Gphn (gephyrin) - Rat Genome Database

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Gene: Gphn (gephyrin) Rattus norvegicus
Analyze
Symbol: Gphn
Name: gephyrin
RGD ID: 69194
Description: Enables several functions, including identical protein binding activity; molybdopterin adenylyltransferase activity; and molybdopterin molybdotransferase activity. Involved in establishment of protein localization; neurotransmitter receptor localization to postsynaptic specialization membrane; and synapse assembly. Acts upstream of or within Mo-molybdopterin cofactor biosynthetic process. Located in several cellular components, including GABA-ergic synapse; cytoplasmic side of plasma membrane; and inhibitory synapse. Is active in glycinergic synapse and postsynaptic specialization, intracellular component. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; Inhibitory synaptic transmission pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Geph; gephyrin isoform; putative glycine receptor-tubulin linker protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86102,687,405 - 103,216,679 (+)NCBIGRCr8
mRatBN7.2696,954,365 - 97,483,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx697,388,022 - 97,920,426 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0697,687,169 - 98,219,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,077,693 - 97,599,233 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06101,327,874 - 101,859,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6101,532,518 - 101,859,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06110,709,516 - 111,190,440 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06111,210,069 - 111,237,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46100,833,004 - 101,302,957 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16100,836,459 - 101,306,408 (+)NCBI
Celera695,358,601 - 95,872,910 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
cerium trichloride  (ISO)
chloroacetaldehyde  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
coumarin  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
Heliotrine  (ISO)
irinotecan  (EXP)
ivermectin  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methoxychlor  (EXP)
N-methyl-D-aspartic acid  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrethrins  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sevoflurane  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. Allison DW, etal., J Neurosci. 2000 Jun 15;20(12):4545-54.
2. Metal insertion into the molybdenum cofactor: product-substrate channelling demonstrates the functional origin of domain fusion in gephyrin. Belaidi AA and Schwarz G, Biochem J. 2013 Feb 15;450(1):149-57. doi: 10.1042/BJ20121078.
3. Localization of components of glycinergic synapses during rat spinal cord development. Colin I, etal., J Comp Neurol. 1998 Aug 31;398(3):359-72.
4. Association of gephyrin with synaptic and extrasynaptic GABAA receptors varies during development in cultured hippocampal neurons. Danglot L, etal., Mol Cell Neurosci. 2003 Jun;23(2):264-78.
5. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. Fuhrmann JC, etal., J Neurosci 2002 Jul 1;22(13):5393-402.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system. Giesemann T, etal., J Neurosci. 2003 Sep 10;23(23):8330-9.
8. The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. Harvey K, etal., J Neurosci. 2004 Jun 23;24(25):5816-26.
9. Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. Hines RM, etal., J Neurosci. 2008 Jun 11;28(24):6055-67. doi: 10.1523/JNEUROSCI.0032-08.2008.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Kins S, etal., Nat Neurosci 2000 Jan;3(1):22-9.
12. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Kirsch J, etal., Nature. 1993 Dec 23-30;366(6457):745-8. doi: 10.1038/366745a0.
13. Postsynaptic scaffolding molecules modulate the localization of neuroligins. Levinson JN, etal., Neuroscience. 2010 Feb 3;165(3):782-93. doi: 10.1016/j.neuroscience.2009.11.016. Epub 2009 Nov 13.
14. Cell biology of molybdenum. Mendel RR and Bittner F, Biochim Biophys Acta. 2006 Jul;1763(7):621-35. Epub 2006 May 12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Poulopoulos A, etal., Neuron. 2009 Sep 10;63(5):628-42. doi: 10.1016/j.neuron.2009.08.023.
19. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Prior P, etal., Neuron 1992 Jun;8(6):1161-70.
20. Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia. Rees MI, etal., J Biol Chem. 2003 Jul 4;278(27):24688-96. Epub 2003 Apr 8.
21. Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. Reiss J and Johnson JL, Hum Mutat 2003 Jun;21(6):569-76.
22. A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency. Reiss J, etal., Am J Hum Genet 2001 Jan;68(1):208-13.
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Synaptogenesis in the rat retina: subcellular localization of glycine receptors, GABA(A) receptors, and the anchoring protein gephyrin. Sassoe-Pognetto M and Wassle H, J Comp Neurol. 1997 May 5;381(2):158-74.
26. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites. Sassoè-Pognetto M, etal., J Comp Neurol. 2000 May 15;420(4):481-98.
27. Biochemical characterization of the high affinity binding between the glycine receptor and gephyrin. Schrader N, etal., J Biol Chem 2004 Apr 30;279(18):18733-41. Epub 2004 Feb 19.
28. Crystal structures of human gephyrin and plant Cnx1 G domains: comparative analysis and functional implications. Schwarz G, etal., J Mol Biol 2001 Sep14;312(2):405-18.
29. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Smith KR, etal., Mol Cell Neurosci. 2010 Aug;44(4):330-41. doi: 10.1016/j.mcn.2010.04.004. Epub 2010 Apr 22.
30. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. Specht CG, etal., EMBO J. 2011 Aug 9;30(18):3842-53. doi: 10.1038/emboj.2011.276.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Molecular basis of the gamma-aminobutyric acid A receptor alpha3 subunit interaction with the clustering protein gephyrin. Tretter V, etal., J Biol Chem. 2011 Oct 28;286(43):37702-11. doi: 10.1074/jbc.M111.291336. Epub 2011 Aug 31.
33. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
34. Gephyrin interacts with the glutamate receptor interacting protein 1 isoforms at GABAergic synapses. Yu W, etal., J Neurochem. 2008 Jun 1;105(6):2300-14. doi: 10.1111/j.1471-4159.2008.05311.x.
Additional References at PubMed
PMID:9812897   PMID:9990024   PMID:10531433   PMID:10900017   PMID:11083919   PMID:11325967   PMID:14760703   PMID:14960612   PMID:15201864   PMID:15647495   PMID:16376568   PMID:16449194  
PMID:16511563   PMID:16616186   PMID:17001074   PMID:17145751   PMID:17698049   PMID:17916433   PMID:18199120   PMID:18204977   PMID:18231803   PMID:18366064   PMID:19105974   PMID:19660531  
PMID:19723286   PMID:19955355   PMID:20206270   PMID:20833253   PMID:21173228   PMID:21404332   PMID:21507951   PMID:22006921   PMID:22290869   PMID:22351777   PMID:22778260   PMID:23294024  
PMID:23408424   PMID:23889935   PMID:24100323   PMID:24297911   PMID:24554721   PMID:24613359   PMID:24894704   PMID:25093719   PMID:25535349   PMID:25663431   PMID:25755278   PMID:26093381  
PMID:26613940   PMID:27002143   PMID:27609886   PMID:27941024   PMID:28026001   PMID:29379879   PMID:29464196   PMID:30053369   PMID:30454851   PMID:34810232  


Genomics

Comparative Map Data
Gphn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86102,687,405 - 103,216,679 (+)NCBIGRCr8
mRatBN7.2696,954,365 - 97,483,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx697,388,022 - 97,920,426 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0697,687,169 - 98,219,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,077,693 - 97,599,233 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06101,327,874 - 101,859,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6101,532,518 - 101,859,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06110,709,516 - 111,190,440 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06111,210,069 - 111,237,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46100,833,004 - 101,302,957 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16100,836,459 - 101,306,408 (+)NCBI
Celera695,358,601 - 95,872,910 (+)NCBICelera
Cytogenetic Map6q24NCBI
GPHN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381466,508,147 - 67,735,355 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1466,507,407 - 67,181,803 (+)EnsemblGRCh38hg38GRCh38
GRCh371466,974,865 - 67,648,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,043,878 - 66,718,278 (+)NCBINCBI36Build 36hg18NCBI36
Build 341466,044,988 - 66,718,268NCBI
Celera1447,033,183 - 47,707,584 (+)NCBICelera
Cytogenetic Map14q23.3-q24.1NCBI
HuRef1447,144,073 - 47,817,837 (+)NCBIHuRef
CHM1_11466,912,247 - 67,587,111 (+)NCBICHM1_1
T2T-CHM13v2.01460,715,132 - 61,942,473 (+)NCBIT2T-CHM13v2.0
Gphn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,264,099 - 78,731,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,273,153 - 78,731,546 (+)EnsemblGRCm39 Ensembl
GRCm381278,217,325 - 78,684,772 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,226,379 - 78,684,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371279,327,642 - 79,785,759 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361279,145,574 - 79,603,578 (+)NCBIMGSCv36mm8
Celera1279,690,472 - 80,148,022 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Gphn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554663,016,479 - 3,526,231 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554663,017,474 - 3,526,375 (-)NCBIChiLan1.0ChiLan1.0
GPHN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21567,610,429 - 68,285,563 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11466,828,972 - 67,502,075 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01447,081,527 - 47,755,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11465,963,473 - 66,634,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,137,166 - 66,634,550 (+)Ensemblpanpan1.1panPan2
GPHN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1840,585,625 - 41,204,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl840,585,883 - 41,203,245 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha840,270,522 - 40,895,744 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0840,807,578 - 41,430,716 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl840,807,424 - 41,430,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1840,427,159 - 41,049,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0840,497,926 - 41,123,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0840,856,432 - 41,482,422 (+)NCBIUU_Cfam_GSD_1.0
Gphn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,626,233 - 64,220,771 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364959,972,007 - 10,564,591 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364959,970,683 - 10,565,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPHN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl790,346,714 - 90,916,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1790,345,726 - 90,913,625 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2796,902,547 - 97,222,781 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPHN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12443,702,384 - 44,421,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2443,880,344 - 44,422,276 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605331,896,980 - 32,651,860 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gphn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,870,997 - 34,483,508 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,871,664 - 34,483,770 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gphn
1570 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:728
Count of miRNA genes:235
Interacting mature miRNAs:296
Transcripts:ENSRNOT00000030470, ENSRNOT00000068469, ENSRNOT00000075054
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat

Markers in Region
D6Got126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,282,002 - 97,282,172 (+)MAPPERmRatBN7.2
Rnor_6.06101,667,852 - 101,668,021NCBIRnor6.0
Rnor_5.06111,044,885 - 111,045,054UniSTSRnor5.0
RGSC_v3.46101,086,289 - 101,086,459RGDRGSC3.4
RGSC_v3.46101,086,290 - 101,086,459UniSTSRGSC3.4
RGSC_v3.16101,089,746 - 101,089,915RGD
Celera695,681,117 - 95,681,286UniSTS
RH 3.4 Map6669.4UniSTS
RH 3.4 Map6669.4RGD
RH 2.0 Map6882.4RGD
Cytogenetic Map6q24UniSTS
D6Got125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,032,092 - 97,032,278 (+)MAPPERmRatBN7.2
Rnor_6.06101,412,420 - 101,412,605NCBIRnor6.0
Rnor_5.06110,794,508 - 110,794,693UniSTSRnor5.0
RGSC_v3.46100,910,815 - 100,911,001RGDRGSC3.4
RGSC_v3.46100,910,816 - 100,911,001UniSTSRGSC3.4
RGSC_v3.16100,914,272 - 100,914,457RGD
Celera695,433,732 - 95,433,917UniSTS
RH 3.4 Map6677.0UniSTS
RH 3.4 Map6677.0RGD
Cytogenetic Map6q24UniSTS
BE106545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,254,738 - 97,254,901 (+)MAPPERmRatBN7.2
Rnor_6.06101,640,586 - 101,640,748NCBIRnor6.0
Rnor_5.06111,017,619 - 111,017,781UniSTSRnor5.0
RGSC_v3.46101,057,182 - 101,057,344UniSTSRGSC3.4
Celera695,653,887 - 95,654,049UniSTS
RH 3.4 Map6688.9UniSTS
Cytogenetic Map6q24UniSTS
RH136931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,483,324 - 97,483,518 (+)MAPPERmRatBN7.2
Rnor_6.06101,858,877 - 101,859,070NCBIRnor6.0
Rnor_5.06111,237,369 - 111,237,562UniSTSRnor5.0
RGSC_v3.46101,302,665 - 101,302,858UniSTSRGSC3.4
Celera695,872,618 - 95,872,811UniSTS
Cytogenetic Map6q24UniSTS
MARC_1069-1070:991929832:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,482,655 - 97,482,823 (+)MAPPERmRatBN7.2
Rnor_6.06101,858,208 - 101,858,375NCBIRnor6.0
Rnor_5.06111,236,700 - 111,236,867UniSTSRnor5.0
RGSC_v3.46101,301,996 - 101,302,163UniSTSRGSC3.4
Celera695,871,949 - 95,872,116UniSTS
Cytogenetic Map6q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 38 27 14 27 8 10 74 35 36 11 8
Low 1 14 19 14 5 14 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC139976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU735541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000030470   ⟹   ENSRNOP00000036544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl697,057,090 - 97,483,612 (+)Ensembl
Rnor_6.0 Ensembl6101,603,319 - 101,859,164 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075054   ⟹   ENSRNOP00000064099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6101,532,518 - 101,858,501 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099019   ⟹   ENSRNOP00000078928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100642   ⟹   ENSRNOP00000091082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101119   ⟹   ENSRNOP00000092405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101616   ⟹   ENSRNOP00000083857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102456   ⟹   ENSRNOP00000080473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104959   ⟹   ENSRNOP00000097129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106781   ⟹   ENSRNOP00000082928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107245   ⟹   ENSRNOP00000082164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108357   ⟹   ENSRNOP00000093484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109396   ⟹   ENSRNOP00000087018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110703   ⟹   ENSRNOP00000085841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114358   ⟹   ENSRNOP00000087130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117509   ⟹   ENSRNOP00000091250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118026   ⟹   ENSRNOP00000088628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl696,892,148 - 97,483,612 (+)Ensembl
RefSeq Acc Id: NM_022865   ⟹   NP_074056
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,653 - 103,216,679 (+)NCBI
mRatBN7.2696,954,573 - 97,483,617 (+)NCBI
Rnor_6.06101,327,874 - 101,859,169 (+)NCBI
Rnor_5.06110,709,516 - 111,190,440 (+)NCBI
Rnor_5.06111,210,069 - 111,237,661 (+)NCBI
RGSC_v3.46100,833,004 - 101,302,957 (+)RGD
Celera695,358,601 - 95,872,910 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112897   ⟹   XP_038968825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,428 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112899   ⟹   XP_038968827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112900   ⟹   XP_038968828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112902   ⟹   XP_038968830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112904   ⟹   XP_038968832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112905   ⟹   XP_038968833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112906   ⟹   XP_038968834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112908   ⟹   XP_038968836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112909   ⟹   XP_038968837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112910   ⟹   XP_038968838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,405 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112911   ⟹   XP_038968839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112912   ⟹   XP_038968840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112913   ⟹   XP_038968841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_039112915   ⟹   XP_038968843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
mRatBN7.2696,954,365 - 97,483,617 (+)NCBI
RefSeq Acc Id: XM_063262450   ⟹   XP_063118520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,775 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262451   ⟹   XP_063118521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262452   ⟹   XP_063118522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262453   ⟹   XP_063118523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262454   ⟹   XP_063118524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262456   ⟹   XP_063118526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262457   ⟹   XP_063118527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262458   ⟹   XP_063118528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,802,585 - 103,216,679 (+)NCBI
RefSeq Acc Id: XM_063262459   ⟹   XP_063118529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86102,687,659 - 103,216,679 (+)NCBI
Protein Sequences
Protein RefSeqs NP_074056 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968825 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968827 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968828 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968830 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968832 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968833 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968834 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968836 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968837 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968838 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968839 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968840 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968841 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968843 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118520 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118521 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118522 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118523 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118524 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118526 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118527 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118528 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118529 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACE06970 (Get FASTA)   NCBI Sequence Viewer  
  CAA47009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036544.7
  ENSRNOP00000078928
  ENSRNOP00000078928.1
  ENSRNOP00000080473.1
  ENSRNOP00000082164
  ENSRNOP00000082164.1
  ENSRNOP00000082928
  ENSRNOP00000082928.1
  ENSRNOP00000083857
  ENSRNOP00000083857.1
  ENSRNOP00000085841
  ENSRNOP00000085841.1
  ENSRNOP00000087018.1
  ENSRNOP00000087130.1
  ENSRNOP00000088628.1
  ENSRNOP00000091082.1
  ENSRNOP00000091250
  ENSRNOP00000091250.1
  ENSRNOP00000092405.1
  ENSRNOP00000093484.1
  ENSRNOP00000097129.1
  ENSRNOP00055025296
  ENSRNOP00055025568
  ENSRNOP00060038170
  ENSRNOP00060039905
  ENSRNOP00065023971
GenBank Protein Q03555 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_074056   ⟸   NM_022865
- UniProtKB: A6HCD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064099   ⟸   ENSRNOT00000075054
RefSeq Acc Id: ENSRNOP00000036544   ⟸   ENSRNOT00000030470
RefSeq Acc Id: XP_038968825   ⟸   XM_039112897
- Peptide Label: isoform X1
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968830   ⟸   XM_039112902
- Peptide Label: isoform X6
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968827   ⟸   XM_039112899
- Peptide Label: isoform X4
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968832   ⟸   XM_039112904
- Peptide Label: isoform X7
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968828   ⟸   XM_039112900
- Peptide Label: isoform X5
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968833   ⟸   XM_039112905
- Peptide Label: isoform X9
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968836   ⟸   XM_039112908
- Peptide Label: isoform X13
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968834   ⟸   XM_039112906
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZQC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968841   ⟸   XM_039112913
- Peptide Label: isoform X21
- UniProtKB: A6HCD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968838   ⟸   XM_039112910
- Peptide Label: isoform X15
- UniProtKB: A6HCD6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968839   ⟸   XM_039112911
- Peptide Label: isoform X17
- UniProtKB: A0A8I6A9T9 (UniProtKB/TrEMBL),   A6HCD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968837   ⟸   XM_039112909
- Peptide Label: isoform X14
- UniProtKB: A0A8I6A568 (UniProtKB/TrEMBL),   A6HCD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968840   ⟸   XM_039112912
- Peptide Label: isoform X19
- UniProtKB: A6HCD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968843   ⟸   XM_039112915
- Peptide Label: isoform X16
- UniProtKB: A6HCD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080473   ⟸   ENSRNOT00000102456
RefSeq Acc Id: ENSRNOP00000082164   ⟸   ENSRNOT00000107245
RefSeq Acc Id: ENSRNOP00000088628   ⟸   ENSRNOT00000118026
RefSeq Acc Id: ENSRNOP00000092405   ⟸   ENSRNOT00000101119
RefSeq Acc Id: ENSRNOP00000097129   ⟸   ENSRNOT00000104959
RefSeq Acc Id: ENSRNOP00000087130   ⟸   ENSRNOT00000114358
RefSeq Acc Id: ENSRNOP00000083857   ⟸   ENSRNOT00000101616
RefSeq Acc Id: ENSRNOP00000091082   ⟸   ENSRNOT00000100642
RefSeq Acc Id: ENSRNOP00000093484   ⟸   ENSRNOT00000108357
RefSeq Acc Id: ENSRNOP00000087018   ⟸   ENSRNOT00000109396
RefSeq Acc Id: ENSRNOP00000085841   ⟸   ENSRNOT00000110703
RefSeq Acc Id: ENSRNOP00000091250   ⟸   ENSRNOT00000117509
RefSeq Acc Id: ENSRNOP00000082928   ⟸   ENSRNOT00000106781
RefSeq Acc Id: ENSRNOP00000078928   ⟸   ENSRNOT00000099019
RefSeq Acc Id: XP_063118522   ⟸   XM_063262452
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063118526   ⟸   XM_063262456
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063118521   ⟸   XM_063262451
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063118523   ⟸   XM_063262453
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063118529   ⟸   XM_063262459
- Peptide Label: isoform X23
RefSeq Acc Id: XP_063118524   ⟸   XM_063262454
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063118527   ⟸   XM_063262457
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063118520   ⟸   XM_063262450
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063118528   ⟸   XM_063262458
- Peptide Label: isoform X22
Protein Domains
MoaB/Mog

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03555-F1-model_v2 AlphaFold Q03555 1-768 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69194 AgrOrtholog
BIND 134400
  134401
BioCyc Gene G2FUF-36999 BioCyc
Ensembl Genes ENSRNOG00000028366 Ensembl
  ENSRNOG00000064046 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000064630 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018422 UniProtKB/Swiss-Prot
  ENSRNOG00055018485 UniProtKB/Swiss-Prot
  ENSRNOG00060026299 UniProtKB/Swiss-Prot
  ENSRNOG00060027041 UniProtKB/Swiss-Prot
  ENSRNOG00065017865 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030470.7 UniProtKB/TrEMBL
  ENSRNOT00000099019.1 UniProtKB/TrEMBL
  ENSRNOT00000100642.1 UniProtKB/Swiss-Prot
  ENSRNOT00000101119.1 UniProtKB/TrEMBL
  ENSRNOT00000101616.1 UniProtKB/Swiss-Prot
  ENSRNOT00000102456.1 UniProtKB/TrEMBL
  ENSRNOT00000104959.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106781.1 UniProtKB/Swiss-Prot
  ENSRNOT00000107245.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108357.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109396.1 UniProtKB/TrEMBL
  ENSRNOT00000110703.1 UniProtKB/TrEMBL
  ENSRNOT00000114358.1 UniProtKB/TrEMBL
  ENSRNOT00000117509 ENTREZGENE
  ENSRNOT00000117509.1 UniProtKB/TrEMBL
  ENSRNOT00000118026.1 UniProtKB/TrEMBL
  ENSRNOT00055031339 UniProtKB/Swiss-Prot
  ENSRNOT00055031637 UniProtKB/Swiss-Prot
  ENSRNOT00060045979 UniProtKB/Swiss-Prot
  ENSRNOT00060047961 UniProtKB/Swiss-Prot
  ENSRNOT00065030170 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.340.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.980.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Molybdopterin biosynthesis moea protein, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Molybdopterin biosynthesis moea protein, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MoaB/Mog-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoaB/Mog_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoCF_biosynth_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_C_domain_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_C_domain_IV_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_linker/N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_linker/N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64845 UniProtKB/Swiss-Prot
NCBI Gene 64845 ENTREZGENE
PANTHER GEPHYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MoCF_biosynth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MoeA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gphn PhenoGen
PROSITE MOCF_BIOSYNTHESIS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOCF_BIOSYNTHESIS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028366 RatGTEx
  ENSRNOG00000064046 RatGTEx
  ENSRNOG00000064630 RatGTEx
  ENSRNOG00055018422 RatGTEx
  ENSRNOG00055018485 RatGTEx
  ENSRNOG00060026299 RatGTEx
  ENSRNOG00060027041 RatGTEx
  ENSRNOG00065017865 RatGTEx
SMART MoCF_biosynth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63867 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63882 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216665
UniProt A0A8I5ZQC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A568 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9T9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AHG6_RAT UniProtKB/TrEMBL
  A6HCD6 ENTREZGENE, UniProtKB/TrEMBL
  A6HCD7 ENTREZGENE, UniProtKB/TrEMBL
  B3GS92_RAT UniProtKB/TrEMBL
  F1MA86_RAT UniProtKB/TrEMBL
  GEPH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gphn  gephyrin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization membrane-associated protein 68677
gene_cellular_localization membrane-associated protein 69377
gene_disease mutation of the human homolog has been identified in a patient with molybdenum cofactor deficiency who does not have a mutation in MOCS1 or MOCS2 68677
gene_function catalyses the insertion of molybdenum into molybdopterin 68677
gene_function catalyses the insertion of molybdenum into molybdopterin 69377
gene_process essential for the postsynaptic localization of receptors for neurotransmitters 68677
gene_process essential for the postsynaptic localization of receptors for neurotransmitters 69377
gene_process plays a role in molybdenum cofactor biosynthesis 68677
gene_process plays a role in molybdenum cofactor biosynthesis 69377