
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G |
Ro60 |
Ro60, Y RNA binding protein |
decreases expression |
ISO |
Fenofibrate results in decreased expression of RO60 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
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G |
Rsrc2 |
arginine and serine rich coiled-coil 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of RSRC2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799
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G |
RT1-CE16 |
RT1 class I, locus CE16 |
affects response to substance |
ISO |
HLA-A gene polymorphism affects the susceptibility to Fenofibrate |
CTD |
PMID:28043905 |
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NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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G |
RT1-Db1 |
RT1 class II, locus Db1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of H2-EB1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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G |
Rxra |
retinoid X receptor alpha |
decreases expression affects expression |
ISO EXP |
Fenofibrate results in decreased expression of RXRA mRNA Fenofibrate affects the expression of RXRA mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
S100a10 |
S100 calcium binding protein A10 |
increases expression |
ISO |
Fenofibrate results in increased expression of S100A10 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
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G |
Sars1 |
seryl-tRNA synthetase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of SARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of SAT1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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G |
Scamp1 |
secretory carrier membrane protein 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SCAMP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
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G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions decreases activity increases expression |
ISO |
[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein Fenofibrate results in decreased activity of SCARB1 protein Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]; Fenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether] Fenofibrate results in increased expression of SCARB1 protein |
CTD |
PMID:16816107 PMID:17533223 |
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NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions affects expression increases expression |
ISO EXP |
[Oleic Acid co-treated with Fenofibrate] results in increased expression of SCD1 mRNA Fenofibrate affects the expression of SCD mRNA Fenofibrate results in increased expression of SCD1 mRNA NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD1 mRNA] |
CTD |
PMID:23063693 PMID:24534255 PMID:27665778 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scd2 |
stearoyl-Coenzyme A desaturase 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SCD mRNA; Fenofibrate results in increased expression of SCD2 mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA] |
CTD |
PMID:17118139 PMID:23063693 |
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NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
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G |
Scly |
selenocysteine lyase |
affects expression |
EXP |
Fenofibrate affects the expression of SCLY mRNA |
CTD |
PMID:20801182 |
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NCBI chr 9:91,890,269...91,910,947
Ensembl chr 9:91,890,306...91,910,941
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G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
increases expression |
ISO |
Fenofibrate results in increased expression of SDHB protein |
CTD |
PMID:24752549 |
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NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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G |
Sec63 |
SEC63 homolog, protein translocation regulator |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SEC63 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SEC63 mRNA |
CTD |
PMID:21318169 |
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NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
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G |
Sele |
selectin E |
multiple interactions |
ISO |
dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA] |
CTD |
PMID:20580385 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Sema6b |
semaphorin 6B |
multiple interactions decreases expression |
ISO |
alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]; alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein] Fenofibrate results in decreased expression of SEMA6B mRNA; Fenofibrate results in decreased expression of SEMA6B protein |
CTD |
PMID:16525649 |
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NCBI chr 9:950,939...967,905
Ensembl chr 9:950,939...961,521
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G |
Senp2 |
SUMO specific peptidase 2 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SENP2 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of SENP2 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238
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G |
Serpina3n |
serine (or cysteine) peptidase inhibitor, clade A, member 3N |
affects expression |
EXP |
Fenofibrate affects the expression of SERPINA3N mRNA |
CTD |
PMID:20801182 |
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NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions affects expression |
ISO EXP |
Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]] [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of SERPINE1 mRNA Fenofibrate affects the expression of SERPINE1 mRNA Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]] |
CTD |
PMID:18253720 PMID:19593819 PMID:20801182 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sertad1 |
SERTA domain containing 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SERTAD1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
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G |
Sesn1 |
sestrin 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SESN1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of SGK2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
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G |
Sh3bgrl2 |
SH3 domain binding glutamate-rich protein like 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of SH3BGRL2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 8:84,461,019...84,553,124
Ensembl chr 8:84,461,121...84,551,564
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G |
Sh3tc1 |
SH3 domain and tetratricopeptide repeats 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of SH3TC1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995
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G |
Siah2 |
siah E3 ubiquitin protein ligase 2 |
affects expression |
EXP |
Fenofibrate affects the expression of SIAH2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
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G |
Sik1 |
salt-inducible kinase 1 |
increases expression decreases expression |
ISO EXP |
Fenofibrate results in increased expression of SIK1 mRNA Fenofibrate results in decreased expression of SIK1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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G |
Sirt1 |
sirtuin 1 |
multiple interactions increases expression |
ISO |
dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]; zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein] |
CTD |
PMID:32730863 PMID:34520103 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Siva1 |
SIVA1, apoptosis-inducing factor |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SIVA1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:25572481 PMID:27765674 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc16a13 |
solute carrier family 16, member 13 |
increases expression |
ISO |
Fenofibrate results in increased expression of SLC16A13 mRNA |
CTD |
PMID:25572481 |
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NCBI chr10:54,925,973...54,937,860
Ensembl chr10:54,926,760...54,937,788
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Slc16a6 |
solute carrier family 16, member 6 |
increases expression |
EXP |
Fenofibrate results in increased expression of SLC16A6 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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Slc1a7 |
solute carrier family 1 member 7 |
increases expression |
ISO |
Fenofibrate results in increased expression of SLC1A7 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:122,731,003...122,775,139
Ensembl chr 5:122,731,003...122,775,134
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Slc22a5 |
solute carrier family 22 member 5 |
increases expression |
EXP |
Fenofibrate results in increased expression of SLC22A5 mRNA |
CTD |
PMID:27665778 PMID:32741897 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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Slc25a20 |
solute carrier family 25 member 20 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of SLC25A20 mRNA |
CTD |
PMID:16707586 PMID:25572481 PMID:25596134 |
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NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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Slc25a30 |
solute carrier family 25, member 30 |
increases expression |
EXP |
Fenofibrate results in increased expression of SLC25A30 mRNA |
CTD |
PMID:32741897 |
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NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
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Slc25a34 |
solute carrier family 25, member 34 |
increases expression |
ISO |
Fenofibrate results in increased expression of SLC25A34 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 5:153,932,081...153,936,854
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Slc25a4 |
solute carrier family 25 member 4 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SLC25A4 protein |
CTD |
PMID:20118634 |
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NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Slc27a1 |
solute carrier family 27 member 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of SLC27A1 mRNA |
CTD |
PMID:11798191 |
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NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
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Slc27a2 |
solute carrier family 27 member 2 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of SLC27A2 mRNA |
CTD |
PMID:17118139 PMID:25572481 PMID:27665778 PMID:32741897 PMID:32741898 |
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NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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Slc27a4 |
solute carrier family 27 member 4 |
multiple interactions increases expression |
ISO |
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 protein] Fenofibrate results in increased expression of SLC27A4 mRNA; Fenofibrate results in increased expression of SLC27A4 protein PPARA protein promotes the reaction [Fenofibrate results in increased expression of SLC27A4 protein] |
CTD |
PMID:24752549 |
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NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943
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Slc34a2 |
solute carrier family 34 member 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of SLC34A2 mRNA |
CTD |
PMID:32741897 |
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NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
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Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of SLC3A2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc6a9 |
solute carrier family 6 member 9 |
decreases expression increases expression |
EXP ISO |
Fenofibrate results in decreased expression of SLC6A9 mRNA Fenofibrate results in increased expression of SLC6A9 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slc7a1 |
solute carrier family 7 member 1 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of SLC7A1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
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Slc7a5 |
solute carrier family 7 member 5 |
increases expression |
ISO |
Fenofibrate results in increased expression of SLC7A5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of SLCO2B1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]] |
CTD |
PMID:19593819 |
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NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smad4 |
SMAD family member 4 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]] |
CTD |
PMID:19593819 |
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NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Smpd2 |
sphingomyelin phosphodiesterase 2 |
multiple interactions |
ISO |
Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD2 mRNA] |
CTD |
PMID:25035112 |
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NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
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G |
Smpd3 |
sphingomyelin phosphodiesterase 3 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SMPD3 mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SMPD3 mRNA |
CTD |
PMID:21318169 |
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NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
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G |
Smpd4 |
sphingomyelin phosphodiesterase 4 |
multiple interactions |
ISO |
Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD4 mRNA] |
CTD |
PMID:25035112 |
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NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA] |
CTD |
PMID:26973390 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Socs6 |
suppressor of cytokine signaling 6 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SOCS6 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219
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G |
Socs7 |
suppressor of cytokine signaling 7 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of SOCS7 mRNA |
CTD |
PMID:21318169 |
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NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830
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Sod2 |
superoxide dismutase 2 |
increases expression |
EXP |
Fenofibrate results in increased expression of SOD2 mRNA |
CTD |
PMID:17264098 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Son |
SON DNA and RNA binding protein |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SON mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167
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G |
Sorl1 |
sortilin related receptor 1 |
increases expression decreases expression |
EXP ISO |
Fenofibrate results in increased expression of SORL1 mRNA Fenofibrate results in decreased expression of SORL1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Sort1 |
sortilin 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of SORT1 mRNA |
CTD |
PMID:24986865 |
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NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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Spmip11 |
sperm microtubule inner protein 11 |
increases expression |
EXP |
Fenofibrate results in increased expression of SPMIP11 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485
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G |
Spns2 |
SPNS lysolipid transporter 2, sphingosine-1-phosphate |
increases expression |
ISO |
Fenofibrate results in increased expression of SPNS2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
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Spop |
speckle type BTB/POZ protein |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SPOP mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of SPOP mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955
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G |
Spsb1 |
splA/ryanodine receptor domain and SOCS box containing 1 |
increases expression |
EXP |
Fenofibrate results in increased expression of SPSB1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Sqle |
squalene epoxidase |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of SQLE mRNA NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA] |
CTD |
PMID:23063693 |
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NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Sqstm1 |
sequestosome 1 |
increases expression multiple interactions |
EXP ISO |
Fenofibrate results in increased expression of SQSTM1 mRNA Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein] |
CTD |
PMID:25596134 PMID:36905866 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Srd5a3 |
steroid 5 alpha-reductase 3 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of SRD5A3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions increases expression |
ISO EXP |
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA] Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein] [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA] |
CTD |
PMID:19593819 PMID:23063693 PMID:24735863 PMID:26973390 PMID:36905866 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of SRXN1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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St3gal4 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of ST3GAL4 mRNA |
CTD |
PMID:11798191 |
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NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389
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Stat5b |
signal transducer and activator of transcription 5B |
decreases activity |
ISO |
Fenofibrate results in decreased activity of STAT5B protein |
CTD |
PMID:30114225 |
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NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
Fenofibrate results in increased expression of and results in increased phosphorylation of STK11 protein |
CTD |
PMID:25545733 |
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NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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G |
Strbp |
spermatid perinuclear RNA binding protein |
increases expression |
ISO |
Fenofibrate results in increased expression of STRBP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
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G |
Suclg1 |
succinate-CoA ligase GDP/ADP-forming subunit alpha |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of SUCLG1 mRNA Fenofibrate results in increased expression of SUCLG1 protein Fenofibrate results in increased expression of SUCLG1 mRNA |
CTD |
PMID:16707586 PMID:20801182 PMID:24752549 |
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NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
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Sulf2 |
sulfatase 2 |
decreases expression |
ISO EXP |
Fenofibrate results in decreased expression of SULF2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Sult1c2a |
sulfotransferase family 1C member 2A |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1C2 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
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G |
Sult1e1 |
sulfotransferase family 1E member 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
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Sult4a1 |
sulfotransferase family 4A, member 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085
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Taldo1 |
transaldolase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of TALDO1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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G |
Tars1 |
threonyl-tRNA synthetase 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of TARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717
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Tcp1 |
t-complex 1 |
multiple interactions |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TCP1 mRNA |
CTD |
PMID:18253720 |
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NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
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Tdo2 |
tryptophan 2,3-dioxygenase |
increases expression |
ISO |
Fenofibrate results in increased expression of TDO2 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
affects expression increases expression |
EXP ISO |
Fenofibrate affects the expression of TFE3 mRNA Fenofibrate results in increased expression of TFE3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO EXP |
Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]] [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA] Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in decreased expression of TRIB3 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]] |
CTD |
PMID:19593819 PMID:26973390 PMID:32613381 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thrsp |
thyroid hormone responsive |
multiple interactions decreases expression |
ISO |
Fenofibrate promotes the reaction [Oleic Acid results in decreased expression of THRSP mRNA] Fenofibrate results in decreased expression of THRSP mRNA |
CTD |
PMID:24534255 PMID:25572481 |
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NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]] |
CTD |
PMID:19593819 PMID:28871336 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA] |
CTD |
PMID:28871336 |
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NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tiparp |
TCDD-inducible poly(ADP-ribose) polymerase |
increases expression |
EXP |
Fenofibrate results in increased expression of TIPARP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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G |
Tmem120a |
transmembrane protein 120A |
decreases expression increases expression |
ISO EXP |
Fenofibrate results in decreased expression of TMEM120A mRNA Fenofibrate results in increased expression of TMEM120A mRNA |
CTD |
PMID:25572481 PMID:32741897 |
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NCBI chr12:20,942,243...20,950,908
Ensembl chr12:20,942,439...20,990,316
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression decreases response to substance |
ISO EXP |
Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]] [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of TNF protein; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of TNF protein]]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]] Fenofibrate results in decreased expression of TNF mRNA; Fenofibrate results in decreased expression of TNF protein [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of TNF mRNA]; Fenofibrate promotes the reaction [Dextran Sulfate results in increased expression of TNF protein]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]] Fenofibrate results in decreased susceptibility to TNF protein; TNF protein results in decreased susceptibility to Fenofibrate |
CTD |
PMID:12586603 PMID:15968640 PMID:18356826 PMID:19593819 PMID:20520642 PMID:21300114 PMID:21999347 PMID:25035112 PMID:26973390 PMID:31241159 PMID:32613381 PMID:36988379 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf11b |
TNF receptor superfamily member 11B |
decreases expression |
ISO |
Fenofibrate results in decreased expression of TNFRSF11B mRNA |
CTD |
PMID:25572481 |
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NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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Tnfrsf21 |
TNF receptor superfamily member 21 |
increases expression |
ISO |
Fenofibrate results in increased expression of TNFRSF21 mRNA |
CTD |
PMID:25572481 PMID:25596134 |
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NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
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Top1 |
DNA topoisomerase I |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA Fenofibrate results in increased expression of TOP1 mRNA |
CTD |
PMID:18253720 PMID:25596134 |
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NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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Top2a |
DNA topoisomerase II alpha |
increases expression |
EXP |
Fenofibrate results in increased expression of TOP2A mRNA |
CTD |
PMID:32741897 |
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NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Topors |
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of TOPORS mRNA [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of TOPORS mRNA |
CTD |
PMID:21318169 |
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NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937
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Tor1b |
torsin family 1, member B |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of TOR1B mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR1B mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:14,243,181...14,249,279
Ensembl chr 3:14,243,243...14,249,272
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Tor3a |
torsin family 3, member A |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of TOR3A mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR3A mRNA] |
CTD |
PMID:21318169 |
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NCBI chr13:68,769,893...68,798,738
Ensembl chr13:68,769,605...68,798,475
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Tp53 |
tumor protein p53 |
increases expression affects activity |
EXP ISO |
Fenofibrate results in increased expression of TP53 mRNA Fenofibrate affects the activity of TP53 protein |
CTD |
PMID:17264098 PMID:25596134 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i3 |
tumor protein p53 inducible protein 3 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of TP53I3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:27,818,327...27,825,753
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Tp53inp1 |
tumor protein p53 inducible nuclear protein 1 |
increases expression affects expression decreases expression |
EXP ISO |
Fenofibrate results in increased expression of TRP53INP1 mRNA Fenofibrate affects the expression of TP53INP1 mRNA Fenofibrate results in decreased expression of TP53INP1 mRNA |
CTD |
PMID:17264098 PMID:25596134 |
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NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Trafd1 |
TRAF type zinc finger domain containing 1 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of TRAFD1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Triap1 |
TP53 regulated inhibitor of apoptosis 1 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of TRIAP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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Trib3 |
tribbles pseudokinase 3 |
multiple interactions decreases expression |
ISO |
[Fenofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; Fenofibrate inhibits the reaction [TGFB1 protein results in decreased expression of TRIB3 mRNA] Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]; Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 protein] Fenofibrate results in decreased expression of TRIB3 mRNA |
CTD |
PMID:19593819 PMID:32929351 |
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NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
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Trim24 |
tripartite motif-containing 24 |
increases expression |
ISO |
Fenofibrate results in increased expression of TRIM24 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
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Trim63 |
tripartite motif containing 63 |
multiple interactions increases expression |
ISO |
Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIM63 mRNA] Fenofibrate results in increased expression of TRIM63 mRNA; Fenofibrate results in increased expression of TRIM63 protein |
CTD |
PMID:33408297 |
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NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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Trip12 |
thyroid hormone receptor interactor 12 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of TRIP12 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIP12 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 9:85,916,691...86,043,312
Ensembl chr 9:85,916,691...86,051,403
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Txnip |
thioredoxin interacting protein |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of TXNIP mRNA |
CTD |
PMID:17264098 PMID:25572481 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
Fenofibrate results in increased expression of TXNRD1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Tyr |
tyrosinase |
multiple interactions decreases expression |
ISO |
[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein]; Fenofibrate results in decreased expression of and results in decreased activity of TYR protein Fenofibrate results in decreased expression of TYR mRNA |
CTD |
PMID:23872139 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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Uba5 |
ubiquitin-like modifier activating enzyme 5 |
decreases expression |
ISO |
Fenofibrate results in decreased expression of UBA5 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 8:104,665,241...104,680,915
Ensembl chr 8:104,665,046...104,680,894
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Ube2g2 |
ubiquitin-conjugating enzyme E2G 2 |
affects expression |
EXP |
Fenofibrate affects the expression of UBE2G2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
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Ube2q2 |
ubiquitin conjugating enzyme E2 Q2 |
multiple interactions increases expression |
ISO |
PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE2Q2 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 8:55,518,402...55,578,342
Ensembl chr 8:55,519,147...55,577,212
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Ube2r2 |
ubiquitin-conjugating enzyme E2R 2 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of UBE2R2 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of UBE2R2 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 5:56,286,604...56,345,160
Ensembl chr 5:56,286,725...56,345,513
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Ube2w |
ubiquitin-conjugating enzyme E2W |
increases expression |
ISO |
Fenofibrate results in increased expression of UBE2W mRNA |
CTD |
PMID:21318169 |
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NCBI chr 5:2,690,742...2,754,491
Ensembl chr 5:2,690,763...2,814,965
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Ube3a |
ubiquitin protein ligase E3A |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of UBE3A mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE3A mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
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Ubr2 |
ubiquitin protein ligase E3 component n-recognin 2 |
multiple interactions increases expression |
ISO |
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of UBR2 mRNA Fenofibrate results in increased expression of UBR2 mRNA |
CTD |
PMID:21318169 |
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NCBI chr 9:13,982,427...14,062,315
Ensembl chr 9:13,982,329...14,062,139
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Ucp2 |
uncoupling protein 2 |
multiple interactions increases expression |
EXP ISO |
[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of UCP2 mRNA Fenofibrate results in increased expression of UCP2 mRNA; Fenofibrate results in increased expression of UCP2 protein PPARA protein promotes the reaction [Fenofibrate results in increased expression of UCP2 protein] PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 protein] |
CTD |
PMID:11341955 PMID:16595124 PMID:21999347 PMID:24752549 PMID:32741897 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Ucp3 |
uncoupling protein 3 |
increases expression multiple interactions |
EXP |
Fenofibrate results in increased expression of UCP3 mRNA fenofibrate co-treated with fructose increases expression of Ucp3 mRNA in liver and muscle fenofibrate increases expression of Ucp3 mRNA in muscle |
CTD RGD |
PMID:16595124 PMID:11934685 PMID:11934685 |
RGD:628329, RGD:628329 |
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
Fenofibrate results in increased expression of UGT1A1 mRNA |
CTD |
PMID:25572481 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
ISO |
Fenofibrate results in increased expression of UGT1A3 mRNA |
CTD |
PMID:17058234 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA Fenofibrate results in increased expression of UGT1A6 mRNA |
CTD |
PMID:18253720 PMID:18775883 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Urad |
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase |
increases expression |
EXP |
Fenofibrate results in increased expression of URAD mRNA |
CTD |
PMID:32741897 |
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NCBI chr12:7,709,278...7,718,925
Ensembl chr12:7,709,312...7,718,923
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Uri1 |
URI1, prefoldin-like chaperone |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of URI1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of URI1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 1:90,646,392...90,704,811
Ensembl chr 1:90,646,393...90,709,026
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Urm1 |
ubiquitin related modifier 1 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of URM1 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of URM1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 3:13,100,340...13,117,064
Ensembl chr 3:13,092,200...13,117,642 Ensembl chr 3:13,092,200...13,117,642
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Usp1 |
ubiquitin specific peptidase 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 5:113,587,564...113,598,934
Ensembl chr 5:113,587,564...113,598,932
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Usp10 |
ubiquitin specific peptidase 10 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP10 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP10 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897
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Usp22 |
ubiquitin specific peptidase 22 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP22 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP22 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:45,828,619...45,855,468
Ensembl chr10:45,828,622...45,855,497
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Usp3 |
ubiquitin specific peptidase 3 |
increases expression |
EXP |
Fenofibrate results in increased expression of USP3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
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Usp36 |
ubiquitin specific peptidase 36 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of USP36 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of USP36 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877
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Usp38 |
ubiquitin specific peptidase 38 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP38 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP38 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr19:27,006,046...27,037,449
Ensembl chr19:27,006,046...27,037,437
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Usp4 |
ubiquitin specific peptidase 4 |
increases expression |
EXP |
Fenofibrate results in increased expression of USP4 mRNA |
CTD |
PMID:32741897 |
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NCBI chr 8:109,035,402...109,079,382
Ensembl chr 8:109,036,099...109,080,427
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Usp7 |
ubiquitin specific peptidase 7 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP7 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP7 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
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Usp9x |
ubiquitin specific peptidase 9, X-linked |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USP9X mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USP9X mRNA] |
CTD |
PMID:21318169 |
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NCBI chr X:9,588,825...9,726,993
Ensembl chr X:9,588,825...9,696,711
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Uspl1 |
ubiquitin specific peptidase like 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of USPL1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of USPL1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366
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Vars1 |
valyl-tRNA synthetase 1 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of VARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298
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Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA] dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA] |
CTD |
PMID:20580385 PMID:21300114 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vcpip1 |
valosin containing protein interacting protein 1 |
increases expression multiple interactions |
ISO |
Fenofibrate results in increased expression of VCPIP1 mRNA PPARA protein affects the reaction [Fenofibrate results in increased expression of VCPIP1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr 5:9,534,247...9,560,889
Ensembl chr 5:9,534,129...9,562,040
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Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]] |
CTD |
PMID:31016362 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb |
vascular endothelial growth factor B |
increases expression |
EXP |
Fenofibrate results in increased expression of VEGFB mRNA |
CTD |
PMID:17264098 PMID:25596134 |
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NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Vnn1 |
vanin 1 |
increases expression |
ISO EXP |
Fenofibrate results in increased expression of VNN1 mRNA |
CTD |
PMID:11798191 PMID:25572481 PMID:27665778 PMID:32741897 |
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NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
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Vsir |
V-set immunoregulatory receptor |
decreases expression |
ISO |
Fenofibrate results in decreased expression of VSIR mRNA |
CTD |
PMID:25572481 |
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NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
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Vwa8 |
von Willebrand factor A domain containing 8 |
increases expression |
EXP |
Fenofibrate results in increased expression of VWA8 mRNA |
CTD |
PMID:32741897 |
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NCBI chr15:54,252,703...54,576,871
Ensembl chr15:54,252,584...54,576,870
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Wsb1 |
WD repeat and SOCS box-containing 1 |
decreases expression multiple interactions |
ISO |
Fenofibrate results in decreased expression of WSB1 mRNA PPARA protein affects the reaction [Fenofibrate results in decreased expression of WSB1 mRNA] |
CTD |
PMID:21318169 |
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NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
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Wsb2 |
WD repeat and SOCS box-containing 2 |
increases expression |
ISO |
Fenofibrate results in increased expression of WSB2 mRNA |
CTD |
PMID:21318169 |
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NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640
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Wwc2 |
WW and C2 domain containing 2 |
decreases expression |
EXP |
Fenofibrate results in decreased expression of WWC2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
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G |
Xbp1 |
X-box binding protein 1 |
affects activity decreases expression |
EXP ISO |
Fenofibrate affects the activity of XBP1 protein Fenofibrate results in decreased expression of XBP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
decreases expression |
EXP |
Fenofibrate results in decreased expression of XPC mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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G |
Xrcc5 |
X-ray repair cross complementing 5 |
multiple interactions increases expression |
EXP |
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of XRCC5 mRNA Fenofibrate results in increased expression of XRCC5 mRNA |
CTD |
PMID:17264098 PMID:18253720 PMID:18775883 |
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NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018
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G |
Yars1 |
tyrosyl-tRNA synthetase 1 |
increases expression |
EXP ISO |
Fenofibrate results in increased expression of YARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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G |
Zfp385d |
zinc finger protein 385D |
increases expression |
ISO |
Fenofibrate results in increased expression of ZNF385D mRNA |
CTD |
PMID:25572481 |
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NCBI chr15:5,040,182...5,849,975
Ensembl chr15:5,042,572...5,423,367
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G |
C6h14orf28 |
similar to human chromosome 14 open reading frame 28 |
multiple interactions |
ISO |
GW 1929 promotes the reaction [C14ORF28 protein binds to PPARG protein] |
CTD |
PMID:32407875 |
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NCBI chr 6:82,965,304...82,973,942
Ensembl chr 6:82,965,328...82,972,558
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [tetrabromobisphenol A results in increased activity of CASP3 protein] |
CTD |
PMID:24132472 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
decreases response to substance |
ISO |
GW 1929 results in decreased susceptibility to CCL5 protein |
CTD |
PMID:18158351 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CREB1 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:20032081 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases response to substance multiple interactions |
ISO |
GW 1929 results in decreased susceptibility to CXCL12 protein GW 1929 inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein] |
CTD |
PMID:18158351 |
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NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
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G |
Efna1 |
ephrin A1 |
increases expression multiple interactions |
EXP |
GW 1929 results in increased expression of EFNA1 mRNA Mercaptopurine promotes the reaction [GW 1929 results in increased expression of EFNA1 mRNA] |
CTD |
PMID:27435855 |
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NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
[GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] |
CTD |
PMID:21734263 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Grk2 |
G protein-coupled receptor kinase 2 |
decreases expression |
EXP |
GW 1929 results in decreased expression of GRK2 mRNA |
CTD |
PMID:19420904 |
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NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:12847270 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Irf1 |
interferon regulatory factor 1 |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] |
CTD |
PMID:12847270 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:12083801 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12083801 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
GW 1929 promotes the reaction [NCOA2 protein binds to PPARG protein] |
CTD |
PMID:32407875 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Ncoa6 |
nuclear receptor coactivator 6 |
multiple interactions |
ISO |
GW 1929 promotes the reaction [NCOA6 protein binds to PPARG protein] |
CTD |
PMID:32407875 |
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NCBI chr 3:143,890,896...143,961,916
Ensembl chr 3:143,890,896...143,952,268
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] |
CTD |
PMID:12847270 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
multiple interactions affects localization |
EXP |
[GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 mRNA; [GW 1929 co-treated with Mercaptopurine] results in increased expression of NR4A2 protein GW 1929 affects the localization of NR4A2 protein |
CTD |
PMID:27435855 |
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NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nrip1 |
nuclear receptor interacting protein 1 |
multiple interactions |
ISO |
GW 1929 promotes the reaction [NRIP1 protein binds to PPARG protein] |
CTD |
PMID:32407875 |
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NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases activity increases expression multiple interactions affects binding |
ISO EXP |
GW 1929 results in increased activity of PPARG protein GW 1929 results in increased expression of PPARG mRNA 4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamide inhibits the reaction [GW 1929 results in increased expression of PPARG mRNA]; GW 1929 binds to and results in increased activity of PPARG protein; GW 1929 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; GW 1929 inhibits the reaction [tetrabromobisphenol A results in decreased expression of PPARG protein] [GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein]; butylbenzyl phthalate inhibits the reaction [GW 1929 binds to PPARG protein]; GW 1929 inhibits the reaction [GW 1929 binds to PPARG protein]; GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PPARG protein]; GW 1929 promotes the reaction [C14ORF28 protein binds to PPARG protein]; GW 1929 promotes the reaction [NCOA2 protein binds to PPARG protein]; GW 1929 promotes the reaction [NCOA6 protein binds to PPARG protein]; GW 1929 promotes the reaction [NRIP1 protein binds to PPARG protein]; GW 1929 promotes the reaction [PPARGC1A protein binds to PPARG protein]; GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]; Pioglitazone inhibits the reaction [GW 1929 binds to PPARG protein]; tributyltin inhibits the reaction [GW 1929 binds to PPARG protein]; ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]] |
CTD |
PMID:12847270 PMID:18292206 PMID:19420904 PMID:20008677 PMID:20516370 PMID:21543282 PMID:21734263 PMID:24132472 PMID:29734669 PMID:31016361 PMID:32407875 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
GW 1929 promotes the reaction [PPARGC1A protein binds to PPARG protein] |
CTD |
PMID:32407875 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prnp |
prion protein |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; GW 1929 inhibits the reaction [Pioglitazone results in increased expression of PRNP protein] |
CTD |
PMID:29734669 |
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NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA] |
CTD |
PMID:20032081 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases activity |
ISO |
GW 1929 results in increased activity of RAF1 protein |
CTD |
PMID:12083801 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]; ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]] |
CTD |
PMID:20008677 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
[GW 1929 co-treated with Mercaptopurine] inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein]; GW 1929 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TH protein] |
CTD |
PMID:27435855 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[GW 1929 binds to and results in increased activity of PPARG protein] promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] |
CTD |
PMID:21734263 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
GW 1929 inhibits the reaction [VEGFA protein results in increased expression of and results in increased activity of PTGS2 protein]; GW 1929 inhibits the reaction [VEGFA protein results in increased expression of PTGS2 mRNA]; GW 1929 inhibits the reaction [VEGFA protein results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:20032081 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Zfp366 |
zinc finger protein 366 |
multiple interactions |
ISO |
ZNF366 protein promotes the reaction [GW 1929 results in increased activity of [PPARG protein binds to RXRA protein]] |
CTD |
PMID:20008677 |
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NCBI chr 2:30,578,552...30,640,546
Ensembl chr 2:30,578,715...30,642,182
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G |
Alb |
albumin |
affects binding |
ISO |
Ketoprofen binds to ALB protein |
CTD |
PMID:9353694 PMID:19596536 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Dhrs11 |
dehydrogenase/reductase 11 |
decreases activity |
ISO |
Ketoprofen results in decreased activity of DHRS11 protein |
CTD |
PMID:30926317 |
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NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Ketoprofen results in increased expression of GCLC mRNA |
CTD |
PMID:11909699 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Ketoprofen results in increased expression of GCLM mRNA |
CTD |
PMID:11909699 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Hpgd |
15-hydroxyprostaglandin dehydrogenase |
multiple interactions |
ISO |
[Ketoprofen co-treated with NAD] binds to HPGD protein |
CTD |
PMID:25526675 |
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NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] |
CTD |
PMID:10903797 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Ketoprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:10903797 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mpo |
myeloperoxidase |
increases expression multiple interactions |
EXP |
Ketoprofen results in increased expression of MPO protein pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein] |
CTD |
PMID:16080005 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Ngfr |
nerve growth factor receptor |
increases expression |
ISO |
Ketoprofen results in increased expression of NGFR protein |
CTD |
PMID:17409433 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Ketoprofen inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone] |
CTD |
PMID:11095985 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ren |
renin |
multiple interactions |
ISO |
Ketoprofen inhibits the reaction [Furosemide results in increased activity of REN protein] |
CTD |
PMID:1924052 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
RT1-Bb |
RT1 class II, locus Bb |
affects expression |
ISO |
Ketoprofen affects the expression of HLA-DQB1 mRNA |
CTD |
PMID:25811541 |
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NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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G |
RT1-Ha |
RT1 class II, locus Ha |
affects expression |
ISO |
Ketoprofen affects the expression of HLA-DPA1 mRNA |
CTD |
PMID:25811541 |
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NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244
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G |
Sell |
selectin L |
decreases expression |
ISO |
Ketoprofen results in decreased expression of SELL protein |
CTD |
PMID:12147693 |
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NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
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G |
Slc22a1 |
solute carrier family 22 member 1 |
decreases activity |
ISO |
Ketoprofen results in decreased activity of SLC22A1 protein |
CTD |
PMID:12388633 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a25 |
solute carrier family 22, member 25 |
decreases activity increases uptake |
ISO |
Ketoprofen results in decreased activity of SLC22A9 protein SLC22A9 protein results in increased uptake of Ketoprofen |
CTD |
PMID:12388633 |
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NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity increases uptake |
ISO |
Ketoprofen results in decreased activity of SLC22A6 protein SLC22A6 protein results in increased uptake of Ketoprofen |
CTD |
PMID:12388633 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a7 |
solute carrier family 22 member 7 |
decreases activity |
ISO |
Ketoprofen results in decreased activity of SLC22A7 protein |
CTD |
PMID:12388633 |
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NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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G |
Slco2a1 |
solute carrier organic anion transporter family, member 2a1 |
multiple interactions |
ISO |
Ketoprofen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] |
CTD |
PMID:19843975 |
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NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ketoprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:10903797 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
decreases activity increases glucuronidation |
ISO |
Ketoprofen results in decreased activity of UGT1A1 protein UGT1A1 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:15593333 PMID:15843492 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:15535975 PMID:15843492 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation |
ISO |
UGT1A4 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:15843492 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
affects metabolic processing increases glucuronidation |
EXP ISO |
UGT1A6 protein affects the metabolism of Ketoprofen UGT1A6 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:15336321 PMID:15843492 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation |
ISO |
UGT1A9 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:15535975 PMID:15843492 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:8302279 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions increases glucuronidation |
ISO |
Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] UGT2B7 protein alternative form results in increased glucuronidation of Ketoprofen; UGT2B7 protein results in increased glucuronidation of Ketoprofen |
CTD |
PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 |
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NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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G |
Lrrc4c |
leucine rich repeat containing 4C |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of LRRC4C gene |
CTD |
PMID:34516295 |
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NCBI chr 3:82,305,495...83,684,039
Ensembl chr 3:83,483,851...83,687,774
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G |
Mfsd4b2 |
major facilitator superfamily domain containing 4B2 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of MFSD4B gene |
CTD |
PMID:34516295 |
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NCBI chr20:43,344,601...43,353,061
Ensembl chr20:43,344,601...43,353,061
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G |
Ms4a4a |
membrane spanning 4-domains A4A |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of MS4A4A gene |
CTD |
PMID:34516295 |
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NCBI chr 1:208,060,507...208,085,121
Ensembl chr 1:208,046,971...208,085,119
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G |
Myo1b |
myosin Ib |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of MYO1B gene |
CTD |
PMID:34516295 |
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NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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G |
Pik3r4 |
phosphoinositide-3-kinase, regulatory subunit 4 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of PIK3R4 gene |
CTD |
PMID:34516295 |
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NCBI chr 8:106,267,908...106,316,585
Ensembl chr 8:106,267,954...106,316,584
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G |
Ppp1r2 |
protein phosphatase 1, regulatory (inhibitor) subunit 2 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of PPP1R2 gene |
CTD |
PMID:34516295 |
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NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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G |
Schip1 |
schwannomin interacting protein 1 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of SCHIP1 gene |
CTD |
PMID:34516295 |
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NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
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G |
Wdr43 |
WD repeat domain 43 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of mesotrione] which affects the methylation of WDR43 gene |
CTD |
PMID:34516295 |
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NCBI chr 6:23,845,499...23,884,846
Ensembl chr 6:23,845,499...23,884,846
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
methyl 2-benzoylbenzoate results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Sulfur co-treated with mancozeb co-treated with metrafenone] results in decreased expression of BAX mRNA; [Sulfur co-treated with metrafenone] results in decreased expression of BAX mRNA; [Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of BAX mRNA |
CTD |
PMID:35564597 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Sulfur co-treated with mancozeb co-treated with metrafenone] results in decreased expression of BCL2 mRNA; [Sulfur co-treated with metrafenone] results in decreased expression of BCL2 mRNA; [Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of BCL2 mRNA |
CTD |
PMID:35564597 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
[Sulfur co-treated with metrafenone] results in decreased expression of NFE2L2 mRNA; [Sulfur co-treated with zoxamide co-treated with metrafenone] results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:35564597 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA |
CTD |
PMID:12899938 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA |
CTD |
PMID:12899938 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA |
CTD |
PMID:12899938 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hpd |
4-hydroxyphenylpyruvate dioxygenase |
multiple interactions |
ISO |
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA |
CTD |
PMID:12899938 |
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NCBI chr12:33,381,397...33,392,750
Ensembl chr12:33,381,231...33,392,766
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA |
CTD |
PMID:12899938 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases activity |
ISO |
(2-hydroxy-4-(octyloxy)phenyl)phenylmethanone results in decreased activity of HSD3B1 protein |
CTD |
PMID:37217011 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Acad10 |
acyl-CoA dehydrogenase family, member 10 |
increases expression |
EXP |
oxybenzone results in increased expression of ACAD10 mRNA |
CTD |
PMID:30316929 |
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NCBI chr12:34,901,211...34,943,973
Ensembl chr12:34,901,219...34,982,521
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G |
Acad9 |
acyl-CoA dehydrogenase family, member 9 |
increases expression |
EXP |
oxybenzone results in increased expression of ACAD9 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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G |
Acbd3 |
acyl-CoA binding domain containing 3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of ACBD3 mRNA |
CTD |
PMID:30316929 |
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NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
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G |
Aco2 |
aconitase 2 |
affects expression |
EXP |
oxybenzone affects the expression of ACO2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G |
Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
EXP |
oxybenzone results in increased expression of ACOT2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases expression |
EXP |
oxybenzone results in increased expression of ACOX1 mRNA |
CTD |
PMID:30316929 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
decreases expression |
EXP |
oxybenzone results in decreased expression of ACSL5 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
increases expression |
EXP |
oxybenzone results in increased expression of ACSS2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein] |
CTD |
PMID:32407875 PMID:34864131 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adprhl1 |
ADP-ribosylhydrolase like 1 |
affects expression |
EXP |
oxybenzone affects the expression of ADPRHL1 mRNA |
CTD |
PMID:30316929 |
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NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440
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G |
Ahr |
aryl hydrocarbon receptor |
decreases expression increases expression |
EXP |
oxybenzone results in decreased expression of AHR mRNA oxybenzone results in increased expression of AHR protein |
CTD |
PMID:15458797 PMID:30099065 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aif1 |
allograft inflammatory factor 1 |
increases expression |
EXP |
oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein |
CTD |
PMID:31368502 |
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NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Akt3 |
AKT serine/threonine kinase 3 |
increases expression |
ISO |
oxybenzone results in increased expression of AKT3 mRNA |
CTD |
PMID:36581016 |
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NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Apc |
APC regulator of WNT signaling pathway |
increases expression |
ISO |
oxybenzone results in increased expression of APC mRNA |
CTD |
PMID:36581016 |
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NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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G |
Apoc3 |
apolipoprotein C3 |
increases expression |
EXP |
oxybenzone results in increased expression of APOC3 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
Apol2 |
apolipoprotein L2 |
increases expression |
EXP |
oxybenzone results in increased expression of APOL2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558
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G |
Aqp1 |
aquaporin 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of AQP1 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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G |
Ar |
androgen receptor |
multiple interactions affects localization |
ISO EXP |
oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] oxybenzone affects the localization of AR protein |
CTD |
PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Areg |
amphiregulin |
increases expression |
ISO |
oxybenzone results in increased expression of AREG mRNA |
CTD |
PMID:31939680 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Atf2 |
activating transcription factor 2 |
increases expression |
ISO |
oxybenzone results in increased expression of ATF2 mRNA |
CTD |
PMID:36581016 |
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NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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G |
Atg2b |
autophagy related 2B |
increases expression |
ISO |
oxybenzone results in increased expression of ATG2B mRNA |
CTD |
PMID:36581016 |
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NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
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G |
Atm |
ATM serine/threonine kinase |
increases expression |
ISO |
oxybenzone results in increased expression of ATM mRNA |
CTD |
PMID:36581016 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
EXP |
oxybenzone results in increased expression of ATP5F1A mRNA |
CTD |
PMID:30316929 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1b |
ATP synthase F1 subunit beta |
increases expression |
EXP |
oxybenzone results in increased expression of ATP5F1B mRNA |
CTD |
PMID:30316929 |
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NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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G |
Atp5f1c |
ATP synthase F1 subunit gamma |
increases expression |
EXP |
oxybenzone results in increased expression of ATP5F1C mRNA |
CTD |
PMID:30316929 |
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NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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G |
Atp5mc2 |
ATP synthase membrane subunit c locus 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of ATP5MC2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
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G |
Atr |
ATR serine/threonine kinase |
increases expression |
ISO |
oxybenzone results in increased expression of ATR mRNA |
CTD |
PMID:36581016 |
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NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
oxybenzone results in increased expression of BAD mRNA |
CTD |
PMID:30316929 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
EXP |
oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein |
CTD |
PMID:30099065 PMID:30316929 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
EXP |
oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein |
CTD |
PMID:30099065 PMID:30316929 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcs1l |
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone |
increases expression |
EXP |
oxybenzone results in increased expression of BCS1L mRNA |
CTD |
PMID:30316929 |
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NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938
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G |
Blm |
BLM RecQ like helicase |
increases expression |
ISO |
oxybenzone results in increased expression of BLM mRNA |
CTD |
PMID:36581016 |
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NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
ISO |
oxybenzone results in increased expression of BRCA1 mRNA |
CTD |
PMID:36581016 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
increases expression |
ISO |
oxybenzone results in increased expression of CACNA2D1 mRNA |
CTD |
PMID:36581016 |
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NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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G |
Casp1 |
caspase 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CASP1 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp2 |
caspase 2 |
increases expression |
EXP |
oxybenzone results in increased expression of CASP2 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
EXP |
oxybenzone results in increased activity of CASP3 protein oxybenzone results in increased expression of and results in increased activity of CASP3 protein |
CTD |
PMID:30099065 PMID:31368502 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CASP4 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp9 |
caspase 9 |
increases activity increases expression |
EXP |
oxybenzone results in increased activity of CASP9 protein oxybenzone results in increased expression of CASP9 mRNA |
CTD |
PMID:30099065 PMID:30316929 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl21 |
C-C motif chemokine ligand 21 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CCL21 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
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G |
Ccne2 |
cyclin E2 |
increases expression |
ISO |
oxybenzone results in increased expression of CCNE2 mRNA |
CTD |
PMID:36581016 |
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NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
increases expression |
ISO |
oxybenzone results in increased expression of CHUK mRNA |
CTD |
PMID:36581016 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cited4 |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 |
increases expression |
EXP |
oxybenzone results in increased expression of CITED4 mRNA |
CTD |
PMID:30316929 |
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NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
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G |
Cox15 |
cytochrome c oxidase assembly homolog COX15 |
increases expression |
EXP |
oxybenzone results in increased expression of COX15 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
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G |
Cox16 |
cytochrome c oxidase assembly factor COX16 |
decreases expression |
EXP |
oxybenzone results in decreased expression of COX16 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 6:101,162,231...101,181,277
Ensembl chr 6:101,019,680...101,181,246
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G |
Cox17 |
cytochrome c oxidase copper chaperone COX17 |
increases expression |
EXP |
oxybenzone results in increased expression of COX17 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr11:62,400,733...62,406,507
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G |
Cox18 |
cytochrome c oxidase assembly factor COX18 |
increases expression |
EXP |
oxybenzone results in increased expression of COX18 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480
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G |
Cox5a |
cytochrome c oxidase subunit 5A |
increases expression |
EXP |
oxybenzone results in increased expression of COX5A mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
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G |
Cox6b2 |
cytochrome c oxidase subunit 6B2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of COX6B2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:69,094,009...69,095,312
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G |
Cox7a2 |
cytochrome c oxidase subunit 7A2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of COX7A2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633 Ensembl chr 8:51,301,168...51,301,633
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G |
Cpt1b |
carnitine palmitoyltransferase 1B |
increases expression |
EXP |
oxybenzone results in increased expression of CPT1B mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
increases expression |
EXP |
oxybenzone results in increased expression of CPT2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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G |
Cpxm2 |
carboxypeptidase X (M14 family), member 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CPXM2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:186,836,797...186,947,222
Ensembl chr 1:186,836,797...186,947,220
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression |
ISO |
oxybenzone results in increased expression of CREB1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Csn2 |
casein beta |
increases expression decreases methylation |
ISO |
oxybenzone results in increased expression of CSN2 mRNA; oxybenzone results in increased expression of CSN2 protein oxybenzone results in decreased methylation of CSN2 promoter |
CTD |
PMID:32946892 |
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NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
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G |
Cstl1 |
cystatin-like 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CSTL1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 3:136,199,914...136,204,912
Ensembl chr 3:136,199,914...136,204,912
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G |
Cybrd1 |
cytochrome b reductase 1 |
increases expression |
EXP |
oxybenzone results in increased expression of CYBRD1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108
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|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP19A1 mRNA |
CTD |
PMID:30599193 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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|
G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CYP24A1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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|
G |
Cyp26c1 |
cytochrome P450, family 26, subfamily C, polypeptide 1 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP26C1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
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|
G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP27B1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CYP2B3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2d3 |
cytochrome P450, family 2, subfamily d, polypeptide 3 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP2D3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
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|
G |
Cyp4a3 |
cytochrome P450, family 4, subfamily a, polypeptide 3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of CYP4A3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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G |
Cyp4f18 |
cytochrome P450, family 4, subfamily f, polypeptide 18 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP4F18 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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|
G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
increases expression |
EXP |
oxybenzone results in increased expression of CYP7A1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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|
G |
Dap |
death-associated protein |
decreases expression |
EXP |
oxybenzone results in decreased expression of DAP mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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|
G |
Dapk3 |
death-associated protein kinase 3 |
increases expression |
EXP |
oxybenzone results in increased expression of DAPK3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558
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|
G |
Daxx |
death-domain associated protein |
increases expression increases methylation |
EXP ISO |
oxybenzone results in increased expression of DAXX mRNA oxybenzone results in increased methylation of DAXX gene |
CTD |
PMID:30316929 PMID:34523531 |
|
NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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G |
Dedd |
death effector domain-containing |
increases expression |
EXP |
oxybenzone results in increased expression of DEDD mRNA |
CTD |
PMID:30316929 |
|
NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
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|
G |
Dffa |
DNA fragmentation factor subunit alpha |
increases expression |
EXP |
oxybenzone results in increased expression of DFFA mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
|
|
G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
increases expression |
EXP |
oxybenzone results in increased expression of DHODH mRNA |
CTD |
PMID:30316929 |
|
NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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|
G |
Dld |
dihydrolipoamide dehydrogenase |
increases expression |
ISO |
oxybenzone results in increased expression of DLD mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
increases expression |
EXP |
oxybenzone results in increased expression of DLST mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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|
G |
Dlx3 |
distal-less homeobox 3 |
affects expression |
EXP |
oxybenzone affects the expression of DLX3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:80,064,489...80,069,891
Ensembl chr10:80,064,489...80,069,872
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|
G |
Dmtf1 |
cyclin D binding myb-like transcription factor 1 |
increases expression |
ISO |
oxybenzone results in increased expression of DMTF1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967
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|
G |
Dnajc15 |
DnaJ heat shock protein family (Hsp40) member C15 |
decreases expression |
EXP |
oxybenzone results in decreased expression of DNAJC15 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
|
|
G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
increases expression |
EXP |
oxybenzone results in increased expression of ECHS1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
|
|
G |
Eif4e |
eukaryotic translation initiation factor 4E |
increases expression |
ISO |
oxybenzone results in increased expression of EIF4E mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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|
G |
Esr1 |
estrogen receptor 1 |
decreases expression increases expression multiple interactions |
EXP ISO |
oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein oxybenzone results in increased expression of ESR1 mRNA oxybenzone binds to and results in increased activity of ESR1 protein |
CTD |
PMID:15458797 PMID:16079615 PMID:30099065 PMID:32946892 PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects expression decreases expression |
ISO EXP |
oxybenzone binds to and results in increased activity of ESR2 protein oxybenzone affects the expression of ESR2 protein oxybenzone results in decreased expression of ESR2 mRNA |
CTD |
PMID:16079615 PMID:30099065 PMID:33049310 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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|
G |
Esrra |
estrogen related receptor, alpha |
decreases expression |
EXP |
oxybenzone results in decreased expression of ESRRA mRNA |
CTD |
PMID:15458797 |
|
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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|
G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] |
CTD |
PMID:32407875 PMID:34864131 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fam180a |
family with sequence similarity 180, member A |
decreases expression |
EXP |
oxybenzone results in decreased expression of FAM180A mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047
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|
G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
ISO |
oxybenzone results in increased expression of FGF2 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Flg |
filaggrin |
affects response to substance multiple interactions |
ISO |
FLG gene mutant form affects the susceptibility to oxybenzone [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone |
CTD |
PMID:30245359 |
|
NCBI chr 2:178,884,793...178,912,986
|
|
G |
Foxl2 |
forkhead box L2 |
increases expression multiple interactions |
EXP |
oxybenzone results in increased expression of FOXL2 mRNA 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA] |
CTD |
PMID:30599193 |
|
NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
|
|
G |
Frzb |
frizzled-related protein |
decreases expression |
EXP |
oxybenzone results in decreased expression of FRZB mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
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|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein |
CTD |
PMID:30245359 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Fst |
follistatin |
increases expression |
EXP |
oxybenzone results in increased expression of FST mRNA |
CTD |
PMID:30599193 |
|
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
|
|
G |
Garin1a |
golgi associated RAB2 interactor 1A |
decreases expression |
EXP |
oxybenzone results in decreased expression of GARIN1A mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820
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G |
Garin3 |
golgi associated RAB2 interactor family member 3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of GARIN3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:30,829,877...30,833,115
Ensembl chr10:30,829,877...30,833,111
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|
G |
Gper1 |
G protein-coupled estrogen receptor 1 |
affects expression |
EXP |
oxybenzone affects the expression of GPER1 protein |
CTD |
PMID:30099065 |
|
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
affects expression |
EXP |
oxybenzone affects the expression of GRIN1 protein |
CTD |
PMID:31368502 |
|
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
affects expression |
EXP |
oxybenzone affects the expression of GRIN2A protein |
CTD |
PMID:31368502 |
|
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of GSTA2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
decreases expression |
EXP |
oxybenzone results in decreased expression of GSTA5 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
EXP |
oxybenzone results in increased expression of GSTM1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
|
|
G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
oxybenzone results in increased expression of GSTP1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
|
|
G |
Gstt2 |
glutathione S-transferase theta 2 |
increases expression |
EXP |
oxybenzone results in increased expression of GSTT2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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G |
Gstt4 |
glutathione S-transferase, theta 4 |
decreases expression |
EXP |
oxybenzone results in decreased expression of GSTT4 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr20:12,835,178...12,842,306
Ensembl chr20:12,835,178...12,842,292
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|
G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
oxybenzone results in increased expression of H2AX protein modified form Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form] |
CTD |
PMID:31939680 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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|
G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
decreases expression |
EXP |
oxybenzone results in decreased expression of HADHA mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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G |
Hdac1 |
histone deacetylase 1 |
increases expression |
EXP |
oxybenzone results in increased expression of HDAC1 protein |
CTD |
PMID:31368502 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
EXP |
oxybenzone results in increased expression of HDAC2 protein |
CTD |
PMID:31368502 |
|
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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|
G |
Hdac9 |
histone deacetylase 9 |
increases expression |
ISO |
oxybenzone results in increased expression of HDAC9 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
ISO |
oxybenzone results in increased expression of HIF1A mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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|
G |
Hltf |
helicase-like transcription factor |
increases expression |
ISO |
oxybenzone results in increased expression of HLTF mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327
|
|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases expression |
ISO |
oxybenzone results in increased expression of HMGCR mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
|
|
G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
oxybenzone results in increased expression of HMGCS1 mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
|
|
G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
|
|
G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
decreases expression |
EXP |
oxybenzone results in decreased expression of HSD17B10 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
|
|
G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
decreases activity |
EXP |
oxybenzone results in decreased activity of HSD3B2 protein |
CTD |
PMID:37217011 |
|
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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|
G |
Hsdl2 |
hydroxysteroid dehydrogenase like 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of HSDL2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
|
|
G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
increases expression |
ISO |
oxybenzone results in increased expression of HSP90AA1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
|
|
G |
Hykk |
hydroxylysine kinase |
increases expression |
EXP |
oxybenzone results in increased expression of HYKK mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
|
|
G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of IDH2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
|
|
G |
Idh3g |
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma |
increases expression |
EXP |
oxybenzone results in increased expression of IDH3G mRNA |
CTD |
PMID:30316929 |
|
NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171
|
|
G |
Il19 |
interleukin 19 |
increases expression |
EXP |
oxybenzone results in increased expression of IL19 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
ISO |
oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] |
CTD |
PMID:32407875 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA] |
CTD |
PMID:34864131 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G |
Iqcf6 |
IQ motif containing F6 |
decreases expression |
EXP |
oxybenzone results in decreased expression of IQCF6 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:107,263,673...107,264,726
Ensembl chr 8:107,263,654...107,264,724
|
|
G |
Itga4 |
integrin subunit alpha 4 |
increases expression |
ISO |
oxybenzone results in increased expression of ITGA4 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
|
|
G |
Kras |
KRAS proto-oncogene, GTPase |
increases expression |
ISO |
oxybenzone results in increased expression of KRAS mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 4:178,185,418...178,218,484
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|
G |
Krt18 |
keratin 18 |
decreases expression |
EXP |
oxybenzone results in decreased expression of KRT18 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
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|
G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
oxybenzone results in decreased expression of LCK mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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|
G |
Ldhd |
lactate dehydrogenase D |
increases methylation |
ISO |
oxybenzone results in increased methylation of LDHD gene |
CTD |
PMID:34523531 |
|
NCBI chr19:39,583,529...39,588,397
Ensembl chr19:39,573,621...39,595,575
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|
G |
Lifr |
LIF receptor subunit alpha |
increases expression |
ISO |
oxybenzone results in increased expression of LIFR mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
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|
G |
Lsmem1 |
leucine-rich single-pass membrane protein 1 |
increases expression |
EXP |
oxybenzone results in increased expression of LSMEM1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653
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|
G |
Magel2 |
MAGE family member L2 |
increases expression |
EXP |
oxybenzone results in increased expression of MAGEL2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250
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|
G |
Mapk6 |
mitogen-activated protein kinase 6 |
increases expression |
ISO |
oxybenzone results in increased expression of MAPK6 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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|
G |
Mcc |
MCC regulator of WNT signaling pathway |
decreases expression |
EXP |
oxybenzone results in decreased expression of MCC mRNA |
CTD |
PMID:30316929 |
|
NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819
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|
G |
Med13 |
mediator complex subunit 13 |
increases expression |
ISO |
oxybenzone results in increased expression of MED13 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242
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|
G |
Medag |
mesenteric estrogen-dependent adipogenesis |
decreases expression |
EXP |
oxybenzone results in decreased expression of MEDAG mRNA |
CTD |
PMID:30316929 |
|
NCBI chr12:5,613,191...5,634,583
Ensembl chr12:5,613,208...5,634,767
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|
G |
Mre11 |
MRE11 homolog, double strand break repair nuclease |
increases expression |
ISO |
oxybenzone results in increased expression of MRE11 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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G |
Msh2 |
mutS homolog 2 |
increases expression |
ISO |
oxybenzone results in increased expression of MSH2 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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|
G |
Mybl1 |
MYB proto-oncogene like 1 |
increases expression multiple interactions |
ISO |
oxybenzone results in increased expression of MYBL1 mRNA Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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G |
Nbn |
nibrin |
increases expression |
ISO |
oxybenzone results in increased expression of NBN mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
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|
G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions increases expression |
ISO |
oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] oxybenzone results in increased expression of NCOA2 mRNA |
CTD |
PMID:32407875 PMID:36581016 |
|
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
|
|
G |
Ndufa11 |
NADH:ubiquinone oxidoreductase subunit A11 |
decreases expression |
EXP |
oxybenzone results in decreased expression of NDUFA11 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 9:1,550,487...1,554,546
Ensembl chr 9:1,550,468...1,555,601
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|
G |
Ndufa3 |
NADH:ubiquinone oxidoreductase subunit A3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of NDUFA3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235
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|
G |
Ndufa9 |
NADH:ubiquinone oxidoreductase subunit A9 |
increases expression |
EXP |
oxybenzone results in increased expression of NDUFA9 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
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|
G |
Ndufab1 |
NADH:ubiquinone oxidoreductase subunit AB1 |
increases expression |
EXP |
oxybenzone results in increased expression of NDUFAB1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
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|
G |
Ndufb10 |
NADH:ubiquinone oxidoreductase subunit B10 |
increases expression |
EXP |
oxybenzone results in increased expression of NDUFB10 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
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|
G |
Ndufb7 |
NADH:ubiquinone oxidoreductase subunit B7 |
increases expression |
EXP |
oxybenzone results in increased expression of NDUFB7 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
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|
G |
Ndufs2 |
NADH:ubiquinone oxidoreductase core subunit S2 |
decreases expression |
EXP |
oxybenzone results in decreased expression of NDUFS2 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
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|
G |
Ndufv3 |
NADH:ubiquinone oxidoreductase subunit V3 |
affects expression |
EXP |
oxybenzone affects the expression of NDUFV3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 Ensembl chr13:9,612,431...9,623,074
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G |
Nf1 |
neurofibromin 1 |
increases expression |
ISO |
oxybenzone results in increased expression of NF1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
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G |
Nfat5 |
nuclear factor of activated T-cells 5 |
increases expression |
ISO |
oxybenzone results in increased expression of NFAT5 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
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|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
oxybenzone binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
oxybenzone results in increased activity of NR1I3 protein |
CTD |
PMID:28927721 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression |
ISO |
oxybenzone results in increased expression of NR3C1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nrf1 |
nuclear respiratory factor 1 |
increases expression |
EXP |
oxybenzone results in increased expression of NRF1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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|
G |
Nrip1 |
nuclear receptor interacting protein 1 |
increases expression |
ISO |
oxybenzone results in increased expression of NRIP1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Ntn5 |
netrin 5 |
increases expression |
EXP |
oxybenzone results in increased expression of NTN5 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:96,156,948...96,165,997
Ensembl chr 1:96,156,985...96,165,630
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|
G |
Ogdh |
oxoglutarate dehydrogenase |
increases expression decreases expression |
EXP |
oxybenzone results in increased expression of OGDH mRNA oxybenzone results in decreased expression of OGDH mRNA |
CTD |
PMID:30316929 |
|
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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|
G |
Pdcd11 |
programmed cell death 11 |
increases expression |
EXP |
oxybenzone results in increased expression of PDCD11 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999
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|
G |
Pdcd6ip |
programmed cell death 6 interacting protein |
decreases expression |
EXP |
oxybenzone results in decreased expression of PDCD6IP mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
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|
G |
Pdcd7 |
programmed cell death 7 |
increases expression |
EXP |
oxybenzone results in increased expression of PDCD7 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333
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|
G |
Pgr |
progesterone receptor |
multiple interactions increases expression |
ISO |
oxybenzone binds to and results in decreased activity of PGR protein oxybenzone results in increased expression of PGR mRNA |
CTD |
PMID:15537743 PMID:31939680 PMID:32946892 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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|
G |
Phf24 |
PHD finger protein 24 |
increases expression |
EXP |
oxybenzone results in increased expression of PHF24 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:57,143,428...57,171,054
Ensembl chr 5:57,142,632...57,168,497
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G |
Pias1 |
protein inhibitor of activated STAT, 1 |
increases expression |
ISO |
oxybenzone results in increased expression of PIAS1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases expression |
ISO |
oxybenzone results in increased expression of PIK3R1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Polm |
DNA polymerase mu |
decreases expression |
EXP |
oxybenzone results in decreased expression of POLM mRNA |
CTD |
PMID:30316929 |
|
NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086
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|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression |
ISO |
oxybenzone results in increased expression of PPARA mRNA |
CTD |
PMID:32407875 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects binding multiple interactions increases expression |
ISO |
oxybenzone binds to PPARG protein oxybenzone binds to and results in increased activity of PPARG protein oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] oxybenzone results in increased expression of PPARG mRNA |
CTD |
PMID:32407875 PMID:33049310 PMID:34864131 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppp1cb |
protein phosphatase 1 catalytic subunit beta |
increases expression |
ISO |
oxybenzone results in increased expression of PPP1CB mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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G |
Prkacb |
protein kinase cAMP-activated catalytic subunit beta |
increases expression |
ISO |
oxybenzone results in increased expression of PRKACB mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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G |
Prkci |
protein kinase C, iota |
increases expression |
ISO |
oxybenzone results in increased expression of PRKCI mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
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|
G |
Prss37 |
serine protease 37 |
decreases expression |
EXP |
oxybenzone results in decreased expression of PRSS37 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555
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|
G |
Pten |
phosphatase and tensin homolog |
increases expression |
ISO |
oxybenzone results in increased expression of PTEN mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
oxybenzone results in increased expression of PTGS2 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn4 |
protein tyrosine phosphatase, non-receptor type 4 |
increases expression |
ISO |
oxybenzone results in increased expression of PTPN4 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170
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|
G |
Rad17 |
RAD17 checkpoint clamp loader component |
increases expression |
ISO |
oxybenzone results in increased expression of RAD17 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
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|
G |
Rad50 |
RAD50 double strand break repair protein |
increases expression |
ISO |
oxybenzone results in increased expression of RAD50 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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G |
Rap2a |
RAP2A, member of RAS oncogene family |
increases expression |
ISO |
oxybenzone results in increased expression of RAP2A mRNA |
CTD |
PMID:36581016 |
|
NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
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|
G |
Rb1 |
RB transcriptional corepressor 1 |
increases expression |
ISO |
oxybenzone results in increased expression of RB1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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|
G |
Rb1cc1 |
RB1-inducible coiled-coil 1 |
increases expression |
ISO |
oxybenzone results in increased expression of RB1CC1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
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|
G |
Rbbp8 |
RB binding protein 8, endonuclease |
increases expression |
ISO |
oxybenzone results in increased expression of RBBP8 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
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|
G |
Rbl1 |
RB transcriptional corepressor like 1 |
increases expression |
ISO |
oxybenzone results in increased expression of RBL1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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|
G |
Rel |
REL proto-oncogene, NF-kB subunit |
increases expression |
ISO |
oxybenzone results in increased expression of REL mRNA |
CTD |
PMID:36581016 |
|
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases expression |
EXP |
oxybenzone results in increased expression of RELA protein |
CTD |
PMID:31368502 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
decreases expression |
EXP |
oxybenzone results in decreased expression of RETN mRNA |
CTD |
PMID:30316929 |
|
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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|
G |
Rfc1 |
replication factor C subunit 1 |
increases expression |
ISO |
oxybenzone results in increased expression of RFC1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
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G |
Rictor |
RPTOR independent companion of MTOR, complex 2 |
increases expression |
ISO |
oxybenzone results in increased expression of RICTOR mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
|
|
G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
increases expression |
ISO |
oxybenzone results in increased expression of ROCK1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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|
G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
increases expression |
ISO |
oxybenzone results in increased expression of ROCK2 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
increases expression |
ISO |
oxybenzone results in increased expression of RPS6KB1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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|
G |
Rrm2b |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
increases expression |
ISO |
oxybenzone results in increased expression of RRM2B mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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|
G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
increases expression |
EXP |
oxybenzone results in increased expression of SDHA mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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|
G |
Serpinc1 |
serpin family C member 1 |
increases expression |
EXP |
oxybenzone results in increased expression of SERPINC1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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|
G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA] |
CTD |
PMID:33405908 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
|
|
G |
Sh3glb1 |
SH3 domain -containing GRB2-like endophilin B1 |
increases expression |
EXP |
oxybenzone results in increased expression of SH3GLB1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784
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|
G |
Shank1 |
SH3 and multiple ankyrin repeat domains 1 |
increases expression |
EXP |
oxybenzone results in increased expression of SHANK1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
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|
G |
Slc1a2 |
solute carrier family 1 member 2 |
affects expression |
EXP |
oxybenzone affects the expression of SLC1A2 protein |
CTD |
PMID:31368502 |
|
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
|
|
G |
Slc7a11 |
solute carrier family 7 member 11 |
affects expression |
EXP |
oxybenzone affects the expression of SLC7A11 protein |
CTD |
PMID:31368502 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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|
G |
Smc3 |
structural maintenance of chromosomes 3 |
increases expression |
ISO |
oxybenzone results in increased expression of SMC3 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
|
|
G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions increases expression |
EXP |
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA] |
CTD |
PMID:30599193 |
|
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Sstr3 |
somatostatin receptor 3 |
increases expression |
EXP |
oxybenzone results in increased expression of SSTR3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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G |
Stag1 |
STAG1 cohesin complex component |
increases expression |
ISO |
oxybenzone results in increased expression of STAG1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
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G |
Stat5a |
signal transducer and activator of transcription 5A |
increases expression affects localization |
ISO |
oxybenzone results in increased expression of STAT5A mRNA oxybenzone affects the localization of STAT5A protein |
CTD |
PMID:32946892 |
|
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of SULT1A1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Taf9b |
TATA-box binding protein associated factor 9b |
increases expression |
ISO |
oxybenzone results in increased expression of TAF9B mRNA |
CTD |
PMID:36581016 |
|
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
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G |
Tbk1 |
TANK-binding kinase 1 |
increases expression |
ISO |
oxybenzone results in increased expression of TBK1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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G |
Tex46 |
testis expressed 46 |
decreases expression |
EXP |
oxybenzone results in decreased expression of TEX46 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 5:148,849,307...148,853,742
Ensembl chr 5:148,849,307...148,853,742
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G |
Tfam |
transcription factor A, mitochondrial |
increases expression |
EXP ISO |
oxybenzone results in increased expression of TFAM mRNA |
CTD |
PMID:30316929 PMID:36581016 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tff1 |
trefoil factor 1 |
multiple interactions increases expression |
ISO |
[oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA oxybenzone results in increased expression of TFF1 mRNA |
CTD |
PMID:16183391 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tgfbr1 |
transforming growth factor, beta receptor 1 |
increases expression |
ISO |
oxybenzone results in increased expression of TGFBR1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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G |
Tmprss4 |
transmembrane serine protease 4 |
increases expression |
EXP |
oxybenzone results in increased expression of TMPRSS4 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
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G |
Topbp1 |
DNA topoisomerase II binding protein 1 |
increases expression |
ISO |
oxybenzone results in increased expression of TOPBP1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
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G |
Tp53 |
tumor protein p53 |
decreases expression |
EXP |
oxybenzone results in decreased expression of TP53 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
increases expression |
ISO |
oxybenzone results in increased expression of TP53BP1 protein |
CTD |
PMID:31939680 |
|
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Tpr |
translocated promoter region, nuclear basket protein |
increases expression |
ISO |
oxybenzone results in increased expression of TPR mRNA |
CTD |
PMID:36581016 |
|
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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G |
Tspo |
translocator protein |
decreases expression |
EXP |
oxybenzone results in decreased expression of TSPO mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases expression |
EXP |
oxybenzone results in decreased expression of UGT1A6 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2a3 |
UDP glucuronosyltransferase family 2 member A3 |
decreases expression |
EXP |
oxybenzone results in decreased expression of UGT2A3 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
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G |
Upk1b |
uroplakin 1B |
decreases expression |
EXP |
oxybenzone results in decreased expression of UPK1B mRNA |
CTD |
PMID:30316929 |
|
NCBI chr11:61,953,687...61,991,029
Ensembl chr11:61,953,648...61,991,029
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G |
Uqcr11 |
ubiquinol-cytochrome c reductase, complex III subunit XI |
affects expression |
EXP |
oxybenzone affects the expression of UQCR11 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
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G |
Uqcrc1 |
ubiquinol-cytochrome c reductase core protein 1 |
increases expression |
EXP |
oxybenzone results in increased expression of UQCRC1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
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G |
Uqcrfs1 |
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of UQCRFS1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
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G |
Uqcrq |
ubiquinol-cytochrome c reductase, complex III subunit VII |
increases expression |
EXP |
oxybenzone results in increased expression of UQCRQ mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169
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G |
Vdac1 |
voltage-dependent anion channel 1 |
decreases expression |
EXP |
oxybenzone results in decreased expression of VDAC1 mRNA |
CTD |
PMID:30316929 |
|
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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G |
Wrn |
WRN RecQ like helicase |
increases expression |
ISO |
oxybenzone results in increased expression of WRN mRNA |
CTD |
PMID:36581016 |
|
NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
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G |
Zeb1 |
zinc finger E-box binding homeobox 1 |
increases expression |
ISO |
oxybenzone results in increased expression of ZEB1 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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G |
Zfp420 |
zinc finger protein 420 |
increases expression |
ISO |
oxybenzone results in increased expression of ZNF420 mRNA |
CTD |
PMID:36581016 |
|
NCBI chr 1:85,092,810...85,143,682
Ensembl chr 1:85,093,085...85,106,693 Ensembl chr 1:85,093,085...85,106,693
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G |
Aadac |
arylacetamide deacetylase |
decreases expression |
EXP |
tolcapone results in decreased expression of AADAC mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
EXP |
Tolcapone results in increased expression of AARS1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
tolcapone results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcd2 |
ATP binding cassette subfamily D member 2 |
affects binding |
EXP |
tolcapone binds to ABCD2 protein |
CTD |
PMID:19783845 |
|
NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
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G |
Abhd10 |
abhydrolase domain containing 10, depalmitoylase |
affects binding |
EXP |
tolcapone binds to ABHD10 protein |
CTD |
PMID:19783845 |
|
NCBI chr11:55,081,273...55,095,044
Ensembl chr11:55,081,049...55,107,866
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G |
Acat2 |
acetyl-CoA acetyltransferase 2 |
increases expression |
EXP |
tolcapone results in increased expression of ACAT2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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G |
Acox3 |
acyl-CoA oxidase 3, pristanoyl |
affects binding |
EXP |
tolcapone binds to ACOX3 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:75,133,986...75,176,767
Ensembl chr14:75,094,676...75,176,205
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
affects binding decreases expression |
EXP ISO |
tolcapone binds to ACSL1 protein tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein |
CTD |
PMID:19783845 PMID:29688484 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
decreases expression |
ISO |
tolcapone results in decreased expression of ACSL5 protein |
CTD |
PMID:29688484 |
|
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
increases expression |
EXP |
tolcapone results in increased expression of ACSS2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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G |
Acta2 |
actin alpha 2, smooth muscle |
affects binding |
EXP |
tolcapone binds to ACTA2 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adprhl1 |
ADP-ribosylhydrolase like 1 |
affects binding |
EXP |
tolcapone binds to ADPRHL1 protein |
CTD |
PMID:19783845 |
|
NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440
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G |
Aga |
aspartylglucosaminidase |
decreases expression |
EXP |
tolcapone results in decreased expression of AGA mRNA |
CTD |
PMID:24136188 |
|
NCBI chr16:38,504,661...38,516,607
Ensembl chr16:38,504,663...38,516,606
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G |
Aif1 |
allograft inflammatory factor 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of AIF1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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G |
Ak2 |
adenylate kinase 2 |
affects binding |
EXP |
tolcapone binds to AK2 protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
affects binding |
EXP |
Tolcapone binds to AKR1C1 protein |
CTD |
PMID:19783845 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases expression |
EXP |
tolcapone results in decreased expression of AKR1C3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Akr1d1 |
aldo-keto reductase family 1, member D1 |
affects binding |
EXP |
tolcapone binds to AKR1D1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
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G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
affects binding |
EXP |
tolcapone binds to ALDH18A1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
affects binding |
EXP |
tolcapone binds to ALDH1B1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Aldh1l1 |
aldehyde dehydrogenase 1 family, member L1 |
increases expression |
EXP |
tolcapone results in increased expression of ALDH1L1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
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G |
Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
affects binding |
EXP |
tolcapone binds to ALDH3A2 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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G |
Alg13 |
ALG13, UDP-N-acetylglucosaminyltransferase subunit |
decreases expression |
EXP |
Tolcapone results in decreased expression of ALG13 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:107,906,320...107,968,232
Ensembl chr X:107,885,093...107,942,695
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G |
Amfr |
autocrine motility factor receptor |
increases expression |
EXP |
tolcapone results in increased expression of AMFR mRNA |
CTD |
PMID:24136188 |
|
NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247
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G |
Apmap |
adipocyte plasma membrane associated protein |
affects binding |
EXP |
tolcapone binds to APMAP protein |
CTD |
PMID:19783845 |
|
NCBI chr 3:139,409,021...139,437,296
Ensembl chr 3:139,409,022...139,437,341
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G |
Apoa1 |
apolipoprotein A1 |
affects binding |
EXP |
tolcapone binds to APOA1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apob |
apolipoprotein B |
decreases expression decreases secretion |
ISO |
tolcapone results in decreased expression of APOB mRNA tolcapone results in decreased secretion of APOB protein alternative form |
CTD |
PMID:29688484 |
|
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc2 |
apolipoprotein C2 |
decreases expression |
EXP |
tolcapone results in decreased expression of APOC2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476
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G |
Apoe |
apolipoprotein E |
affects binding |
EXP |
tolcapone binds to APOE protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
Apool |
apolipoprotein O-like |
decreases expression |
EXP |
tolcapone results in decreased expression of APOOL mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:77,377,723...77,443,672
Ensembl chr X:77,377,781...77,443,900
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G |
Arf4 |
ADP-ribosylation factor 4 |
affects binding |
EXP |
tolcapone binds to ARF4 protein |
CTD |
PMID:19783845 |
|
NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arl1 |
ADP-ribosylation factor like GTPase 1 |
affects binding |
EXP |
tolcapone binds to ARL1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Atad1 |
ATPase family, AAA domain containing 1 |
affects binding |
EXP |
tolcapone binds to ATAD1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:230,544,227...230,610,524
Ensembl chr 1:230,544,047...230,596,548
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G |
Atad3a |
ATPase family, AAA domain containing 3A |
affects binding |
EXP |
tolcapone binds to ATAD3A protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482
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G |
Atf5 |
activating transcription factor 5 |
increases expression |
EXP |
tolcapone results in increased expression of ATF5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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G |
Atp1b3 |
ATPase Na+/K+ transporting subunit beta 3 |
affects binding |
EXP |
tolcapone binds to ATP1B3 protein |
CTD |
PMID:19783845 |
|
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
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G |
Atp5f1b |
ATP synthase F1 subunit beta |
affects binding |
EXP |
tolcapone binds to ATP5F1B protein |
CTD |
PMID:19783845 |
|
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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G |
Atp5f1c |
ATP synthase F1 subunit gamma |
affects binding |
EXP |
Tolcapone binds to ATP5F1C protein |
CTD |
PMID:19783845 |
|
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
decreases expression |
EXP |
tolcapone results in decreased expression of ATP5F1E mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp5me |
ATP synthase membrane subunit e |
decreases expression affects binding |
EXP |
tolcapone results in decreased expression of ATP5ME mRNA tolcapone binds to ATP5ME protein |
CTD |
PMID:19783845 PMID:24136188 |
|
NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013
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G |
Atp5mf |
ATP synthase membrane subunit f |
affects binding |
EXP |
tolcapone binds to ATP5MF protein |
CTD |
PMID:19783845 |
|
NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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G |
Atp5mg |
ATP synthase membrane subunit G |
decreases expression affects binding |
EXP |
tolcapone results in decreased expression of ATP5MG mRNA tolcapone binds to ATP5MG protein |
CTD |
PMID:19783845 PMID:24136188 |
|
NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559
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G |
Atp5mk |
ATP synthase membrane subunit K |
decreases expression |
EXP |
Tolcapone results in decreased expression of ATP5MK mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:245,973,910...245,980,702
Ensembl chr 1:245,973,914...245,980,761 Ensembl chr10:245,973,914...245,980,761
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G |
Atp5pf |
ATP synthase peripheral stalk subunit F6 |
decreases expression |
EXP |
tolcapone results in decreased expression of ATP5PF mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
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G |
Atp5po |
ATP synthase peripheral stalk subunit OSCP |
affects binding |
EXP |
tolcapone binds to ATP5PO protein |
CTD |
PMID:19783845 |
|
NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
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G |
Auh |
AU RNA binding methylglutaconyl-CoA hydratase |
affects binding |
EXP |
tolcapone binds to AUH protein |
CTD |
PMID:19783845 |
|
NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896
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G |
Bbox1 |
gamma-butyrobetaine hydroxylase 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of BBOX1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
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G |
Bcam |
basal cell adhesion molecule (Lutheran blood group) |
affects binding |
EXP |
tolcapone binds to BCAM protein |
CTD |
PMID:19783845 |
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NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
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G |
Bcap29 |
B-cell receptor-associated protein 29 |
decreases expression |
EXP |
tolcapone results in decreased expression of BCAP29 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720
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G |
Bcas2 |
BCAS2, pre-mRNA processing factor |
decreases expression |
EXP |
tolcapone results in decreased expression of BCAS2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
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G |
Bltp1 |
bridge-like lipid transfer protein family member 1 |
increases expression |
EXP |
Tolcapone results in increased expression of BLTP1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695
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G |
Bmper |
BMP-binding endothelial regulator |
affects binding |
EXP |
tolcapone binds to BMPER protein |
CTD |
PMID:19783845 |
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NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
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G |
Bms1 |
BMS1 ribosome biogenesis factor |
affects binding |
EXP |
tolcapone binds to BMS1 protein |
CTD |
PMID:19783845 |
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NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127
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G |
Bpgm |
bisphosphoglycerate mutase |
decreases expression |
EXP |
tolcapone results in decreased expression of BPGM mRNA |
CTD |
PMID:24136188 |
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NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
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G |
Btf3l4 |
basic transcription factor 3-like 4 |
decreases expression |
EXP |
tolcapone results in decreased expression of BTF3L4 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:123,567,902...123,587,527
Ensembl chr 5:123,567,907...123,586,866
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G |
C1d |
C1D nuclear receptor corepressor |
decreases expression |
EXP |
tolcapone results in decreased expression of C1D mRNA |
CTD |
PMID:24136188 |
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NCBI chr14:91,660,951...91,673,177
Ensembl chr14:91,660,989...91,672,852
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G |
C1galt1c1 |
C1GALT1-specific chaperone 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of C1GALT1C1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr X:117,378,123...117,382,620
Ensembl chr X:117,375,525...117,382,787
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G |
C4b |
complement C4B |
increases expression |
EXP |
tolcapone results in increased expression of C4B mRNA |
CTD |
PMID:24136188 |
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NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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G |
C5 |
complement C5 |
increases expression |
EXP |
tolcapone results in increased expression of C5 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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G |
C8a |
complement C8 alpha chain |
increases expression |
EXP |
tolcapone results in increased expression of C8A mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754
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G |
C8h11orf71 |
similar to human chromosome 11 open reading frame 71 |
decreases expression |
EXP |
Tolcapone results in decreased expression of C8H11ORF71 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 8:48,838,556...48,838,970
Ensembl chr 8:48,838,100...48,842,270
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G |
C8h15orf61 |
similar to human chromosome 15 open reading frame 61 |
decreases expression |
EXP |
Tolcapone results in decreased expression of C8H15ORF61 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 8:63,868,125...63,872,863
Ensembl chr 8:63,868,125...63,872,751
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G |
Cbr4 |
carbonyl reductase 4 |
decreases expression |
EXP |
tolcapone results in decreased expression of CBR4 mRNA |
CTD |
PMID:24136188 |
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NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712
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G |
Ccnl2 |
cyclin L2 |
increases expression |
EXP |
tolcapone results in increased expression of CCNL2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882
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G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
affects binding |
EXP |
tolcapone binds to CCT7 protein |
CTD |
PMID:19783845 |
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NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
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G |
Cd36 |
CD36 molecule |
increases expression |
ISO |
tolcapone results in increased expression of CD36 mRNA |
CTD |
PMID:29688484 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cfb |
complement factor B |
increases expression |
EXP |
tolcapone results in increased expression of CFB mRNA |
CTD |
PMID:24136188 |
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NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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G |
Chchd1 |
coiled-coil-helix-coiled-coil-helix domain containing 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of CHCHD1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr15:3,592,719...3,593,901
Ensembl chr15:3,592,727...3,593,901
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G |
Chchd7 |
coiled-coil-helix-coiled-coil-helix domain containing 7 |
decreases expression |
EXP |
tolcapone results in decreased expression of CHCHD7 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:16,957,127...16,961,682
Ensembl chr 5:16,957,188...16,961,184
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G |
Chrac1 |
chromatin accessibility complex subunit 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of CHRAC1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136
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G |
Churc1 |
churchill domain containing 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of CHURC1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586
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G |
Ciao2a |
cytosolic iron-sulfur assembly component 2A |
decreases expression |
EXP |
tolcapone results in decreased expression of CIAO2A mRNA |
CTD |
PMID:24136188 |
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NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455
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G |
Cidea |
cell death-inducing DFFA-like effector a |
increases expression |
ISO |
tolcapone results in increased expression of CIDEA mRNA |
CTD |
PMID:29688484 |
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NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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G |
Cisd1 |
CDGSH iron sulfur domain 1 |
affects binding |
EXP |
tolcapone binds to CISD1 protein |
CTD |
PMID:19783845 |
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NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924
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G |
Clec4a3 |
C-type lectin domain family 4, member A3 |
decreases expression |
EXP |
Tolcapone results in decreased expression of CLEC4A3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817
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G |
Cltc |
clathrin heavy chain |
affects binding |
EXP |
tolcapone binds to CLTC protein |
CTD |
PMID:19783845 |
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NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
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G |
Cnih4 |
cornichon family member 4 |
decreases expression |
EXP |
tolcapone results in decreased expression of CNIH4 mRNA |
CTD |
PMID:24136188 |
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NCBI chr13:92,910,315...92,926,428
Ensembl chr13:92,910,315...92,927,853
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G |
Commd6 |
COMM domain containing 6 |
decreases expression |
EXP |
tolcapone results in decreased expression of COMMD6 mRNA |
CTD |
PMID:24136188 |
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NCBI chr15:78,467,333...78,474,382
Ensembl chr15:78,467,804...78,474,382
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G |
Comt |
catechol-O-methyltransferase |
decreases activity multiple interactions increases methylation affects binding |
ISO EXP |
tolcapone results in decreased activity of COMT protein [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa] [tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine] COMT protein results in increased methylation of tolcapone tolcapone binds to COMT protein |
CTD |
PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 PMID:10047930 PMID:10064789 PMID:10809409 PMID:10872643 PMID:11248589 PMID:11432539 PMID:11793163 PMID:11793426 PMID:12584150 PMID:12898346 PMID:14975680 PMID:15190105 PMID:15566291 PMID:16012872 PMID:16758261 PMID:19783845 PMID:20334432 PMID:23206800 PMID:29688484 More...
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NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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G |
Copg1 |
COPI coat complex subunit gamma 1 |
affects binding |
EXP |
tolcapone binds to COPG1 protein |
CTD |
PMID:19783845 |
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NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
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G |
Copg2 |
COPI coat complex subunit gamma 2 |
decreases expression |
EXP |
tolcapone results in decreased expression of COPG2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618
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G |
Coq10a |
coenzyme Q10A |
decreases expression |
EXP |
tolcapone results in decreased expression of COQ10A mRNA |
CTD |
PMID:24136188 |
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NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161
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G |
Coq3 |
coenzyme Q3 methyltransferase |
decreases expression |
EXP |
tolcapone results in decreased expression of COQ3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
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G |
Cox6c |
cytochrome c oxidase subunit 6C |
affects binding decreases expression |
EXP |
tolcapone binds to COX6C protein tolcapone results in decreased expression of COX6C mRNA |
CTD |
PMID:19783845 PMID:24136188 |
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NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
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G |
Cox7a2 |
cytochrome c oxidase subunit 7A2 |
decreases expression |
EXP |
tolcapone results in decreased expression of COX7A2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633 Ensembl chr 8:51,301,168...51,301,633
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G |
Cox7b |
cytochrome c oxidase subunit 7B |
decreases expression |
EXP |
tolcapone results in decreased expression of COX7B mRNA |
CTD |
PMID:24136188 |
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NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732
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G |
Cp |
ceruloplasmin |
increases expression |
EXP |
tolcapone results in increased expression of CP mRNA |
CTD |
PMID:24136188 |
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NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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G |
Crem |
cAMP responsive element modulator |
decreases expression |
EXP |
tolcapone results in decreased expression of CREM mRNA |
CTD |
PMID:24136188 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Crip2 |
cysteine-rich protein 2 |
increases expression |
EXP |
tolcapone results in increased expression of CRIP2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
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G |
Cse1l |
chromosome segregation 1 like |
affects binding |
EXP |
tolcapone binds to CSE1L protein |
CTD |
PMID:19783845 |
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NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
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G |
Cstb |
cystatin B |
decreases expression |
EXP |
tolcapone results in decreased expression of CSTB mRNA |
CTD |
PMID:24136188 |
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NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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G |
Cyc1 |
cytochrome c-1 |
affects binding |
EXP |
tolcapone binds to CYC1 protein |
CTD |
PMID:19783845 |
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NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
EXP ISO |
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Tolcapone results in decreased activity of CYP1A1 protein |
CTD |
PMID:18493746 PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression |
EXP ISO |
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] tolcapone results in increased expression of CYP1A2 mRNA |
CTD |
PMID:18493746 PMID:24136188 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Tolcapone results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases response to substance |
ISO |
CYP3A4 protein results in increased susceptibility to Tolcapone |
CTD |
PMID:21540358 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp51 |
cytochrome P450, family 51 |
increases expression |
EXP |
tolcapone results in increased expression of CYP51 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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G |
Dap |
death-associated protein |
increases expression |
EXP |
tolcapone results in increased expression of DAP mRNA |
CTD |
PMID:24136188 |
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NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dctd |
dCMP deaminase |
affects binding |
EXP |
tolcapone binds to DCTD protein |
CTD |
PMID:19783845 |
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NCBI chr16:44,066,952...44,098,654
Ensembl chr16:44,055,128...44,098,446
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
affects binding |
EXP |
tolcapone binds to DDOST protein |
CTD |
PMID:19783845 |
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NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Ddx18 |
DEAD-box helicase 18 |
affects binding |
EXP |
tolcapone binds to DDX18 protein |
CTD |
PMID:19783845 |
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NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
affects binding increases expression |
EXP |
tolcapone binds to DHCR24 protein tolcapone results in increased expression of DHCR24 mRNA |
CTD |
PMID:19783845 PMID:24136188 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
affects binding |
EXP |
tolcapone binds to DHCR7 protein |
CTD |
PMID:19783845 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dmac1 |
distal membrane arm assembly component 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of DMAC1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:89,241,173...89,243,793
Ensembl chr 5:89,242,661...89,243,757
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G |
Dnajc15 |
DnaJ heat shock protein family (Hsp40) member C15 |
decreases expression |
EXP |
tolcapone results in decreased expression of DNAJC15 mRNA |
CTD |
PMID:24136188 |
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NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
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G |
Dock11 |
dedicator of cytokinesis 11 |
decreases expression |
EXP |
tolcapone results in decreased expression of DOCK11 mRNA |
CTD |
PMID:24136188 |
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NCBI chr X:115,131,720...115,314,854
Ensembl chr X:115,131,909...115,314,854
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G |
Dpm3 |
dolichyl-phosphate mannosyltransferase subunit 3, regulatory |
decreases expression |
EXP |
tolcapone results in decreased expression of DPM3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 2:174,676,532...174,677,047
Ensembl chr 2:174,676,363...174,677,668 Ensembl chr15:174,676,363...174,677,668
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G |
Dpy30 |
dpy-30 histone methyltransferase complex regulatory subunit |
decreases expression |
EXP |
tolcapone results in decreased expression of DPY30 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 6:21,120,947...21,141,720
Ensembl chr 6:21,120,947...21,141,432
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G |
Dtymk |
deoxythymidylate kinase |
decreases expression |
EXP |
tolcapone results in decreased expression of DTYMK mRNA |
CTD |
PMID:24136188 |
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NCBI chr 9:94,315,552...94,324,386
Ensembl chr 9:94,315,552...94,324,870
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G |
Dynll1 |
dynein light chain LC8-type 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of DYNLL1 mRNA |
CTD |
PMID:24136188 |
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NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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G |
Dynlt3 |
dynein light chain Tctex-type 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of DYNLT3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139
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G |
Ebp |
EBP, cholestenol delta-isomerase |
increases expression |
EXP |
tolcapone results in increased expression of EBP mRNA |
CTD |
PMID:24136188 |
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NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
affects binding |
EXP |
tolcapone binds to ECHS1 protein |
CTD |
PMID:19783845 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Eloc |
elongin C |
decreases expression |
EXP |
tolcapone results in decreased expression of ELOC mRNA |
CTD |
PMID:24136188 |
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NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890
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G |
Ereg |
epiregulin |
decreases expression |
ISO |
Tolcapone results in decreased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
F5 |
coagulation factor V |
increases expression |
EXP |
tolcapone results in increased expression of F5 mRNA |
CTD |
PMID:24136188 |
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NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317
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G |
Fam162a |
family with sequence similarity 162, member A |
affects binding |
EXP |
tolcapone binds to FAM162A protein |
CTD |
PMID:19783845 |
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NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239
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G |
Fbll1 |
fibrillarin-like 1 |
affects binding |
EXP |
tolcapone binds to FBLL1 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:20,258,656...20,260,299
Ensembl chr10:20,258,656...20,260,299
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G |
Fcf1 |
Fcf1 rRNA-processing protein |
decreases expression |
EXP |
tolcapone results in decreased expression of FCF1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 6:104,617,780...104,629,643
Ensembl chr 6:104,617,770...104,629,643
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G |
Fga |
fibrinogen alpha chain |
affects binding |
EXP |
tolcapone binds to FGA protein |
CTD |
PMID:19783845 |
|
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
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G |
Fmc1 |
formation of mitochondrial complex V assembly factor 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of FMC1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140
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G |
Gcdh |
glutaryl-CoA dehydrogenase |
affects binding |
EXP |
tolcapone binds to GCDH protein |
CTD |
PMID:19783845 |
|
NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681
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G |
Glg1 |
golgi glycoprotein 1 |
affects binding |
EXP |
tolcapone binds to GLG1 protein |
CTD |
PMID:19783845 |
|
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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G |
Gmfg |
glia maturation factor, gamma |
decreases expression |
EXP |
tolcapone results in decreased expression of GMFG mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:83,728,797...83,739,189
Ensembl chr 1:83,728,776...83,739,183
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G |
Gng10 |
G protein subunit gamma 10 |
decreases expression |
EXP |
tolcapone results in decreased expression of GNG10 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:73,856,124...73,863,017
Ensembl chr 5:73,856,164...73,863,012 Ensembl chr 5:73,856,164...73,863,012
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G |
Gng5 |
G protein subunit gamma 5 |
decreases expression |
EXP |
tolcapone results in decreased expression of GNG5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513
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G |
Gpc3 |
glypican 3 |
affects binding |
EXP |
tolcapone binds to GPC3 protein |
CTD |
PMID:19783845 |
|
NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798
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G |
Gtf2h5 |
general transcription factor IIH subunit 5 |
decreases expression |
EXP |
tolcapone results in decreased expression of GTF2H5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
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G |
H2az2 |
H2A.Z variant histone 2 |
affects binding |
EXP |
Tolcapone binds to H2AZ2 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:81,293,304...81,312,209
Ensembl chr14:81,293,299...81,312,144
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G |
Hbb |
hemoglobin subunit beta |
affects binding |
EXP |
tolcapone binds to HBB protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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G |
Higd1a |
HIG1 hypoxia inducible domain family, member 1A |
decreases expression |
EXP |
tolcapone results in decreased expression of HIGD1A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:121,514,152...121,523,382
Ensembl chr 8:121,514,156...121,523,443
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G |
Hint3 |
histidine triad nucleotide binding protein 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of HINT3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:27,035,936...27,045,799
Ensembl chr 1:27,035,905...27,047,721
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G |
Hist1h4b |
histone cluster 1 H4 family member B |
decreases expression |
EXP |
Tolcapone results in decreased expression of HIST1H4B mRNA |
CTD |
PMID:24136188 |
|
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
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G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
affects binding |
EXP |
tolcapone binds to HNRNPH1 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846
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G |
Hsd17b11 |
hydroxysteroid (17-beta) dehydrogenase 11 |
affects binding |
EXP |
tolcapone binds to HSD17B11 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161
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G |
Hsd17b12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
affects binding |
EXP |
tolcapone binds to HSD17B12 protein |
CTD |
PMID:19783845 |
|
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
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G |
Hsd17b13 |
hydroxysteroid (17-beta) dehydrogenase 13 |
affects binding |
EXP |
tolcapone binds to HSD17B13 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:5,751,697...5,766,809
Ensembl chr14:5,752,132...5,768,166
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
affects binding |
EXP |
tolcapone binds to HSD17B4 protein |
CTD |
PMID:19783845 |
|
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsdl2 |
hydroxysteroid dehydrogenase like 2 |
increases expression |
EXP |
tolcapone results in increased expression of HSDL2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
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G |
Iftap |
intraflagellar transport associated protein |
decreases expression |
EXP |
Tolcapone results in decreased expression of IFTAP mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
tolcapone results in increased expression of IGFBP1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Il24 |
interleukin 24 |
decreases expression |
ISO |
Tolcapone results in decreased expression of IL24 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Ipo7 |
importin 7 |
affects binding |
EXP |
tolcapone binds to IPO7 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938
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|
G |
Itm2a |
integral membrane protein 2A |
affects binding |
EXP |
tolcapone binds to ITM2A protein |
CTD |
PMID:19783845 |
|
NCBI chr X:72,486,383...72,492,344
Ensembl chr X:72,486,381...72,492,363
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G |
Jagn1 |
jagunal homolog 1 |
affects binding |
EXP |
tolcapone binds to JAGN1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:146,591,577...146,596,287
Ensembl chr 4:146,591,510...146,596,288
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
tolcapone results in decreased activity of KCNH2 protein |
CTD |
PMID:24052561 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Kgd4 |
alpha-ketoglutarate dehydrogenase subunit 4 |
decreases expression |
EXP |
Tolcapone results in decreased expression of KGD4 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:31,870,549...31,878,335
Ensembl chr 2:31,870,551...31,880,730
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G |
Kng1 |
kininogen 1 |
increases expression |
EXP |
Tolcapone results in increased expression of KNG1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Lage3 |
L antigen family, member 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of LAGE3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:152,138,209...152,139,632
Ensembl chr X:152,138,218...152,139,632
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G |
Lbp |
lipopolysaccharide binding protein |
increases expression |
EXP |
tolcapone results in increased expression of LBP mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
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G |
Lrrc59 |
leucine rich repeat containing 59 |
affects binding |
EXP |
tolcapone binds to LRRC59 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533
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G |
Lsm3 |
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated |
decreases expression |
EXP |
tolcapone results in decreased expression of LSM3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:124,021,023...124,027,269
Ensembl chr 4:124,021,023...124,027,269
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G |
Lsm5 |
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated |
decreases expression |
EXP |
tolcapone results in decreased expression of LSM5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165 Ensembl chr 4:104,652,477...104,654,165
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G |
Lsm7 |
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated |
decreases expression |
EXP |
tolcapone results in decreased expression of LSM7 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:8,856,698...8,859,113
Ensembl chr 7:8,856,489...8,859,119
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G |
Magoh |
mago homolog, exon junction complex subunit |
decreases expression |
EXP |
tolcapone results in decreased expression of MAGOH mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617
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G |
Masp1 |
MBL associated serine protease 1 |
increases expression |
EXP |
tolcapone results in increased expression of MASP1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
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G |
Matr3 |
matrin 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of MATR3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166
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G |
Mcee |
methylmalonyl CoA epimerase |
decreases expression |
EXP |
tolcapone results in decreased expression of MCEE mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:117,964,576...117,987,779
Ensembl chr 1:117,964,576...117,988,484
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G |
Mcts1 |
MCTS1, re-initiation and release factor |
decreases expression |
EXP |
tolcapone results in decreased expression of MCTS1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:117,350,723...117,362,504
Ensembl chr X:117,350,889...117,362,504
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G |
Med21 |
mediator complex subunit 21 |
decreases expression |
EXP |
tolcapone results in decreased expression of MED21 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548
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G |
Med28 |
mediator complex subunit 28 |
decreases expression |
EXP |
tolcapone results in decreased expression of MED28 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583
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G |
Med31 |
mediator complex subunit 31 |
decreases expression |
EXP |
tolcapone results in decreased expression of MED31 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
Tolcapone results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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G |
Mettl5 |
methyltransferase 5, N6-adenosine |
decreases expression |
EXP |
tolcapone results in decreased expression of METTL5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:54,625,790...54,638,066
Ensembl chr 3:54,625,793...54,638,039
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G |
Mfsd5 |
major facilitator superfamily domain containing 5 |
decreases expression |
EXP |
tolcapone results in decreased expression of MFSD5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:133,409,096...133,411,377
Ensembl chr 7:133,402,537...133,411,396
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
affects binding |
EXP |
tolcapone binds to MGST1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Mia3 |
MIA SH3 domain ER export factor 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of MIA3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr13:94,970,421...95,012,071
Ensembl chr13:94,970,424...95,011,972
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G |
Mkks |
MKKS centrosomal shuttling protein |
decreases expression |
EXP |
tolcapone results in decreased expression of MKKS mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162
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G |
Mkrn1 |
makorin ring finger protein 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of MKRN1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:68,175,908...68,197,216
Ensembl chr 4:68,175,909...68,197,165
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G |
Mmadhc |
metabolism of cobalamin associated D |
decreases expression |
EXP |
tolcapone results in decreased expression of MMADHC mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:34,708,649...34,726,554
Ensembl chr 3:34,708,649...34,726,771
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G |
Mrpl1 |
mitochondrial ribosomal protein L1 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:13,300,522...13,359,654
Ensembl chr14:13,300,522...13,359,721
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G |
Mrpl13 |
mitochondrial ribosomal protein L13 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL13 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:86,951,541...86,973,147
Ensembl chr 7:86,951,541...86,973,577
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G |
Mrpl14 |
mitochondrial ribosomal protein L14 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL14 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 9:15,302,840...15,315,195
Ensembl chr 9:15,302,427...15,315,267
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G |
Mrpl18 |
mitochondrial ribosomal protein L18 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL18 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
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G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL20 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:166,408,962...166,413,492
Ensembl chr 5:166,408,962...166,413,492
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G |
Mrpl22 |
mitochondrial ribosomal protein L22 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL22 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:42,345,446...42,355,779
Ensembl chr10:42,342,776...42,355,779
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G |
Mrpl23 |
mitochondrial ribosomal protein L23 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL23 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:197,687,452...197,695,222
Ensembl chr 1:197,687,347...197,695,222
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G |
Mrpl30 |
mitochondrial ribosomal protein L30 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL30 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 9:40,125,352...40,136,189
Ensembl chr 9:40,125,430...40,137,257
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G |
Mrpl32 |
mitochondrial ribosomal protein L32 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL32 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010
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G |
Mrpl36 |
mitochondrial ribosomal protein L36 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL36 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:29,965,481...29,968,896
Ensembl chr 1:29,965,317...29,968,807
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G |
Mrpl40 |
mitochondrial ribosomal protein L40 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL40 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:82,133,398...82,139,234
Ensembl chr11:82,133,398...82,139,233
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G |
Mrpl53 |
mitochondrial ribosomal protein L53 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPL53 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:115,615,329...115,616,219
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G |
Mrps14 |
mitochondrial ribosomal protein S14 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPS14 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr13:72,429,168...72,434,915
Ensembl chr13:72,408,558...72,434,915
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G |
Mrps18c |
mitochondrial ribosomal protein S18C |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPS18C mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:8,812,301...8,818,538
Ensembl chr14:8,791,330...8,818,516
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G |
Mrps24 |
mitochondrial ribosomal protein S24 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPS24 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:80,584,671...80,588,801
Ensembl chr14:80,584,673...80,588,871
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G |
Mrps33 |
mitochondrial ribosomal protein S33 |
decreases expression |
EXP |
tolcapone results in decreased expression of MRPS33 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:68,596,729...68,605,547
Ensembl chr 4:68,596,729...68,605,428
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G |
Mtap |
methylthioadenosine phosphorylase |
affects binding |
EXP |
tolcapone binds to MTAP protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:103,874,460...103,920,684
Ensembl chr 5:103,873,020...103,939,406
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G |
Mttp |
microsomal triglyceride transfer protein |
increases expression |
ISO |
tolcapone results in increased expression of MTTP protein |
CTD |
PMID:29688484 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Mvk |
mevalonate kinase |
increases expression |
EXP |
tolcapone results in increased expression of MVK mRNA |
CTD |
PMID:24136188 |
|
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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G |
Naa20 |
N(alpha)-acetyltransferase 20, NatB catalytic subunit |
decreases expression |
EXP |
tolcapone results in decreased expression of NAA20 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:133,322,036...133,336,843
Ensembl chr 3:133,322,064...133,337,009
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G |
Nat10 |
N-acetyltransferase 10 |
affects binding |
EXP |
tolcapone binds to NAT10 protein |
CTD |
PMID:19783845 |
|
NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927
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G |
Ndufa1 |
NADH:ubiquinone oxidoreductase subunit A1 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFA1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633
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G |
Ndufa2 |
NADH:ubiquinone oxidoreductase subunit A2 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFA2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
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G |
Ndufa6 |
NADH:ubiquinone oxidoreductase subunit A6 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFA6 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239
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G |
Ndufa7 |
NADH:ubiquinone oxidoreductase subunit A7 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFA7 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
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G |
Ndufa9 |
NADH:ubiquinone oxidoreductase subunit A9 |
affects binding |
EXP |
tolcapone binds to NDUFA9 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
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G |
Ndufb6 |
NADH:ubiquinone oxidoreductase subunit B6 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFB6 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
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G |
Ndufc2 |
NADH:ubiquinone oxidoreductase subunit C2 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFC2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFS4 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Ndufs5 |
NADH:ubiquinone oxidoreductase subunit S5 |
decreases expression |
EXP |
tolcapone results in decreased expression of NDUFS5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603 Ensembl chr14:135,974,034...135,979,603 Ensembl chr 2:135,974,034...135,979,603
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression |
ISO |
tolcapone results in decreased expression of NFE2L2 mRNA |
CTD |
PMID:28526448 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nipsnap1 |
nipsnap homolog 1 |
affects binding |
EXP |
tolcapone binds to NIPSNAP1 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:79,734,234...79,758,101
Ensembl chr14:79,734,209...79,758,098
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G |
Nipsnap2 |
nipsnap homolog 2 |
affects binding |
EXP |
tolcapone binds to NIPSNAP2 protein |
CTD |
PMID:19783845 |
|
NCBI chr12:26,906,068...26,944,201
Ensembl chr12:26,911,723...26,944,166
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G |
Nme3 |
NME/NM23 nucleoside diphosphate kinase 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of NME3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:13,917,309...13,918,415
Ensembl chr10:13,917,403...13,918,359
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G |
Nop56 |
NOP56 ribonucleoprotein |
affects binding |
EXP |
tolcapone binds to NOP56 protein |
CTD |
PMID:19783845 |
|
NCBI chr 3:117,476,963...117,481,847
Ensembl chr 3:117,477,053...117,481,841
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G |
Nphp1 |
nephrocystin 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of NPHP1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234
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G |
Nploc4 |
NPL4 homolog, ubiquitin recognition factor |
increases expression |
EXP |
tolcapone results in increased expression of NPLOC4 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:105,654,395...105,709,958
Ensembl chr10:105,654,812...105,709,913
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of NR3C1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nupr2 |
nuclear protein 2, transcriptional regulator |
decreases expression |
EXP |
tolcapone results in decreased expression of NUPR2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304
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G |
P4ha1 |
prolyl 4-hydroxylase subunit alpha 1 |
affects binding |
EXP |
tolcapone binds to P4HA1 protein |
CTD |
PMID:19783845 |
|
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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G |
Pc |
pyruvate carboxylase |
affects binding |
EXP |
tolcapone binds to PC protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
EXP |
tolcapone results in decreased expression of PCNA mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcyt1a |
phosphate cytidylyltransferase 1A, choline |
affects binding |
EXP |
tolcapone binds to PCYT1A protein |
CTD |
PMID:19783845 |
|
NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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G |
Pdzd11 |
PDZ domain containing 11 |
decreases expression |
EXP |
tolcapone results in decreased expression of PDZD11 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:65,718,689...65,721,742
Ensembl chr X:65,704,067...65,721,642
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G |
Pfdn1 |
prefoldin subunit 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of PFDN1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064
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G |
Pfdn5 |
prefoldin subunit 5 |
decreases expression |
EXP |
tolcapone results in decreased expression of PFDN5 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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G |
Pgm1 |
phosphoglucomutase 1 |
increases expression |
EXP |
tolcapone results in increased expression of PGM1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
tolcapone binds to and results in decreased activity of PGR protein |
CTD |
PMID:25752796 |
|
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Pigp |
phosphatidylinositol glycan anchor biosynthesis, class P |
decreases expression |
EXP |
tolcapone results in decreased expression of PIGP mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321
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G |
Pigs |
phosphatidylinositol glycan anchor biosynthesis, class S |
affects binding |
EXP |
tolcapone binds to PIGS protein |
CTD |
PMID:19783845 |
|
NCBI chr10:63,222,611...63,237,190
Ensembl chr10:63,222,572...63,237,187
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G |
Pin4 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 4 |
decreases expression |
EXP |
tolcapone results in decreased expression of PIN4 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:67,232,066...67,238,709
Ensembl chr X:67,232,081...67,238,702
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G |
Plin2 |
perilipin 2 |
affects binding |
EXP |
tolcapone binds to PLIN2 protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Plin3 |
perilipin 3 |
affects binding |
EXP |
tolcapone binds to PLIN3 protein |
CTD |
PMID:19783845 |
|
NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147
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G |
Pnpla2 |
patatin-like phospholipase domain containing 2 |
increases expression |
EXP |
tolcapone results in increased expression of PNPLA2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
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G |
Polr1h |
RNA polymerase I subunit H |
decreases expression |
EXP |
Tolcapone results in decreased expression of POLR1H mRNA |
CTD |
PMID:24136188 |
|
NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854
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G |
Polr2g |
RNA polymerase II subunit G |
decreases expression |
EXP |
tolcapone results in decreased expression of POLR2G mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686
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G |
Prpf8 |
pre-mRNA processing factor 8 |
affects binding |
EXP |
tolcapone binds to PRPF8 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606
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G |
Prxl2a |
peroxiredoxin like 2A |
affects binding |
EXP |
tolcapone binds to PRXL2A protein |
CTD |
PMID:19783845 |
|
NCBI chr16:16,866,601...16,886,378
Ensembl chr16:16,866,603...16,886,433
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G |
Psmc5 |
proteasome 26S subunit, ATPase 5 |
affects binding |
EXP |
tolcapone binds to PSMC5 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
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G |
Psme2 |
proteasome activator subunit 2 |
affects binding |
EXP |
tolcapone binds to PSME2 protein |
CTD |
PMID:19783845 |
|
NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
Tolcapone results in increased expression of PTGS2 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptrh2 |
peptidyl-tRNA hydrolase 2 |
affects binding |
EXP |
tolcapone binds to PTRH2 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398
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G |
Ramac |
RNA guanine-7 methyltransferase activating subunit |
decreases expression |
EXP |
tolcapone results in decreased expression of RAMAC mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
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G |
Ran |
RAN, member RAS oncogene family |
affects binding |
EXP |
tolcapone binds to RAN protein |
CTD |
PMID:19783845 |
|
NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276
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G |
Rap1a |
RAP1A, member of RAS oncogene family |
decreases expression |
EXP |
tolcapone results in decreased expression of RAP1A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
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G |
Rbis |
ribosomal biogenesis factor |
decreases expression |
EXP |
Tolcapone results in decreased expression of RBIS mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339
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G |
Rbm8a |
RNA binding motif protein 8A |
decreases expression |
EXP |
tolcapone results in decreased expression of RBM8A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:184,165,189...184,167,959
Ensembl chr 2:184,165,193...184,167,959
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G |
Rbp1 |
retinol binding protein 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of RBP1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
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G |
Reep6 |
receptor accessory protein 6 |
affects binding |
EXP |
tolcapone binds to REEP6 protein |
CTD |
PMID:19783845 |
|
NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597
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G |
RGD1311745 |
similar to RIKEN cDNA 1110059G10 |
decreases expression |
EXP |
tolcapone results in decreased expression of RGD1311745 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168
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G |
Rnf7 |
ring finger protein 7 |
decreases expression |
EXP |
tolcapone results in decreased expression of RNF7 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:97,038,845...97,048,080
Ensembl chr 8:97,038,840...97,047,824
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G |
Rnls |
renalase, FAD-dependent amine oxidase |
decreases expression |
EXP |
tolcapone results in decreased expression of RNLS mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
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G |
Romo1 |
reactive oxygen species modulator 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of ROMO1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:144,659,709...144,661,310
Ensembl chr 3:144,659,826...144,661,310
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G |
Rpa3 |
replication protein A3 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPA3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
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G |
Rpl10a |
ribosomal protein L10A |
affects binding |
EXP |
tolcapone binds to RPL10A protein |
CTD |
PMID:19783845 |
|
NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
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G |
Rpl15 |
ribosomal protein L15 |
affects binding |
EXP |
tolcapone binds to RPL15 protein |
CTD |
PMID:19783845 |
|
NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165
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G |
Rpl18a |
ribosomal protein L18A |
affects binding |
EXP |
tolcapone binds to RPL18A protein |
CTD |
PMID:19783845 |
|
NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546
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G |
Rpl22 |
ribosomal protein L22 |
affects binding |
EXP |
tolcapone binds to RPL22 protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:162,835,241...162,843,394
Ensembl chr 5:162,833,740...162,843,368 Ensembl chr 7:162,833,740...162,843,368 Ensembl chr 4:162,833,740...162,843,368
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G |
Rpl22l1 |
ribosomal protein L22 like 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPL22L1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:111,754,687...111,756,623
Ensembl chr 2:111,754,687...111,756,625
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G |
Rpl23 |
ribosomal protein L23 |
affects binding |
EXP |
tolcapone binds to RPL23 protein |
CTD |
PMID:19783845 |
|
NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
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G |
Rpl35a |
ribosomal protein L35A |
decreases expression |
EXP |
tolcapone results in decreased expression of RPL35A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr11:67,726,031...67,729,953
Ensembl chr11:67,726,032...67,729,942 Ensembl chr 5:67,726,032...67,729,942
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G |
Rpl36a |
ribosomal protein L36A |
decreases expression |
EXP |
tolcapone results in decreased expression of RPL36A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:97,766,179...97,768,892
Ensembl chr X:97,766,179...97,768,892
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G |
Rpl41 |
ribosomal protein L41 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPL41 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:977,885...978,965
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G |
Rpl7a |
ribosomal protein L7A |
affects binding |
EXP |
tolcapone binds to RPL7A protein |
CTD |
PMID:19783845 |
|
NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716
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G |
Rpl7l1 |
ribosomal protein L7-like 1 |
affects binding |
EXP |
tolcapone binds to RPL7L1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 9:14,198,101...14,206,119
Ensembl chr 9:14,198,092...14,206,110
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G |
Rpl9 |
ribosomal protein L9 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPL9 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136 Ensembl chr 3:42,893,942...42,897,136
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G |
Rpp21 |
ribonuclease P/MRP subunit p21 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPP21 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106
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G |
Rps11 |
ribosomal protein S11 |
affects binding |
EXP |
tolcapone binds to RPS11 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874
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G |
Rps14 |
ribosomal protein S14 |
affects binding |
EXP |
tolcapone binds to RPS14 protein |
CTD |
PMID:19783845 |
|
NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
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G |
Rps15a |
ribosomal protein S15a |
decreases expression |
EXP |
tolcapone results in decreased expression of RPS15A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
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G |
Rps20 |
ribosomal protein S20 |
affects binding |
EXP |
tolcapone binds to RPS20 protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475 Ensembl chr 9:16,819,304...16,820,475 Ensembl chr 3:16,819,304...16,820,475
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|
G |
Rps21-ps1 |
ribosomal protein S21, pseudogene 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPS21 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427
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G |
Rps24 |
ribosomal protein S24 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPS24 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr16:89,538...94,267
Ensembl chr16:89,604...94,279
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G |
Rps25 |
ribosomal protein s25 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPS25 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
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G |
Rps27 |
ribosomal protein S27 |
decreases expression |
EXP |
tolcapone results in decreased expression of RPS27 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
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G |
Rps27a |
ribosomal protein S27a |
affects binding |
EXP |
tolcapone binds to RPS27A protein |
CTD |
PMID:19783845 |
|
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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G |
S100a10 |
S100 calcium binding protein A10 |
decreases expression |
EXP |
tolcapone results in decreased expression of S100A10 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
EXP |
tolcapone results in increased expression of SC5D mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Scd |
stearoyl-CoA desaturase |
affects binding decreases expression |
EXP |
tolcapone binds to SCD protein tolcapone results in decreased expression of SCD1 mRNA |
CTD |
PMID:19783845 PMID:24136188 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Sdha |
succinate dehydrogenase complex flavoprotein subunit A |
affects binding |
EXP |
tolcapone binds to SDHA protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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G |
Sdhb |
succinate dehydrogenase complex iron sulfur subunit B |
affects binding |
EXP |
tolcapone binds to SDHB protein |
CTD |
PMID:19783845 |
|
NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
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G |
Sec11c |
SEC11 homolog C, signal peptidase complex subunit |
affects binding |
EXP |
tolcapone binds to SEC11C protein |
CTD |
PMID:19783845 |
|
NCBI chr18:59,320,932...59,337,272
Ensembl chr18:59,320,884...59,337,364
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G |
Sec31a |
SEC31 homolog A, COPII coat complex component |
affects binding |
EXP |
tolcapone binds to SEC31A protein |
CTD |
PMID:19783845 |
|
NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
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G |
Serbp1 |
Serpine1 mRNA binding protein 1 |
affects binding |
EXP |
tolcapone binds to SERBP1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813
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G |
Sf3b6 |
splicing factor 3B, subunit 6 |
affects binding |
EXP |
tolcapone binds to SF3B6 protein |
CTD |
PMID:19783845 |
|
NCBI chr 6:27,826,044...27,835,086
Ensembl chr 6:27,826,029...27,835,156
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G |
Sfxn1 |
sideroflexin 1 |
affects binding |
EXP |
tolcapone binds to SFXN1 protein |
CTD |
PMID:19783845 |
|
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
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G |
Sik3 |
SIK family kinase 3 |
increases expression |
EXP |
tolcapone results in increased expression of SIK3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:46,312,253...46,522,444
Ensembl chr 8:46,311,989...46,522,444
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G |
Slc1a5 |
solute carrier family 1 member 5 |
affects binding |
EXP |
tolcapone binds to SLC1A5 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952
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G |
Slc25a1 |
solute carrier family 25 member 1 |
affects binding |
EXP |
tolcapone binds to SLC25A1 protein |
CTD |
PMID:19783845 |
|
NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
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G |
Slc25a13 |
solute carrier family 25 member 13 |
affects binding |
EXP |
tolcapone binds to SLC25A13 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
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G |
Slc25a4 |
solute carrier family 25 member 4 |
affects binding |
EXP |
tolcapone binds to SLC25A4 protein |
CTD |
PMID:19783845 |
|
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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G |
Slc25a5 |
solute carrier family 25 member 5 |
affects binding |
EXP |
tolcapone binds to SLC25A5 protein |
CTD |
PMID:19783845 |
|
NCBI chr X:116,031,896...116,034,963
Ensembl chr X:116,031,803...116,034,967
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G |
Slc25a6 |
solute carrier family 25 member 6 |
affects binding |
EXP |
tolcapone binds to SLC25A6 protein |
CTD |
PMID:19783845 |
|
NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
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G |
Slc39a7 |
solute carrier family 39 member 7 |
affects binding |
EXP |
tolcapone binds to SLC39A7 protein |
CTD |
PMID:19783845 |
|
NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537
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G |
Slc7a11 |
solute carrier family 7 member 11 |
decreases expression |
ISO |
Tolcapone results in decreased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
decreases expression |
ISO |
Tolcapone results in decreased expression of SLPI mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Smim26 |
small integral membrane protein 26 |
decreases expression |
EXP |
tolcapone results in decreased expression of SMIM26 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:131,990,147...131,991,779
Ensembl chr 3:131,990,291...131,992,132
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G |
Snapin |
SNAP-associated protein |
decreases expression |
EXP |
tolcapone results in decreased expression of SNAPIN mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
tolcapone inhibits the reaction [SNCA protein binds to SNCA protein] |
CTD |
PMID:20150427 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G |
Snrnp27 |
small nuclear ribonucleoprotein U4/U6.U5 subunit 27 |
decreases expression |
EXP |
Tolcapone results in decreased expression of SNRNP27 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 4:119,123,676...119,133,234
Ensembl chr 4:119,121,877...119,133,234
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G |
Snrpb2 |
small nuclear ribonucleoprotein polypeptide B2 |
decreases expression |
EXP |
tolcapone results in decreased expression of SNRPB2 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812
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G |
Snrpd3 |
small nuclear ribonucleoprotein D3 polypeptide |
decreases expression |
EXP |
tolcapone results in decreased expression of SNRPD3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978
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G |
Snrpe |
small nuclear ribonucleoprotein polypeptide E |
decreases expression |
EXP |
tolcapone results in decreased expression of SNRPE mRNA |
CTD |
PMID:24136188 |
|
NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310 Ensembl chr 8:45,050,986...45,057,310
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G |
Snrpf |
small nuclear ribonucleoprotein polypeptide F |
decreases expression |
EXP |
tolcapone results in decreased expression of SNRPF mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:28,130,427...28,137,129
Ensembl chr 7:28,130,427...28,137,129
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G |
Snrpg |
small nuclear ribonucleoprotein polypeptide G |
decreases expression |
EXP |
tolcapone results in decreased expression of SNRPG mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:118,812,278...118,819,827
Ensembl chr 4:118,812,252...118,819,826
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G |
Sod1 |
superoxide dismutase 1 |
decreases expression |
ISO |
tolcapone results in decreased expression of SOD1 mRNA |
CTD |
PMID:28526448 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
decreases expression |
ISO |
tolcapone results in decreased expression of SOD2 mRNA |
CTD |
PMID:28526448 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Srp14 |
signal recognition particle 14 |
decreases expression |
EXP |
tolcapone results in decreased expression of SRP14 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859
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G |
Srprb |
SRP receptor subunit beta |
affects binding |
EXP |
tolcapone binds to SRPRB protein |
CTD |
PMID:19783845 |
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NCBI chr 8:103,768,685...103,782,632
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G |
Ss18l2 |
SS18 like 2 |
decreases expression |
EXP |
tolcapone results in decreased expression of SS18L2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 8:121,375,263...121,377,877
Ensembl chr 8:121,375,308...121,377,877
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G |
Ssr1 |
signal sequence receptor subunit 1 |
affects binding |
EXP |
tolcapone binds to SSR1 protein |
CTD |
PMID:19783845 |
|
NCBI chr17:26,833,720...26,861,821
Ensembl chr17:26,833,741...26,861,821
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G |
Stac3 |
SH3 and cysteine rich domain 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of STAC3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
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G |
Stat3 |
signal transducer and activator of transcription 3 |
increases expression |
EXP |
tolcapone results in increased expression of STAT3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
affects binding |
EXP |
tolcapone binds to SULT2A1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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G |
Taf9 |
TATA-box binding protein associated factor 9 |
decreases expression |
EXP |
tolcapone results in decreased expression of TAF9 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769
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G |
Tbca |
tubulin folding cofactor A |
decreases expression |
EXP |
tolcapone results in decreased expression of TBCA mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907
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G |
Tceal8 |
transcription elongation factor A like 8 |
decreases expression |
EXP |
tolcapone results in decreased expression of TCEAL8 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:99,171,307...99,173,377
Ensembl chr X:99,171,177...99,173,710
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G |
Tfr2 |
transferrin receptor 2 |
increases expression |
EXP |
tolcapone results in increased expression of TFR2 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591
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G |
Timm10 |
translocase of inner mitochondrial membrane 10 |
decreases expression |
EXP |
tolcapone results in decreased expression of TIMM10 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:69,908,397...69,911,943
Ensembl chr 3:69,908,456...69,911,940
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G |
Timm44 |
translocase of inner mitochondrial membrane 44 |
affects binding |
EXP |
tolcapone binds to TIMM44 protein |
CTD |
PMID:19783845 |
|
NCBI chr12:2,612,581...2,629,374
Ensembl chr12:2,612,581...2,629,351
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G |
Timm8b |
translocase of inner mitochondrial membrane 8 homolog B |
decreases expression |
EXP |
tolcapone results in decreased expression of TIMM8B mRNA |
CTD |
PMID:24136188 |
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NCBI chr 8:50,954,350...50,955,730
Ensembl chr 8:50,954,342...50,955,729
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G |
Tk2 |
thymidine kinase 2 |
affects binding |
EXP |
tolcapone binds to TK2 protein |
CTD |
PMID:19783845 |
|
NCBI chr19:708,859...731,786
Ensembl chr19:708,891...730,924
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G |
Tm2d1 |
TM2 domain containing 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of TM2D1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:113,020,793...113,062,134
Ensembl chr 5:113,020,760...113,050,933
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G |
Tmed10 |
transmembrane p24 trafficking protein 10 |
affects binding |
EXP |
tolcapone binds to TMED10 protein |
CTD |
PMID:19783845 |
|
NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
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G |
Tmed4 |
transmembrane p24 trafficking protein 4 |
affects binding |
EXP |
tolcapone binds to TMED4 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:81,125,049...81,129,646
Ensembl chr14:81,125,053...81,129,631
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G |
Tmed9 |
transmembrane p24 trafficking protein 9 |
affects binding |
EXP |
tolcapone binds to TMED9 protein |
CTD |
PMID:19783845 |
|
NCBI chr17:9,029,646...9,034,160
Ensembl chr17:9,029,646...9,034,176
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G |
Tmem126a |
transmembrane protein 126A |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM126A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:144,424,481...144,430,730
Ensembl chr 1:144,422,703...144,430,628
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G |
Tmem126b |
transmembrane protein 126B |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM126B mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:144,437,142...144,451,508
Ensembl chr 1:144,437,145...144,451,435
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G |
Tmem128 |
transmembrane protein 128 |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM128 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr14:72,539,530...72,548,623
Ensembl chr14:72,539,532...72,548,550
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G |
Tmem203 |
transmembrane protein 203 |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM203 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:8,070,904...8,071,732
Ensembl chr 3:8,070,914...8,071,867
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G |
Tmem238 |
transmembrane protein 238 |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM238 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:69,057,083...69,062,477
Ensembl chr 1:69,056,805...69,076,133
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G |
Tmem256 |
transmembrane protein 256 |
decreases expression |
EXP |
tolcapone results in decreased expression of TMEM256 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:54,559,030...54,560,146
Ensembl chr10:54,555,360...54,560,120
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G |
Tmsb4x |
thymosin beta 4, X-linked |
decreases expression |
EXP |
tolcapone results in decreased expression of TMSB4X mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667
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G |
Tnfaip8 |
TNF alpha induced protein 8 |
affects binding |
EXP |
tolcapone binds to TNFAIP8 protein |
CTD |
PMID:19783845 |
|
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
EXP |
tolcapone results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tomm20 |
translocase of outer mitochondrial membrane 20 |
affects binding |
EXP |
tolcapone binds to TOMM20 protein |
CTD |
PMID:19783845 |
|
NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
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G |
Tomm40 |
translocase of outer mitochondrial membrane 40 |
affects binding |
EXP |
tolcapone binds to TOMM40 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:79,358,781...79,370,882
Ensembl chr 1:79,358,786...79,370,915
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G |
Tomm7 |
translocase of outer mitochondrial membrane 7 |
affects binding |
EXP |
tolcapone binds to TOMM7 protein |
CTD |
PMID:19783845 |
|
NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962
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G |
Tp53i3 |
tumor protein p53 inducible protein 3 |
decreases expression |
EXP |
Tolcapone results in decreased expression of TP53I3 mRNA |
CTD |
PMID:24136188 |
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NCBI chr 6:27,818,327...27,825,753
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G |
Trappc2l |
trafficking protein particle complex subunit 2L |
decreases expression |
EXP |
tolcapone results in decreased expression of TRAPPC2L mRNA |
CTD |
PMID:24136188 |
|
NCBI chr19:50,662,507...50,666,193
Ensembl chr19:50,662,507...50,666,192
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G |
Tspan6 |
tetraspanin 6 |
decreases expression |
EXP |
tolcapone results in decreased expression of TSPAN6 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr X:97,092,394...97,099,659
Ensembl chr X:97,092,388...97,099,309
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G |
Tubb6 |
tubulin, beta 6 class V |
affects binding |
EXP |
tolcapone binds to TUBB6 protein |
CTD |
PMID:19783845 |
|
NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
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G |
Txndc17 |
thioredoxin domain containing 17 |
decreases expression |
EXP |
tolcapone results in decreased expression of TXNDC17 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr10:56,832,749...56,835,721
|
|
G |
Uchl3-ps1 |
ubiquitin C-terminal hydrolase L3, pseudogene 1 |
decreases expression |
EXP |
tolcapone results in decreased expression of UCHL3-PS1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 3:161,856,954...161,857,835
|
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
decreases glucuronidation increases glucuronidation |
ISO |
UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone UGT1A9 protein results in increased glucuronidation of tolcapone |
CTD |
PMID:16344532 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Uqcrc2 |
ubiquinol cytochrome c reductase core protein 2 |
affects binding |
EXP |
tolcapone binds to UQCRC2 protein |
CTD |
PMID:19783845 |
|
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
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G |
Uqcrfs1 |
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
affects binding |
EXP |
tolcapone binds to UQCRFS1 protein |
CTD |
PMID:19783845 |
|
NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
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G |
Uvrag |
UV radiation resistance associated |
increases expression |
EXP |
tolcapone results in increased expression of UVRAG mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
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|
G |
Vdac2 |
voltage-dependent anion channel 2 |
affects binding |
EXP |
tolcapone binds to VDAC2 protein |
CTD |
PMID:19783845 |
|
NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
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G |
Vdac3 |
voltage-dependent anion channel 3 |
affects binding |
EXP |
tolcapone binds to VDAC3 protein |
CTD |
PMID:19783845 |
|
NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471
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G |
Vsnl1 |
visinin-like 1 |
affects binding |
EXP |
tolcapone binds to VSNL1 protein |
CTD |
PMID:19783845 |
|
NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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G |
Washc3 |
WASH complex subunit 3 |
decreases expression |
EXP |
tolcapone results in decreased expression of WASHC3 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696
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G |
Wfs1 |
wolframin ER transmembrane glycoprotein |
affects binding |
EXP |
tolcapone binds to WFS1 protein |
CTD |
PMID:19783845 |
|
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
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|
G |
Yars1 |
tyrosyl-tRNA synthetase 1 |
increases expression |
EXP |
Tolcapone results in increased expression of YARS1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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|
G |
Yeats4 |
YEATS domain containing 4 |
decreases expression |
EXP |
tolcapone results in decreased expression of YEATS4 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr 7:52,858,313...52,865,454
Ensembl chr 7:52,858,305...52,865,635
|
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G |
Znrf1 |
zinc and ring finger 1 |
increases expression |
EXP |
tolcapone results in increased expression of ZNRF1 mRNA |
CTD |
PMID:24136188 |
|
NCBI chr19:39,496,414...39,581,600
Ensembl chr19:39,496,527...39,580,969
|
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