Gene: Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase) Rattus norvegicus
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Symbol: Hmgcr
Name: 3-hydroxy-3-methylglutaryl-CoA reductase
Description: ENCODES a protein that exhibits hydroxymethylglutaryl-CoA reductase activity; protein homodimerization activity; protein phosphatase 2A binding; INVOLVED IN aging; cholesterol biosynthetic process; isoprenoid biosynthetic process; PARTICIPATES IN metabolic syndrome pathway; alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; ASSOCIATED WITH Brain Injuries; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; FOUND IN intracellular membrane-bounded organelle; endoplasmic reticulum (ortholog); peroxisomal membrane (ortholog); INTERACTS WITH (+)-alpha-tocopherol; (25R)-cholest-5-ene-3beta,26-diol; (R)-mevalonic acid
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMG-CoA reductase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0227,480,224 - 27,500,654 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0246,592,881 - 46,614,276 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4227,127,504 - 27,149,580 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1227,047,872 - 27,069,949 (-)NCBI
Celera224,043,814 - 24,065,183 (-)NCBI
Cytogenetic Map2q12NCBImapview
RH 3.4 Map213.3RGD
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hmgcr
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RGD Object Information
RGD ID: 2803
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-11-18
Status: ACTIVE