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Strain Registration

Strain: LH/MavRrrc

Symbol: LH/MavRrrc
Strain: LH
Substrain: MavRrrc
Full Name: Lyon Hypertensive
RGD ID: 60990
Citation ID: RRID:RRRC_00057
Ontology ID: RS:0000554
Type: inbred
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: Lyon Hypertensive. In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed, unrestrained, conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F27(Lyon).
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2020-02-13)





References

References - curated
# Reference Title Reference Citation
1. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
2. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
3. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
4. Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Ohta KY, etal., Drug Metab Dispos. 2006 Nov;34(11):1868-74. Epub 2006 Aug 23.
5. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. New target regions for human hypertension via comparative genomics. Stoll M, etal., Genome Res 2000 Apr;10(4):473-82.
8. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. Vincent M, etal., J Clin Invest 1997 Oct 15;100(8):2000-6

Region

Strain QTL Data
Symbol Name Trait
Bp357 Blood pressure QTL 357 arterial blood pressure trait   (VT:2000000)    
Bp50 Blood pressure QTL 50 arterial blood pressure trait   (VT:2000000)    
BpQTLCluster2 Blood pressure QTL cluster 2 arterial blood pressure trait   (VT:2000000)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 LH/MavRrrc (ICL) View Damaging Variants
Rnor_5.0 LH/MavRrrc (KNAW) View Damaging Variants
Rnor_6.0 LH/MavRrrc (RGD) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
null The strain exhibits mild hypertension (approx 165mmHg in males and 140mmHg in females at 14 weeks of age in 1984) with increased body weight and plasma lipids. There is reduced life-span (compared with LN and LL) with histopathological lesions characterisitc of hypertensive disease in rats. The renin-angiotensin system, renal synthesis of prostaglandins and the secretion of vasopressin do not seem to be involved, but there is increased efficiency of the sympathetic nervous system (Vincent et al 1984). Develop marked cardiovascular habituation to repeated stress, with a low level of emotional responsiveness (Julien et al, 1992). Renin release of isolated kidneys is independent of perfusion pressure and renal thromboxane A2/prostaglandin H-2 receptor activation participates in renin release and in the altered kidney function of these rats (Medeiros et al, 1992). A significant association has been observed between blood pressure and a microsatellite marker near the renin gene on chromosome 13 and between pulse pressure and the carboxypeptidase B gene on chromosome 2. (Dubay et al, 1993). Blood pressure also co-segregated with plasma cholesterol levels, and to a lesser degree insulin levels in crosses involving LH and LN (Vincent et al, 1993). Neonatal thymectomy prevents the development of hypertension. This is not secondary to a decreased secretion of catecholamines, renin, mineralcorticoids and testosterone, suggesting that the role of the thymus is probably mediated by cellular immune mechanisms (Bataillard et al, 1993).Other papers using this strain include Lortet et al, (1993), Medeiros et al, (1994)  

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-01 LH/MavRrrc  Lyon Hypertensive  LH  Lyon Hypertensive  Symbol and/or name change 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00057 RGD