Adprhl1 (ADP-ribosylhydrolase like 1) - Rat Genome Database

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Gene: Adprhl1 (ADP-ribosylhydrolase like 1) Rattus norvegicus
Analyze
Symbol: Adprhl1
Name: ADP-ribosylhydrolase like 1
RGD ID: 1305641
Description: Predicted to enable ADP-ribosylarginine hydrolase activity and magnesium ion binding activity. Predicted to be involved in cardiac chamber ballooning and cardiac myofibril assembly. Predicted to be located in sarcomere. Orthologous to human ADPRHL1 (ADP-ribosylhydrolase like 1); INTERACTS WITH 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: [Protein ADP-ribosylarginine] hydrolase-like protein 1; AABR07026536.1; ADP-ribosylhydrolase 2; ADP-ribosylhydrolase-like protein 1; inactive ADP-ribosyltransferase ARH2; LOC120093091; LOC290880; uncharacterized LOC120093091
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,985,355 - 83,017,240 (+)NCBIGRCr8
mRatBN7.21676,283,186 - 76,315,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,283,103 - 76,354,440 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01681,616,098 - 81,648,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01681,104,502 - 81,136,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,139,855 - 81,155,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,140,119 - 81,156,050 (+)NCBI
Celera1674,089,906 - 74,105,320 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
sarcomere  (IEA,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:26316108  


Genomics

Comparative Map Data
Adprhl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81682,985,355 - 83,017,240 (+)NCBIGRCr8
mRatBN7.21676,283,186 - 76,315,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,283,103 - 76,354,440 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01681,616,098 - 81,648,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01681,104,502 - 81,136,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,139,855 - 81,155,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11681,140,119 - 81,156,050 (+)NCBI
Celera1674,089,906 - 74,105,320 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
ADPRHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,399,610 - 113,453,488 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,399,611 - 113,453,488 (-)EnsemblGRCh38hg38GRCh38
GRCh3713114,053,925 - 114,107,803 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,124,261 - 113,155,840 (-)NCBINCBI36Build 36hg18NCBI36
Celera1394,904,802 - 94,935,830 (-)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,515,694 - 94,547,434 (-)NCBIHuRef
CHM1_113114,044,997 - 114,075,611 (-)NCBICHM1_1
T2T-CHM13v2.013112,655,703 - 112,712,331 (-)NCBIT2T-CHM13v2.0
Adprhl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,268,449 - 13,304,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,271,663 - 13,304,162 (-)EnsemblGRCm39 Ensembl
GRCm38813,218,788 - 13,254,542 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,221,663 - 13,254,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,235,662 - 13,254,162 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,235,639 - 13,254,139 (-)NCBIMGSCv36mm8
Celera813,403,746 - 13,422,397 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
Adprhl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404494,123 - 524,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404494,185 - 512,295 (+)NCBIChiLan1.0ChiLan1.0
ADPRHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,897,179 - 114,961,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,592,355 - 113,650,566 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,563,333 - 94,598,128 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,626,862 - 113,656,944 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,608,795 - 113,656,541 (-)Ensemblpanpan1.1panPan2
ADPRHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,726,916 - 60,748,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,438,860 - 60,460,642 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,412,272 - 61,434,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,412,274 - 61,434,152 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12260,851,116 - 60,872,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02260,853,246 - 60,874,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02260,884,334 - 60,906,120 (-)NCBIUU_Cfam_GSD_1.0
Adprhl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,629,951 - 195,642,464 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936472309,850 - 328,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADPRHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11178,662,293 - 78,677,945 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,368,290 - 86,404,163 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADPRHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,399,781 - 91,424,996 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604648,464,810 - 48,491,714 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adprhl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793597,504 - 610,847 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793597,391 - 610,426 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adprhl1
192 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 30 4
Low 2 12 1
Below cutoff 18 18 18 35 14 18

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026392   ⟹   ENSRNOP00000026391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,283,103 - 76,308,735 (+)Ensembl
Rnor_6.0 Ensembl1681,616,604 - 81,632,030 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000026546   ⟹   ENSRNOP00000026546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,331,762 - 76,354,440 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000057740   ⟹   ENSRNOP00000054552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,283,103 - 76,312,350 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073240   ⟹   ENSRNOP00000065337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,331,762 - 76,354,439 (+)Ensembl
RefSeq Acc Id: NM_001013054   ⟹   NP_001013072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,985,355 - 83,000,794 (+)NCBI
mRatBN7.21676,283,186 - 76,298,626 (+)NCBI
Rnor_6.01681,616,604 - 81,632,018 (+)NCBI
Rnor_5.01681,104,502 - 81,136,225 (+)NCBI
RGSC_v3.41681,139,855 - 81,155,785 (+)RGD
Celera1674,089,906 - 74,105,320 (+)RGD
Sequence:
RefSeq Acc Id: NM_001409008   ⟹   NP_001395937
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,985,355 - 83,017,236 (+)NCBI
mRatBN7.21676,283,186 - 76,315,071 (+)NCBI
RefSeq Acc Id: XM_039095253   ⟹   XP_038951181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,006,966 - 83,017,240 (+)NCBI
mRatBN7.21676,298,777 - 76,315,075 (+)NCBI
RefSeq Acc Id: XM_063275261   ⟹   XP_063131331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81682,996,209 - 83,017,240 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013072   ⟸   NM_001013054
- Peptide Label: isoform 1
- UniProtKB: Q5XIB3 (UniProtKB/Swiss-Prot),   A6IWI7 (UniProtKB/TrEMBL),   A0A8L2QE10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026391   ⟸   ENSRNOT00000026392
RefSeq Acc Id: ENSRNOP00000065337   ⟸   ENSRNOT00000073240
RefSeq Acc Id: ENSRNOP00000026546   ⟸   ENSRNOT00000026546
RefSeq Acc Id: ENSRNOP00000054552   ⟸   ENSRNOT00000057740
RefSeq Acc Id: XP_038951181   ⟸   XM_039095253
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001395937   ⟸   NM_001409008
- Peptide Label: isoform 2
- UniProtKB: A0A8J8XAN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131331   ⟸   XM_063275261
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIB3-F1-model_v2 AlphaFold Q5XIB3 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305641 AgrOrtholog
BioCyc Gene G2FUF-10715 BioCyc
Ensembl Genes ENSRNOG00000019504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000062013 Ensembl
Ensembl Transcript ENSRNOT00000026392 ENTREZGENE
  ENSRNOT00000026392.9 UniProtKB/TrEMBL
  ENSRNOT00000057740 ENTREZGENE
  ENSRNOT00000057740.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.4080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193406 IMAGE-MGC_LOAD
InterPro ADP-ribosylarg_hydro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosyl_crysJ1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94724 IMAGE-MGC_LOAD
NCBI Gene 290880 ENTREZGENE
PANTHER [PROTEIN ADP-RIBOSYLARGININE] HYDROLASE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADP-RIBOSYLGLYCOHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADP_ribosyl_GH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adprhl1 PhenoGen
PIRSF ADP_ribslarg_hdr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019504 RatGTEx
  ENSRNOG00000062013 RatGTEx
Superfamily-SCOP SSF101478 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8J8XAN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QE10 ENTREZGENE, UniProtKB/TrEMBL
  A6IWI6_RAT UniProtKB/TrEMBL
  A6IWI7 ENTREZGENE, UniProtKB/TrEMBL
  ARHL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-07 Adprhl1  ADP-ribosylhydrolase like 1  LOC120093091  uncharacterized LOC120093091  Data merged from RGD:41323014 737654 PROVISIONAL
2022-06-02 Adprhl1  ADP-ribosylhydrolase like 1  AABR07026536.1    Data merged from RGD:15003482 737654 PROVISIONAL
2021-09-02 AABR07026536.1    Adprhl1  ADP-ribosylhydrolase like 1  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Adprhl1  ADP-ribosylhydrolase like 1  AABR07026536.1    Symbol and/or name change 19259462 PROVISIONAL
2021-01-27 LOC120093091  uncharacterized LOC120093091      Symbol and Name status set to provisional 70820 PROVISIONAL
2019-11-08 AABR07026536.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2005-12-06 Adprhl1  ADP-ribosylhydrolase like 1  Adprhl1_predicted  ADP-ribosylhydrolase like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Adprhl1_predicted  ADP-ribosylhydrolase like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED