Fbxo32 (F-box protein 32) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fbxo32 (F-box protein 32) Rattus norvegicus
Analyze
Symbol: Fbxo32
Name: F-box protein 32
RGD ID: 620373
Description: Predicted to enable ubiquitin-protein transferase activity. Involved in muscle atrophy; positive regulation of cardiac muscle cell apoptotic process; and regulation of muscle adaptation. Predicted to be located in Z disc; cytosol; and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Used to study muscular atrophy. Orthologous to human FBXO32 (F-box protein 32); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: atrogin-1; Atrogin1; atrophy gene 1; F-box only protein 32; MAFbx; muscle atrophy F-box protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,620,925 - 91,654,491 (-)NCBIGRCr8
mRatBN7.2789,731,428 - 89,764,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,607,526 - 91,640,897 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,808,794 - 93,842,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,639,384 - 93,672,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0798,065,664 - 98,098,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,669,144 - 98,701,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,909,568 - 94,942,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,943,797 - 94,976,674 (-)NCBI
Celera786,503,248 - 86,536,357 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-(-)-perillyl alcohol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-hydroxyisovaleric acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Botulinum toxin type A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celastrol  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glucose  (ISO)
hexadecanoic acid  (ISO)
indoxyl sulfate  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (ISO)
LY294002  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
ouabain  (ISO)
ozone  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perillyl alcohol  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)
SCF ubiquitin ligase complex  (IBA,IEA,ISO)
ubiquitin ligase complex  (NAS)
Z disc  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
2. Identification of ubiquitin ligases required for skeletal muscle atrophy. Bodine SC, etal., Science 2001 Nov 23;294(5547):1704-8.
3. Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection. Dehoux MJ, etal., FEBS Lett 2003 Jun 5;544(1-3):214-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. Macpherson PC, etal., J Cell Biochem. 2011 Aug;112(8):2149-59. doi: 10.1002/jcb.23136.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Song DW, etal., Biochem J. 2014 Jan 1;457(1):151-62. doi: 10.1042/BJ20130833.
Additional References at PubMed
PMID:15284206   PMID:15726428   PMID:16714087   PMID:16949134   PMID:17034040   PMID:17622304   PMID:17721978   PMID:17916612   PMID:18644837   PMID:19028597   PMID:19211729   PMID:19728616  
PMID:19777444   PMID:19803207   PMID:19850579   PMID:20191313   PMID:20349269   PMID:20371624   PMID:20519361   PMID:20555375   PMID:21611832   PMID:21617130   PMID:21691063   PMID:22146233  
PMID:22328594   PMID:22702057   PMID:22854904   PMID:23084640   PMID:23335977   PMID:23388481   PMID:23526547   PMID:23752591   PMID:23866982   PMID:24084216   PMID:25300705   PMID:26483344  
PMID:26691660   PMID:26753747   PMID:26768247   PMID:27521792   PMID:27841025   PMID:28000044   PMID:28246104   PMID:30312703   PMID:31311969   PMID:32646070  


Genomics

Comparative Map Data
Fbxo32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,620,925 - 91,654,491 (-)NCBIGRCr8
mRatBN7.2789,731,428 - 89,764,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,607,526 - 91,640,897 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,808,794 - 93,842,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,639,384 - 93,672,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0798,065,664 - 98,098,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,669,144 - 98,701,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,909,568 - 94,942,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,943,797 - 94,976,674 (-)NCBI
Celera786,503,248 - 86,536,357 (-)NCBICelera
Cytogenetic Map7q33NCBI
FBXO32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388123,497,889 - 123,541,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8123,497,889 - 123,541,206 (-)EnsemblGRCh38hg38GRCh38
GRCh378124,510,129 - 124,553,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368124,584,539 - 124,622,627 (-)NCBINCBI36Build 36hg18NCBI36
Build 348124,584,539 - 124,613,564NCBI
Celera8120,703,016 - 120,741,104 (-)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8119,835,717 - 119,879,094 (-)NCBIHuRef
CHM1_18124,550,510 - 124,593,876 (-)NCBICHM1_1
T2T-CHM13v2.08124,628,980 - 124,672,309 (-)NCBIT2T-CHM13v2.0
Fbxo32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391558,039,275 - 58,078,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1558,039,275 - 58,078,328 (-)EnsemblGRCm39 Ensembl
GRCm381558,175,879 - 58,214,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1558,175,879 - 58,214,932 (-)EnsemblGRCm38mm10GRCm38
MGSCv371558,011,634 - 58,046,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361558,010,162 - 58,044,957 (-)NCBIMGSCv36mm8
Celera1559,700,046 - 59,734,826 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1524.43NCBI
Fbxo32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555402,309,315 - 2,340,956 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555402,309,315 - 2,334,735 (-)NCBIChiLan1.0ChiLan1.0
FBXO32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27140,929,665 - 140,973,569 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18116,440,872 - 116,484,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08120,192,822 - 120,236,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18122,948,853 - 122,992,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8122,954,343 - 122,992,157 (-)Ensemblpanpan1.1panPan2
FBXO32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11321,804,442 - 21,838,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1321,809,292 - 21,838,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1321,770,175 - 21,803,891 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01322,146,431 - 22,178,526 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1322,148,672 - 22,178,548 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11321,873,240 - 21,906,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01321,975,418 - 22,009,111 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01322,218,984 - 22,252,700 (-)NCBIUU_Cfam_GSD_1.0
Fbxo32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530316,460,677 - 16,496,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647023,886,970 - 23,918,258 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647023,886,836 - 23,919,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl415,895,689 - 15,930,931 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1415,895,875 - 15,925,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2416,639,187 - 16,669,235 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18118,071,856 - 118,115,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603922,118,961 - 22,162,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473531,475,041 - 31,509,245 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473531,475,008 - 31,511,837 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo32
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000010361
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat

Markers in Region
D7Uwm16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2789,740,273 - 89,740,457 (+)MAPPERmRatBN7.2
Rnor_6.0798,074,313 - 98,074,496NCBIRnor6.0
Rnor_5.0798,677,793 - 98,677,976UniSTSRnor5.0
RGSC_v3.4794,918,217 - 94,918,401RGDRGSC3.4
RGSC_v3.4794,918,218 - 94,918,401UniSTSRGSC3.4
RGSC_v3.1794,952,447 - 94,952,631RGD
Celera786,511,895 - 86,512,068UniSTS
Cytogenetic Map7q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 12 8 8 11 3 1 16 11 8
Low 1 31 27 11 27 71 34 24
Below cutoff 14 14 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010361   ⟹   ENSRNOP00000010361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)Ensembl
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)Ensembl
RefSeq Acc Id: NM_133521   ⟹   NP_598205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8791,620,925 - 91,654,491 (-)NCBI
mRatBN7.2789,731,428 - 89,764,997 (-)NCBI
Rnor_6.0798,065,664 - 98,098,071 (-)NCBI
Rnor_5.0798,669,144 - 98,701,551 (-)NCBI
RGSC_v3.4794,909,568 - 94,942,444 (-)RGD
Celera786,503,248 - 86,536,357 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598205 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL16406 (Get FASTA)   NCBI Sequence Viewer  
  EDM16222 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010361
  ENSRNOP00000010361.1
GenBank Protein Q91Z62 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_598205   ⟸   NM_133521
- UniProtKB: G3V6Z4 (UniProtKB/TrEMBL),   A6HRK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010361   ⟸   ENSRNOT00000010361
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91Z62-F1-model_v2 AlphaFold Q91Z62 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695348
Promoter ID:EPDNEW_R5872
Type:multiple initiation site
Name:Fbxo32_1
Description:F-box protein 32
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0798,098,307 - 98,098,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620373 AgrOrtholog
BioCyc Gene G2FUF-33323 BioCyc
Ensembl Genes ENSRNOG00000006738 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010361 ENTREZGENE
  ENSRNOT00000010361.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FBX25/32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171043 UniProtKB/Swiss-Prot
NCBI Gene 171043 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxo32 PhenoGen
RatGTEx ENSRNOG00000006738 RatGTEx
Superfamily-SCOP SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HRK0 ENTREZGENE, UniProtKB/TrEMBL
  FBX32_RAT UniProtKB/Swiss-Prot
  G3V6Z4 ENTREZGENE, UniProtKB/TrEMBL
  Q91Z62 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Fbxo32  F-box protein 32  Fbxo32  F-box only protein 32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Fbxo32  F-box only protein 32    f-box only protein 32  Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Fbxo32  f-box only protein 32      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease displays increased mRNA expression in denervation, immobilization, and hindlimb suspension models of muscle atrophy 633893