Gene: Brca1 (breast cancer 1, early onset) Rattus norvegicus
Symbol: Brca1
Name: breast cancer 1, early onset
Description: ENCODES a protein that exhibits chromatin binding; damaged DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN brain development; positive regulation of protein import into nucleus, translocation; response to estradiol; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Hypertension; Mammary Neoplasms, Experimental; Aging, Premature (ortholog); FOUND IN mitochondrial matrix; BRCA1-A complex (ortholog); BRCA1-BARD1 complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: breast cancer 1; breast cancer type 1 susceptibility protein homolog
Allele / Splice: Brca1m1Uwm  
Is Marker For: Strains:   SD   SD-Brca1m1Uwm  
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01089,394,821 - 89,455,009-NCBI
Rat Cytogenetic Map10q32.1 NCBI
RGSC Genome Assembly v5.01089,192,653 - 89,252,760-NCBI
RGSC Genome Assembly v3.41090,513,630 - 90,572,676-NCBI
Rat Celera Assembly1085,140,052 - 85,200,670-NCBI
Genome Assembly 3.11090,527,999 - 90,587,046-NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants