Gene: Brca1 (breast cancer 1, early onset) Rattus norvegicus
Symbol: Brca1
Name: breast cancer 1, early onset
Description: ENCODES a protein that exhibits damaged DNA binding (ortholog); enzyme binding (ortholog); RNA binding (ortholog); INVOLVED IN brain development; response to estradiol; response to lipid; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Hypertension; Mammary Neoplasms, Experimental; Breast Neoplasms (ortholog); FOUND IN mitochondrial matrix; BRCA1-A complex (ortholog); BRCA1-BARD1 complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: breast cancer 1; breast cancer type 1 susceptibility protein homolog
Allele / Splice: Brca1m1Uwm  
Latest Assembly: RGSC Genome Assembly v3.4
RGSC Genome Assembly v6.01089,394,821 - 89,455,009-NCBI
Rat Cytogenetic Map10q32.1 NCBI
RGSC Genome Assembly v5.01089,192,653 - 89,252,760-NCBI
RGSC Genome Assembly v3.41090,513,630 - 90,572,676-NCBI
Rat Celera Assembly1085,140,052 - 85,200,670-NCBI
Genome Assembly 3.11090,527,999 - 90,587,046-NCBI

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References - curated
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RGD Disease Portals


Candidate Gene Status
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Position Markers
QTLs in Region (RGSC Genome Assembly v3.4)
Related Rat Strains


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

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Nomenclature History
RGD Curation Notes
More on Brca1
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RGD Object Information
RGD ID: 2218
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2014-09-10
Status: ACTIVE