The Hybrid Rat Diversity Panel

The HXB/BXH recombinant inbred strains were derived from the Spontaneously Hypertensive Rat (SHR/Olalpcv) and the normotensive BN-Lx (BN-Lx/Cub), a Brown Norway congenic rat strain with polydactyly-luxate syndrome. The FXLE x LEXF recombinant inbred strains were derived from the Long Evans strain (LE/Stm) and the Fischer F344 strain (F344/Stm).

Notes:

• In the tables below, an asterisk (*) designates that the tagged strain has been sequenced. The VCF files for these (48 strains in total) are available for download. These data have been mapped to both Rn6 and Rn7 and can be accessed here.
• The double dagger icons (‡) designate the strains that have been found by whole genome sequence comparison to be the most genetically similar to the Heterogeneous Stock (HS) Founder Strains. This data is courtesy of Dr. Abraham Palmer (University of California, San Diego) and Dr. Hao Chen (University of Tennessee Health Sciences Center). For more information about the HS Founders and the HRDP strains that are similar to them, click here.
• The inbred Wistar WN/N strain is no longer available and no closely related substrains are included in the HRDP panel. However, DNA from a frozen tissue sample from the original NIH strain has been sequenced and that sequence compared to WGS from the HRDP strains. Of the strains currently available from the HRDP, the one found in this analysis to be most closely related to WN/N is WAG/RijCrl with a sequence similarity of approximately 76%.

 
Click here to use RGD’s Variant Visualizer tool to explore variants in HRDP strains mapped against the mRatBN7.2 reference (all HRDP strains pre-selected) or click here to begin your own query in Variant Visualizer.

Quantitative phenotype measurements are available for many of the HRDP strains. Click here to explore this data in RGD’s PhenoMiner tool. Select a measurement or a phenotype category on the resulting page to view a graph of the data.

The strains included in the HRDP panel are: