HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) - Rat Genome Database

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Gene: HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha) Sus scrofa
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Symbol: HADHA
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
RGD ID: 13912259
Description: ENCODES a protein that exhibits 3-hydroxyacyl-CoA dehydratase activity (ortholog); 3-hydroxyacyl-CoA dehydrogenase activity (ortholog); acetyl-CoA C-acyltransferase activity (ortholog); INVOLVED IN cardiolipin acyl-chain remodeling (ortholog); fatty acid beta-oxidation (ortholog); response to insulin (ortholog); PARTICIPATES IN carnitine palmitoyltransferase I deficiency pathway; ethylmalonic encephalopathy pathway; fatty acid beta degradation pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN mitochondrial fatty acid beta-oxidation multienzyme complex (ortholog); mitochondrial nucleoid (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 78 kDa gastrin-binding protein; gastrin-binding protein; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit; monolysocardiolipin acyltransferase; TP-alpha; trifunctional enzyme subunit alpha, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,690,643 - 119,782,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:7881821   PMID:8297352   PMID:8399347   PMID:8448993   PMID:8512557   PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HADHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,690,643 - 119,782,862 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HADHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,190,635 - 26,244,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,190,635 - 26,244,672 (-)EnsemblGRCh38hg38GRCh38
GRCh37226,413,504 - 26,467,500 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,267,008 - 26,321,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34226,325,159 - 26,379,140NCBI
Celera226,253,733 - 26,307,825 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef226,149,287 - 26,203,382 (-)NCBIHuRef
CHM1_1226,343,424 - 26,397,498 (-)NCBICHM1_1
T2T-CHM13v2.0226,225,960 - 26,279,973 (-)NCBIT2T-CHM13v2.0
Hadha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39530,324,421 - 30,359,978 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl530,323,302 - 30,360,160 (-)EnsemblGRCm39 Ensembl
GRCm38530,119,423 - 30,154,980 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,118,304 - 30,155,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv37530,444,844 - 30,481,520 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36530,449,091 - 30,485,767 (-)NCBIMGSCv36mm8
Celera527,635,841 - 27,672,518 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map515.95NCBI
Hadha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,907,801 - 31,947,434 (+)NCBIGRCr8
mRatBN7.2626,187,969 - 26,227,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,187,956 - 26,227,869 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,480,604 - 26,520,240 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,796,486 - 26,836,120 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,275,476 - 26,314,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,589,840 - 27,628,921 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,589,657 - 27,629,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,400,511 - 37,439,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,173,798 - 26,191,433 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,176,752 - 26,194,387NCBI
Celera625,664,847 - 25,704,584 (+)NCBICelera
Cytogenetic Map6q14NCBI
Hadha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,183,945 - 8,233,869 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,183,945 - 8,233,869 (-)NCBIChiLan1.0ChiLan1.0
HADHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,273,366 - 100,327,709 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,277,338 - 100,331,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,185,938 - 26,240,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,279,761 - 26,334,068 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,279,995 - 26,334,068 (-)Ensemblpanpan1.1panPan2
HADHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,307,207 - 20,355,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,307,226 - 20,355,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,202,960 - 20,251,371 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,629,967 - 20,678,383 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,629,967 - 20,678,631 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,316,604 - 20,365,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,326,338 - 20,376,047 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,374,308 - 20,422,731 (-)NCBIUU_Cfam_GSD_1.0
Hadha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,615,197 - 64,656,732 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,182,261 - 6,224,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,182,786 - 6,224,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,411,620 - 81,468,415 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,411,648 - 81,472,257 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,689,160 - 30,746,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,338,250 - 8,384,704 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,338,250 - 8,384,701 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HADHA
1327 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 15 2 3 3
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009377   ⟹   ENSSSCP00000009137
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000069687   ⟹   ENSSSCP00000071677
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000091553   ⟹   ENSSSCP00000071691
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3112,752,865 - 112,797,733 (+)Ensembl
RefSeq Acc Id: NM_213962   ⟹   NP_999127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13112,753,343 - 112,797,627 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999127   ⟸   NM_213962
- UniProtKB: Q29554 (UniProtKB/Swiss-Prot),   A0A480VWY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009137   ⟸   ENSSSCT00000009377
RefSeq Acc Id: ENSSSCP00000071677   ⟸   ENSSSCT00000069687
RefSeq Acc Id: ENSSSCP00000071691   ⟸   ENSSSCT00000091553
Protein Domains
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000008571 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025056700 UniProtKB/TrEMBL
  ENSSSCG00050040834 UniProtKB/TrEMBL
  ENSSSCG00055008692 UniProtKB/Swiss-Prot
  ENSSSCG00060051183 UniProtKB/TrEMBL
  ENSSSCG00070012038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009377 ENTREZGENE
  ENSSSCT00000009377.5 UniProtKB/Swiss-Prot
  ENSSSCT00000069687.2 UniProtKB/TrEMBL
  ENSSSCT00000091553.2 UniProtKB/TrEMBL
  ENSSSCT00025078629.1 UniProtKB/TrEMBL
  ENSSSCT00050055314.1 UniProtKB/TrEMBL
  ENSSSCT00055017005.1 UniProtKB/Swiss-Prot
  ENSSSCT00060069661.1 UniProtKB/TrEMBL
  ENSSSCT00070023491.1 UniProtKB/Swiss-Prot
  ENSSSCT00070023508.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1040.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hyd/isom_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Enoyl-CoA_hydra/iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fa_ox_alpha_mit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397012 UniProtKB/Swiss-Prot
NCBI Gene HADHA ENTREZGENE
PANTHER TRIFUNCTIONAL ENZYME SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HCDH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ECH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENOYL_COA_HYDRATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480VWY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1TSV0_PIG UniProtKB/TrEMBL
  A0A5G2R3M6_PIG UniProtKB/TrEMBL
  A0A5G2RBW4_PIG UniProtKB/TrEMBL
  B2ZF49_PIG UniProtKB/TrEMBL
  ECHA_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:88772 ENTREZGENE