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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620373
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxo32
Name: F-box protein 32
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxo32increases expressionEXP 6480464CTDSimvastatin results in increased expression of FBXO32 mRNAPMID:19001041 PMID:25300705
Fbxo32increases expressionISOFbxo32 (Mus musculus)6480464CTDSimvastatin results in increased expression of FBXO32 mRNA; Simvastatin results in increased expression of FBXO32 proteinPMID:25300705 PMID:27734117 PMID:33034787
Fbxo32multiple interactionsISOFbxo32 (Mus musculus)6480464CTDFST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]; FST protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 protein]; IGF1 protein inhibits the reaction [Simvastatin results in increased expression of FBXO32 mRNA]PMID:27734117 PMID:33034787
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