Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)

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Keyword

Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus

Symbol:

Hmgcr

Name:

3-hydroxy-3-methylglutaryl-CoA reductase

Description:

ENCODES a protein that exhibits hydroxymethylglutaryl-CoA reductase activity; protein homodimerization activity; coenzyme binding (ortholog); INVOLVED IN aging; cholesterol biosynthetic process; isoprenoid biosynthetic process; PARTICIPATES IN metabolic syndrome pathway; cholesterol biosynthetic pathway; statin pharmacodynamics pathway; ASSOCIATED WITH Brain Injuries; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; FOUND IN intracellular membrane-bounded organelle; endoplasmic reticulum (ortholog); peroxisomal membrane (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (R)-mevalonic acid; 1,2,4-trimethylbenzene

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3H3M; HMG-CoA reductase

Orthologs:

Homo sapiens : HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) HGNC
Mus musculus : Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase) MGI

Latest Assembly:

RGSC Genome Assembly v3.4

Position:

Map	Chr	Position	Strand	Source
Rat Cytogenetic Map	2	q12		NCBI
RGSC Genome Assembly v5.0	2	46,592,883 - 46,614,276	-	NCBI
RGSC Genome Assembly v3.4	2	27,127,504 - 27,149,580	-	NCBI
Rat Celera Assembly	2	24,043,814 - 24,065,183	-	NCBI
Genome Assembly 3.1	2	27,047,872 - 27,069,949	-	NCBI
RH 3.4	2	13.3		RGD