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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1-chloro-2,4-dinitrobenzene | increases expression | ISO | RGD:1353193 | 6480464 | Dinitrochlorobenzene results in increased expression of BMP6 mRNA | CTD | PMID:17374397 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:732562 | 6480464 | Ethinyl Estradiol affects the expression of BMP6 mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732562 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of BMP6 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732562 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of BMP6 mRNA | CTD | PMID:19770486 PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732562 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of BMP6 mRNA | CTD | PMID:19933214 PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1353193 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA] | CTD | PMID:14761676 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of BMP6 mRNA | CTD | PMID:21346803 | 2-amino-2-deoxy-D-glucopyranose | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of BMP6 mRNA] | CTD | PMID:17109745 | 2-amino-2-deoxy-D-glucopyranose | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of BMP6 mRNA | CTD | PMID:17109745 | 3,3',5-triiodo-L-thyronine | multiple interactions | ISO | RGD:1353193 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of BMP6 mRNA]; more ... | CTD | PMID:14761676 | 3,3',5-triiodo-L-thyronine | decreases expression | ISO | RGD:1353193 | 6480464 | Triiodothyronine results in decreased expression of BMP6 mRNA | CTD | PMID:14761676 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:732562 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BMP6 mRNA | CTD | PMID:20188158 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1353193 | 6480464 | [decitabine affects the methylation of BMP6 promoter] which affects the expression of BMP6 mRNA | CTD | PMID:18688853 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1353193 | 6480464 | [decitabine affects the methylation of BMP6 promoter] which affects the expression of BMP6 mRNA | CTD | PMID:18688853 PMID:18688853 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of BMP6 mRNA | CTD | PMID:22504374 | 8-bromo-3',5'-cyclic AMP | decreases expression | ISO | RGD:1353193 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of BMP6 mRNA | CTD | PMID:22079614 | aflatoxin B1 | decreases expression | ISO | RGD:732562 | 6480464 | Aflatoxin B1 results in decreased expression of BMP6 mRNA | CTD | PMID:19770486 | aldehydo-D-glucosamine | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of BMP6 mRNA] | CTD | PMID:17109745 | aldehydo-D-glucosamine | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of BMP6 mRNA | CTD | PMID:17109745 | all-trans-retinoic acid | increases expression | ISO | RGD:1353193 | 6480464 | Tretinoin results in increased expression of BMP6 mRNA | CTD | PMID:17196394 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1353193 | 6480464 | Tretinoin promotes the reaction [BMP6 protein results in increased expression of SOST mRNA] | CTD | PMID:15268896 | aluminium oxide | decreases expression | ISO | RGD:1353193 | 6480464 | Aluminum Oxide results in decreased expression of BMP6 mRNA | CTD | PMID:19464052 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of BMP6 mRNA | CTD | PMID:16483693 | atropine | multiple interactions | EXP | | 6480464 | Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] | CTD | PMID:18472332 | benzo[a]pyrene | decreases expression | ISO | RGD:1353193 | 6480464 | Benzo(a)pyrene results in decreased expression of BMP6 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases expression | ISO | RGD:732562 | 6480464 | Benzo(a)pyrene results in increased expression of BMP6 mRNA | CTD | PMID:22228805 PMID:22610609 | benzo[a]pyrene | increases expression | ISO | RGD:732562 | 6480464 | Benzo(a)pyrene results in increased expression of BMP6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:732562 | 6480464 | Benzo(a)pyrene results in decreased expression of BMP6 mRNA | CTD | PMID:19770486 | beta-D-glucosamine | multiple interactions | EXP | | 6480464 | Glucosamine inhibits the reaction [IL1B results in increased expression of BMP6 mRNA] | CTD | PMID:17109745 | beta-D-glucosamine | decreases expression | EXP | | 6480464 | Glucosamine results in decreased expression of BMP6 mRNA | CTD | PMID:17109745 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:732562 | 6480464 | Mustard Gas results in increased expression of BMP6 mRNA | CTD | PMID:15674843 | calcitriol | multiple interactions | ISO | RGD:1353193 | 6480464 | Calcitriol promotes the reaction [BMP6 protein results in increased expression of SOST mRNA] | CTD | PMID:15268896 | calcitriol | increases expression | ISO | RGD:1353193 | 6480464 | Calcitriol results in increased expression of BMP6 mRNA | CTD | PMID:16002434 | cobalt dichloride | decreases expression | ISO | RGD:1353193 | 6480464 | cobaltous chloride results in decreased expression of BMP6 mRNA | CTD | PMID:19320972 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of BMP6 mRNA | CTD | PMID:20164366 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of BMP6 mRNA | CTD | PMID:20164366 | corticosterone | increases expression | EXP | | 6480464 | Corticosterone results in increased expression of BMP6 mRNA | CTD | PMID:15755911 | dexamethasone | multiple interactions | ISO | RGD:1353193 | 6480464 | Dexamethasone inhibits the reaction [BMP6 protein results in increased expression of GREM1 mRNA]; more ... | CTD | PMID:15268896 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of BMP6 mRNA | CTD | PMID:19560483 | dipentyl phthalate | decreases expression | EXP | | 6480464 | di-n-pentyl phthalate results in decreased expression of BMP6 mRNA | CTD | PMID:19560483 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of BMP6 mRNA | CTD | PMID:21551480 | ellagic acid | decreases expression | ISO | RGD:1353193 | 6480464 | Ellagic Acid results in decreased expression of BMP6 mRNA | CTD | PMID:12002526 | esculetin | multiple interactions | EXP | | 6480464 | esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] | CTD | PMID:21450970 | eugenol | increases expression | ISO | RGD:1353193 | 6480464 | Eugenol results in increased expression of BMP6 mRNA | CTD | PMID:17374397 | iron atom | increases abundance | ISO | RGD:732562 | 6480464 | BMP6 gene mutant form results in increased abundance of Iron | CTD | PMID:19252486 PMID:19252488 | iron atom | increases expression | EXP | | 6480464 | Iron results in increased expression of BMP6 mRNA | CTD | PMID:20164366 | iron atom | decreases expression | EXP | | 6480464 | Iron deficiency results in decreased expression of BMP6 mRNA | CTD | PMID:20164366 | iron atom | increases abundance | ISO | RGD:732562 | 6480464 | BMP6 gene mutant form results in increased abundance of Iron | CTD | PMID:19252488 PMID:19252486 | iron atom | decreases abundance | ISO | RGD:732562 | 6480464 | BMP6 protein results in decreased abundance of Iron | CTD | PMID:19252486 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of BMP6 mRNA | CTD | PMID:22504374 | nickel sulfate | increases expression | ISO | RGD:1353193 | 6480464 | nickel sulfate results in increased expression of BMP6 mRNA | CTD | PMID:16780908 | nickel sulfate | increases expression | ISO | RGD:1353193 | 6480464 | nickel sulfate results in increased expression of BMP6 mRNA | CTD | PMID:16780908 PMID:17374397 | nickel sulfate | increases expression | ISO | RGD:1353193 | 6480464 | nickel sulfate results in increased expression of BMP6 mRNA | CTD | PMID:17374397 PMID:16780908 | paracetamol | affects expression | ISO | RGD:732562 | 6480464 | Acetaminophen affects the expression of BMP6 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:732562 | 6480464 | Acetaminophen results in decreased expression of BMP6 mRNA | CTD | PMID:22610607 | paracetamol | increases expression | ISO | RGD:1353193 | 6480464 | Acetaminophen results in increased expression of BMP6 mRNA | CTD | PMID:21420995 | phosgene | affects expression | ISO | RGD:732562 | 6480464 | Phosgene affects the expression of BMP6 mRNA | CTD | PMID:16300373 | resveratrol | decreases expression | ISO | RGD:1353193 | 6480464 | resveratrol results in decreased expression of BMP6 mRNA | CTD | PMID:12002526 | streptozocin | decreases expression | EXP | | 6480464 | Streptozocin results in decreased expression of BMP6 mRNA | CTD | PMID:21450970 | streptozocin | multiple interactions | EXP | | 6480464 | esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA] | CTD | PMID:21450970 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of BMP6 mRNA | CTD | PMID:18472332 | tetrachloromethane | multiple interactions | EXP | | 6480464 | Atropine inhibits the reaction [Carbon Tetrachloride results in increased expression of BMP6 mRNA] | CTD | PMID:18472332 | trans-resveratrol | decreases expression | ISO | RGD:1353193 | 6480464 | resveratrol results in decreased expression of BMP6 mRNA | CTD | PMID:12002526 | triclosan | multiple interactions | ISO | RGD:1353193 | 6480464 | Triclosan promotes the reaction [Lipopolysaccharides results in increased expression of BMP6 mRNA] | CTD | PMID:20507366 | valproic acid | affects expression | ISO | RGD:732562 | 6480464 | Valproic Acid affects the expression of BMP6 mRNA | CTD | PMID:17963808 | valproic acid | increases expression | ISO | RGD:732562 | 6480464 | Valproic Acid results in increased expression of BMP6 mRNA | CTD | PMID:21427059 | valproic acid | increases expression | ISO | RGD:732562 | 6480464 | Valproic Acid results in increased expression of BMP6 mRNA | CTD | PMID:19136453 PMID:21427059 | valproic acid | increases expression | ISO | RGD:732562 | 6480464 | Valproic Acid results in increased expression of BMP6 mRNA | CTD | PMID:21427059 PMID:19136453 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Hippo signaling pathway |
| TGF-beta signaling pathway | |
| Pathway Interaction Database | BMP receptor signaling (PID:200144) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Hippo signaling pathway |
| TGF-beta signaling pathway | |
| Pathway Interaction Database | BMP receptor signaling (PID:200144) |
References - curated| 1. |
Alarmo EL, etal., Breast Cancer Res Treat. 2007 Jun;103(2):239-46. Epub 2006 Sep 21. |
| 2. |
Basic-Jukic N, etal., Kidney Blood Press Res. 2009;32(6):445-50. doi: 10.1159/000266479. Epub 2009 Dec 17. |
| 3. |
Boden SD, etal., Endocrinology. 1997 Jul;138(7):2820-8. |
| 4. |
Dai J, etal., Cancer Res. 2005 Sep 15;65(18):8274-85. |
| 5. |
Darby S, etal., J Pathol. 2007 Dec 10;214(3):394-404. |
| 6. |
Dendooven A, etal., Am J Pathol. 2011 Mar;178(3):1069-79. doi: 10.1016/j.ajpath.2010.12.005. |
| 7. |
Fischerauer EE, etal., J Orthop Res. 2013 Mar;31(3):357-63. doi: 10.1002/jor.22238. Epub 2012 Oct 23. |
| 8. |
Gazit D, etal., Mol Endocrinol. 1993 Feb;7(2):189-98. |
| 9. |
Ishizaki N, etal., Br J Nutr. 2011 Oct;106(8):1169-72. doi: 10.1017/S0007114511001553. Epub 2011 May 18. |
| 10. |
Kayabasi GK, etal., J Biomed Mater Res A. 2013 May;101(5):1353-61. doi: 10.1002/jbm.a.34430. Epub 2012 Oct 18. |
| 11. |
Knittel T, etal., Exp Cell Res 1997 May 1;232(2):263-9. |
| 12. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 13. |
Li H, etal., Int J Med Sci. 2006;3(3):97-105. Epub 2006 Jun 1. |
| 14. |
Maric I, etal., Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1151-62. doi: 10.1152/ajpgi.00244.2011. Epub 2012 Feb 23. |
| 15. |
Martinez G, etal., Brain Res. 2001 Mar 9;894(1):1-11. |
| 16. |
Matsumoto Y, etal., J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):8-14. doi: 10.1016/j.jsbmb.2012.04.004. Epub 2012 Apr 17. |
| 17. |
MGD data from the GO Consortium |
| 18. |
Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30. |
| 19. |
Nam J, etal., Tissue Eng Part A. 2013 Mar;19(5-6):783-92. doi: 10.1089/ten.tea.2012.0103. Epub 2012 Nov 30. |
| 20. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 21. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 22. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 23. |
RGD automated data pipeline |
| 24. |
RGD automated import pipeline for gene-chemical interactions |
| 25. |
Sauermann U, etal., J Neurosci Res 1992 Sep;33(1):142-7. |
| 26. |
Sipe JB, etal., Bone. 2004 Dec;35(6):1316-22. |
| 27. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 28. |
Theurl I, etal., Haematologica. 2011 Dec;96(12):1761-9. doi: 10.3324/haematol.2011.048926. Epub 2011 Aug 22. |
| 29. |
Yamamoto N, etal., Biol Pharm Bull. 2002 Apr;25(4):509-15. |
| 30. |
Yuen HF, etal., Cancer Sci. 2012 Jun;103(6):1145-54. doi: 10.1111/j.1349-7006.2012.02252.x. Epub 2012 Apr 3. |
| 31. |
Zhang Z, etal., Neuroscience. 2006;138(1):47-53. Epub 2006 Jan 4. |
References - uncurated
RGD Disease Portals| Bmp6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Bmp6 (Rattus norvegicus) |
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| BMP6 (Homo sapiens) |
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| Bmp6 (Mus musculus) |
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Position Markers| RH133030 |
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| RH94639 |
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| BE107569 |
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| Bmp6 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013107 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06091061 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06091062 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091063 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091064 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091065 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091066 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091067 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091068 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091069 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091070 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091071 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091072 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06091073 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090786 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090787 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090788 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090789 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090790 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090791 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090792 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090793 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01090794 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY184240 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473977 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U66298 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X58830 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013107 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037239 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037239 | (Get FASTA) |
| GenBank Protein | AAB65471 | (Get FASTA) |
| AAO25744 | (Get FASTA) | |
| CAA41634 | (Get FASTA) | |
| EDL98254 | (Get FASTA) | |
| EDL98255 | (Get FASTA) | |
| Q04906 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000013717 | UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000018359 | UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000018359 | UniProtKB/Swiss-Prot |
| Entrez Gene | 25644 | ENTREZGENE |
| HomoloGene Group ID | 1300 | ENTREZGENE |
| InterPro | TGFb | UniProtKB/Swiss-Prot |
| TGFb_CS | UniProtKB/Swiss-Prot | |
| TGFb_N | UniProtKB/Swiss-Prot | |
| TGFbeta | UniProtKB/Swiss-Prot | |
| IPI | IPI00324269 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25644 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | TGFbeta | UniProtKB/Swiss-Prot |
| Pfam | TGF_beta | UniProtKB/Swiss-Prot |
| TGFb_propeptide | UniProtKB/Swiss-Prot | |
| PROSITE | TGF_BETA_1 | UniProtKB/Swiss-Prot |
| TGF_BETA_2 | UniProtKB/Swiss-Prot | |
| SMART | TGFB | UniProtKB/Swiss-Prot |
| TIGR | TC218331 | |
| UniGene | Rn.40476 | ENTREZGENE |
| UniProt | BMP6_RAT | UniProtKB/Swiss-Prot |
| P97835_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2003-04-09 | Bmp6 | bone morphogenetic protein 6 | Bone morphogenetic protein 6 | Name updated | 2575 | APPROVED | |
| 2002-06-10 | Bmp6 | Bone morphogenetic protein 6 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed constitutively in the central nervous system | 631795 |
| gene_expression | expressed in lung and in minor quantities in spleen, kidney, heart, brain, and liver | 631742 |
| gene_function | growth factor molecule | 631742 |
| gene_process | involve in induction of osteogenesis, control of growth and differentiation during embryogenesis and liver organogenesis | 631742 |
| gene_product | member of the transforming growth factor beta superfamily | 631742 |
| gene_product | member of the transforming growth factor beta superfamily | 631795 |
| gene_regulation | upregulated by transforming growth factor-beta 1 | 631742 |
| gene_transcript | 3.7 kb | 631742 |
| gene_transcript | 3.7 kb | 631795 |
| More on Bmp6 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2214 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




