Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:10066 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACO1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | RGD:10066 | 6480464 | Estradiol affects the expression of ACO1 mRNA | CTD | PMID:16684588 | 17beta-estradiol | decreases expression | ISO | RGD:10067 | 6480464 | Estradiol results in decreased expression of ACO1 mRNA | CTD | PMID:21185374 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10066 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ACO1 mRNA | CTD | PMID:18163543 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10066 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ACO1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10066 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACO1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases activity | ISO | RGD:10066 | 6480464 | Tetrachlorodibenzodioxin results in decreased activity of ACO1 protein | CTD | PMID:9443932 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of ACO1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ACO1 mRNA | CTD | PMID:21346803 | 2-butoxyethanol | increases expression | ISO | RGD:10066 | 6480464 | n-butoxyethanol results in increased expression of ACO1 mRNA | CTD | PMID:19812364 | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:10066 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of ACO1 mRNA | CTD | PMID:18648102 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of ACO1 mRNA | CTD | PMID:19483382 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | aluminium atom | decreases activity | EXP | | 6480464 | Aluminum results in decreased activity of ACO1 protein | CTD | PMID:10806405 | aluminium(0) | decreases activity | EXP | | 6480464 | Aluminum results in decreased activity of ACO1 protein | CTD | PMID:10806405 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of ACO1 mRNA | CTD | PMID:19483382 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ACO1 mRNA | CTD | PMID:16483693 | arsenic atom | increases activity | ISO | RGD:10067 | 6480464 | Arsenic results in increased activity of ACO1 protein | CTD | PMID:16386771 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of ACO1 mRNA | CTD | PMID:19483382 | benzo[a]pyrene | multiple interactions | ISO | RGD:10066 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of ACO1 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | ISO | RGD:10066 | 6480464 | Benzo(a)pyrene results in increased expression of ACO1 mRNA | CTD | PMID:22228805 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of ACO1 mRNA | CTD | PMID:19483382 | clofibrate | increases activity | EXP | | 6480464 | Clofibrate results in increased activity of ACO1 protein | CTD | PMID:11969379 | clofibric acid | affects expression | EXP | | 6480464 | Clofibric Acid affects the expression of ACO1 mRNA | CTD | PMID:17602206 | cobalt atom | increases activity | ISO | RGD:10067 | 6480464 | Cobalt results in increased activity of ACO1 protein | CTD | PMID:16877034 PMID:16386771 | cobalt atom | increases activity | ISO | RGD:10067 | 6480464 | Cobalt results in increased activity of ACO1 protein | CTD | PMID:16386771 PMID:16877034 | copper atom | increases activity | ISO | RGD:10067 | 6480464 | Copper results in increased activity of ACO1 protein | CTD | PMID:16386771 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of ACO1 mRNA | CTD | PMID:22465980 | copper(0) | increases activity | ISO | RGD:10067 | 6480464 | Copper results in increased activity of ACO1 protein | CTD | PMID:16386771 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of ACO1 mRNA | CTD | PMID:22465980 | coumarin | affects expression | EXP | | 6480464 | coumarin affects the expression of ACO1 mRNA | CTD | PMID:16963487 | cyclosporin A | decreases expression | ISO | RGD:10067 | 6480464 | Cyclosporine results in decreased expression of ACO1 mRNA | CTD | PMID:20106945 | desferrioxamine B | increases activity | ISO | RGD:10066 | 6480464 | Deferoxamine results in increased activity of ACO1 protein | CTD | PMID:11054110 | desferrioxamine B | increases activity | ISO | RGD:10066 | 6480464 | Deferoxamine results in increased activity of ACO1 protein | CTD | PMID:11054110 PMID:18073202 | desferrioxamine B | multiple interactions | EXP | | 6480464 | [Deferoxamine results in decreased abundance of Iron] which results in increased activity of ACO1 protein | CTD | PMID:15893546 | desferrioxamine B | increases activity | EXP | | 6480464 | Deferoxamine results in increased activity of ACO1 protein | CTD | PMID:16568477 | diarsenic trioxide | decreases expression | ISO | RGD:10067 | 6480464 | arsenic trioxide results in decreased expression of ACO1 protein | CTD | PMID:19364129 | diarsenic trioxide | increases expression | ISO | RGD:10067 | 6480464 | arsenic trioxide results in increased expression of ACO1 mRNA | CTD | PMID:20458559 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | doxorubicin | affects response to substance | ISO | RGD:10067 | 6480464 | ACO1 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | doxorubicin | affects activity | EXP | | 6480464 | Doxorubicin affects the activity of ACO1 protein | CTD | PMID:11731422 | fenofibrate | increases expression | EXP | | 6480464 | Fenofibrate results in increased expression of ACO1 mRNA | CTD | PMID:17264098 | ferric ammonium citrate | increases activity | ISO | RGD:10066 | 6480464 | ferric ammonium citrate results in increased activity of ACO1 protein | CTD | PMID:11054110 | ferric ammonium citrate | decreases activity | ISO | RGD:10066 | 6480464 | ferric ammonium citrate results in decreased activity of ACO1 protein | CTD | PMID:18073202 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of ACO1 gene | CTD | PMID:22079235 | hemin | decreases activity | EXP | | 6480464 | Hemin results in decreased activity of ACO1 protein | CTD | PMID:16568477 | hydrogen peroxide | increases activity | ISO | RGD:10066 | 6480464 | Hydrogen Peroxide results in increased activity of ACO1 protein | CTD | PMID:15664434 | hydrogen peroxide | affects expression | ISO | RGD:10067 | 6480464 | Hydrogen Peroxide affects the expression of ACO1 mRNA | CTD | PMID:20044591 | iron atom | multiple interactions | ISO | RGD:10067 | 6480464 | Iron inhibits the reaction [Nickel results in increased activity of ACO1 protein] | CTD | PMID:16877034 | iron atom | multiple interactions | EXP | | 6480464 | [Deferoxamine results in decreased abundance of Iron] which results in increased activity of ACO1 protein | CTD | PMID:15893546 | iron atom | multiple interactions | ISO | RGD:10067 | 6480464 | Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein] | CTD | PMID:16039939 | iron atom | affects metabolic processing | ISO | RGD:10066 | 6480464 | ACO1 protein affects the metabolism of Iron | CTD | PMID:17194590 | iron(3+) sulfate | multiple interactions | ISO | RGD:10067 | 6480464 | ferric sulfate inhibits the reaction [Nickel results in increased activity of ACO1 protein] | CTD | PMID:16877034 | isotretinoin | decreases expression | ISO | RGD:10067 | 6480464 | Isotretinoin results in decreased expression of ACO1 mRNA | CTD | PMID:20436886 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of ACO1 mRNA | CTD | PMID:19483382 | manganese atom | decreases activity | EXP | | 6480464 | Manganese results in decreased activity of ACO1 protein | CTD | PMID:17469137 | manganese atom | increases activity | EXP | | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16545456 PMID:16568477 | manganese atom | multiple interactions | EXP | | 6480464 | Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA] | CTD | PMID:16729984 | manganese atom | increases activity | EXP | | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16568477 PMID:16545456 | manganese atom | increases activity | ISO | RGD:10067 | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16386771 | manganese(0) | decreases activity | EXP | | 6480464 | Manganese results in decreased activity of ACO1 protein | CTD | PMID:17469137 | manganese(0) | increases activity | EXP | | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16545456 PMID:16568477 | manganese(0) | multiple interactions | EXP | | 6480464 | Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA] | CTD | PMID:16729984 | manganese(0) | increases activity | EXP | | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16568477 PMID:16545456 | manganese(0) | increases activity | ISO | RGD:10067 | 6480464 | Manganese results in increased activity of ACO1 protein | CTD | PMID:16386771 | manganese(II) chloride | increases activity | EXP | | 6480464 | manganese chloride results in increased activity of ACO1 protein | CTD | PMID:16568477 PMID:16545456 | manganese(II) chloride | increases activity | EXP | | 6480464 | manganese chloride results in increased activity of ACO1 protein | CTD | PMID:15893546 more ... | manganese(II) chloride | increases activity | EXP | | 6480464 | manganese chloride results in increased activity of ACO1 protein | CTD | PMID:16545456 PMID:16568477 | menadione | affects activity | ISO | RGD:10066 | 6480464 | Vitamin K 3 affects the activity of ACO1 protein | CTD | PMID:10037708 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of ACO1 protein | CTD | PMID:19826936 | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | mitomycin C | affects response to substance | ISO | RGD:10067 | 6480464 | ACO1 protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of ACO1 mRNA | CTD | PMID:15890375 | nickel atom | multiple interactions | ISO | RGD:10067 | 6480464 | ferric sulfate inhibits the reaction [Nickel results in increased activity of ACO1 protein]; more ... | CTD | PMID:16877034 | nickel atom | increases activity | ISO | RGD:10067 | 6480464 | Nickel results in increased activity of ACO1 protein | CTD | PMID:16877034 PMID:16386771 | nickel atom | increases activity | ISO | RGD:10067 | 6480464 | Nickel results in increased activity of ACO1 protein | CTD | PMID:16386771 PMID:16877034 | nickel dichloride | decreases activity | ISO | RGD:10067 | 6480464 | nickel chloride results in decreased activity of ACO1 protein | CTD | PMID:17018869 | nickel dichloride | increases activity | ISO | RGD:10067 | 6480464 | nickel chloride results in increased activity of ACO1 protein | CTD | PMID:16039939 PMID:16649251 | nickel dichloride | increases activity | ISO | RGD:10067 | 6480464 | nickel chloride results in increased activity of ACO1 protein | CTD | PMID:16649251 PMID:16039939 | nickel dichloride | multiple interactions | ISO | RGD:10067 | 6480464 | Iron inhibits the reaction [nickel chloride results in increased activity of ACO1 protein]; more ... | CTD | PMID:16039939 | nickel dichloride | increases activity | ISO | RGD:10067 | 6480464 | nickel chloride results in increased activity of ACO1 protein | CTD | PMID:16649251 | nickel sulfate | decreases expression | ISO | RGD:10067 | 6480464 | nickel sulfate results in decreased expression of ACO1 mRNA | CTD | PMID:16780908 | nitric oxide | decreases expression | ISO | RGD:10066 | 6480464 | Nitric Oxide results in decreased expression of ACO1 mRNA | CTD | PMID:16886906 | nitric oxide | multiple interactions | ISO | RGD:10066 | 6480464 | STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]; more ... | CTD | PMID:16886906 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of ACO1 mRNA | CTD | PMID:19483382 | paracetamol | affects expression | ISO | RGD:10066 | 6480464 | Acetaminophen affects the expression of ACO1 mRNA | CTD | PMID:17562736 | paraquat | increases activity | ISO | RGD:10066 | 6480464 | Paraquat results in increased activity of ACO1 protein | CTD | PMID:15664434 | paraquat | decreases activity | EXP | | 6480464 | Paraquat results in decreased activity of ACO1 protein | CTD | PMID:17324120 PMID:11520895 | paraquat | decreases activity | EXP | | 6480464 | Paraquat results in decreased activity of ACO1 protein | CTD | PMID:11520895 PMID:17324120 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of ACO1 mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:10067 | 6480464 | Phenobarbital affects the expression of ACO1 mRNA | CTD | PMID:19159669 | phlorizin | decreases expression | ISO | RGD:10066 | 6480464 | Phlorhizin results in decreased expression of ACO1 mRNA | CTD | PMID:22538082 | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of ACO1 mRNA | CTD | PMID:15890375 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:16940010 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:15890375 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:15890375 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:15890375 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:16940010 more ... | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACO1 mRNA | CTD | PMID:19162173 more ... | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of ACO1 mRNA | CTD | PMID:19483382 | quercetin | increases expression | EXP | | 6480464 | Quercetin results in increased expression of ACO1 mRNA | CTD | PMID:17103110 | rosiglitazone | increases expression | EXP | | 6480464 | rosiglitazone results in increased expression of ACO1 mRNA | CTD | PMID:21515302 | rotenone | decreases activity | ISO | RGD:10067 | 6480464 | Rotenone results in decreased activity of ACO1 protein | CTD | PMID:21570952 | rotenone | increases activity | ISO | RGD:10067 | 6480464 | Rotenone results in increased activity of ACO1 protein | CTD | PMID:21570952 | tert-butyl hydroperoxide | increases expression | ISO | RGD:10067 | 6480464 | tert-Butylhydroperoxide results in increased expression of ACO1 mRNA | CTD | PMID:15336504 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of ACO1 mRNA | CTD | PMID:19483382 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of ACO1 mRNA | CTD | PMID:21515302 | vanadium atom | increases activity | ISO | RGD:10067 | 6480464 | Vanadium results in increased activity of ACO1 protein | CTD | PMID:16386771 | vanadium(0) | increases activity | ISO | RGD:10067 | 6480464 | Vanadium results in increased activity of ACO1 protein | CTD | PMID:16386771 | zinc atom | decreases activity | ISO | RGD:10066 | 6480464 | Zinc deficiency results in decreased activity of ACO1 protein | CTD | PMID:18073202 | zinc(0) | decreases activity | ISO | RGD:10066 | 6480464 | Zinc deficiency results in decreased activity of ACO1 protein | CTD | PMID:18073202 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











