Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) - Rat Genome Database

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Gene: Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) Rattus norvegicus
Analyze
Symbol: Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
RGD ID: 620512
Description: Enables several functions, including 3-hydroxyacyl-CoA dehydratase activity; adenyl nucleotide binding activity; and long-chain-3-hydroxyacyl-CoA dehydrogenase activity. Involved in fatty acid beta-oxidation and response to xenobiotic stimulus. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in mitochondrial trifunctional protein deficiency and steatotic liver disease. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha); PARTICIPATES IN fatty acid metabolic pathway; carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A hiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; MGC105338; monolysocardiolipin acyltransferase; RGD1560655; TP-alpha; trifunctional enzyme subunit alpha, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,907,801 - 31,947,434 (+)NCBIGRCr8
mRatBN7.2626,187,969 - 26,227,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,187,956 - 26,227,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,480,604 - 26,520,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,796,486 - 26,836,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,275,476 - 26,314,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,589,840 - 27,628,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,400,511 - 37,439,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,173,798 - 26,191,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,176,752 - 26,194,387NCBI
Celera625,664,847 - 25,704,584 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(R)-carnitine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
allethrin  (EXP)
allopurinol  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aspartame  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
Clofop  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
glutathione  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
linsidomine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
oleic acid  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
perflubutane  (ISO)
perfluorobutanesulfonic acid  (EXP,ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP,ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis. Asano J, etal., Cancer Sci. 2010 Apr;101(4):869-75. Epub 2009 Dec 8.
2. Potential roles of PINK1 for increased PGC-1alpha-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes. Choi J, etal., Mitochondrion. 2014 Sep;18:41-8. doi: 10.1016/j.mito.2014.09.005. Epub 2014 Sep 23.
3. The mitochondrial trifunctional protein: centre of a beta-oxidation metabolon? Eaton S, etal., Biochem Soc Trans. 2000 Feb;28(2):177-82.
4. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. Furuhashi M, etal., J Endocrinol. 2002 Aug;174(2):321-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular cloning of the cDNAs for the subunits of rat mitochondrial fatty acid beta-oxidation multienzyme complex. Structural and functional relationships to other mitochondrial and peroxisomal beta-oxidation enzymes. Kamijo T, etal., J Biol Chem 1993 Dec 15;268(35):26452-60.
8. Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Lane RH, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Jan;280(1):R183-90.
9. Proteomic analysis of liver mitochondria from rats with nonalcoholic steatohepatitis. Li L, etal., World J Gastroenterol. 2014 Apr 28;20(16):4778-86. doi: 10.3748/wjg.v20.i16.4778.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Widespread tissue expression of gastrin-binding-protein mRNA. Monstein HJ, etal., Eur J Biochem 1997 Jun 1;246(2):502-7.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. The molecular basis of pediatric long chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with maternal acute fatty liver of pregnancy. Sims HF, etal., Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):841-5.
20. Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. Uchida Y, etal., J Biol Chem. 1992 Jan 15;267(2):1034-41.
Additional References at PubMed
PMID:11390422   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15240869   PMID:15887119   PMID:18063578   PMID:18614015   PMID:18640292   PMID:20833797   PMID:23106098   PMID:23152787  
PMID:23979707   PMID:25002582   PMID:26316108   PMID:29476059   PMID:30053369   PMID:32357304   PMID:35352799  


Genomics

Comparative Map Data
Hadha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,907,801 - 31,947,434 (+)NCBIGRCr8
mRatBN7.2626,187,969 - 26,227,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,187,956 - 26,227,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,480,604 - 26,520,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,796,486 - 26,836,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,275,476 - 26,314,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,589,840 - 27,628,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,400,511 - 37,439,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,173,798 - 26,191,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,176,752 - 26,194,387NCBI
Celera625,664,847 - 25,704,584 (+)NCBICelera
Cytogenetic Map6q14NCBI
HADHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,190,635 - 26,244,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,190,635 - 26,244,672 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,413,504 - 26,467,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,267,008 - 26,321,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,325,159 - 26,379,140NCBI
Celera226,253,733 - 26,307,825 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,149,287 - 26,203,382 (-)NCBIHuRef
CHM1_1226,343,424 - 26,397,498 (-)NCBICHM1_1
T2T-CHM13v2.0226,225,960 - 26,279,973 (-)NCBIT2T-CHM13v2.0
Hadha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,324,421 - 30,359,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,323,302 - 30,360,160 (-)EnsemblGRCm39 Ensembl
GRCm38530,119,423 - 30,154,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,118,304 - 30,155,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,444,844 - 30,481,520 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,449,091 - 30,485,767 (-)NCBIMGSCv36mm8
Celera527,635,841 - 27,672,518 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.95NCBI
Hadha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,183,945 - 8,233,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,183,945 - 8,233,869 (-)NCBIChiLan1.0ChiLan1.0
HADHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,273,366 - 100,327,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,277,338 - 100,331,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,185,938 - 26,240,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,279,761 - 26,334,068 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,279,995 - 26,334,068 (-)Ensemblpanpan1.1panPan2
HADHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,307,207 - 20,355,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,307,226 - 20,355,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,202,960 - 20,251,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,629,967 - 20,678,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,629,967 - 20,678,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,316,604 - 20,365,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,326,338 - 20,376,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,374,308 - 20,422,731 (-)NCBIUU_Cfam_GSD_1.0
Hadha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,182,261 - 6,224,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,690,643 - 119,782,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HADHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,411,620 - 81,468,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,411,648 - 81,472,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,689,160 - 30,746,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,338,250 - 8,384,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,338,250 - 8,384,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hadha
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000038649
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH128498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,227,508 - 26,227,692 (+)MAPPERmRatBN7.2
Rnor_6.0627,628,825 - 27,629,008NCBIRnor6.0
Rnor_5.0637,439,496 - 37,439,679UniSTSRnor5.0
Celera625,704,488 - 25,704,671UniSTS
RH 3.4 Map6118.88UniSTS
Cytogenetic Map6q14UniSTS
RH143343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,198,809 - 26,199,470 (+)MAPPERmRatBN7.2
Rnor_6.0627,600,679 - 27,601,339NCBIRnor6.0
Rnor_5.0637,411,350 - 37,412,010UniSTSRnor5.0
RGSC_v3.4626,184,637 - 26,185,297UniSTSRGSC3.4
Celera625,675,686 - 25,676,346UniSTS
RH 3.4 Map6118.48UniSTS
Cytogenetic Map6q14UniSTS
AI535136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,191,495 - 26,191,587 (+)MAPPERmRatBN7.2
Rnor_6.0627,593,365 - 27,593,456NCBIRnor6.0
Rnor_5.0637,404,036 - 37,404,127UniSTSRnor5.0
RGSC_v3.4626,177,323 - 26,177,414UniSTSRGSC3.4
Celera625,668,372 - 25,668,463UniSTS
RH 3.4 Map6119.8UniSTS
Cytogenetic Map6q14UniSTS
BE100255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,187,268 - 26,187,482 (+)MAPPERmRatBN7.2
Rnor_6.0627,589,140 - 27,589,353NCBIRnor6.0
Rnor_5.0637,399,811 - 37,400,024UniSTSRnor5.0
RGSC_v3.4626,173,098 - 26,173,311UniSTSRGSC3.4
Celera625,664,147 - 25,664,360UniSTS
RH 3.4 Map6118.2UniSTS
Cytogenetic Map6q14UniSTS
D12S1229E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,224,176 - 26,224,299 (+)MAPPERmRatBN7.2
Rnor_6.0627,625,409 - 27,625,531NCBIRnor6.0
Rnor_5.0637,436,080 - 37,436,202UniSTSRnor5.0
Celera625,701,174 - 25,701,296UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038649   ⟹   ENSRNOP00000038073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl626,187,956 - 26,227,862 (+)Ensembl
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102817   ⟹   ENSRNOP00000087470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl626,187,962 - 26,227,869 (+)Ensembl
RefSeq Acc Id: NM_130826   ⟹   NP_570839
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,907,801 - 31,947,434 (+)NCBI
mRatBN7.2626,187,969 - 26,227,605 (+)NCBI
Rnor_6.0627,589,840 - 27,628,921 (+)NCBI
Rnor_5.0637,400,511 - 37,439,592 (+)NCBI
RGSC_v3.4626,173,798 - 26,191,433 (+)RGD
Celera625,664,847 - 25,704,584 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_570839   ⟸   NM_130826
- Peptide Label: precursor
- UniProtKB: Q5BIZ5 (UniProtKB/Swiss-Prot),   Q64428 (UniProtKB/Swiss-Prot),   A6HAE4 (UniProtKB/TrEMBL),   A0A8I6A8P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038073   ⟸   ENSRNOT00000038649
RefSeq Acc Id: ENSRNOP00000087470   ⟸   ENSRNOT00000102817
Protein Domains
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64428-F1-model_v2 AlphaFold Q64428 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694468
Promoter ID:EPDNEW_R4993
Type:multiple initiation site
Name:Hadha_1
Description:hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complexsubunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0627,589,818 - 27,589,878EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620512 AgrOrtholog
BioCyc Gene G2FUF-38302 BioCyc
Ensembl Genes ENSRNOG00000024629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055020140 UniProtKB/Swiss-Prot
  ENSRNOG00060011914 UniProtKB/Swiss-Prot
  ENSRNOG00065024062 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038649 ENTREZGENE
  ENSRNOT00000038649.7 UniProtKB/Swiss-Prot
  ENSRNOT00000102817.1 UniProtKB/TrEMBL
  ENSRNOT00055034408 UniProtKB/Swiss-Prot
  ENSRNOT00060020179 UniProtKB/Swiss-Prot
  ENSRNOT00065041333 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1040.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301707 IMAGE-MGC_LOAD
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fa_ox_alpha_mit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105338 IMAGE-MGC_LOAD
NCBI Gene 170670 ENTREZGENE
PANTHER TRIFUNCTIONAL ENZYME SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HCDH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hadha PhenoGen
PROSITE 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024629 RatGTEx
  ENSRNOG00055020140 RatGTEx
  ENSRNOG00060011914 RatGTEx
  ENSRNOG00065024062 RatGTEx
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A8P4 ENTREZGENE, UniProtKB/TrEMBL
  A6HAE4 ENTREZGENE, UniProtKB/TrEMBL
  ECHA_RAT UniProtKB/Swiss-Prot
  Q5BIZ5 ENTREZGENE
  Q64428 ENTREZGENE
UniProt Secondary Q5BIZ5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-19 Hadha  hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha  Hadha  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Hadha  hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit  Hadha  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hadha  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit    hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A hiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit  Name updated 1299863 APPROVED
2002-08-07 Hadha  hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A hiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL