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Phenotype AnnotationsPhenotype Annotations
Phenotype AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | crystalluria | Induced | IED | | 2313354 | hydroxyproline induced | RGD | | decreased renin activity | | IED | | 727992 | | RGD | | mammary adenocarcinoma | Resistance | IED | | 2301186 | induced by DMBA | RGD | | | |||||||||||||||||||||||||||||||||||||||||||||||||
Phenotype Values via PhenominerDisease AnnotationsPhenotype Annotations
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Phenotype Values via Phenominer| Options: | View chart | | | Download data table | | | View expanded data table |
References - curatedRGD Disease Portals| BN/NHsdMcwi has been annotated in the following RGD Disease Portals. |
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Strain QTL Data| Symbol | Name | Trait | Subtrait |
| Bp349 | Blood pressure QTL 349 | Blood pressure | salt-loaded |
| Bp350 | Blood pressure QTL 350 | Blood pressure | salt-loaded |
| Bp351 | Blood pressure QTL 351 | Blood pressure | salt-loaded |
| Bp352 | Blood pressure QTL 352 | Blood pressure | salt-loaded |
| Bp353 | Blood pressure QTL 353 | Blood pressure | salt-loaded |
| Bp354 | Blood pressure QTL 354 | Blood pressure | salt-depleted |
| Bp355 | Blood pressure QTL 355 | Blood pressure | salt-loaded |
| Gluco57 | Glucose level QTL 57 | Glucose level | postprandial |
| Gluco58 | Glucose level QTL 58 | Glucose level | postprandial |
| Gluco59 | Glucose level QTL 59 | Glucose level | postprandial |
| Gluco60 | Glucose level QTL 60 | Glucose level | postprandial |
| Pur21 | Proteinuria QTL 21 | Renal function | urine protein level |
| Pur22 | Proteinuria QTL 22 | Renal function | urine protein level |
| Rf57 | Renal function QTL 57 | Renal function | structural damage of the kidney |
| Rf58 | Renal function QTL 58 | Renal function | structural damage of the kidney |
| Scl66 | Serum cholesterol level QTL 66 | Lipid level | serum cholesterol |
| Stl24 | Serum triglyceride level QTL 24 | Lipid level | serum triglyceride level |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| strain_drgs_chems | The aortic rings of animals on low-salt diet and high salt-diet were less sensitive to phenylephrine as compared to the parental SS and less sensitive to acetylcholine when on high salt-diet. | 1598768 |
| strain_life_disease | These are a suitable model for resistance to myocardial ischemia. | 1342469 |
| strain_other | Mitochondrial DNA is 16,313 bp in size | 2325144 |
| strain_phys_biochem | Cowley et al. reported the following arterial blood pressure measurements for this strain: Systolic arterial pressure (SAP) averaged 127 +/- 3 mmHg, and diastolic arterial pressure (DAP) averaged 94 +/- 2 mmHg. Mean arterial blood pressure determined during the inactive light cycle of male rats (n = 42) maintained for nearly 4 wk on 8% NaCl rat chow averaged 109 +/- 2 mmHg and ranged from 89 to 145 mmHg. Active MAP of rats on day 2 of recording averaged 114 +/- 4 mmHg, Inactive MAP on the same day averaged 109 +/- 3 mmHg. The reduction of MAP that occurs during the 36 h following sodium depletion averaged 14 +/- 2 mmHg. | 629526 |
| strain_reproduction | Cowley et al. maintained their stock on a 0.4% NaCl rat chow as a 0.1%NaCl diet impairs fertility in SS though it has not been tested in BN. | 629526 |
| strain_reproduction | The average generation is 49 days and the average litter size is 2.7 pups. | 629526 |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2013-04-15 | BN/NHsdMcwi | BN/NHsdMcwi | Name updated | 853 | APPROVED | ||
| 2013-04-15 | BN/NHsdMcwi | BN/NHsdMcwi | Name updated | 853 | APPROVED | ||
| 2012-04-06 | BN/NHsdMcwi | BN/NHsdMcwi | Name updated | 853 | APPROVED | ||
| 2012-04-06 | BN/NHsdMcwi | BN/NHsdMcwi | Name updated | 853 | APPROVED |
 | Strain Nomenclature |
| Strain Registration |
| RGD Object Information | |
| RGD ID: | 61498 |
| Created: | 2001-02-13 |
| Species: | Rattus norvegicus |
| Last Modified: | 2003-01-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.