Ccne2 (cyclin E2) - Rat Genome Database

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Gene: Ccne2 (cyclin E2) Rattus norvegicus
Analyze
Symbol: Ccne2
Name: cyclin E2
RGD ID: 1307783
Description: Enables protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and regulation of protein localization. Predicted to be part of cyclin E1-CDK2 complex and cyclin E2-CDK2 complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; measles pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G1/S-specific cyclin-E2; LOC362485
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,082,169 - 29,094,879 (+)NCBIGRCr8
mRatBN7.2524,285,078 - 24,298,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,284,922 - 24,297,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx526,474,294 - 26,485,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,067,313 - 28,078,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0527,868,181 - 27,879,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0524,434,077 - 24,446,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,159,666 - 29,171,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,032,748 - 25,044,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,032,749 - 25,042,590 (+)NCBI
Celera523,504,417 - 23,515,951 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
adefovir pivoxil  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
atropine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BQ 123  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
Calpeptin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethidium  (ISO)
ethyl methanesulfonate  (ISO)
fenbendazole  (EXP)
fluoranthene  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
harmine  (ISO)
hexaconazole  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
isoliquiritigenin  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nobiletin  (EXP,ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phthalaldehyde  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
PX-866  (ISO)
pyrazinecarboxamide  (EXP)
pyrvinium  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. D-type cyclins and G1 progression during liver development in the rat. Boylan JM and Gruppuso PA, Biochem Biophys Res Commun. 2005 May 13;330(3):722-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
10. Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Wan L, etal., Cancer Prev Res (Phila). 2014 Dec;7(12):1228-39. doi: 10.1158/1940-6207.CAPR-14-0182. Epub 2014 Oct 14.
11. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Zhang L, etal., Mol Med Rep. 2016 Sep;14(3):2077-84. doi: 10.3892/mmr.2016.5469. Epub 2016 Jul 6.
Additional References at PubMed
PMID:7739547   PMID:9840927   PMID:12941272   PMID:24586195  


Genomics

Comparative Map Data
Ccne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,082,169 - 29,094,879 (+)NCBIGRCr8
mRatBN7.2524,285,078 - 24,298,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,284,922 - 24,297,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx526,474,294 - 26,485,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,067,313 - 28,078,833 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0527,868,181 - 27,879,706 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0524,434,077 - 24,446,406 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,159,666 - 29,171,995 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,032,748 - 25,044,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,032,749 - 25,042,590 (+)NCBI
Celera523,504,417 - 23,515,951 (+)NCBICelera
Cytogenetic Map5q13NCBI
CCNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38894,880,224 - 94,896,693 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl894,879,770 - 94,896,678 (-)EnsemblGRCh38hg38GRCh38
GRCh37895,892,452 - 95,907,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,961,628 - 95,976,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 34895,961,630 - 95,976,658NCBI
Celera892,077,652 - 92,092,680 (-)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef891,100,427 - 91,115,467 (-)NCBIHuRef
CHM1_1895,932,798 - 95,947,824 (-)NCBICHM1_1
T2T-CHM13v2.0896,005,210 - 96,021,694 (-)NCBIT2T-CHM13v2.0
Ccne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,190,489 - 11,204,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,191,351 - 11,204,779 (+)EnsemblGRCm39 Ensembl
GRCm38411,190,433 - 11,204,779 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,191,351 - 11,204,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37411,118,501 - 11,131,926 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,118,501 - 11,131,829 (+)NCBIMGSCv36mm8
Celera411,001,670 - 11,015,258 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.07NCBI
Ccne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541711,027,749 - 11,040,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541711,027,749 - 11,039,945 (-)NCBIChiLan1.0ChiLan1.0
CCNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27112,208,849 - 112,225,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1887,745,867 - 87,765,107 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0891,499,647 - 91,518,488 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1893,702,104 - 93,717,151 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,702,104 - 93,717,151 (-)Ensemblpanpan1.1panPan2
CCNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,534,872 - 39,551,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,534,968 - 39,546,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,695,158 - 39,709,126 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02939,737,647 - 39,751,438 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2939,737,869 - 39,750,817 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,749,904 - 39,763,614 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02939,745,755 - 39,759,521 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02940,186,991 - 40,200,957 (-)NCBIUU_Cfam_GSD_1.0
Ccne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,939,436 - 39,953,135 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,839,113 - 7,851,335 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,839,730 - 7,852,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,804,377 - 41,821,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,802,090 - 41,821,870 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,119,630 - 45,139,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCNE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,846,670 - 89,863,432 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl889,848,077 - 89,862,037 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603950,971,304 - 50,986,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccne2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247632,243,305 - 2,257,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247632,242,584 - 2,258,332 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccne2
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:123
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000010696
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat

Markers in Region
UniSTS:496751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2524,296,107 - 24,296,238 (+)MAPPERmRatBN7.2
Rnor_6.0524,444,866 - 24,444,996NCBIRnor6.0
Rnor_5.0529,170,455 - 29,170,585UniSTSRnor5.0
RGSC_v3.4525,042,743 - 25,042,873UniSTSRGSC3.4
Celera523,514,411 - 23,514,541UniSTS
Cytogenetic Map5q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 26 30 22 17 22 46 17 34 7
Low 2 17 25 17 2 17 8 10 28 18 7 4 8
Below cutoff 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010696   ⟹   ENSRNOP00000010696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,285,833 - 24,297,632 (+)Ensembl
Rnor_6.0 Ensembl524,434,872 - 24,446,406 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108289   ⟹   ENSRNOP00000084976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,284,922 - 24,297,312 (+)Ensembl
RefSeq Acc Id: NM_001108656   ⟹   NP_001102126
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,083,345 - 29,094,879 (+)NCBI
mRatBN7.2524,286,110 - 24,297,648 (+)NCBI
Rnor_6.0524,434,872 - 24,446,406 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
RGSC_v3.4525,032,748 - 25,044,509 (+)RGD
Celera523,504,417 - 23,515,951 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237873   ⟹   XP_006237935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,724 - 29,094,549 (+)NCBI
mRatBN7.2524,285,810 - 24,298,233 (+)NCBI
Rnor_6.0524,434,077 - 24,446,076 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237874   ⟹   XP_006237936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,083,314 - 29,094,549 (+)NCBI
mRatBN7.2524,286,075 - 24,298,233 (+)NCBI
Rnor_6.0524,434,863 - 24,446,076 (+)NCBI
Rnor_5.0529,159,666 - 29,171,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593468   ⟹   XP_017448957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,911 - 29,094,549 (+)NCBI
mRatBN7.2524,285,810 - 24,298,233 (+)NCBI
Rnor_6.0524,434,077 - 24,446,076 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110217   ⟹   XP_038966145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,236 - 29,094,549 (+)NCBI
mRatBN7.2524,285,078 - 24,298,258 (+)NCBI
RefSeq Acc Id: XM_063287900   ⟹   XP_063143970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,082,169 - 29,094,549 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001102126   ⟸   NM_001108656
- UniProtKB: D3ZQ41 (UniProtKB/TrEMBL),   A6JFS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237935   ⟸   XM_006237873
- Peptide Label: isoform X1
- UniProtKB: D3ZQ41 (UniProtKB/TrEMBL),   A6JFS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237936   ⟸   XM_006237874
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A291 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448957   ⟸   XM_017593468
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A291 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010696   ⟸   ENSRNOT00000010696
RefSeq Acc Id: XP_038966145   ⟸   XM_039110217
- Peptide Label: isoform X1
- UniProtKB: D3ZQ41 (UniProtKB/TrEMBL),   A6JFS7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084976   ⟸   ENSRNOT00000108289
RefSeq Acc Id: XP_063143970   ⟸   XM_063287900
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A291 (UniProtKB/TrEMBL)
Protein Domains
Cyclin C-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQ41-F1-model_v2 AlphaFold D3ZQ41 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693563
Promoter ID:EPDNEW_R4087
Type:multiple initiation site
Name:Ccne2_1
Description:cyclin E2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0524,434,929 - 24,434,989EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307783 AgrOrtholog
BioCyc Gene G2FUF-41960 BioCyc
Ensembl Genes ENSRNOG00000008055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010696.6 UniProtKB/TrEMBL
  ENSRNOT00000108289.1 UniProtKB/TrEMBL
Gene3D-CATH Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
  Cyclin_related UniProtKB/TrEMBL
  Cyclins_cyclin-box UniProtKB/TrEMBL
KEGG Report rno:362485 UniProtKB/TrEMBL
NCBI Gene 362485 ENTREZGENE
PANTHER PTHR10177 UniProtKB/TrEMBL
  PTHR10177:SF70 UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/TrEMBL
  Cyclin_N UniProtKB/TrEMBL
PhenoGen Ccne2 PhenoGen
PROSITE CYCLINS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008055 RatGTEx
SMART CYCLIN UniProtKB/TrEMBL
  Cyclin_C UniProtKB/TrEMBL
Superfamily-SCOP Cyclin_like UniProtKB/TrEMBL
UniProt A0A8I6A291 ENTREZGENE, UniProtKB/TrEMBL
  A6JFS7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQ41 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-01-25 Ccne2  cyclin E2  Ccne2_predicted  cyclin E2 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Ccne2_predicted  cyclin E2 (predicted)      Symbol and Name status set to approved 70820 APPROVED