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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1558147 | 6480464 | Ethinyl Estradiol affects the expression of H2-EB1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:1558147 | 6480464 | Ethinyl Estradiol results in decreased expression of H2-EB1 mRNA | CTD | PMID:17942748 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1558147 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA] | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2-EB1 mRNA | CTD | PMID:18343893 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin affects the expression of H2-EB1 mRNA | CTD | PMID:18343893 PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA | CTD | PMID:15800033 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1558147 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA] | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA | CTD | PMID:16960034 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA | CTD | PMID:21041162 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA | CTD | PMID:21041162 more ... | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1558147 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of H2-EB1 mRNA | CTD | PMID:15800033 PMID:16960034 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of RT1-DB1 mRNA | CTD | PMID:19162173 | acetylsalicylic acid | affects response to substance | ISO | RGD:1349823 | 6480464 | HLA-DRB1 gene SNP affects the susceptibility to Aspirin | CTD | PMID:20485159 | amitriptyline | increases expression | EXP | | 6480464 | Amitriptyline results in increased expression of RT1-DB1 mRNA | CTD | PMID:22341215 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of RT1-DB1 mRNA | CTD | PMID:16483693 | arsenic atom | affects expression | ISO | RGD:1349823 | 6480464 | Arsenic affects the expression of HLA-DRB1 mRNA | CTD | PMID:18414638 | auranofin | increases response to substance | ISO | RGD:1349823 | 6480464 | HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin | CTD | PMID:11436868 | benzo[a]pyrene | decreases expression | ISO | RGD:1349823 | 6480464 | Benzo(a)pyrene results in decreased expression of HLA-DRB1 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | multiple interactions | ISO | RGD:1558147 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of H2-EB1 mRNA] | CTD | PMID:22228805 | beryllium sulfate | increases response to substance | ISO | RGD:1349823 | 6480464 | HLA-DRB1 protein mutant form results in increased susceptibility to beryllium sulfate | CTD | PMID:16272364 | beryllium sulfate | increases expression | ISO | RGD:1349823 | 6480464 | beryllium sulfate results in increased expression of HLA-DRB1 mRNA | CTD | PMID:16314022 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1558147 | 6480464 | PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of H2-EB1 mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1558147 | 6480464 | Diethylhexyl Phthalate results in decreased expression of H2-EB1 mRNA | CTD | PMID:19850644 | C60 fullerene | increases expression | ISO | RGD:1558147 | 6480464 | fullerene C60 results in increased expression of H2-EB1 mRNA | CTD | PMID:20064541 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of RT1-DB1 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of RT1-DB1 mRNA | CTD | PMID:22465980 | cyclosporin A | decreases expression | ISO | RGD:1349823 | 6480464 | Cyclosporine results in decreased expression of HLA-DRB1 mRNA | CTD | PMID:20106945 | D-penicillamine | increases response to substance | ISO | RGD:1349823 | 6480464 | HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine | CTD | PMID:6420562 | dexamethasone | increases expression | ISO | RGD:1558147 | 6480464 | Dexamethasone results in increased expression of H2-EB1 mRNA | CTD | PMID:21041162 | dexamethasone | multiple interactions | EXP | | 6480464 | Dexamethasone inhibits the reaction [Freund's Adjuvant results in increased expression of RT1-DB1 mRNA] | CTD | PMID:21149847 | diazoxide | decreases expression | ISO | RGD:1558147 | 6480464 | Isoproterenol results in decreased expression of H2-EB1 mRNA | CTD | PMID:20003209 | dichloromethane | increases expression | EXP | | 6480464 | Methylene Chloride results in increased expression of RT1-DB1 mRNA | CTD | PMID:20955722 | diethylstilbestrol | increases expression | ISO | RGD:1558147 | 6480464 | Diethylstilbestrol results in increased expression of H2-EB1 mRNA | CTD | PMID:21041162 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of RT1-DB1 mRNA | CTD | PMID:21551480 | ethylbenzene | increases expression | EXP | | 6480464 | ethylbenzene results in increased expression of RT1-DB1 mRNA | CTD | PMID:20955722 | fenofibrate | decreases expression | ISO | RGD:1558147 | 6480464 | Fenofibrate results in decreased expression of H2-EB1 mRNA | CTD | PMID:11798191 | ferric oxide | multiple interactions | ISO | RGD:1558147 | 6480464 | [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of H2-EB1 mRNA | CTD | PMID:20540983 | hexachlorobenzene | affects expression | EXP | | 6480464 | Hexachlorobenzene affects the expression of RT1-DB1 mRNA | CTD | PMID:15159207 | iron atom | increases expression | EXP | | 6480464 | Iron deficiency results in increased expression of RT1-DB1 mRNA | CTD | PMID:16629162 | isoprenaline | decreases expression | ISO | RGD:1558147 | 6480464 | Isoproterenol results in decreased expression of H2-EB1 mRNA | CTD | PMID:20003209 | lead(0) | decreases expression | ISO | RGD:1349823 | 6480464 | Lead results in decreased expression of HLA-DRB1 mRNA | CTD | PMID:19921347 | mercaptopurine | decreases expression | EXP | | 6480464 | 6-Mercaptopurine results in decreased expression of RT1-DB1 mRNA | CTD | PMID:23358152 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | RGD:1349823 | 6480464 | Methylnitronitrosoguanidine results in increased expression of HLA-DRB1 mRNA | CTD | PMID:12634122 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of RT1-DB1 mRNA | CTD | PMID:19638242 | nickel atom | decreases expression | ISO | RGD:1558147 | 6480464 | Nickel results in decreased expression of H2-EB1 mRNA | CTD | PMID:12540486 | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of RT1-DB1 mRNA | CTD | PMID:16716893 | ozone | decreases expression | ISO | RGD:1558147 | 6480464 | Ozone results in decreased expression of H2-EB1 mRNA | CTD | PMID:12763052 PMID:20032013 | ozone | multiple interactions | ISO | RGD:1558147 | 6480464 | [H2-AB1 gene mutant form co-treated with H2-AA gene mutant form co-treated with H2-EB1 gene mutant form co-treated with H2-EB2 gene mutant form co-treated with H2-EA gene mutant form] inhibits the reaction [Ozone results in increased expression of LTA mRNA]; more ... | CTD | PMID:20032013 | ozone | decreases expression | ISO | RGD:1558147 | 6480464 | Ozone results in decreased expression of H2-EB1 mRNA | CTD | PMID:12763052 | pirinixic acid | decreases expression | ISO | RGD:1558147 | 6480464 | pirinixic acid results in decreased expression of H2-EB1 mRNA | CTD | PMID:11798191 PMID:17426115 | pirinixic acid | decreases expression | ISO | RGD:1558147 | 6480464 | pirinixic acid results in decreased expression of H2-EB1 mRNA | CTD | PMID:17426115 PMID:11798191 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of RT1-DB1 mRNA | CTD | PMID:19162173 | purine-6-thiol | decreases expression | EXP | | 6480464 | 6-Mercaptopurine results in decreased expression of RT1-DB1 mRNA | CTD | PMID:23358152 | quercetin | increases expression | ISO | RGD:1558147 | 6480464 | Quercetin results in increased expression of HLA-DRB1 mRNA | CTD | PMID:16455785 | S-adenosyl-L-methionine | decreases expression | ISO | RGD:1558147 | 6480464 | S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA | CTD | PMID:18098314 | succimer | multiple interactions | ISO | RGD:1558147 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of H2-EB1 mRNA | CTD | PMID:21641980 | tamoxifen | affects expression | ISO | RGD:1558147 | 6480464 | Tamoxifen affects the expression of H2-EB1 mRNA | CTD | PMID:17555576 | tamoxifen | multiple interactions | EXP | | 6480464 | [bexarotene co-treated with Tamoxifen] results in decreased expression of RT1-DB1 mRNA | CTD | PMID:17630414 | titanium dioxide | increases expression | ISO | RGD:1558147 | 6480464 | titanium dioxide results in increased expression of H2-EB1 mRNA | CTD | PMID:19464567 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of RT1-DB1 mRNA | CTD | PMID:20955722 | vancomycin | decreases expression | ISO | RGD:1558147 | 6480464 | Vancomycin results in decreased expression of H2-EB1 mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Allograft rejection |
| Antigen processing and presentation | |
| Asthma | |
| Autoimmune thyroid disease | |
| Cell adhesion molecules (CAMs) | |
| Graft-versus-host disease | |
| Hematopoietic cell lineage | |
| Herpes simplex infection | |
| HTLV-I infection | |
| Influenza A | |
| Intestinal immune network for IgA production | |
| Leishmaniasis | |
| Phagosome | |
| Rheumatoid arthritis | |
| Staphylococcus aureus infection | |
| Systemic lupus erythematosus | |
| Toxoplasmosis | |
| Tuberculosis | |
| Type I diabetes mellitus | |
| Viral myocarditis | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
| IL12 signaling mediated by STAT4 (PID:200229) | |
| IL12-mediated signaling events (PID:200045) | |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
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References - uncurated
RGD Disease Portals| RT1-Db1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| RT1-Db1 (Rattus norvegicus) |
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| HLA-DRB1 (Homo sapiens) |
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| H2-Eb1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001008884 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06099861 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01099643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF084933 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF246657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ003231 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ003234 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY626207 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC087691 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BX883043 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473988 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CO563535 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CV111238 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ225193 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226724 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226759 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ226850 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227087 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228005 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228124 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228129 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ228185 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ230360 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ231709 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232046 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232100 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232453 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233049 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233335 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233396 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233493 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233800 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ233801 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234464 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ234907 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X53054 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001008884 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001008884 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001008884 | (Get FASTA) |
| GenBank Protein | AAD39083 | (Get FASTA) |
| AAH87691 | (Get FASTA) | |
| AAK37421 | (Get FASTA) | |
| AAV40636 | (Get FASTA) | |
| CAA06021 | (Get FASTA) | |
| CAA06024 | (Get FASTA) | |
| CAA37221 | (Get FASTA) | |
| CAE83947 | (Get FASTA) | |
| EDL96798 | (Get FASTA) | |
| P18211 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000033215 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000000522 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000057075 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000000522 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000060327 | UniProtKB/TrEMBL | |
| Entrez Gene | 294270 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| MHC_II_alpha_N | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000033215 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 128336 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7310949 | IMAGE-MGC_LOAD |
| InterPro | Ig-like | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig/MHC_CS | UniProtKB/Swiss-Prot | |
| Ig_C1-set | UniProtKB/Swiss-Prot | |
| MHC_I/II-like_Ag-recog | UniProtKB/Swiss-Prot | |
| MHC_II_a/b_N | UniProtKB/Swiss-Prot | |
| MHC_II_b_N | UniProtKB/Swiss-Prot | |
| IPI | IPI00188923 | UniProtKB/TrEMBL |
| IPI00476115 | UniProtKB/Swiss-Prot | |
| IPI00780822 | UniProtKB/TrEMBL | |
| KEGG Report | rno:294270 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:105710 | IMAGE-MGC_LOAD |
| Pfam | C1-set | UniProtKB/Swiss-Prot |
| MHC_II_beta | UniProtKB/Swiss-Prot | |
| PharmGKB | HLA-DRB1 | RGD |
| ProDom | MHC_II_b_N | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| IG_MHC | UniProtKB/Swiss-Prot | |
| SMART | IGc1 | UniProtKB/Swiss-Prot |
| MHC_II_beta | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | MHC_I/II-like_Ag-recog | UniProtKB/Swiss-Prot |
| UniGene | Rn.33311 | ENTREZGENE |
| UniProt | F1M7F9_RAT | UniProtKB/TrEMBL |
| HB2D_RAT | UniProtKB/Swiss-Prot | |
| Q9TQA6_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2007-04-12 | RT1-Db1 | RT1 class II, locus Db1 | RT1-Db1_mapped | RT1 class II, locus Db1 (mapped) | Data Merged | 9333 | APPROVED |
| 2006-11-20 | RT1-Db1_mapped | RT1 class II, locus Db1(mapped) | RT1-Db1 | RT1 class II, locus Db1 | Symbol set to symbol_mapped, name set to name (mapped) | 17121 | APPROVED |
| 2006-11-20 | RT1-Db1 | RT1 class II, locus Db1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2004-02-11 | RT1-Db1 | RT1 class II, locus Db1 | Symbol and Name status set to approved | 2225 | APPROVED | ||
| 2002-06-10 | RT1-Db1 | RT1 class II, locus Db1 | Symbol and Name status set to approved | 1490 | APPROVED |
| More on RT1-Db1 | |
![]() |
Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1593282 |
| Created: | 2006-11-20 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




