Slc22a6 (solute carrier family 22 member 6) - Rat Genome Database

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Gene: Slc22a6 (solute carrier family 22 member 6) Rattus norvegicus
Analyze
Symbol: Slc22a6
Name: solute carrier family 22 member 6
RGD ID: 69338
Description: Enables several functions, including chloride ion binding activity; prostaglandin transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in metanephric proximal tubule development; organic anion transport; and response to organic cyclic compound. Acts upstream of or within organic anion transport. Located in caveola. Part of protein-containing complex. Orthologous to human SLC22A6 (solute carrier family 22 member 6); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (-)-citrinin; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC124962; Oat1; Orctl1; organic anion transporter 1; organic cationic transporter-like 1; Paht; renal organic anion transporter 1; Roat1; rROAT1; solute carrier family 22 (organic anion transporter) member 6; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22, member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD-Slc22a6em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,951,493 - 214,960,317 (+)NCBIGRCr8
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1213,928,527 - 213,936,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,966,506 - 220,974,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,659,221 - 213,667,443 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Celera1203,036,078 - 203,044,298 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azaorotic acid  (EXP,ISO)
5-formyltetrahydrofolic acid  (EXP,ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
9-[2-(phosphonomethoxy)ethyl]guanine  (ISO)
acetylsalicylic acid  (ISO)
adefovir  (EXP,ISO)
adipic acid  (ISO)
aflatoxin B1  (ISO)
allopurinol  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
angelicin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP,ISO)
aurantio-obtusin  (ISO)
bacitracin  (EXP)
baicalein  (ISO)
bendroflumethiazide  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromosulfophthalein  (ISO)
cadmium dichloride  (EXP,ISO)
cefaclor  (ISO)
cefaloridine  (EXP,ISO)
cefdinir  (ISO)
cefoselis sulfate  (ISO)
cefotiam  (ISO)
ceftibuten  (ISO)
ceftizoxime  (ISO)
chlorpyrifos-methyl  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (EXP)
clothianidin  (ISO)
cyazofamid  (ISO)
D-gluconic acid  (ISO)
diazepam  (ISO)
diclofenac  (ISO)
diethyl hydrogen phosphate  (EXP)
diiodine  (ISO)
disodium cromoglycate  (EXP)
doxycycline  (ISO)
emodin  (ISO)
estrone 3-sulfate  (ISO)
fenitrothion  (ISO)
fluorescein (lactone form)  (ISO)
folic acid  (EXP)
fructose  (EXP)
furan  (EXP)
furosemide  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutaric acid  (ISO)
glutathione  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
herbicide  (EXP)
hydrochlorothiazide  (EXP)
hypoxanthine  (ISO)
ibuprofen  (ISO)
imperatorin  (ISO)
indometacin  (ISO)
isoimperatorin  (ISO)
ketoprofen  (ISO)
linoleic acid  (ISO)
luteolin  (ISO)
malathion  (ISO)
mefenamic acid  (ISO)
Mercuric oxide  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (EXP)
mianserin  (ISO)
minocycline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (ISO)
Nonylphenol  (EXP)
Obtusifolin  (ISO)
ochratoxin A  (EXP,ISO)
octanoic acid  (EXP)
oroxylin A  (ISO)
oxytetracycline  (ISO)
p-aminohippuric acid  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenacetin  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
piroxicam  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prostaglandin E2  (EXP)
purines  (EXP)
pyrazine-2-carboxylic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-sulfate  (ISO)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
riddelliine  (EXP)
rutin  (EXP)
salicylates  (ISO)
salicylic acid  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium hydrogencarbonate  (EXP)
streptozocin  (EXP)
succinic acid  (ISO)
sulindac  (ISO)
taurocholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
trans-piceid  (ISO)
triazolam  (ISO)
valsartan  (EXP)
vancomycin  (EXP,ISO)
wedelolactone  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression. Beery E, etal., Endocrinology 2003 Oct;144(10):4519-26. Epub 2003 Jun 26.
2. Characterization of uremic toxin transport by organic anion transporters in the kidney. Deguchi T, etal., Kidney Int. 2004 Jan;65(1):162-74. doi: 10.1111/j.1523-1755.2004.00354.x.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rapid isolation of tissue-specific genes from rat kidney. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
6. Cell free expression and functional reconstitution of eukaryotic drug transporters. Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
7. Differential gene expression of organic anion transporters in male and female rats. Kobayashi Y, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):482-7.
8. Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney. Kwak JO, etal., Exp Mol Med. 2005 Jun 30;37(3):204-12.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Expression cloning and characterization of a novel multispecific organic anion transporter. Sekine T, etal., J Biol Chem 1997 Jul 25;272(30):18526-9.
17. Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. Shibayama Y, etal., Cancer Sci. 2006 Nov;97(11):1260-6. Epub 2006 Aug 22.
18. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. Sweet DH, etal., J Biol Chem 1997 Nov 28;272(48):30088-95.
19. Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3. Uwai Y and Honjo E, Biosci Biotechnol Biochem. 2013;77(7):1517-21. doi: 10.1271/bbb.130178. Epub 2013 Jul 7.
20. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Youngblood GL and Sweet DH, Am J Physiol Renal Physiol 2004 Aug;287(2):F236-44. Epub 2004 Apr 06.
Additional References at PubMed
PMID:9887087   PMID:9950961   PMID:10049739   PMID:10751225   PMID:12477932   PMID:12877347   PMID:14749323   PMID:15037815   PMID:15122767   PMID:16024787   PMID:16316345   PMID:16844357  
PMID:17244891   PMID:17245393   PMID:18946499   PMID:18953184   PMID:19028678   PMID:19056867   PMID:19403644   PMID:21652719   PMID:22015764   PMID:22169006   PMID:22759781   PMID:22808265  
PMID:22992436   PMID:23280877   PMID:23376485   PMID:24531880   PMID:25266751   PMID:25391897   PMID:26065488   PMID:26846716   PMID:27053689   PMID:27226107   PMID:27282888   PMID:28534121  
PMID:29436232   PMID:32271169   PMID:32451678   PMID:33790363  


Genomics

Comparative Map Data
Slc22a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,951,493 - 214,960,317 (+)NCBIGRCr8
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1213,928,527 - 213,936,740 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,966,506 - 220,974,728 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,659,221 - 213,667,443 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Celera1203,036,078 - 203,044,298 (+)NCBICelera
Cytogenetic Map1q43NCBI
SLC22A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,936,385 - 62,984,967 (-)EnsemblGRCh38hg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBINCBI36Build 36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBIT2T-CHM13v2.0
Slc22a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,595,360 - 8,605,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,595,403 - 8,605,663 (+)EnsemblGRCm39 Ensembl
GRCm38198,617,996 - 8,628,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,618,039 - 8,628,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv37198,692,486 - 8,702,789 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36198,685,086 - 8,693,568 (+)NCBIMGSCv36mm8
Celera198,376,155 - 8,386,458 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.44NCBI
Slc22a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599301,981 - 311,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599302,026 - 307,503 (+)NCBIChiLan1.0ChiLan1.0
SLC22A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,198,167 - 64,206,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,243,334 - 65,251,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,328,476 - 58,336,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,680,016 - 61,688,223 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,680,016 - 61,688,223 (-)Ensemblpanpan1.1panPan2
SLC22A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,736,669 - 53,745,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,736,959 - 53,744,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,342,543 - 52,350,303 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,782,055 - 54,789,820 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,782,215 - 54,790,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,884,029 - 53,891,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,458,362 - 53,466,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,245,739 - 54,253,490 (+)NCBIUU_Cfam_GSD_1.0
Slc22a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,235,014 - 10,242,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581349,057 - 356,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581348,719 - 356,246 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,802,349 - 8,817,337 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,809,547 - 8,817,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,152,459 - 8,160,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,918,081 - 10,926,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,918,770 - 10,925,983 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,270,857 - 108,278,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,363,431 - 1,368,534 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,363,322 - 1,368,768 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc22a6
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:72
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000024757
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat


Related Rat Strains
The following Strains have been annotated to Slc22a6
SD-Slc22a6em1Sage    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 29 1
Low 10 3 1 3 32 2 13 5
Below cutoff 1 14 33 24 15 24 8 8 4 4 24 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024757   ⟹   ENSRNOP00000024756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)Ensembl
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)Ensembl
RefSeq Acc Id: NM_017224   ⟹   NP_058920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,952,097 - 214,960,317 (+)NCBI
mRatBN7.21205,522,959 - 205,531,179 (+)NCBI
Rnor_6.01224,825,064 - 224,833,284 (+)NCBI
Rnor_5.01231,761,600 - 231,772,550 (+)NCBI
RGSC_v3.41211,294,178 - 211,302,398 (+)RGD
Celera1203,036,078 - 203,044,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230978   ⟹   XP_006231040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,951,493 - 214,960,312 (+)NCBI
mRatBN7.21205,522,579 - 205,531,174 (+)NCBI
Rnor_6.01224,824,809 - 224,833,284 (+)NCBI
Rnor_5.01231,761,600 - 231,772,550 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058920   ⟸   NM_017224
- UniProtKB: O35956 (UniProtKB/Swiss-Prot),   A6HZR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231040   ⟸   XM_006230978
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000024756   ⟸   ENSRNOT00000024757
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35956-F1-model_v2 AlphaFold O35956 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690728
Promoter ID:EPDNEW_R1253
Type:multiple initiation site
Name:Slc22a6_1
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,824,839 - 224,824,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69338 AgrOrtholog
BioCyc Gene G2FUF-56524 BioCyc
Ensembl Genes ENSRNOG00000018215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055023538 UniProtKB/Swiss-Prot
  ENSRNOG00060033018 UniProtKB/Swiss-Prot
  ENSRNOG00065032764 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024757 ENTREZGENE
  ENSRNOT00000024757.5 UniProtKB/Swiss-Prot
  ENSRNOT00055040476 UniProtKB/Swiss-Prot
  ENSRNOT00060057288 UniProtKB/Swiss-Prot
  ENSRNOT00065056349 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109188 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29509 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124962 IMAGE-MGC_LOAD
NCBI Gene Slc22a6 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 22 MEMBER 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC22A6 RGD
PhenoGen Slc22a6 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018215 RatGTEx
  ENSRNOG00055023538 RatGTEx
  ENSRNOG00060033018 RatGTEx
  ENSRNOG00065032764 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HZR6 ENTREZGENE, UniProtKB/TrEMBL
  O35956 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc22a6  solute carrier family 22 member 6  Slc22a6  solute carrier family 22 (organic anion transporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc22a6  solute carrier family 22 (organic anion transporter), member 6    solute carrier family 22, member 6  Name updated 1299863 APPROVED
2002-06-10 Slc22a6  solute carrier family 22, member 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization basalateral membrane of proximal tube in kidney 68821
gene_cellular_localization basalateral membrane of proximal tube in kidney 68822
gene_domains contains 12 putative membrane-spannning domains 68821
gene_expression no sex differences in expression in brain, liver and kidney 70250
gene_expression expressed predominantly in a segment of the proximal tubule in kidney 68822
gene_expression expresse in the outer zona fasciculata of the adreneal cortex 1299206
gene_function organic anion/dicarboxylate exchanger 68822
gene_function transports cyclic nucleotides, prostaglandin, uric acid, and a variety of drugs including antibiotics and diuretics 68681
gene_process mediates sodium-independent para-aminohippurate (PAH) uptake 70250
gene_process may have a possible role in cortisol release 1299206
gene_product organic anion transporter family 68822
gene_protein 551 aa 68822