Gene: Keap1 (Kelch-like ECH-associated protein 1) Rattus norvegicus
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Description: ENCODES a protein that exhibits transcription factor binding (ortholog); INVOLVED IN cellular response to organic cyclic compound; cytoplasmic sequestering of transcription factor; negative regulation of gene expression; PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH Diabetic Nephropathies; Diabetic Retinopathy; Kidney Failure, Chronic; FOUND IN cell-cell adherens junction; cytoplasm; focal adhesion; INTERACTS WITH 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene; 7,12-dimethyltetraphene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cytosolic inhibitor of Nrf2; Inrf2
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBI
Cytogenetic Map8q13NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Keap1
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621619
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2016-10-11
Status: ACTIVE