Cyp7b1 (cytochrome P450 family 7 subfamily B member 1) - Rat Genome Database

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Gene: Cyp7b1 (cytochrome P450 family 7 subfamily B member 1) Rattus norvegicus
Analyze
Symbol: Cyp7b1
Name: cytochrome P450 family 7 subfamily B member 1
RGD ID: 2483
Description: Predicted to enable oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including circadian rhythm; memory; and response to cAMP. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25-hydroxycholesterol 7-alpha-hydroxylase; Cytochrom P450; cytochrome P450 7B1; cytochrome P450, family 7, subfamily b, polypeptide 1; cytochrome P450, subfamily 7B, polypeptide 1; HCT-1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi  
Genetic Models: F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82102,419,011 - 102,586,047 (-)NCBIGRCr8
mRatBN7.22100,502,791 - 100,669,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2107,017,449 - 107,190,606 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02105,138,553 - 105,311,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02100,132,313 - 100,164,609 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
Celera295,908,860 - 96,075,269 (-)NCBICelera
RH 3.4 Map2606.1RGD
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-arachidonoylglycerol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetaldehyde  (ISO)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
androstane-3,17-diol  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenofibrate  (EXP)
flumequine  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lycopene  (ISO)
MeIQx  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (EXP)
metronidazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oleanolic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phytosterols  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
resveratrol  (ISO)
rifaximin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (EXP)
taurodeoxycholic acid  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zaragozic acid A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. Pandak WM, etal., Hepatology 2002 Jun;35(6):1400-8.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat. Ren S, etal., Metabolism 2003 May;52(5):636-42.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. A novel cytochrome P450 expressed primarily in brain. Stapleton G, etal., J Biol Chem 1995 Dec 15;270(50):29739-45.
17. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. Yau JL, etal., J Neurosci. 2006 Oct 25;26(43):11034-40.
Additional References at PubMed
PMID:10748047   PMID:12370428   PMID:12914530   PMID:18395092   PMID:21029595   PMID:22384504   PMID:22999953   PMID:25263657  


Genomics

Comparative Map Data
Cyp7b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82102,419,011 - 102,586,047 (-)NCBIGRCr8
mRatBN7.22100,502,791 - 100,669,713 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2107,017,449 - 107,190,606 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02105,138,553 - 105,311,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02100,132,313 - 100,164,609 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02102,701,903 - 102,871,257 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02122,442,002 - 122,610,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42103,102,679 - 103,271,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12103,048,320 - 103,073,714 (-)NCBI
Celera295,908,860 - 96,075,269 (-)NCBICelera
RH 3.4 Map2606.1RGD
Cytogenetic Map2q24NCBI
CYP7B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38864,586,575 - 64,798,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl864,587,763 - 64,798,737 (-)EnsemblGRCh38hg38GRCh38
GRCh37865,499,132 - 65,711,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36865,671,246 - 65,873,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34865,671,245 - 65,873,902NCBI
Celera861,498,536 - 61,701,760 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef860,998,772 - 61,201,422 (-)NCBIHuRef
CHM1_1865,562,219 - 65,765,057 (-)NCBICHM1_1
T2T-CHM13v2.0865,011,997 - 65,224,254 (-)NCBIT2T-CHM13v2.0
Cyp7b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39318,126,108 - 18,298,054 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl318,126,114 - 18,297,502 (-)EnsemblGRCm39 Ensembl
GRCm38318,071,944 - 18,243,890 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl318,071,950 - 18,243,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37317,971,950 - 18,143,338 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36318,264,101 - 18,435,480 (-)NCBIMGSCv36mm8
Celera318,067,760 - 18,239,527 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map34.98NCBI
LOC102022645
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544414,275,345 - 14,444,426 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544414,274,818 - 14,446,068 (+)NCBIChiLan1.0ChiLan1.0
CYP7B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2780,323,834 - 80,531,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1855,962,915 - 56,170,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0861,135,307 - 61,335,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1862,806,129 - 63,006,450 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl862,806,637 - 63,006,386 (-)Ensemblpanpan1.1panPan2
CYP7B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12914,443,036 - 14,613,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2914,444,853 - 14,613,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2914,762,658 - 14,936,799 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02914,537,942 - 14,712,338 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2914,537,947 - 14,712,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12914,550,483 - 14,724,576 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02914,664,658 - 14,838,558 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02914,932,049 - 15,106,453 (-)NCBIUU_Cfam_GSD_1.0
LOC101955077
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530365,707,508 - 65,885,081 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364968,899,965 - 9,072,089 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364968,900,320 - 9,072,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP7B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl469,616,049 - 69,806,496 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1469,615,953 - 69,793,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2475,915,950 - 75,973,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP7B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1860,496,607 - 60,691,457 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl860,496,733 - 60,524,238 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603981,044,277 - 81,069,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101721563
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474426,792,890 - 26,991,425 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474426,791,829 - 26,999,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp7b1
1078 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:87
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000013116
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat

Markers in Region
D2Got54  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02102,774,990 - 102,775,099NCBIRnor6.0
Rnor_5.02122,515,089 - 122,515,198UniSTSRnor5.0
RGSC_v3.42103,176,564 - 103,176,680UniSTSRGSC3.4
RGSC_v3.42103,176,563 - 103,176,680RGDRGSC3.4
RGSC_v3.12103,121,526 - 103,121,642RGD
Celera295,981,934 - 95,982,050UniSTS
RH 3.4 Map2623.3RGD
RH 3.4 Map2623.3UniSTS
RH 2.0 Map2506.9RGD
Cytogenetic Map2q24UniSTS
RH94670  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22100,503,471 - 100,503,635 (+)MAPPERmRatBN7.2
Rnor_6.02102,702,584 - 102,702,747NCBIRnor6.0
Rnor_5.02122,442,683 - 122,442,846UniSTSRnor5.0
RGSC_v3.42103,103,573 - 103,103,736UniSTSRGSC3.4
Celera295,909,541 - 95,909,704UniSTS
RH 3.4 Map2606.1UniSTS
Cytogenetic Map2q24UniSTS
AU049273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22100,554,056 - 100,554,228 (+)MAPPERmRatBN7.2
Rnor_6.02102,753,172 - 102,753,343NCBIRnor6.0
Rnor_5.02122,493,271 - 122,493,442UniSTSRnor5.0
RGSC_v3.42103,154,747 - 103,154,918UniSTSRGSC3.4
Celera295,960,122 - 95,960,293UniSTS
Cytogenetic Map2q24UniSTS
ECD14651  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02122,514,089 - 122,515,145UniSTSRnor5.0
RGSC_v3.42103,175,565 - 103,176,628UniSTSRGSC3.4
Celera295,980,935 - 95,981,998UniSTS
Cytogenetic Map2q24UniSTS


Genetic Models
This gene Cyp7b1 is modified in the following models/strains:
F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 1 1 1 25 3 4
Low 3 42 55 40 18 40 8 11 49 35 33 7 8
Below cutoff 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013116   ⟹   ENSRNOP00000013116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2100,502,791 - 100,669,698 (-)Ensembl
Rnor_6.0 Ensembl2102,701,903 - 102,871,257 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082084   ⟹   ENSRNOP00000073111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2100,502,791 - 100,535,586 (-)Ensembl
Rnor_6.0 Ensembl2102,702,689 - 102,838,745 (-)Ensembl
RefSeq Acc Id: NM_019138   ⟹   NP_062011
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,011 - 102,585,905 (-)NCBI
mRatBN7.22100,502,791 - 100,669,698 (-)NCBI
Rnor_6.02102,701,903 - 102,871,257 (-)NCBI
Rnor_5.02122,442,002 - 122,610,354 (-)NCBI
RGSC_v3.42103,102,679 - 103,271,273 (-)RGD
Celera295,908,860 - 96,075,269 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101794   ⟹   XP_038957722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,477 - 102,586,047 (-)NCBI
mRatBN7.22100,503,928 - 100,669,713 (-)NCBI
RefSeq Acc Id: XM_063281357   ⟹   XP_063137427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82102,419,477 - 102,585,800 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062011 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957722 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137427 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA92616 (Get FASTA)   NCBI Sequence Viewer  
  EDM01054 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013116
  ENSRNOP00000013116.4
  ENSRNOP00000073111.2
GenBank Protein Q63688 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062011   ⟸   NM_019138
- UniProtKB: A6IHA6 (UniProtKB/TrEMBL),   G3V787 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073111   ⟸   ENSRNOT00000082084
RefSeq Acc Id: ENSRNOP00000013116   ⟸   ENSRNOT00000013116
RefSeq Acc Id: XP_038957722   ⟸   XM_039101794
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137427   ⟸   XM_063281357
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63688-F1-model_v2 AlphaFold Q63688 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691251
Promoter ID:EPDNEW_R1776
Type:initiation region
Name:Cyp7b1_1
Description:cytochrome P450 family 7 subfamily B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02102,871,237 - 102,871,297EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2483 AgrOrtholog
BioCyc Gene G2FUF-53640 BioCyc
Ensembl Genes ENSRNOG00000009730 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013116 ENTREZGENE
  ENSRNOT00000013116.7 UniProtKB/TrEMBL
  ENSRNOT00000082084.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25429 UniProtKB/Swiss-Prot
NCBI Gene 25429 ENTREZGENE
PANTHER CYTOCHROME P450 7B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp7b1 PhenoGen
PIRSF Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009730 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220574
UniProt A0A0G2K4N5_RAT UniProtKB/TrEMBL
  A6IHA6 ENTREZGENE, UniProtKB/TrEMBL
  CP7B1_RAT UniProtKB/Swiss-Prot
  G3V787 ENTREZGENE, UniProtKB/TrEMBL
  Q63688 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp7b1  cytochrome P450, family 7, subfamily b, polypeptide 1    cytochrome P450, subfamily 7B, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp7b1  cytochrome P450, subfamily 7B, polypeptide 1    Cytochrom P450  Name updated 625702 APPROVED
2002-06-10 Cyp7b1  Cytochrom P450      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains possesses a steroidogenic domain 1298867
gene_expression expressed at low levels in testis, ovary and adrenal gland 1298867
gene_expression taurocholic acid and taurodeoxycholic acid decrease expression in primary hepatocytes 1298868
gene_expression expression is enriched in brain, liver and kidney 1298867
gene_expression expression is sexually dimorphic in liver but not in brain 1298867
gene_process may metabolize steroids in brain 1298867
gene_regulation squalestatin added to primary hepatocytes decreases enzymatic activity 1298868
gene_regulation cholesterol, phorbol myristate acetate (PMA) or cyclic AMP (cAMP) added to primary hepatocytes increase enzymatic activity 1298868