Adam22 (ADAM metallopeptidase domain 22) - Rat Genome Database

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Gene: Adam22 (ADAM metallopeptidase domain 22) Rattus norvegicus
Analyze
Symbol: Adam22
Name: ADAM metallopeptidase domain 22
RGD ID: 1585016
Description: Predicted to enable metalloendopeptidase activity. Involved in positive regulation of protein localization. Located in axon initial segment. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metalloprotease domain (ADAM) 22; a disintegrin and metalloprotease domain (ADAM) 22 (mapped); a disintegrin and metalloprotease domain 22; Adam22_mapped; disintegrin and metalloproteinase domain-containing protein 22; disintegrin and metalloproteinase domain-containing protein 22-like; LOC108350662; LOC683655; MDC2; similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,670,984 - 26,925,843 (+)NCBIGRCr8
mRatBN7.2425,716,055 - 25,970,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,715,990 - 25,964,962 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0422,864,485 - 23,002,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,859,622 - 22,996,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,873,544 - 22,935,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0422,632,816 - 22,827,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,332,086 - 22,507,086 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera421,356,458 - 21,453,378 (+)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
clofibrate  (EXP)
clotrimazole  (EXP)
crocidolite asbestos  (ISO)
diazinon  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pyridaben  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. Hivert B, etal., J Cell Sci. 2019 Jan 16;132(2). pii: jcs.219774. doi: 10.1242/jcs.219774.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. Poindexter K, etal., Gene 1999 Sep 3;237(1):61-70.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15876356   PMID:16990550   PMID:20089912   PMID:20133599   PMID:20220021   PMID:21068328   PMID:21700703   PMID:23525710   PMID:27066583   PMID:29358191   PMID:37555799  


Genomics

Comparative Map Data
Adam22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,670,984 - 26,925,843 (+)NCBIGRCr8
mRatBN7.2425,716,055 - 25,970,932 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,715,990 - 25,964,962 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0422,864,485 - 23,002,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,859,622 - 22,996,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,873,544 - 22,935,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0422,632,816 - 22,827,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,332,086 - 22,507,086 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera421,356,458 - 21,453,378 (+)NCBICelera
Cytogenetic Map4q12NCBI
ADAM22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,934,251 - 88,202,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,934,143 - 88,202,889 (+)EnsemblGRCh38hg38GRCh38
GRCh37787,563,566 - 87,832,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36787,401,638 - 87,664,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34787,208,352 - 87,471,098NCBI
Celera782,268,261 - 82,531,056 (+)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef782,173,445 - 82,442,057 (+)NCBIHuRef
CHM1_1787,493,737 - 87,762,729 (+)NCBICHM1_1
T2T-CHM13v2.0789,184,170 - 89,453,378 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,894,883 - 87,163,561 (+)NCBI
Adam22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,122,353 - 8,418,312 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,122,352 - 8,418,160 (-)EnsemblGRCm39 Ensembl
GRCm3858,072,347 - 8,368,312 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,072,352 - 8,368,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv3758,072,352 - 8,368,081 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,098,266 - 8,374,087 (-)NCBIMGSCv36mm8
Celera58,005,837 - 8,298,614 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.39NCBI
Adam22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554325,305,611 - 5,536,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554325,306,018 - 5,536,282 (+)NCBIChiLan1.0ChiLan1.0
ADAM22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,815,638 - 106,084,719 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17154,080,277 - 154,349,357 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,930,613 - 80,197,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1793,578,988 - 93,846,903 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl793,579,306 - 93,840,484 (+)Ensemblpanpan1.1panPan2
ADAM22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11414,032,434 - 14,256,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1414,032,475 - 14,250,554 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,603,791 - 13,828,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01413,797,440 - 14,021,747 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,797,158 - 14,021,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11414,001,060 - 14,231,713 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,726,826 - 13,951,335 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01414,012,429 - 14,236,782 (+)NCBIUU_Cfam_GSD_1.0
Adam22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511827,048,939 - 27,263,377 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936763739,629 - 952,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936763738,051 - 952,435 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl968,253,065 - 68,487,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1968,253,023 - 68,490,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,687,666 - 74,925,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12160,753,344 - 60,999,283 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2160,759,980 - 60,998,600 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604243,076,021 - 43,348,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248095,197,147 - 5,448,283 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248095,190,974 - 5,448,317 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam22
1567 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:477
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000068410, ENSRNOT00000070872, ENSRNOT00000071635, ENSRNOT00000071921, ENSRNOT00000072068, ENSRNOT00000073044, ENSRNOT00000073501, ENSRNOT00000073723, ENSRNOT00000074832, ENSRNOT00000074918
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat

Markers in Region
D4Got302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,727,841 - 25,728,107 (+)MAPPERmRatBN7.2
Rnor_6.0422,931,319 - 22,931,584NCBIRnor6.0
Rnor_6.0422,712,288 - 22,712,533NCBIRnor6.0
Rnor_5.0422,644,273 - 22,644,518UniSTSRnor5.0
Rnor_5.0422,866,183 - 22,866,448UniSTSRnor5.0
RGSC_v3.4422,495,335 - 22,495,600UniSTSRGSC3.4
Celera421,213,806 - 21,214,071UniSTS
Cytogenetic Map4 RGD
RH142562  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,839,092 - 25,839,324 (+)MAPPERmRatBN7.2
Rnor_6.0422,826,418 - 22,826,649NCBIRnor6.0
Rnor_5.0422,759,764 - 22,759,995UniSTSRnor5.0
RGSC_v3.4422,388,493 - 22,388,724UniSTSRGSC3.4
Celera421,323,301 - 21,323,532UniSTS
RH 3.4 Map4156.0UniSTS
RH137701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,948,216 - 25,948,430 (+)MAPPERmRatBN7.2
Rnor_6.0422,979,966 - 22,980,179NCBIRnor6.0
Rnor_5.0422,912,585 - 22,912,798UniSTSRnor5.0
Celera421,430,668 - 21,430,881UniSTS
RH 3.4 Map4156.0UniSTS
RH137892  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,737,633 - 25,737,858 (+)MAPPERmRatBN7.2
Rnor_6.0422,721,516 - 22,721,740NCBIRnor6.0
Rnor_5.0422,653,501 - 22,653,725UniSTSRnor5.0
RGSC_v3.4422,485,585 - 22,485,809UniSTSRGSC3.4
Celera421,223,600 - 21,223,824UniSTS
RH 3.4 Map4169.4UniSTS
Adam22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,897,112 - 25,897,445 (+)MAPPERmRatBN7.2
Rnor_6.0422,889,134 - 22,889,466NCBIRnor6.0
Rnor_5.0422,824,848 - 22,825,180UniSTSRnor5.0
Celera421,381,100 - 21,381,432UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 60 5 1
Low 24 23 8 10 8 8 10 14 30 38 11 8
Below cutoff 3 18 19 18 9 18 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001843290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005503424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010065701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000068410   ⟹   ENSRNOP00000059289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,716,044 - 25,964,962 (+)Ensembl
Rnor_6.0 Ensembl422,859,622 - 22,996,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073501   ⟹   ENSRNOP00000064723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,864,422 - 25,961,471 (+)Ensembl
Rnor_6.0 Ensembl422,859,622 - 22,996,645 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094468   ⟹   ENSRNOP00000093947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,716,044 - 25,964,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099765   ⟹   ENSRNOP00000077847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,716,122 - 25,964,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101856   ⟹   ENSRNOP00000094391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,716,044 - 25,951,817 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108037   ⟹   ENSRNOP00000081703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,716,044 - 25,964,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111685   ⟹   ENSRNOP00000094323
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,715,990 - 25,964,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114747   ⟹   ENSRNOP00000085571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,715,990 - 25,964,962 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115124   ⟹   ENSRNOP00000081419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,715,990 - 25,964,962 (+)Ensembl
RefSeq Acc Id: NM_001427457   ⟹   NP_001414386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,671,112 - 26,925,843 (+)NCBI
RefSeq Acc Id: XM_039108561   ⟹   XP_038964489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,984 - 26,925,843 (+)NCBI
mRatBN7.2425,716,056 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108563   ⟹   XP_038964491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,984 - 26,925,843 (+)NCBI
mRatBN7.2425,716,056 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108564   ⟹   XP_038964492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,984 - 26,925,843 (+)NCBI
mRatBN7.2425,716,056 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108565   ⟹   XP_038964493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,985 - 26,925,843 (+)NCBI
mRatBN7.2425,716,056 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108567   ⟹   XP_038964495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,986 - 26,925,843 (+)NCBI
mRatBN7.2425,716,057 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108568   ⟹   XP_038964496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,987 - 26,925,843 (+)NCBI
mRatBN7.2425,716,058 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108569   ⟹   XP_038964497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,986 - 26,925,843 (+)NCBI
mRatBN7.2425,716,057 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108571   ⟹   XP_038964499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,987 - 26,925,843 (+)NCBI
mRatBN7.2425,716,058 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_039108572   ⟹   XP_038964500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,989 - 26,925,843 (+)NCBI
mRatBN7.2425,716,059 - 25,970,932 (+)NCBI
RefSeq Acc Id: XM_063286643   ⟹   XP_063142713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,986 - 26,925,843 (+)NCBI
RefSeq Acc Id: XM_063286644   ⟹   XP_063142714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,987 - 26,925,843 (+)NCBI
RefSeq Acc Id: XM_063286645   ⟹   XP_063142715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,986 - 26,925,843 (+)NCBI
RefSeq Acc Id: XM_063286646   ⟹   XP_063142716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,841,637 - 26,925,843 (+)NCBI
RefSeq Acc Id: XM_063286647   ⟹   XP_063142717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,984 - 26,925,843 (+)NCBI
RefSeq Acc Id: XR_005503424
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,985 - 26,919,529 (+)NCBI
mRatBN7.2425,716,057 - 25,961,372 (+)NCBI
RefSeq Acc Id: XR_010065699
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,987 - 26,919,529 (+)NCBI
RefSeq Acc Id: XR_010065700
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,987 - 26,919,529 (+)NCBI
RefSeq Acc Id: XR_010065701
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,670,984 - 26,850,107 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000064723   ⟸   ENSRNOT00000073501
RefSeq Acc Id: ENSRNOP00000059289   ⟸   ENSRNOT00000068410
RefSeq Acc Id: XP_038964489   ⟸   XM_039108561
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964492   ⟸   XM_039108564
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y6E8 (UniProtKB/TrEMBL),   A0A8I6G7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964491   ⟸   XM_039108563
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964493   ⟸   XM_039108565
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964495   ⟸   XM_039108567
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G6D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964497   ⟸   XM_039108569
- Peptide Label: isoform X9
- UniProtKB: A0A8I6G6D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964496   ⟸   XM_039108568
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AMW2 (UniProtKB/TrEMBL),   A0A8I6G7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964499   ⟸   XM_039108571
- Peptide Label: isoform X11
- UniProtKB: F1M542 (UniProtKB/TrEMBL),   A0A8I6G6D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964500   ⟸   XM_039108572
- Peptide Label: isoform X12
- UniProtKB: A0A8I6G6D0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081419   ⟸   ENSRNOT00000115124
RefSeq Acc Id: ENSRNOP00000094391   ⟸   ENSRNOT00000101856
RefSeq Acc Id: ENSRNOP00000077847   ⟸   ENSRNOT00000099765
RefSeq Acc Id: ENSRNOP00000094323   ⟸   ENSRNOT00000111685
RefSeq Acc Id: ENSRNOP00000093947   ⟸   ENSRNOT00000094468
RefSeq Acc Id: ENSRNOP00000081703   ⟸   ENSRNOT00000108037
RefSeq Acc Id: ENSRNOP00000085571   ⟸   ENSRNOT00000114747
RefSeq Acc Id: XP_063142717   ⟸   XM_063286647
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063142713   ⟸   XM_063286643
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063142715   ⟸   XM_063286645
- Peptide Label: isoform X10
- UniProtKB: A0A8I6GKI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142714   ⟸   XM_063286644
- Peptide Label: isoform X8
RefSeq Acc Id: NP_001414386   ⟸   NM_001427457
- Peptide Label: precursor
RefSeq Acc Id: XP_063142716   ⟸   XM_063286646
- Peptide Label: isoform X13
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R5P8-F1-model_v2 AlphaFold M0R5P8 1-775 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585016 AgrOrtholog
BioCyc Gene G2FUF-45821 BioCyc
Ensembl Genes ENSRNOG00000042478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068410.5 UniProtKB/TrEMBL
  ENSRNOT00000073501.4 UniProtKB/TrEMBL
  ENSRNOT00000094468.1 UniProtKB/TrEMBL
  ENSRNOT00000099765 ENTREZGENE
  ENSRNOT00000099765.1 UniProtKB/TrEMBL
  ENSRNOT00000101856.1 UniProtKB/TrEMBL
  ENSRNOT00000108037.1 UniProtKB/TrEMBL
  ENSRNOT00000111685.1 UniProtKB/TrEMBL
  ENSRNOT00000114747.1 UniProtKB/TrEMBL
  ENSRNOT00000115124.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF_extracell UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 57033 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 22 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam22 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042478 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A8I5Y6E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0F9_RAT UniProtKB/TrEMBL
  A0A8I6AMW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARH6_RAT UniProtKB/TrEMBL
  A0A8I6G6D0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKI4 ENTREZGENE, UniProtKB/TrEMBL
  F1M542 ENTREZGENE, UniProtKB/TrEMBL
  M0R5P8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Adam22  ADAM metallopeptidase domain 22  LOC108350662  disintegrin and metalloproteinase domain-containing protein 22-like  Data merged from RGD:11445113 737654 PROVISIONAL
2016-08-02 LOC108350662  disintegrin and metalloproteinase domain-containing protein 22-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-17 Adam22  ADAM metallopeptidase domain 22  LOC683655  similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)  Data merged from RGD:1584497 737654 PROVISIONAL
2012-07-13 Adam22  ADAM metallopeptidase domain 22  Adam22  a disintegrin and metalloprotease domain (ADAM) 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-10 Adam22  a disintegrin and metalloprotease domain (ADAM) 22  Adam22_mapped  a disintegrin and metalloprotease domain (ADAM) 22 (mapped)  Data merged from RGD:620414 737654 APPROVED
2006-11-19 Adam22_mapped  a disintegrin and metalloprotease domain (ADAM) 22(mapped)  Adam22  a disintegrin and metalloprotease domain (ADAM) 22  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-19 Adam22  a disintegrin and metalloprotease domain (ADAM) 22      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683655  similar to ADAM 22 precursor (A disintegrin and metalloproteinase domain 22)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Adam22  a disintegrin and metalloprotease domain (ADAM) 22      Symbol and Name status set to provisional 70820 PROVISIONAL