Gene: Il12b (interleukin 12B)  Rattus norvegicus Symbol: Il12b Name: interleukin 12B Description: ENCODES a protein that exhibits interleukin-12 alpha subunit binding; protein heterodimerization activity; cytokine activity (ortholog); INVOLVED IN natural killer cell activation involved in immune response; sensory perception of pain; cell cycle arrest (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH Encephalomyelitis, Autoimmune, Experimental; Sepsis; Asthma (ortholog); FOUND IN extracellular space; interleukin-12 complex; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 2-amino-2-deoxy-D-galactopyranose Type: protein-coding RefSeq Status: PROVISIONAL Also known as: Il12; Interleukin 12; interleukin-12 p40; interleukin-12 p40 precursor; interleukin-12 subunit beta Orthologs: Homo sapiens : IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))  HGNC Mus musculus : Il12b (interleukin 12b)  MGI Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 10 q21   NCBI RGSC Genome Assembly v5.0 10 29,872,453 - 29,881,829 + NCBI RGSC Genome Assembly v3.4 10 29,558,955 - 29,568,331 + NCBI Rat Celera Assembly 10 28,372,232 - 28,381,601 + NCBI Genome Assembly 3.1 10 29,560,003 - 29,569,378 + NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Asthma Susceptibility ISS RGD:1353629 4145438 DNA:polymorphisms:promoter, 3'utr: RGD   Asthma   ISS RGD:1353629 7240710   OMIM   Asthma Severity ISS RGD:1353629 4145428 DNA:polymorphism:promoter RGD   Asthma Severity ISS RGD:1353629 1600043 DNA:polymorphisms:introns: RGD   Encephalomyelitis, Autoimmune, Experimental   IEP   4831840 mRNA, protein:increased expression:lymph node RGD   Farmer's Lung   ISS RGD:732857 4145430   RGD   Influenza, Human   ISS RGD:732857 4145426   RGD   Mycobacterium Infections, Nontuberculous Susceptibility ISS RGD:1353629 1600042 disseminated BCG and Salmonella enteritidis infection, OMIM:209950 RGD   Mycobacterium Infections, Nontuberculous   ISS RGD:1353629 7240710   OMIM   Pulmonary Disease, Chronic Obstructive   ISS RGD:1353629 4145423 DNA:polymorphism: : RGD   Pulmonary Fibrosis   ISS RGD:732857 4889581 protein:increased expression:lung RGD   Pulmonary Fibrosis   ISS RGD:732857 4888529   RGD   Salmonella Infections Susceptibility ISS RGD:1353629 1600042 disseminated BCG and Salmonella enteritidis infection, OMIM:209950 RGD   Sepsis   IED   4888507 protein:increased expression:peritoneal fluid, plasma RGD   Thyroid Neoplasms   ISS RGD:732857 4145421   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-pilocarpine increases expression ISO RGD:732857 6480464 Pilocarpine results in increased expression of IL12B mRNA CTD PMID:15193289 (R)-mevalonic acid multiple interactions ISO RGD:732857 6480464 Mevalonic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 (S)-nicotine multiple interactions ISO RGD:732857 6480464 Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA]; more ... CTD PMID:21237301 (S)-nicotine increases expression ISO RGD:732857 6480464 Nicotine results in increased expression of IL12B mRNA CTD PMID:21237301 1,3,5-trinitrobenzene multiple interactions ISO RGD:732857 6480464 Eicosapentaenoic Acid analog inhibits the reaction [sym-trinitrobenzene results in increased expression of IL12B mRNA] CTD PMID:15890784 1,3,5-trinitrobenzene decreases response to substance ISO RGD:732857 6480464 IL12B protein results in decreased susceptibility to sym-trinitrobenzene CTD PMID:11782017 1,3,5-trinitrobenzene increases expression ISO RGD:732857 6480464 sym-trinitrobenzene results in increased expression of IL12B mRNA CTD PMID:15890784 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:732857 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein; more ... CTD PMID:17371993 1-chloro-2,4,6-trinitrobenzene increases expression ISO RGD:732857 6480464 Picryl Chloride results in increased expression of IL12B mRNA CTD PMID:11708898 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased expression of IL12B mRNA CTD PMID:10199581 more ... 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased expression of IL12B mRNA CTD PMID:10199581 more ... 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased expression of IL12B mRNA CTD PMID:11708898 more ... 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:732857 6480464 Dinitrochlorobenzene affects the expression of IL12B mRNA CTD PMID:22302311 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased expression of IL12B mRNA CTD PMID:18652873 more ... 1-chloro-2,4-dinitrobenzene increases secretion ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased secretion of IL12B protein CTD PMID:10199581 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrochlorobenzene results in increased expression of IL12B protein CTD PMID:18652873 1-fluoro-2,4-dinitrobenzene increases expression ISO RGD:732857 6480464 Dinitrofluorobenzene results in increased expression of IL12B mRNA CTD PMID:11708898 1-O-(alpha-D-galactopyranosyl)-N-hexacosanoylphytosphingosine increases expression ISO RGD:1353629 6480464 KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732857 6480464 Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:21097750 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of IL12B mRNA CTD PMID:15644576 2,4,6-trinitrobenzenesulfonic acid decreases response to substance ISO RGD:732857 6480464 IL12B protein results in decreased susceptibility to Trinitrobenzenesulfonic Acid CTD PMID:11782017 2,4,6-trinitrobenzenesulfonic acid increases expression EXP   6480464 Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA CTD PMID:16867261 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]; more ... CTD PMID:16867261 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:732857 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA; more ... CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP   6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] CTD PMID:22310181 2-amino-2-deoxy-D-galactopyranose increases expression EXP   6480464 Galactosamine results in increased expression of IL12B mRNA CTD PMID:22310181 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO RGD:732857 6480464 geranylgeranyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 2-trans,6-trans-farnesyl diphosphate multiple interactions ISO RGD:732857 6480464 farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 3',5'-cyclic AMP multiple interactions ISO RGD:1353629 6480464 Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein] CTD PMID:15843518 3-iodobenzyl-5'-N-methylcarboxamidoadenosine multiple interactions ISO RGD:1353629 6480464 N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]; more ... CTD PMID:16116186 4,4'-diaminodiphenylmethane decreases expression ISO RGD:732857 6480464 4,4'-diaminodiphenylmethane results in decreased expression of IL12B mRNA CTD PMID:18648102 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid multiple interactions ISO RGD:732857 6480464 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:732857 6480464 Oxazolone results in increased expression of IL12B mRNA CTD PMID:11708898 PMID:11379042 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:732857 6480464 Oxazolone results in increased expression of IL12B mRNA CTD PMID:11379042 PMID:11708898 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:732857 6480464 Oxazolone results in increased expression of IL12B protein CTD PMID:18652873 4-nitroquinoline N-oxide decreases expression ISO RGD:732857 6480464 4-Nitroquinoline-1-oxide results in decreased expression of IL12B mRNA CTD PMID:22561872 4-nitroquinoline N-oxide increases expression ISO RGD:732857 6480464 4-Nitroquinoline-1-oxide results in increased expression of IL12B mRNA CTD PMID:22561872 5-fluorouracil decreases expression ISO RGD:732857 6480464 Fluorouracil results in decreased expression of IL12B protein CTD PMID:15754409 9-cis-retinoic acid multiple interactions ISO RGD:1353629 6480464 alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:17475839 9-cis-retinoic acid multiple interactions ISO RGD:732857 6480464 alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16303184 9-cis-retinoic acid multiple interactions ISO RGD:1353629 6480464 alitretinoin results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:17118196 acetylsalicylic acid multiple interactions ISO RGD:1353629 6480464 Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:15379866 acrolein multiple interactions ISO RGD:732857 6480464 CD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IL12B mRNA] CTD PMID:17950725 acrolein increases expression ISO RGD:732857 6480464 Acrolein results in increased expression of IL12B mRNA CTD PMID:17950725 adenosine decreases expression ISO RGD:732857 6480464 Adenosine results in decreased expression of IL12B protein CTD PMID:11023991 adenosine multiple interactions ISO RGD:732857 6480464 Adenosine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:11023991 adenosine 5'-[gamma-thio]triphosphate increases expression ISO RGD:732857 6480464 adenosine 5'-O-(3-thiotriphosphate) results in increased expression of IL12B protein CTD PMID:15944274 aflatoxin B1 multiple interactions ISO RGD:732857 6480464 [aflatoxin G1 co-treated with Aflatoxin B1] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; more ... CTD PMID:22445859 all-trans-retinoic acid multiple interactions ISO RGD:1353629 6480464 RARA protein affects the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:16872382 all-trans-retinoic acid decreases expression ISO RGD:1353629 6480464 Tretinoin results in decreased expression of IL12B mRNA CTD PMID:15189689 PMID:16872382 all-trans-retinoic acid multiple interactions ISO RGD:1353629 6480464 Tretinoin results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:17118196 all-trans-retinoic acid multiple interactions ISO RGD:1353629 6480464 Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:17253143 all-trans-retinoic acid decreases expression ISO RGD:1353629 6480464 Tretinoin results in decreased expression of IL12B mRNA CTD PMID:16872382 PMID:15189689 alpha-hexylcinnamaldehyde affects expression ISO RGD:732857 6480464 hexyl cinnamic aldehyde affects the expression of IL12B mRNA CTD PMID:22302311 amiloride multiple interactions ISO RGD:732857 6480464 Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of IL12B mRNA CTD PMID:16483693 anandamide multiple interactions ISO RGD:732857 6480464 [OMDM-1 cpd co-treated with anandamide] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; more ... CTD PMID:15748152 anthranilic acid multiple interactions ISO RGD:1353629 6480464 anthranilic acid analog inhibits the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 antimony(0) affects response to substance ISO RGD:732857 6480464 IL12B protein affects the susceptibility to Antimony CTD PMID:11023473 arachidonic acid multiple interactions ISO RGD:1353629 6480464 Arachidonic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15684433 ATP multiple interactions ISO RGD:1353629 6480464 Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:17707769 azathioprine multiple interactions ISO RGD:1353629 6480464 Azathioprine results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 benzene multiple interactions ISO RGD:732857 6480464 Benzene metabolite inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15894107 benzene increases expression ISO RGD:732857 6480464 Benzene metabolite results in increased expression of IL12B mRNA CTD PMID:15894107 benzo[a]pyrene multiple interactions ISO RGD:732857 6480464 [Benzo(a)pyrene co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNA CTD PMID:17275222 benzo[a]pyrene decreases expression ISO RGD:732857 6480464 Benzo(a)pyrene results in decreased expression of IL12B mRNA CTD PMID:21569818 bis(2-chloroethyl) sulfide increases expression ISO RGD:732857 6480464 Mustard Gas results in increased expression of IL12B mRNA CTD PMID:15674843 bisphenol A decreases expression EXP   6480464 bisphenol A results in decreased expression of IL12B mRNA CTD PMID:18569609 bleomycin A2 increases expression ISO RGD:732857 6480464 Bleomycin results in increased expression of IL12B mRNA; more ... CTD PMID:11350791 bromosulfophthalein multiple interactions ISO RGD:732857 6480464 Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 cadmium dichloride increases methylation EXP   6480464 Cadmium Chloride results in increased methylation of IL12B promoter CTD PMID:22457795 calcitriol decreases expression ISO RGD:732857 6480464 Calcitriol results in decreased expression of IL12B protein CTD PMID:15939587 capsaicin decreases expression ISO RGD:1353629 6480464 Capsaicin results in decreased expression of IL12B mRNA CTD PMID:18533110 carbon monoxide multiple interactions ISO RGD:732857 6480464 Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 carmustine multiple interactions ISO RGD:732857 6480464 Carmustine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:12688424 carvedilol multiple interactions ISO RGD:1353629 6480464 carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:15229385 choline multiple interactions ISO RGD:732857 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL12B mRNA CTD PMID:20938992 ciprofibrate multiple interactions ISO RGD:732857 6480464 ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 copper atom multiple interactions ISO RGD:732857 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of IL12B mRNA CTD PMID:15467011 copper atom increases secretion ISO RGD:732857 6480464 Copper results in increased secretion of IL12B protein CTD PMID:19635393 copper(0) multiple interactions ISO RGD:732857 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of IL12B mRNA CTD PMID:15467011 copper(0) increases secretion ISO RGD:732857 6480464 Copper results in increased secretion of IL12B protein CTD PMID:19635393 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA] CTD PMID:16867261 cyclophosphamide affects expression ISO RGD:732857 6480464 Cyclophosphamide affects the expression of IL12B mRNA CTD PMID:18957084 cyclophosphamide increases expression ISO RGD:732857 6480464 Cyclophosphamide results in increased expression of IL12B mRNA CTD PMID:15331540 PMID:22842586 cyclophosphamide increases expression ISO RGD:732857 6480464 Cyclophosphamide results in increased expression of IL12B mRNA CTD PMID:15331540 cyclosporin A multiple interactions ISO RGD:732857 6480464 Cyclosporine inhibits the reaction [Zymosan results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:17312158 daidzein multiple interactions ISO RGD:732857 6480464 daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]; more ... CTD PMID:21945492 Delta(9)-tetrahydrocannabinol multiple interactions ISO RGD:732857 6480464 Tetrahydrocannabinol inhibits the reaction [Streptozocin results in increased expression of IL12B mRNA] CTD PMID:11357882 dexamethasone multiple interactions ISO RGD:732857 6480464 Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:16880258 dexamethasone increases expression ISO RGD:732857 6480464 Dexamethasone results in increased expression of IL12B mRNA CTD PMID:22842586 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA] CTD PMID:16867261 diazinon affects expression ISO RGD:732857 6480464 Diazinon affects the expression of IL12B protein CTD PMID:17499902 diazinon decreases expression ISO RGD:732857 6480464 Diazinon results in decreased expression of IL12B mRNA CTD PMID:17499902 dichlorine increases expression ISO RGD:732857 6480464 Chlorine results in increased expression of IL12B protein CTD PMID:23146759 diltiazem multiple interactions ISO RGD:1353629 6480464 Diltiazem inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:15652234 diltiazem decreases expression ISO RGD:1353629 6480464 Diltiazem results in decreased expression of IL12B mRNA CTD PMID:15652234 estriol decreases expression ISO RGD:732857 6480464 Estriol results in decreased expression of IL12B mRNA CTD PMID:21317386 ethanol affects secretion ISO RGD:732857 6480464 Ethanol affects the secretion of IL12B protein CTD PMID:20624996 ethanol multiple interactions ISO RGD:732857 6480464 Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein] CTD PMID:19500611 ethanol multiple interactions ISO RGD:732857 6480464 Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; more ... CTD PMID:10798593 eugenol multiple interactions ISO RGD:732857 6480464 Eugenol inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; more ... CTD PMID:21237301 famotidine multiple interactions ISO RGD:1353629 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:12364868 PMID:11752121 famotidine multiple interactions ISO RGD:1353629 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 farnesyl diphosphate multiple interactions ISO RGD:732857 6480464 farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 fenofibrate multiple interactions ISO RGD:732857 6480464 Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 folic acid multiple interactions ISO RGD:732857 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL12B mRNA CTD PMID:20938992 formaldehyde increases expression ISO RGD:732857 6480464 Formaldehyde results in increased expression of IL12B mRNA CTD PMID:12161283 gemfibrozil multiple interactions ISO RGD:732857 6480464 Gemfibrozil inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 glucuronoxylomannan multiple interactions ISO RGD:1353629 6480464 glucuronoxylomannan results in decreased secretion of [IL12A protein binds to IL12B protein] CTD PMID:12864811 glyburide multiple interactions ISO RGD:732857 6480464 Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; more ... CTD PMID:11907163 glycyrrhizinic acid multiple interactions ISO RGD:732857 6480464 [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; more ... CTD PMID:11412311 histamine multiple interactions ISO RGD:1353629 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:12364868 PMID:11752121 histamine multiple interactions ISO RGD:1353629 6480464 Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 histamine multiple interactions ISO RGD:1353629 6480464 Cyclic AMP promotes the reaction [[Histamine results in increased activity of HRH2 protein] which results in decreased expression of IL12B protein]; more ... CTD PMID:15843518 histamine multiple interactions ISO RGD:1353629 6480464 HRH2 protein promotes the reaction [Histamine results in decreased expression of IL12B protein]; more ... CTD PMID:9819373 histamine increases expression ISO RGD:1353629 6480464 Histamine results in increased expression of IL12B protein CTD PMID:15843518 histamine multiple interactions ISO RGD:1353629 6480464 HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; more ... CTD PMID:11752121 histamine decreases expression ISO RGD:1353629 6480464 Histamine results in decreased expression of IL12B mRNA; more ... CTD PMID:9819373 hyaluronic acid increases secretion ISO RGD:732857 6480464 Hyaluronic Acid analog results in increased secretion of IL12B protein CTD PMID:9278343 hydrogen peroxide decreases expression ISO RGD:732857 6480464 Hydrogen Peroxide results in decreased expression of IL12B protein CTD PMID:16249388 hydrogen peroxide multiple interactions ISO RGD:732857 6480464 Hydrogen Peroxide results in decreased expression of [IL12A protein binds to IL12B protein]; more ... CTD PMID:16249388 hydrogen peroxide multiple interactions ISO RGD:732857 6480464 Hydrogen Peroxide inhibits the reaction [N-bromotaurine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:15723204 hydroquinone multiple interactions ISO RGD:732857 6480464 hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:15894107 PMID:17464197 hydroquinone multiple interactions ISO RGD:732857 6480464 hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:17464197 PMID:15894107 hydroquinone increases expression ISO RGD:732857 6480464 hydroquinone results in increased expression of IL12B mRNA CTD PMID:15894107 imiquimod multiple interactions ISO RGD:732857 6480464 [imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]; more ... CTD PMID:21097750 indomethacin multiple interactions ISO RGD:732857 6480464 Indomethacin results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:11703811 iron atom multiple interactions ISO RGD:1353629 6480464 Iron affects the reaction [[IL12A protein binds to IL12B protein] which results in increased secretion of IFNG protein] CTD PMID:15799959 L-methionine multiple interactions ISO RGD:732857 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IL12B mRNA CTD PMID:20938992 lenalidomide multiple interactions ISO RGD:732857 6480464 lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 leukotriene B4 multiple interactions ISO RGD:732857 6480464 Leukotriene B4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16313356 leukotriene D4 multiple interactions ISO RGD:1353629 6480464 BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:19118273 lithium atom multiple interactions ISO RGD:732857 6480464 Lithium inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:19159680 lupane multiple interactions ISO RGD:1353629 6480464 lupane results in increased secretion of [IL12A protein binds to IL12B protein] CTD PMID:16388738 luteolin multiple interactions ISO RGD:732857 6480464 Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]; more ... CTD PMID:19426678 mangiferin multiple interactions EXP   6480464 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] CTD PMID:22310181 mercury dichloride multiple interactions ISO RGD:732857 6480464 Mercuric Chloride results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:21984480 mercury dichloride decreases expression ISO RGD:732857 6480464 Mercuric Chloride results in decreased expression of IL12B protein CTD PMID:21984480 methoxychlor increases expression ISO RGD:732857 6480464 Methoxychlor results in increased expression of IL12B mRNA CTD PMID:22842586 mevalonic acid multiple interactions ISO RGD:732857 6480464 Mevalonic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 mifepristone multiple interactions ISO RGD:732857 6480464 [Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:16321413 montelukast multiple interactions ISO RGD:1353629 6480464 montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 morphine affects expression ISO RGD:732857 6480464 Morphine affects the expression of IL12B protein CTD PMID:16299287 morphine multiple interactions ISO RGD:732857 6480464 Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 muramyl dipeptide increases secretion ISO RGD:1353629 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased secretion of IL12B protein CTD PMID:15905553 muramyl dipeptide multiple interactions ISO RGD:1353629 6480464 [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; more ... CTD PMID:18490488 muramyl dipeptide multiple interactions ISO RGD:732857 6480464 Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:19897531 muramyl dipeptide increases secretion ISO RGD:732857 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased secretion of IL12B protein CTD PMID:15905553 muramyl dipeptide multiple interactions ISO RGD:1353629 6480464 [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; more ... CTD PMID:16299289 N-acetyl-L-cysteine multiple interactions ISO RGD:732857 6480464 Acetylcysteine inhibits the reaction [Nicotine results in increased secretion of [IL12A protein co-treated with IL12B protein]]; more ... CTD PMID:21237301 nadolol multiple interactions ISO RGD:732857 6480464 [Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:16321413 nickel sulfate affects expression ISO RGD:1353629 6480464 nickel sulfate affects the expression of IL12B mRNA CTD PMID:18202158 nickel sulfate increases secretion ISO RGD:1353629 6480464 nickel sulfate results in increased secretion of IL12B protein CTD PMID:17636246 more ... nickel sulfate multiple interactions ISO RGD:1353629 6480464 BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein] CTD PMID:17636246 PMID:20525893 nickel sulfate multiple interactions ISO RGD:1353629 6480464 SB 203580 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein] CTD PMID:19101624 PMID:20525893 nickel sulfate increases secretion ISO RGD:1353629 6480464 nickel sulfate results in increased secretion of IL12B protein CTD PMID:19101624 PMID:20525893 nickel sulfate multiple interactions ISO RGD:1353629 6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; more ... CTD PMID:19101624 nickel sulfate multiple interactions ISO RGD:1353629 6480464 BAY 11-7085 inhibits the reaction [nickel sulfate results in increased secretion of IL12B protein]; more ... CTD PMID:20525893 nickel sulfate increases secretion ISO RGD:1353629 6480464 nickel sulfate results in increased secretion of IL12B protein CTD PMID:20525893 nitric oxide decreases expression ISO RGD:1353629 6480464 Nitric Oxide results in decreased expression of IL12B protein CTD PMID:13678430 nonanoic acid increases expression ISO RGD:732857 6480464 pelargonic acid results in increased expression of IL12B mRNA CTD PMID:11379042 PMID:18652873 nonanoic acid increases expression ISO RGD:732857 6480464 pelargonic acid results in increased expression of IL12B mRNA CTD PMID:18652873 PMID:11379042 nonanoic acid affects expression ISO RGD:732857 6480464 pelargonic acid affects the expression of IL12B mRNA CTD PMID:22302311 nonanoic acid increases expression ISO RGD:732857 6480464 pelargonic acid results in increased expression of IL12B protein CTD PMID:18652873 ozone multiple interactions ISO RGD:732857 6480464 [Ozone co-treated with Lipopolysaccharides] results in increased expression of IL12B protein CTD PMID:18929643 paclitaxel multiple interactions ISO RGD:732857 6480464 CD14 protein affects the reaction [Paclitaxel results in increased expression of IL12B mRNA]; more ... CTD PMID:11123339 paclitaxel increases expression ISO RGD:732857 6480464 Paclitaxel results in increased expression of IL12B mRNA CTD PMID:11123339 paracetamol increases expression ISO RGD:732857 6480464 Acetaminophen results in increased expression of IL12B mRNA CTD PMID:22575169 paracetamol multiple interactions ISO RGD:732857 6480464 MST1R protein affects the reaction [Acetaminophen results in increased expression of IL12B mRNA] CTD PMID:22575169 parathion multiple interactions ISO RGD:732857 6480464 [Parathion co-treated with Antigens, Dermatophagoides] affects the expression of IL12B protein CTD PMID:21864637 parathion increases expression ISO RGD:732857 6480464 Parathion results in increased expression of IL12B mRNA CTD PMID:22842586 perfluorooctanoic acid increases expression EXP   6480464 perfluorooctanoic acid results in increased expression of IL12B mRNA CTD PMID:19162173 phorbol 12,13-dibutanoate increases expression ISO RGD:1353629 6480464 Phorbol 12,13-Dibutyrate results in increased expression of IL12B mRNA CTD PMID:15516327 phorbol 13-acetate 12-myristate increases expression ISO RGD:1353629 6480464 Tetradecanoylphorbol Acetate results in increased expression of IL12B mRNA CTD PMID:15614042 phthalaldehyde affects expression ISO RGD:732857 6480464 o-Phthalaldehyde affects the expression of IL12B mRNA CTD PMID:22302311 pirinixic acid multiple interactions ISO RGD:732857 6480464 [Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein; more ... CTD PMID:17371993 pirinixic acid multiple interactions ISO RGD:732857 6480464 pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 pirinixic acid decreases expression ISO RGD:732857 6480464 pirinixic acid results in decreased expression of IL12B protein CTD PMID:20131406 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of IL12B mRNA CTD PMID:19162173 polymyxin B2 multiple interactions ISO RGD:732857 6480464 Polymyxin B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:9278343 prednisone multiple interactions ISO RGD:1353629 6480464 Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 prostaglandin E2 multiple interactions ISO RGD:1353629 6480464 Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:11369638 prostaglandin E2 increases expression ISO RGD:732857 6480464 Dinoprostone results in increased expression of IL12B protein CTD PMID:15180965 prostaglandin E2 multiple interactions ISO RGD:732857 6480464 CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]] CTD PMID:15180965 prostaglandin E2 multiple interactions ISO RGD:1353629 6480464 [TNF protein co-treated with IL1B protein co-treated with Dinoprostone] results in increased expression of IL12B protein CTD PMID:10614771 prostaglandin E2 increases expression ISO RGD:1353629 6480464 Dinoprostone results in increased expression of IL12B protein CTD PMID:16303787 prostaglandin E2 increases secretion ISO RGD:1353629 6480464 Dinoprostone results in increased secretion of IL12B protein CTD PMID:11369638 prostaglandin E2 increases expression ISO RGD:1353629 6480464 Dinoprostone results in increased expression of IL12B mRNA CTD PMID:11369638 ranitidine multiple interactions ISO RGD:1353629 6480464 Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein] CTD PMID:9819373 ranitidine multiple interactions ISO RGD:1353629 6480464 Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 resveratrol multiple interactions ISO RGD:732857 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:14996416 resveratrol multiple interactions ISO RGD:1353629 6480464 resveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; more ... CTD PMID:15135313 ribavirin multiple interactions ISO RGD:1353629 6480464 [Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:9722937 rosiglitazone multiple interactions ISO RGD:1353629 6480464 rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:17475839 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:732857 6480464 Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:12688424 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:732857 6480464 Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:19339665 S-nitrosoglutathione decreases expression ISO RGD:1353629 6480464 S-Nitrosoglutathione results in decreased expression of IL12B protein CTD PMID:13678430 serotonin affects secretion ISO RGD:1353629 6480464 Serotonin affects the secretion of IL12B protein CTD PMID:15802305 silicon dioxide multiple interactions ISO RGD:732857 6480464 IL12A gene mutant form promotes the reaction [Silicon Dioxide results in increased expression of and results in increased secretion of IL12B protein] CTD PMID:12193738 silicon dioxide affects response to substance ISO RGD:732857 6480464 IL12B protein affects the susceptibility to Silicon Dioxide CTD PMID:12193738 silicon dioxide decreases response to substance ISO RGD:732857 6480464 IL12B gene mutant form results in decreased susceptibility to Silicon Dioxide CTD PMID:12193738 simvastatin multiple interactions ISO RGD:732857 6480464 FOS inhibits the reaction [Simvastatin results in increased expression of IL12B mRNA]; more ... CTD PMID:15187114 simvastatin increases expression ISO RGD:732857 6480464 Simvastatin results in increased expression of IL12B mRNA CTD PMID:15187114 sirolimus multiple interactions ISO RGD:732857 6480464 Sirolimus inhibits the reaction [IL4 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:12531798 streptozocin increases expression ISO RGD:732857 6480464 Streptozocin results in increased expression of IL12B mRNA CTD PMID:11357882 streptozocin multiple interactions ISO RGD:732857 6480464 Tetrahydrocannabinol inhibits the reaction [Streptozocin results in increased expression of IL12B mRNA] CTD PMID:11357882 sulfapyridine multiple interactions ISO RGD:732857 6480464 Sulfapyridine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 sulfasalazine multiple interactions ISO RGD:732857 6480464 Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; more ... CTD PMID:11529938 suramin increases expression ISO RGD:1353629 6480464 Suramin results in increased expression of IL12B protein CTD PMID:15914193 thalidomide multiple interactions ISO RGD:1353629 6480464 Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:11788559 thalidomide multiple interactions ISO RGD:732857 6480464 Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 theophylline multiple interactions ISO RGD:1353629 6480464 Theophylline results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:15569413 theophylline decreases expression ISO RGD:1353629 6480464 Theophylline results in decreased expression of IL12B protein CTD PMID:15569413 toluene 2,4-diisocyanate increases expression ISO RGD:732857 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL12B mRNA CTD PMID:11379042 toluene 2,4-diisocyanate increases expression ISO RGD:732857 6480464 Toluene 2,4-Diisocyanate results in increased expression of IL12B protein CTD PMID:18652873 trans-resveratrol multiple interactions ISO RGD:732857 6480464 resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:14996416 trans-resveratrol multiple interactions ISO RGD:1353629 6480464 resveratrol promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; more ... CTD PMID:15135313 trichostatin A multiple interactions ISO RGD:1353629 6480464 trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] CTD PMID:12470611 trifluoperazine multiple interactions ISO RGD:732857 6480464 Trifluoperazine inhibits the reaction [Hydrogen Peroxide results in decreased expression of IL12B protein] CTD PMID:16249388 trimellitic anhydride affects expression ISO RGD:732857 6480464 trimellitic anhydride affects the expression of IL12B mRNA CTD PMID:22302311 tunicamycin multiple interactions ISO RGD:1353629 6480464 Tunicamycin inhibits the reaction [IL12A protein binds to IL12B protein]; more ... CTD PMID:10779781 urethane multiple interactions ISO RGD:732857 6480464 Freund's Adjuvant promotes the reaction [Urethane results in decreased expression of IL12B mRNA] CTD PMID:12810352 wortmannin multiple interactions ISO RGD:1353629 6480464 wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; more ... CTD PMID:16116186 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell cycle arrest   ISO RGD:1353629 1624291 PMID:16942485 RGD PMID:16942485 cell migration   ISO RGD:1353629 1624291 PMID:7903063 RGD PMID:7903063 cell surface receptor signaling pathway   ISO RGD:732857 1624291 MGI:MGI:2667551|PMID:12871593 RGD MGI:MGI:2667551 PMID:12871593 cellular response to interferon-gamma   ISO RGD:732857 1624291 MGI:MGI:4412460|PMID:18025219 RGD MGI:MGI:4412460 PMID:18025219 cellular response to lipopolysaccharide   ISO RGD:732857 1624291 MGI:MGI:4412460|PMID:18025219 RGD MGI:MGI:4412460 PMID:18025219 defense response to Gram-negative bacterium   ISO RGD:1353629 1624291 PMID:15114670 RGD PMID:15114670 defense response to Gram-negative bacterium   ISO RGD:1353629 1624291 PMID:20027291 RGD PMID:20027291 defense response to protozoan   ISO RGD:732857 1624291 MGI:MGI:96539 RGD MGI:MGI:3653161 PMID:9348310 defense response to virus   ISO RGD:732857 1624291 MGI:MGI:3829555|PMID:17277142 RGD MGI:MGI:3829555 PMID:17277142 natural killer cell activation   ISO RGD:1353629 1624291 PMID:1673147 RGD PMID:1673147 natural killer cell activation involved in immune response   IMP   1600048   RGD   negative regulation of growth of symbiont in host   ISO RGD:732857 1624291 MGI:MGI:1857201 RGD MGI:MGI:3653161 PMID:9348310 negative regulation of inflammatory response to antigenic stimulus   ISO RGD:732857 1624291 MGI:MGI:3686795|PMID:16949315 RGD MGI:MGI:3686795 PMID:16949315 negative regulation of interleukin-10 production   ISO RGD:1353629 1624291 PMID:16751425 RGD PMID:16751425 negative regulation of interleukin-17 production   ISO RGD:1353629 1624291 PMID:16482511 RGD PMID:16482511 negative regulation of smooth muscle cell proliferation   ISO RGD:1353629 1624291 PMID:16942485 RGD PMID:16942485 positive regulation of activated T cell proliferation   ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 positive regulation of activated T cell proliferation   ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 positive regulation of activation of JAK2 kinase activity   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 positive regulation of cell adhesion   ISO RGD:1353629 1624291 PMID:7903063 RGD PMID:7903063 positive regulation of defense response to virus by host   ISO RGD:732857 1624291 MGI:MGI:3027369|PMID:14688363 RGD MGI:MGI:3027369 PMID:14688363 positive regulation of defense response to virus by host   ISO RGD:1353629 1624291 PMID:12421946 RGD PMID:12421946 positive regulation of granulocyte macrophage colony-stimulating factor production   ISO RGD:1353629 1624291 PMID:20027291 RGD PMID:20027291 positive regulation of interferon-gamma production   ISO RGD:732857 1624291 MGI:MGI:3686795|PMID:16949315 RGD MGI:MGI:3686795 PMID:16949315 positive regulation of interferon-gamma production   ISO RGD:1353629 1624291 PMID:20027291 RGD PMID:20027291 positive regulation of interferon-gamma production   ISO RGD:1353629 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of interferon-gamma production   ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 positive regulation of interferon-gamma production   ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 positive regulation of interferon-gamma production   ISO RGD:732857 1624291 MGI:MGI:96539 RGD MGI:MGI:3653161 PMID:9348310 positive regulation of interleukin-10 production   ISO RGD:1353629 1624291 PMID:15265908 RGD PMID:15265908 positive regulation of interleukin-12 production   ISO RGD:1353629 1624291 PMID:20027291 RGD PMID:20027291 positive regulation of interleukin-17 production   ISO RGD:1353629 1624291 PMID:16482511 RGD PMID:16482511 positive regulation of interleukin-17 production   ISO RGD:1353629 1624291 PMID:17888176 RGD PMID:17888176 positive regulation of interleukin-17 production   ISO RGD:1353629 1624291 PMID:16751425 RGD PMID:16751425 positive regulation of lymphocyte proliferation   ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 positive regulation of natural killer cell activation   ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target   ISO RGD:1353629 1624291 PMID:7903063 RGD PMID:7903063 positive regulation of natural killer cell proliferation   ISO RGD:1353629 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of NK T cell activation   ISO RGD:1353629 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of NK T cell proliferation   ISO RGD:1353629 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of osteoclast differentiation   ISO RGD:1353629 1624291 PMID:17888176 RGD PMID:17888176 positive regulation of smooth muscle cell apoptotic process   ISO RGD:1353629 1624291 PMID:16942485 RGD PMID:16942485 positive regulation of T cell mediated cytotoxicity   ISO RGD:732857 1624291 MGI:MGI:3027369|PMID:14688363 RGD MGI:MGI:3027369 PMID:14688363 positive regulation of T cell proliferation   ISO RGD:732857 1624291 MGI:MGI:1926579|PMID:11057672 RGD MGI:MGI:1926579 PMID:11057672 positive regulation of T cell proliferation   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 positive regulation of T-helper 1 type immune response   ISO RGD:732857 1624291 MGI:MGI:3027369|PMID:14688363 RGD MGI:MGI:3027369 PMID:14688363 positive regulation of T-helper 1 type immune response   ISO RGD:1353629 1624291 PMID:15114670 RGD PMID:15114670 positive regulation of tumor necrosis factor production   ISO RGD:1353629 1624291 PMID:16751425 RGD PMID:16751425 positive regulation of tyrosine phosphorylation of Stat3 protein   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 positive regulation of tyrosine phosphorylation of Stat4 protein   ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 positive regulation of tyrosine phosphorylation of Stat4 protein   ISO RGD:1353629 1624291 PMID:19088061 RGD PMID:19088061 positive regulation of tyrosine phosphorylation of Stat4 protein   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 positive regulation of tyrosine phosphorylation of Stat5 protein   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 regulation of tyrosine phosphorylation of Stat1 protein   ISO RGD:1353629 1624291 PMID:12023369 RGD PMID:12023369 response to UV-B   ISO RGD:1353629 1624291 PMID:8992506 RGD PMID:8992506 sensory perception of pain   IDA   1600053   RGD   T-helper cell differentiation   ISO RGD:1353629 1624291 PMID:1673147 RGD PMID:1673147 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytoplasm   ISO RGD:732857 1624291 MGI:MGI:2155044|PMID:11737071 RGD MGI:MGI:2155044 PMID:11737071 extracellular space   IDA   1600057   RGD   extracellular space   ISO RGD:732857 1624291 MGI:MGI:3608246|PMID:16236719 RGD MGI:MGI:3608246 PMID:16236719 extracellular space   ISO RGD:732857 1624291 MGI:MGI:3829555|PMID:17277142 RGD MGI:MGI:3829555 PMID:17277142 extracellular space   ISO RGD:732857 1624291 MGI:MGI:63529|PMID:7690439 RGD MGI:MGI:63529 PMID:7690439 extracellular space   ISO RGD:732857 1624291 MGI:MGI:3050756|PMID:15220916 RGD MGI:MGI:3050756 PMID:15220916 extracellular space   ISO RGD:732857 1624291 MGI:MGI:3528786|PMID:15692051 RGD MGI:MGI:3528786 PMID:15692051 extracellular space   ISO RGD:732857 1624291 MGI:MGI:2669022|PMID:12855817 RGD MGI:MGI:2669022 PMID:12855817 extracellular space   ISO RGD:732857 1624291 MGI:MGI:3051177|PMID:15240714 RGD MGI:MGI:3051177 PMID:15240714 extracellular space   ISO RGD:732857 1624291 MGI:MGI:2667551|PMID:12871593 RGD MGI:MGI:2667551 PMID:12871593 extracellular space   ISO RGD:732857 1624291 MGI:MGI:3653161|PMID:9348310 RGD MGI:MGI:3653161 PMID:9348310 interleukin-12 complex   IDA   1600058   RGD   interleukin-12 complex   ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 interleukin-12 complex   ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 interleukin-12 complex   ISO RGD:732857 1624291 MGI:MGI:96539 RGD MGI:MGI:63529 PMID:7690439 interleukin-12 complex   ISO RGD:732857 1624291 MGI:MGI:3050756|PMID:15220916 RGD MGI:MGI:3050756 PMID:15220916 interleukin-23 complex   ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 membrane   IEA InterPro:IPR003530 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine activity contributes_to ISO RGD:732857 1624291 MGI:MGI:1926579|PMID:11057672 RGD MGI:MGI:1926579 PMID:11057672 cytokine activity contributes_to ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 cytokine receptor activity   IEA InterPro:IPR003530 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cytokine receptor binding contributes_to ISO RGD:732857 1624291 UniProtKB:Q60837 RGD MGI:MGI:1927676 PMID:11114383 growth factor activity contributes_to ISO RGD:1353629 1624291 PMID:1674604 RGD PMID:1674604 identical protein binding   ISO RGD:1353629 1624291 UniProtKB:P29460 RGD PMID:7527811 interleukin-12 alpha subunit binding   IDA   1600058   RGD   interleukin-12 alpha subunit binding   ISO RGD:732857 1624291 UniProtKB:P43431 RGD MGI:MGI:3050756 PMID:15220916 interleukin-23 receptor binding contributes_to ISO RGD:1353629 1624291 PMID:11114383 RGD PMID:11114383 protein binding   ISO RGD:732857 1624291 UniProtKB:Q9EQ14 RGD MGI:MGI:1927676 PMID:11114383 protein binding   ISO RGD:1353629 1624291 UniProtKB:P29459 RGD PMID:7527811 protein binding   ISO RGD:1353629 1624291 UniProtKB:Q9EQ14 RGD PMID:11114383 protein binding   ISO RGD:1353629 1624291 UniProtKB:P29459 RGD PMID:10899108 protein heterodimerization activity   IDA   1600058   RGD   protein heterodimerization activity   ISO RGD:1353629 1624291 UniProtKB:P29459 RGD PMID:1674604 protein homodimerization activity   ISO RGD:732857 1624291 MGI:MGI:2667551|PMID:12871593 RGD MGI:MGI:2667551 PMID:12871593 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) allograft rejection pathway   IEA RGD:628704 6907045   KEGG rno:05330 cytokine mediated signaling pathway   IEA RGD:628704 6907045   KEGG rno:04060 Entamoeba histolyca infection pathway   IEA RGD:628704 6907045   KEGG rno:05146 influenza A virus infection pathway   IEA RGD:628704 6907045   KEGG rno:05164 interleukin-12 signaling pathway   ISO RGD:1353629 6484113   PID PID:200045 interleukin-23 signaling pathway   ISO RGD:1353629 6484113   PID PID:200154 interleukin-27 signaling pathway   ISO RGD:1353629 6484113   PID PID:200028 Jak-Stat signaling pathway   IEA RGD:628704 6907045   KEGG rno:04630 Leishmania infection pathway   IEA RGD:628704 6907045   KEGG rno:05140 measles infection pathway   IEA RGD:628704 6907045   KEGG rno:05162 Mycobacterium tuberculosis infection pathway   IEA RGD:628704 6907045   KEGG rno:05152 Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway   IEA RGD:628704 6907045   KEGG rno:04622 Toll-like receptor signaling pathway   IEA RGD:628704 6907045   KEGG rno:04620 Toxoplasma gondii infection pathway   IEA RGD:628704 6907045   KEGG rno:05145 Trypanosoma brucei infection pathway   IEA RGD:628704 6907045   KEGG rno:05143 Trypanosoma cruzi infection pathway   IEA RGD:628704 6907045   KEGG rno:05142 type 1 diabetes mellitus pathway   IEA RGD:628704 6907045   KEGG rno:04940 External Database Links KEGG Pathway African trypanosomiasis Allograft rejection Amoebiasis Chagas disease (American trypanosomiasis) Cytokine-cytokine receptor interaction Herpes simplex infection Influenza A Jak-STAT signaling pathway Legionellosis Leishmaniasis Measles Pertussis RIG-I-like receptor signaling pathway Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Type I diabetes mellitus Pathway Interaction Database IL12-mediated signaling events (PID:200045) IL23-mediated signaling events (PID:200154) IL27-mediated signaling events (PID:200028) Disease Annotations Asthma  (ISS) Encephalomyelitis, Autoimmune, Experimental  (IEP) Farmer's Lung  (ISS) Influenza, Human  (ISS) Mycobacterium Infections, Nontuberculous  (ISS) Pulmonary Disease, Chronic Obstructive  (ISS) Pulmonary Fibrosis  (ISS) Salmonella Infections  (ISS) Sepsis  (IED) Thyroid Neoplasms  (ISS) Gene-Chemical Interaction Annotations (+)-pilocarpine  (ISO) (R)-mevalonic acid  (ISO) (S)-nicotine  (ISO) 1,3,5-trinitrobenzene  (ISO) 1-chloro-2,4,6-trinitrobenzene  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 1-fluoro-2,4-dinitrobenzene  (ISO) 1-O-(alpha-D-galactopyranosyl)-N-hexacosanoylphytosphingosine  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO) 2-amino-2-deoxy-D-galactopyranose  (EXP,ISO) 2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO) 2-trans,6-trans-farnesyl diphosphate  (ISO) 3',5'-cyclic AMP  (ISO) 3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO) 4,4'-diaminodiphenylmethane  (ISO) 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO) 4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO) 4-nitroquinoline N-oxide  (ISO) 5-fluorouracil  (ISO) 9-cis-retinoic acid  (ISO) acetylsalicylic acid  (ISO) acrolein  (ISO) adenosine  (ISO) adenosine 5'-[gamma-thio]triphosphate  (ISO) aflatoxin B1  (ISO) all-trans-retinoic acid  (ISO) alpha-hexylcinnamaldehyde  (ISO) amiloride  (ISO) ammonium chloride  (EXP) anandamide  (ISO) anthranilic acid  (ISO) antimony(0)  (ISO) arachidonic acid  (ISO) ATP  (ISO) azathioprine  (ISO) benzene  (ISO) benzo[a]pyrene  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisphenol A  (EXP) bleomycin A2  (ISO) bromosulfophthalein  (ISO) cadmium dichloride  (EXP) calcitriol  (ISO) capsaicin  (ISO) carbon monoxide  (ISO) carmustine  (ISO) carvedilol  (ISO) choline  (ISO) ciprofibrate  (ISO) copper atom  (ISO) copper(0)  (ISO) curcumin  (EXP) cyclophosphamide  (ISO) cyclosporin A  (ISO) daidzein  (ISO) Delta(9)-tetrahydrocannabinol  (ISO) dexamethasone  (EXP,ISO) diazinon  (ISO) dichlorine  (ISO) diltiazem  (ISO) estriol  (ISO) ethanol  (ISO) eugenol  (ISO) famotidine  (ISO) farnesyl diphosphate  (ISO) fenofibrate  (ISO) folic acid  (ISO) formaldehyde  (ISO) gemfibrozil  (ISO) glucuronoxylomannan  (ISO) glyburide  (ISO) glycyrrhizinic acid  (ISO) histamine  (ISO) hyaluronic acid  (ISO) hydrogen peroxide  (ISO) hydroquinone  (ISO) imiquimod  (ISO) indomethacin  (ISO) iron atom  (ISO) L-methionine  (ISO) lenalidomide  (ISO) leukotriene B4  (ISO) leukotriene D4  (ISO) lithium atom  (ISO) lupane  (ISO) luteolin  (ISO) mangiferin  (EXP) mercury dichloride  (ISO) methoxychlor  (ISO) mevalonic acid  (ISO) mifepristone  (ISO) montelukast  (ISO) morphine  (ISO) muramyl dipeptide  (ISO) N-acetyl-L-cysteine  (ISO) nadolol  (ISO) nickel sulfate  (ISO) nitric oxide  (ISO) nonanoic acid  (ISO) ozone  (ISO) paclitaxel  (ISO) paracetamol  (ISO) parathion  (ISO) perfluorooctanoic acid  (EXP) phorbol 12,13-dibutanoate  (ISO) phorbol 13-acetate 12-myristate  (ISO) phthalaldehyde  (ISO) pirinixic acid  (EXP,ISO) polymyxin B2  (ISO) prednisone  (ISO) prostaglandin E2  (ISO) ranitidine  (ISO) resveratrol  (ISO) ribavirin  (ISO) rosiglitazone  (ISO) S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO) S-nitrosoglutathione  (ISO) serotonin  (ISO) silicon dioxide  (ISO) simvastatin  (ISO) sirolimus  (ISO) streptozocin  (ISO) sulfapyridine  (ISO) sulfasalazine  (ISO) suramin  (ISO) thalidomide  (ISO) theophylline  (ISO) toluene 2,4-diisocyanate  (ISO) trans-resveratrol  (ISO) trichostatin A  (ISO) trifluoperazine  (ISO) trimellitic anhydride  (ISO) tunicamycin  (ISO) urethane  (ISO) wortmannin  (ISO) Gene Ontology Annotations Biological Process cell cycle arrest  (ISO) cell migration  (ISO) cell surface receptor signaling pathway  (ISO) cellular response to interferon-gamma  (ISO) cellular response to lipopolysaccharide  (ISO) defense response to Gram-negative bacterium  (ISO) defense response to protozoan  (ISO) defense response to virus  (ISO) natural killer cell activation  (ISO) natural killer cell activation involved in immune response  (IMP) negative regulation of growth of symbiont in host  (ISO) negative regulation of inflammatory response to antigenic stimulus  (ISO) negative regulation of interleukin-10 production  (ISO) negative regulation of interleukin-17 production  (ISO) negative regulation of smooth muscle cell proliferation  (ISO) positive regulation of activated T cell proliferation  (ISO) positive regulation of activation of JAK2 kinase activity  (ISO) positive regulation of cell adhesion  (ISO) positive regulation of defense response to virus by host  (ISO) positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO) positive regulation of interferon-gamma production  (ISO) positive regulation of interleukin-10 production  (ISO) positive regulation of interleukin-12 production  (ISO) positive regulation of interleukin-17 production  (ISO) positive regulation of lymphocyte proliferation  (ISO) positive regulation of natural killer cell activation  (ISO) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (ISO) positive regulation of natural killer cell proliferation  (ISO) positive regulation of NK T cell activation  (ISO) positive regulation of NK T cell proliferation  (ISO) positive regulation of osteoclast differentiation  (ISO) positive regulation of smooth muscle cell apoptotic process  (ISO) positive regulation of T cell mediated cytotoxicity  (ISO) positive regulation of T cell proliferation  (ISO) positive regulation of T-helper 1 type immune response  (ISO) positive regulation of tumor necrosis factor production  (ISO) positive regulation of tyrosine phosphorylation of Stat3 protein  (ISO) positive regulation of tyrosine phosphorylation of Stat4 protein  (ISO) positive regulation of tyrosine phosphorylation of Stat5 protein  (ISO) regulation of tyrosine phosphorylation of Stat1 protein  (ISO) response to UV-B  (ISO) sensory perception of pain  (IDA) T-helper cell differentiation  (ISO) Cellular Component cytoplasm  (ISO) extracellular space  (IDA,ISO) interleukin-12 complex  (IDA,ISO) interleukin-23 complex  (ISO) membrane  (IEA) Molecular Function cytokine activity  (ISO) cytokine receptor activity  (IEA) cytokine receptor binding  (ISO) growth factor activity  (ISO) identical protein binding  (ISO) interleukin-12 alpha subunit binding  (IDA,ISO) interleukin-23 receptor binding  (ISO) protein binding  (ISO) protein heterodimerization activity  (IDA,ISO) protein homodimerization activity  (ISO) Molecular Pathway Annotations allograft rejection pathway  (IEA) cytokine mediated signaling pathway  (IEA) Entamoeba histolyca infection pathway  (IEA) influenza A virus infection pathway  (IEA) interleukin-12 signaling pathway  (ISO) interleukin-23 signaling pathway  (ISO) interleukin-27 signaling pathway  (ISO) Jak-Stat signaling pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Mycobacterium tuberculosis infection pathway  (IEA) Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA) Toll-like receptor signaling pathway  (IEA) Toxoplasma gondii infection pathway  (IEA) Trypanosoma brucei infection pathway  (IEA) Trypanosoma cruzi infection pathway  (IEA) type 1 diabetes mellitus pathway  (IEA) External Database Links KEGG Pathway African trypanosomiasis Allograft rejection Amoebiasis Chagas disease (American trypanosomiasis) Cytokine-cytokine receptor interaction Herpes simplex infection Influenza A Jak-STAT signaling pathway Legionellosis Leishmaniasis Measles Pertussis RIG-I-like receptor signaling pathway Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Type I diabetes mellitus Pathway Interaction Database IL12-mediated signaling events (PID:200045) IL23-mediated signaling events (PID:200154) IL27-mediated signaling events (PID:200028) References - curated 1. Alli RS and Khar A, FEBS Lett. 2004 Feb 13;559(1-3):71-6. 2. Altare F, etal., J Clin Invest. 1998 Dec 15;102(12):2035-40. 3. Griffiths MM, etal., Curr Opin Immunol 1999 Dec;11(6):689-700 4. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31 5. Halpern MD, etal., Pediatr Res 2002 Jun;51(6):733-9. 6. Hirota T, etal., J Allergy Clin Immunol. 2005 Oct;116(4):789-95. Epub 2005 Aug 8. 7. Khalife J, etal., Eur Cytokine Netw 1998 Mar;9(1):69-73. 8. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23. 9. MGD data from the GO Consortium 10. Morahan G, etal., Lancet. 2002 Aug 10;360(9331):455-9. 11. Muthana M, etal., Immunobiology. 2006;211(5):391-402. Epub 2006 Mar 14. 12. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16. 13. Orson FM, etal., J Gene Med. 2006 Apr;8(4):488-97. 14. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 15. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 16. Randolph AG, etal., Am J Hum Genet. 2004 Oct;75(4):709-15. Epub 2004 Aug 20. 17. RGD automated data pipeline 18. RGD automated import pipeline for gene-chemical interactions 19. RGD Automated Pipelines 20. Rice L, etal., J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3. 21. Schuyler M, etal., Int J Exp Pathol. 2002 Apr;83(2):87-98. 22. Trajkov D, etal., Iran J Allergy Asthma Immunol. 2009 Mar;8(1):31-42. 23. Valenti S, etal., Ann N Y Acad Sci. 1999 Jun 22;876:259-61. 24. Verri WA Jr, etal., J Pharmacol Exp Ther. 2005 Nov;315(2):609-15. Epub 2005 Jul 15. 25. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8 26. Wilson MS, etal., J Exp Med. 2010 Mar 15;207(3):535-52. Epub 2010 Feb 22. 27. Zhang R and DeGroot LJ, Clin Endocrinol (Oxf). 2000 Jun;52(6):687-94. References - uncurated PubMed 12432235   15371491   15781254   19299163   19420081   19710466   19922500 RGD Disease Portals Il12b has been annotated in the following RGD Disease Portals. Biological Process Cancer Pathways Biological Process Cardiovascular Pathways Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Candidate Gene Status Il12b is a candidate Gene for Cia10 Il12b is a candidate Gene for Eau7 Comparative Map Data Il12b   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 10 q21   NCBI RGSC Genome Assembly v5.0 10 29,872,453 - 29,881,829 + NCBI RGSC Genome Assembly v3.4 10 29,558,955 - 29,568,331 + NCBI Rat Celera Assembly 10 28,372,232 - 28,381,601 + NCBI Genome Assembly 3.1 10 29,560,003 - 29,569,378 + NCBI IL12B   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 158,969,635 - 158,985,325 - NCBI Human Genome Assembly HuRef 5 153,836,180 - 153,851,870 - NCBI Human Genome Assembly GRCh37 5 158,741,791 - 158,757,481 - NCBI Human Genome Assembly Build 36 5 158,674,369 - 158,690,059 - NCBI Human Cytogenetic Map 5 q31.1-q33.1   NCBI Human Genome Assembly 5 158,674,368 - 158,690,059   NCBI Il12b   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 11 44,400,063 - 44,414,017 + NCBI Mouse cM Map 11 25.94   NCBI Mouse Celera Assembly 11 49,032,464 - 49,046,411 + NCBI Mouse Genome Assembly Build 37 11 44,213,565 - 44,227,519 + NCBI Mouse Genome Assembly Build 36.1 11 44,213,565 - 44,227,519 + NCBI Mouse Cytogenetic Map 11 A5-B2   NCBI Position Markers PMC355839P1   Map Chr Position Strand Source Rat Cytogenetic Map 10 q21   UniSTS RGSC Genome Assembly v5.0 10 29,876,100 - 29,876,833   UniSTS RGSC Genome Assembly v3.4 10 29,562,602 - 29,563,335   UniSTS Rat Celera Assembly 10 28,375,879 - 28,376,612   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2293680 Bss40 Bone structure and strength QTL 40 5.66 .0001 Bone strength 10 1 35460104 Rat 634327 Hc4 Hypercalciuria QTL 4 2.4 Renal function calcium excretion 10 1 38576664 Rat 1576304 Schws7 Schwannoma susceptibility QTL 7 .0115 Neural tumor susceptibility tumor incidence 10 1 41641939 Rat 631554 Bp133 Blood pressure QTL 133 .005 Blood pressure systolic 10 666709 65072453 Rat 1581497 Esta1 Estrogen-induced thymic atrophy QTL 1 Gland mass thymus 10 4831560 67678060 Rat 2298544 Neuinf9 Neuroinflammation QTL 9 4.6 Neuroinflammation 10 5761138 65668639 Rat 631660 Hcar1 Hepatocarcinoma resistance QTL 1 3.4 .0001 Liver tumor resistance nodule volume 10 6172805 36254741 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 Joint/bone inflammation type II collagen induced 10 6380753 100633982 Rat 1578761 Stresp21 Stress response QTL 21 3.3 Stress response thymus weight 10 7041744 52041744 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 .003 Mammary tumor resistance 10 9762188 108776963 Rat 2301967 Cm73 Cardiac mass QTL 73 4.55 Cardiac mass left ventricle 10 14721135 92841289 Rat 2316949 Gluco60 Glucose level QTL 60 3.7 Glucose level postprandial 10 14721135 154166503 Rat 631268 Cia21 Collagen induced arthritis QTL 21 3.1 Joint/bone inflammation arthritis severity 10 14721135 159833317 Rat 1354587 Kidm21 Kidney mass QTL 21 3.3 Kidney mass left kidney mass adjusted for body weight 10 15274216 62791536 Rat 631564 Apr3 Acute phase response QTL 3 3.9 IL-6 level pristane induced 10 16579339 61579339 Rat 6893350 Bw99 Body weight QTL 99 .87 .16 Body weight 1 17185640 62185640 Rat 6893352 Bw100 Body weight QTL 100 .33 .6 Body weight 1 17185640 62185640 Rat 631532 Cm50 Cardiac mass QTL 50 6.6 Cardiac mass 10 18217625 53793117 Rat 1598852 Anxrr19 Anxiety related response QTL 19 5.07 Anxiety response open field test- rearing 10 19468218 64468218 Rat 1554317 Bmd4 Bone mineral density QTL 4 9.4 .0001 Bone mineral density spine volumetric BMD by pQCT 10 20233281 104013574 Rat 70223 Bp57 Blood pressure QTL 57 5 Blood pressure indirect systolic 10 21607719 84443989 Rat 70188 BpQTLcluster1 Blood pressure QTL cluster 1 4.82 Blood pressure 1 21607719 91471072 Rat 70198 BpQTLcluster9 Blood pressure QTL cluster 9 2.94 Blood pressure 10 21607719 91471072 Rat 724556 Pur2 Proteinuria QTL 2 5.5 Renal function 10 22915259 95066632 Rat 631531 Iresp2 Immunoglobin response QTL2 6.3 Glomerular IgG atps (aurothiopropanol sulfonate) induced 10 23428127 32725718 Rat 1581559 Eae18 Experimental allergic encephalomyelitis QTL 18 .00002 Brain/spinal cord inflammation demyelination 10 23843272 68843272 Rat 61354 Pia10 Pristane induced arthritis QTL 10 .01 Joint/bone inflammation pristane induced 10 24006429 160657542 Rat 631267 Cia20 Collagen induced arthritis QTL 20 3.2 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 61325 Aia5 Adjuvant induced arthritis QTL 5 .01 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 634329 Pia15 Pristane induced arthritis QTL 15 3.1 Joint/bone inflammation arthritis severity 10 24731630 47777990 Rat 70224 Eae3 Experimental allergic encephalomyelitis QTL 3 4.1 Brain/spinal cord inflammation severity of disease 10 27184741 67678060 Rat 1298069 Bp168 Blood pressure QTL 168 5.5 Blood pressure salt-loaded systolic 10 27184741 102587587 Rat 631542 Bp82 Blood pressure QTL 82 6.8 Blood pressure systolic 10 27184741 103551039 Rat 2300171 Bmd58 Bone mineral density QTL 58 4.9 .0001 Bone mineral density 10 28599269 73599269 Rat 1600371 Mcs21 Mammary carcinoma susceptibility QTL 21 3 Mammary tumor susceptibility 10 29541648 54220239 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_022611 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06063543 (Get FASTA) Search GEO for Microarray Profiles   AAHX01063521 (Get FASTA) Search GEO for Microarray Profiles   AF133197 (Get FASTA) Search GEO for Microarray Profiles   CH473948 (Get FASTA) Search GEO for Microarray Profiles   U16674 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_022611 RefSeq Status: PROVISIONAL Type: CODING Protein Acc Id: NP_072133 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 10 29,872,453 - 29,881,829 + NCBI RGSC Genome Assembly v3.4 10 29,558,955 - 29,568,331 + RGD Rat Celera Assembly 10 28,372,232 - 28,381,601 + RGD Protein Sequences Protein RefSeqs NP_072133 (Get FASTA) GenBank Protein AAA52229 (Get FASTA)   AAD24190 (Get FASTA)   EDM04146 (Get FASTA)   EDM04147 (Get FASTA) Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000004380 ENTREZGENE, UniProtKB/TrEMBL Ensembl Protein ENSRNOP00000005898 ENTREZGENE, UniProtKB/TrEMBL Ensembl Transcript ENSRNOT00000005898 ENTREZGENE, UniProtKB/TrEMBL Entrez Gene 64546 ENTREZGENE Gene3D-CATH Ig-like_fold UniProtKB/TrEMBL HomoloGene Group ID 1648 ENTREZGENE InterPro Fibronectin_type3 UniProtKB/TrEMBL   Hematopoietin_rcpt_L_F3_CS UniProtKB/TrEMBL   Ig-like UniProtKB/TrEMBL   Ig-like_fold UniProtKB/TrEMBL   Ig_sub2 UniProtKB/TrEMBL   IL_12_beta UniProtKB/TrEMBL   Immunoglobulin UniProtKB/TrEMBL   Interleukin-12_bsu_cen-dom UniProtKB/TrEMBL IPI IPI00207823 UniProtKB/TrEMBL   IPI00951334 UniProtKB/TrEMBL KEGG Report rno:64546 ENTREZGENE, UniProtKB/TrEMBL PANTHER IL_12_beta UniProtKB/TrEMBL Pfam IL12p40_C UniProtKB/TrEMBL   PF00047 UniProtKB/TrEMBL PharmGKB IL12B RGD PIRSF IL_12_beta UniProtKB/TrEMBL PRINTS INTRLEUKN12B UniProtKB/TrEMBL PROSITE HEMATOPO_REC_L_F3 UniProtKB/TrEMBL   IG_LIKE UniProtKB/TrEMBL SMART IGc2 UniProtKB/TrEMBL Superfamily-SCOP FN_III-like UniProtKB/TrEMBL UniGene Rn.48686 ENTREZGENE UniProt E9PU71_RAT UniProtKB/TrEMBL   Q9R278_RAT UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-04-29 Il12b  interleukin 12B  Il12b  interleukin 12b  Nomenclature updated to reflect human and mouse nomenclature 10779 APPROVED 2006-03-30 Il12b  interleukin 12b      Symbol and Name status set to approved 10779 APPROVED 2003-04-14 Il12b  interleukin 12b  Il12  Interleukin 12  Data Merged 2447 PENDING 2003-02-27 Il12b  interleukin 12b      Symbol and Name status set to provisional 1724 PROVISIONAL 2001-08-29 Il12  Interleukin 12      Symbol updated 627 APPROVED RGD Curation Notes Note Type Note Reference gene_homology shows 92% and 65% identity to mouse and human homologs 633120 gene_transcript contains six exons and five introns 633120

More on Il12b Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 628704 Created: 2003-02-27 Species: Rattus norvegicus Last Modified: 2013-04-16 Status: ACTIVE