Il19 (interleukin 19) - Rat Genome Database

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Gene: Il19 (interleukin 19) Rattus norvegicus
Analyze
Symbol: Il19
Name: interleukin 19
RGD ID: 1583546
Description: Predicted to enable cytokine activity. Predicted to be involved in negative regulation of low-density lipoprotein particle clearance. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in extracellular space. Biomarker of periodontal disease. Orthologous to human IL19 (interleukin 19); PARTICIPATES IN interleukin-23 signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interleukin-19; LOC681145; similar to interleukin 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,949,989 - 44,958,714 (-)NCBIGRCr8
mRatBN7.21342,397,715 - 42,411,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,399,138 - 42,405,473 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01347,663,592 - 47,677,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,664,080 - 47,670,407 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,751,661 - 52,758,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,878,668 - 43,885,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1342,747,840 - 42,762,111 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IL-19 is involved in the pathogenesis of endotoxic shock. Hsing CH, etal., Shock. 2008 Jan;29(1):7-15.
2. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Li Y, etal., Mol Oral Microbiol. 2010 Aug;25(4):275-92.
3. IL-19 induced Th2 cytokines and was up-regulated in asthma patients. Liao SC, etal., J Immunol. 2004 Dec 1;173(11):6712-8.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12370360   PMID:23468852   PMID:28257760  


Genomics

Comparative Map Data
Il19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,949,989 - 44,958,714 (-)NCBIGRCr8
mRatBN7.21342,397,715 - 42,411,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,399,138 - 42,405,473 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01347,663,592 - 47,677,869 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,664,080 - 47,670,407 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,751,661 - 52,758,048 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,878,668 - 43,885,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1342,747,840 - 42,762,111 (-)NCBICelera
Cytogenetic Map13q13NCBI
IL19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,770,773 - 206,842,981 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,770,764 - 206,842,981 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,944,118 - 207,016,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,038,838 - 205,082,948 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,360,609 - 203,404,719NCBI
Celera1180,223,655 - 180,267,841 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,670,510 - 177,714,575 (+)NCBIHuRef
CHM1_11208,244,767 - 208,288,882 (+)NCBICHM1_1
T2T-CHM13v2.01206,034,974 - 206,107,261 (+)NCBIT2T-CHM13v2.0
Il19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,860,393 - 130,873,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,860,393 - 130,867,852 (-)EnsemblGRCm39 Ensembl
GRCm381130,932,656 - 130,945,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,932,656 - 130,940,115 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,829,233 - 132,835,818 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,760,202 - 132,766,787 (-)NCBIMGSCv36mm8
Celera1133,555,187 - 133,561,772 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Il19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,376,104 - 42,384,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,376,102 - 42,384,902 (+)NCBIChiLan1.0ChiLan1.0
IL19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,531,737 - 42,556,495 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,497,692 - 42,522,458 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,372,339 - 182,446,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,680,606 - 186,724,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,651,640 - 186,724,748 (+)Ensemblpanpan1.1panPan2
IL19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,000,994 - 6,006,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,000,907 - 6,006,870 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,565,084 - 5,571,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,690,270 - 5,696,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,690,393 - 5,696,158 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,624,790 - 5,630,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,725,835 - 5,731,813 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,765,463 - 5,771,442 (+)NCBIUU_Cfam_GSD_1.0
Il19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,524,432 - 68,529,571 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,765,093 - 5,769,853 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,765,093 - 5,769,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,469,524 - 67,479,813 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,469,519 - 67,479,597 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,826,995 - 73,836,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,514,199 - 22,523,680 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,514,559 - 22,520,499 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,185,637 - 23,225,958 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,636,374 - 4,641,022 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,636,357 - 4,641,022 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il19
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:53
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000035044
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 6 8 2 9
Below cutoff 21 14 5 11 5 1 1 36 27 29 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035044   ⟹   ENSRNOP00000036434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,399,138 - 42,405,473 (-)Ensembl
Rnor_6.0 Ensembl1347,664,080 - 47,670,407 (-)Ensembl
RefSeq Acc Id: NM_001427834   ⟹   NP_001414763
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,949,989 - 44,958,714 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414763 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000036434.7
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000036434   ⟸   ENSRNOT00000035044
RefSeq Acc Id: NP_001414763   ⟸   NM_001427834

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFI7-F1-model_v2 AlphaFold D3ZFI7 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583546 AgrOrtholog
BioCyc Gene G2FUF-18360 BioCyc
Ensembl Genes ENSRNOG00000025571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035044.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interleukin-10/19/20/24 UniProtKB/TrEMBL
  Interleukin-10_CS UniProtKB/TrEMBL
  Interleukin-19 UniProtKB/TrEMBL
NCBI Gene 681145 ENTREZGENE
PANTHER INTERLEUKIN-19 UniProtKB/TrEMBL
  INTERLEUKIN-19-RELATED UniProtKB/TrEMBL
Pfam IL10 UniProtKB/TrEMBL
PhenoGen Il19 PhenoGen
PRINTS INTRLEUKIN19 UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025571 RatGTEx
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A6IC10_RAT UniProtKB/TrEMBL
  D3ZFI7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Il19  interleukin 19  LOC681145  similar to interleukin 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681145  similar to interleukin 19      Symbol and Name status set to provisional 70820 PROVISIONAL