Ben Gurion University Barzilai Medical Center, Ashkelon, Israel
Bred from the original SBH colony established by Ben-Ishay at the Hebrew University Medical Center in Jerusalem. The original colony was found to be partly outbred and display phenotypic variability. To purify the colony and establish phenotypic homogeneity breeding pairs from the original colony were transferred to Ben Gurion University Barzilai Medical Center in Ashkelon, Israel in 1992 where renewed secondary breeding was performed.
Baseline systolic BP of SBH/Ygl has been measured as 139+/-1mmHg, no sex differences between male and female rats were observed. SBP rises to 192 +/-2 mmHg following 4 weeks of salt loading with DOCA-salt. Develop diastolic hypertension, DBP rising from baseline of 88 +/-1mmHg to around 125mmHg following 4 weeks of salt loading.