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Gene Ontology AnnotationsGene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cellular response to insulin stimulus | | IMP | | | PMID:17715136 | MGI | PMID:17715136 | mitochondrial genome maintenance | | ISO | RGD:735623 | 1624291 | PMID:18524868 | RGD | PMID:18524868 | positive regulation of sodium ion transport | | IMP | | | PMID:17715136 | MGI | PMID:17715136 | protein phosphorylation | | IDA | | 2306431 | | RGD | | signal transduction | | ISO | RGD:735623 | 1624291 | PMID:18524868 | RGD | PMID:18524868 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Adipocytokine signaling pathway | |
| Apoptosis | |
| B cell receptor signaling pathway | |
| Carbohydrate digestion and absorption | |
| Chagas disease (American trypanosomiasis) | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Dopaminergic synapse | |
| Endometrial cancer | |
| Epstein-Barr virus infection | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Fc gamma R-mediated phagocytosis | |
| Focal adhesion | |
| Glioma | |
| Hepatitis B | |
| Hepatitis C | |
| HIF-1 signaling pathway | |
| HTLV-I infection | |
| Influenza A | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| MAPK signaling pathway | |
| Measles | |
| Melanoma | |
| mTOR signaling pathway | |
| Neurotrophin signaling pathway | |
| Non-small cell lung cancer | |
| Osteoclast differentiation | |
| Pancreatic cancer | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Progesterone-mediated oocyte maturation | |
| Prostate cancer | |
| Renal cell carcinoma | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Tight junction | |
| Toll-like receptor signaling pathway | |
| Toxoplasmosis | |
| Tuberculosis | |
| VEGF signaling pathway | |
| Pathway Interaction Database | Class I PI3K signaling events mediated by Akt (PID:200197) |
| S1P3 pathway (PID:200046) | |
References - curated| 1. |
Franke TF Oncogene. 2008 Oct 27;27(50):6473-88. |
| 2. |
GOA data from the GO Consortium |
| 3. |
Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56. |
| 4. |
Kageyama K, etal., J Biol Chem 2002 May 31;277(22):19255-64. |
| 5. |
Konishi H, etal., Biochem Biophys Res Commun 1995 Nov 13;216(2):526-34. |
| 6. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
Turinsky J and Damrau-Abney A, Am J Physiol. 1999 Jan;276(1 Pt 2):R277-82. |
| 12. |
Webster CR, etal., J Biol Chem 2002 Aug 9;277(32):28578-83. |
References - uncuratedRGD Disease Portals| Akt3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Akt3 (Rattus norvegicus) |
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| AKT3 (Homo sapiens) |
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| Akt3 (Mus musculus) |
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Position Markers| RH128880 |
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| RH132276 |
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| RH133674 |
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| RH134046 |
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| BI301874 |
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| BF416653 |
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| AI413057 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031575 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06076289 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06076290 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076291 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076292 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076293 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076294 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076295 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076296 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076297 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076298 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076299 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076881 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076882 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076883 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076884 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076885 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076886 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076887 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01076888 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473985 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D49836 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031575 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_113763 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_113763 | (Get FASTA) |
| GenBank Protein | BAA08637 | (Get FASTA) |
| EDL94786 | (Get FASTA) | |
| Q63484 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000021497 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000054688 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000057879 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 29414 | ENTREZGENE |
| Gene3D-CATH | PH_type | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 55904 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| PH_type | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| Pleckstrin_homology | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00209156 | UniProtKB/Swiss-Prot |
| IPI00782206 | UniProtKB/TrEMBL | |
| KEGG Report | rno:29414 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | PF00169 | UniProtKB/Swiss-Prot |
| Pkinase | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| PharmGKB | AKT3 | RGD |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PH_DOMAIN | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TK_X | UniProtKB/Swiss-Prot |
| S_TKc | UniProtKB/Swiss-Prot | |
| SM00233 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Rn.10506 | ENTREZGENE |
| UniProt | AKT3_RAT | UniProtKB/Swiss-Prot |
| F1M6A8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-26 | Akt3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | Akt3 | thymoma viral proto-oncogene 3 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Akt3 | thymoma viral proto-oncogene 3 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | capable of phosphorylating several known proteins | 724707 |
| gene_regulation | activated by igf-1, which may play a role in regulating cell survival. | 724707 |
| More on Akt3 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62390 |
| Created: | 2001-04-26 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.