Gene: Wfs1 (Wolfram syndrome 1 (wolframin)) Rattus norvegicus
Symbol: Wfs1
Name: Wolfram syndrome 1 (wolframin)
Description: ENCODES a protein that exhibits activating transcription factor binding; calcium-dependent protein binding; calmodulin binding; INVOLVED IN negative regulation of ATF6-mediated unfolded protein response; negative regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH Seizures; Stress Disorders, Post-Traumatic; Cataract, Nuclear Total (ortholog); FOUND IN proteasome complex; endoplasmic reticulum (ortholog); integral component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; Decabromodiphenyl oxide
Type: protein-coding
Also known as: Wolfram syndrome 1; Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.01478,640,707 - 78,665,224+NCBI
Rat Cytogenetic Map14q21 NCBI
RGSC Genome Assembly v5.01478,606,172 - 78,630,689+NCBI
RGSC Genome Assembly v3.41479,379,680 - 79,404,003+NCBI
Rat Celera Assembly1472,756,725 - 72,781,236+NCBI
Genome Assembly 3.11479,389,637 - 79,406,394+NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (RGSC Genome Assembly v5.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Wfs1
Entrez Gene
Ensembl Gene
Genome Browser
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 68954
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2015-05-12
Status: ACTIVE