Mcc (MCC regulator of WNT signaling pathway) - Rat Genome Database

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Gene: Mcc (MCC regulator of WNT signaling pathway) Rattus norvegicus
Analyze
Symbol: Mcc
Name: MCC regulator of WNT signaling pathway
RGD ID: 1561988
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: colorectal mutant cancer protein-like; LOC100909795; LOC307449; MCC, WNT signaling pathway regulator; mutated in colorectal cancers; RGD1561988; similar to Colorectal mutant cancer protein (MCC protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81837,042,350 - 37,517,114 (-)NCBIGRCr8
mRatBN7.21836,794,206 - 37,266,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,798,372 - 37,266,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,902,353 - 37,359,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,620,712 - 38,077,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,997,619 - 37,454,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,006,663 - 12,128,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01835,683,185 - 35,817,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,683,185 - 35,817,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,006,660 - 12,128,845 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0113,595,971 - 13,952,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01835,348,808 - 35,484,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41838,099,803 - 38,576,214NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dichromium trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
oxybenzone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1848370   PMID:18591935   PMID:19555689   PMID:24824780  


Genomics

Comparative Map Data
Mcc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81837,042,350 - 37,517,114 (-)NCBIGRCr8
mRatBN7.21836,794,206 - 37,266,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,798,372 - 37,266,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,902,353 - 37,359,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,620,712 - 38,077,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,997,619 - 37,454,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0112,006,663 - 12,128,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01835,683,185 - 35,817,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,683,185 - 35,817,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl112,006,660 - 12,128,845 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0113,595,971 - 13,952,963 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01835,348,808 - 35,484,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41838,099,803 - 38,576,214NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
MCC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385113,022,106 - 113,488,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5113,022,106 - 113,488,823 (-)EnsemblGRCh38hg38GRCh38
GRCh375112,357,803 - 112,824,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365112,385,695 - 112,852,426 (-)NCBINCBI36Build 36hg18NCBI36
Build 345112,389,427 - 112,658,201NCBI
Celera5108,303,413 - 108,772,341 (-)NCBICelera
Cytogenetic Map5q22.2NCBI
HuRef5107,537,529 - 108,007,449 (-)NCBIHuRef
CHM1_15111,791,093 - 112,258,011 (-)NCBICHM1_1
T2T-CHM13v2.05113,532,656 - 114,001,170 (-)NCBIT2T-CHM13v2.0
Mcc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,558,127 - 44,945,573 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,558,127 - 44,945,249 (-)EnsemblGRCm39 Ensembl
GRCm381844,425,060 - 44,812,182 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,425,060 - 44,812,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv371844,584,714 - 44,971,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,550,392 - 44,555,234 (-)NCBIMGSCv36mm8
Celera1845,807,563 - 46,200,023 (-)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
Mcc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540832,928,519 - 33,264,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540832,928,519 - 33,265,049 (-)NCBIChiLan1.0ChiLan1.0
MCC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24108,274,421 - 108,743,460 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15106,428,077 - 106,895,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05108,382,066 - 108,845,503 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15114,184,907 - 114,457,400 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5114,184,907 - 114,647,847 (-)Ensemblpanpan1.1panPan2
MCC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,291,297 - 35,592,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,312,814 - 35,592,282 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,258,841 - 35,559,927 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0435,656,537 - 35,958,139 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl435,677,049 - 35,958,083 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1435,480,416 - 35,784,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,668,029 - 35,970,362 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,176,583 - 36,478,012 (-)NCBIUU_Cfam_GSD_1.0
Mcc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213125,905,158 - 126,351,432 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365974,934,788 - 5,376,481 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365974,930,065 - 5,191,311 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2116,287,018 - 116,740,581 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12116,286,353 - 116,748,620 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22121,307,432 - 121,321,926 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12316,309,574 - 16,773,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2316,310,968 - 16,579,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603461,661,123 - 62,145,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247338,607,680 - 9,032,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247338,607,645 - 9,035,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mcc
1464 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:143
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000015172
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat

Markers in Region
D18Chm48  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0113,805,931 - 13,806,114NCBIRnor5.0
Rnor_5.0113,569,503 - 13,569,686NCBIRnor5.0
Rnor_5.0X87,473,210 - 87,473,393NCBIRnor5.0
Rnor_5.0X87,467,408 - 87,467,591NCBIRnor5.0
RGSC_v3.41838,369,050 - 38,369,232UniSTSRGSC3.4
Cytogenetic Map18q11UniSTS
Tceb1l-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01835,610,106 - 35,610,325NCBIRnor5.0
Rnor_5.01835,405,109 - 35,405,328NCBIRnor5.0
Rnor_5.01037,382,354 - 37,382,565NCBIRnor5.0
RGSC_v3.41037,679,722 - 37,679,932UniSTSRGSC3.4
RGSC_v3.41838,158,463 - 38,158,681UniSTSRGSC3.4
Celera1035,770,882 - 35,771,092UniSTS
Cytogenetic Map18q11UniSTS
Cytogenetic Map10q22UniSTS
RH144300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21837,231,506 - 37,231,808 (-)MAPPERmRatBN7.2
Rnor_6.0112,028,319 - 12,028,620NCBIRnor6.0
Rnor_5.0113,618,193 - 13,618,494UniSTSRnor5.0
RGSC_v3.41838,552,331 - 38,552,632UniSTSRGSC3.4
Cytogenetic Map18q11UniSTS
BF390789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21837,180,184 - 37,180,347 (-)MAPPERmRatBN7.2
Rnor_6.0112,089,076 - 12,089,238NCBIRnor6.0
Rnor_5.0113,677,423 - 13,677,585UniSTSRnor5.0
RGSC_v3.41838,497,248 - 38,497,410UniSTSRGSC3.4
Cytogenetic Map18q11UniSTS
AU049155  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21836,953,376 - 36,953,669 (-)MAPPERmRatBN7.2
Rnor_6.0112,337,447 - 12,337,741NCBIRnor6.0
Rnor_6.01564,575,723 - 64,576,017NCBIRnor6.0
Rnor_5.01568,208,757 - 68,209,051UniSTSRnor5.0
Rnor_5.0113,923,668 - 13,923,962UniSTSRnor5.0
RGSC_v3.41838,264,260 - 38,264,554UniSTSRGSC3.4
Cytogenetic Map18q11UniSTS
fc33h10.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01838,043,730 - 38,044,631NCBIRnor5.0
Rnor_5.01838,043,730 - 38,044,623NCBIRnor5.0
Rnor_5.01835,481,779 - 35,482,680NCBIRnor5.0
Rnor_5.0113,954,405 - 13,955,298NCBIRnor5.0
Rnor_5.0113,954,397 - 13,955,298NCBIRnor5.0
Rnor_5.01835,481,779 - 35,482,672NCBIRnor5.0
RGSC_v3.41838,228,930 - 38,229,830UniSTSRGSC3.4
RGSC_v3.41838,228,930 - 38,229,822UniSTSRGSC3.4
Cytogenetic Map18q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 30 20 14 6 14 3 23 30 11
Low 3 12 37 27 13 27 8 10 71 12 7 8
Below cutoff 1 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015172   ⟹   ENSRNOP00000015172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1836,798,372 - 36,955,066 (-)Ensembl
Rnor_6.0 Ensembl1835,683,185 - 35,817,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079667   ⟹   ENSRNOP00000073806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1836,798,372 - 37,266,819 (-)Ensembl
Rnor_6.0 Ensembl1835,683,501 - 35,780,519 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085714   ⟹   ENSRNOP00000071358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1836,798,372 - 37,073,955 (-)Ensembl
Rnor_6.0 Ensembl1835,683,185 - 35,817,127 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093439   ⟹   ENSRNOP00000076146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl112,006,660 - 12,128,845 (+)Ensembl
RefSeq Acc Id: NM_001170534   ⟹   NP_001164005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,049,253 - 37,505,915 (-)NCBI
mRatBN7.21836,798,372 - 37,255,038 (-)NCBI
Rnor_6.0112,006,663 - 12,128,849 (+)NCBI
Rnor_6.01835,683,185 - 35,817,117 (-)NCBI
Rnor_5.01835,348,808 - 35,484,229 (-)NCBI
Rnor_5.0113,595,971 - 13,952,963 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096841   ⟹   XP_038952769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,082 (-)NCBI
mRatBN7.21836,794,206 - 37,266,206 (-)NCBI
RefSeq Acc Id: XM_039096842   ⟹   XP_038952770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,114 (-)NCBI
mRatBN7.21836,794,206 - 37,266,237 (-)NCBI
RefSeq Acc Id: XM_039096843   ⟹   XP_038952771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,082 (-)NCBI
mRatBN7.21836,794,206 - 37,266,206 (-)NCBI
RefSeq Acc Id: XM_039096844   ⟹   XP_038952772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,083 (-)NCBI
mRatBN7.21836,794,206 - 37,266,192 (-)NCBI
RefSeq Acc Id: XM_039096845   ⟹   XP_038952773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,108 (-)NCBI
mRatBN7.21836,794,206 - 37,266,228 (-)NCBI
RefSeq Acc Id: XM_039096846   ⟹   XP_038952774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,324,261 (-)NCBI
mRatBN7.21836,794,206 - 37,073,364 (-)NCBI
RefSeq Acc Id: XM_039096847   ⟹   XP_038952775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,208,772 (-)NCBI
mRatBN7.21836,794,206 - 36,957,781 (-)NCBI
RefSeq Acc Id: XM_039096848   ⟹   XP_038952776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,227,464 (-)NCBI
mRatBN7.21836,794,206 - 36,976,589 (-)NCBI
RefSeq Acc Id: XM_039096849   ⟹   XP_038952777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,205,646 (-)NCBI
mRatBN7.21836,794,206 - 36,954,765 (-)NCBI
RefSeq Acc Id: XM_063277360   ⟹   XP_063133430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,517,082 (-)NCBI
RefSeq Acc Id: XM_063277361   ⟹   XP_063133431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81837,042,350 - 37,324,261 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001164005   ⟸   NM_001170534
- UniProtKB: F1LZS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073806   ⟸   ENSRNOT00000079667
RefSeq Acc Id: ENSRNOP00000076146   ⟸   ENSRNOT00000093439
RefSeq Acc Id: ENSRNOP00000071358   ⟸   ENSRNOT00000085714
RefSeq Acc Id: ENSRNOP00000015172   ⟸   ENSRNOT00000015172
RefSeq Acc Id: XP_038952770   ⟸   XM_039096842
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952773   ⟸   XM_039096845
- Peptide Label: isoform X3
- UniProtKB: F1LZS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952771   ⟸   XM_039096843
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K6G7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952769   ⟸   XM_039096841
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952772   ⟸   XM_039096844
- Peptide Label: isoform X3
- UniProtKB: F1LZS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952774   ⟸   XM_039096846
- Peptide Label: isoform X5
- UniProtKB: F1LZS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952776   ⟸   XM_039096848
- Peptide Label: isoform X8
- UniProtKB: A6KUC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952775   ⟸   XM_039096847
- Peptide Label: isoform X6
- UniProtKB: F1LZS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952777   ⟸   XM_039096849
- Peptide Label: isoform X8
- UniProtKB: A6KUC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133430   ⟸   XM_063277360
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133431   ⟸   XM_063277361
- Peptide Label: isoform X7
- UniProtKB: A0A0G2K098 (UniProtKB/TrEMBL),   A6KUB9 (UniProtKB/TrEMBL)
Protein Domains
EF-hand   Harmonin-binding protein USHBP1 PDZ-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K098-F1-model_v2 AlphaFold A0A0G2K098 1-811 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561988 AgrOrtholog
BioCyc Gene G2FUF-7658 BioCyc
Ensembl Genes ENSRNOG00000011271 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000062232 Ensembl
Ensembl Transcript ENSRNOT00000015172.8 UniProtKB/TrEMBL
  ENSRNOT00000079667 ENTREZGENE
  ENSRNOT00000079667.2 UniProtKB/TrEMBL
  ENSRNOT00000085714.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.3110 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  USBP1-like UniProtKB/TrEMBL
  USH1C-bd_PDZ_domain UniProtKB/TrEMBL
NCBI Gene 307449 ENTREZGENE
PANTHER COLORECTAL MUTANT CANCER PROTEIN UniProtKB/TrEMBL
  PTHR23347 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  MCC-bdg_PDZ UniProtKB/TrEMBL
PhenoGen Mcc PhenoGen
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011271 RatGTEx
  ENSRNOG00000062232 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A0G2K098 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K6G7 ENTREZGENE, UniProtKB/TrEMBL
  A6KUB9 ENTREZGENE, UniProtKB/TrEMBL
  A6KUC0 ENTREZGENE, UniProtKB/TrEMBL
  F1LZS6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mcc  MCC regulator of WNT signaling pathway  LOC100909795  colorectal mutant cancer protein-like  Data merged from RGD:6501555 737654 PROVISIONAL
2019-04-10 Mcc  MCC regulator of WNT signaling pathway  Mcc  MCC, WNT signaling pathway regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-05-18 Mcc  MCC, WNT signaling pathway regulator  Mcc  mutated in colorectal cancers  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909795  colorectal mutant cancer protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-06-22 Mcc  mutated in colorectal cancers  RGD1561988  similar to Colorectal mutant cancer protein (MCC protein)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 RGD1561988  similar to Colorectal mutant cancer protein (MCC protein)   Mcc_mapped  mutated in colorectal cancers (mapped)  Data merged from RGD:3059 1643240 APPROVED
2008-04-30 RGD1561988  similar to Colorectal mutant cancer protein (MCC protein)   RGD1561988_predicted  similar to Colorectal mutant cancer protein (MCC protein) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561988_predicted  similar to Colorectal mutant cancer protein (MCC protein) (predicted)  LOC307449  similar to Colorectal mutant cancer protein (MCC protein)  Symbol and Name status set to approved 1299863 APPROVED
2005-11-17 Mcc_mapped  mutated in colorectal cancers (mapped)  Mcc  mutated in colorectal cancers  Symbol and Name updated 1556543 APPROVED