Fbxo36 (F-box protein 36) - Rat Genome Database

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Gene: Fbxo36 (F-box protein 36) Rattus norvegicus
Analyze
Symbol: Fbxo36
Name: F-box protein 36
RGD ID: 1307870
Description: Orthologous to human FBXO36 (F-box protein 36); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 36; LOC363268
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8993,490,618 - 93,555,298 (+)NCBIGRCr8
mRatBN7.2986,042,522 - 86,107,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,040,862 - 86,107,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx994,458,732 - 94,524,071 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0999,587,213 - 99,652,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0997,971,515 - 98,035,964 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0992,435,872 - 92,500,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl992,435,896 - 92,500,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,168,447 - 92,231,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,085,586 - 84,164,927 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1984,269,026 - 84,348,355 (+)NCBI
Celera983,466,342 - 83,530,596 (+)NCBICelera
Cytogenetic Map9q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fbxo36
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8993,490,618 - 93,555,298 (+)NCBIGRCr8
mRatBN7.2986,042,522 - 86,107,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl986,040,862 - 86,107,229 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx994,458,732 - 94,524,071 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0999,587,213 - 99,652,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0997,971,515 - 98,035,964 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0992,435,872 - 92,500,765 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl992,435,896 - 92,500,765 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0992,168,447 - 92,231,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4984,085,586 - 84,164,927 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1984,269,026 - 84,348,355 (+)NCBI
Celera983,466,342 - 83,530,596 (+)NCBICelera
Cytogenetic Map9q35NCBI
FBXO36
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,922,503 - 230,013,119 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,922,302 - 230,013,119 (+)EnsemblGRCh38hg38GRCh38
GRCh372230,787,219 - 230,877,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,495,451 - 230,586,069 (+)NCBINCBI36Build 36hg18NCBI36
Build 342230,612,718 - 230,701,430NCBI
Celera2224,563,142 - 224,653,752 (+)NCBICelera
Cytogenetic Map2q36.3NCBI
HuRef2222,626,953 - 222,717,570 (+)NCBIHuRef
CHM1_12230,793,470 - 230,884,098 (+)NCBICHM1_1
T2T-CHM13v2.02230,405,191 - 230,495,787 (+)NCBIT2T-CHM13v2.0
Fbxo36
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39184,817,562 - 84,878,208 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl184,817,562 - 84,878,208 (+)EnsemblGRCm39 Ensembl
GRCm38184,839,841 - 84,900,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl184,839,841 - 84,900,487 (+)EnsemblGRCm38mm10GRCm38
MGSCv37184,836,416 - 84,897,061 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36184,718,881 - 84,779,509 (+)NCBIMGSCv36mm8
Celera184,899,916 - 84,960,760 (+)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.43NCBI
Fbxo36
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554535,053,132 - 5,133,485 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554535,051,138 - 5,133,884 (-)NCBIChiLan1.0ChiLan1.0
FBXO36
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213132,549,809 - 132,683,511 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B132,564,728 - 132,698,478 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B117,174,590 - 117,263,324 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B235,978,710 - 236,066,904 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B235,978,710 - 236,066,904 (+)Ensemblpanpan1.1panPan2
FBXO36
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12542,207,070 - 42,312,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2542,206,984 - 42,320,054 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2542,830,731 - 42,937,331 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02542,461,196 - 42,568,177 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2542,461,727 - 42,558,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12542,392,114 - 42,498,850 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02542,233,205 - 42,340,333 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02542,406,172 - 42,485,566 (+)NCBIUU_Cfam_GSD_1.0
Fbxo36
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303184,399,119 - 184,480,487 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365256,459,299 - 6,486,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365256,454,343 - 6,486,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO36
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15130,940,093 - 131,029,086 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115130,939,865 - 131,029,088 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215144,719,075 - 144,726,267 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO36
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110115,946,209 - 116,036,984 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10115,998,262 - 116,039,612 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604083,414,423 - 83,510,796 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo36
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248433,722,531 - 3,786,575 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248433,722,328 - 3,786,575 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo36
489 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:42
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000022901
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat

Markers in Region
D9Got106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2986,080,304 - 86,080,475 (+)MAPPERmRatBN7.2
Rnor_6.0992,473,856 - 92,474,027NCBIRnor6.0
Rnor_5.0992,206,431 - 92,206,602UniSTSRnor5.0
RGSC_v3.4984,123,979 - 84,124,151RGDRGSC3.4
RGSC_v3.4984,123,980 - 84,124,151UniSTSRGSC3.4
RGSC_v3.1984,307,398 - 84,307,570RGD
Celera983,504,116 - 83,504,287UniSTS
RH 2.0 Map9853.2RGD
Cytogenetic Map9q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 9
Low 2 4 15 6 4 6 1 1 74 29 30 11 1
Below cutoff 1 37 42 35 15 35 7 10 2 2 7

Sequence


RefSeq Acc Id: ENSRNOT00000022901   ⟹   ENSRNOP00000022901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,042,540 - 86,107,229 (+)Ensembl
Rnor_6.0 Ensembl992,435,896 - 92,500,765 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093695   ⟹   ENSRNOP00000076250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,040,862 - 86,107,220 (+)Ensembl
Rnor_6.0 Ensembl992,435,940 - 92,500,739 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100969   ⟹   ENSRNOP00000089548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,070,450 - 86,107,220 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101399   ⟹   ENSRNOP00000097800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,042,831 - 86,107,220 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107588   ⟹   ENSRNOP00000087733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl986,042,450 - 86,107,220 (+)Ensembl
RefSeq Acc Id: NM_001108804   ⟹   NP_001102274
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8993,490,618 - 93,555,298 (+)NCBI
mRatBN7.2986,042,522 - 86,107,220 (+)NCBI
Rnor_6.0992,435,872 - 92,500,756 (+)NCBI
Rnor_5.0992,168,447 - 92,231,811 (+)NCBI
RGSC_v3.4984,085,586 - 84,164,927 (+)RGD
Celera983,466,342 - 83,530,596 (+)RGD
Sequence:
RefSeq Acc Id: NP_001102274   ⟸   NM_001108804
- UniProtKB: A6JWD0 (UniProtKB/TrEMBL),   A0A8I6AH86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076250   ⟸   ENSRNOT00000093695
RefSeq Acc Id: ENSRNOP00000022901   ⟸   ENSRNOT00000022901
RefSeq Acc Id: ENSRNOP00000097800   ⟸   ENSRNOT00000101399
RefSeq Acc Id: ENSRNOP00000089548   ⟸   ENSRNOT00000100969
RefSeq Acc Id: ENSRNOP00000087733   ⟸   ENSRNOT00000107588
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9E4-F1-model_v2 AlphaFold D3Z9E4 1-188 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696812
Promoter ID:EPDNEW_R7336
Type:multiple initiation site
Name:Fbxo36_1
Description:F-box protein 36
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0992,435,890 - 92,435,950EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307870 AgrOrtholog
BioCyc Gene G2FUF-26952 BioCyc
Ensembl Genes ENSRNOG00000017053 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022901.7 UniProtKB/TrEMBL
  ENSRNOT00000093695 ENTREZGENE
  ENSRNOT00000093695.2 UniProtKB/TrEMBL
  ENSRNOT00000100969.1 UniProtKB/TrEMBL
  ENSRNOT00000101399.1 UniProtKB/TrEMBL
  ENSRNOT00000107588.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
KEGG Report rno:363268 UniProtKB/TrEMBL
NCBI Gene 363268 ENTREZGENE
PANTHER DACTYLIN UniProtKB/TrEMBL
  F-BOX_WD REPEAT-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxo36 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017053 RatGTEx
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
UniProt A0A1W2Q6H0_RAT UniProtKB/TrEMBL
  A0A8I6AH86 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARV1_RAT UniProtKB/TrEMBL
  A0A8I6GHE7_RAT UniProtKB/TrEMBL
  A6JWD0 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9E4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Fbxo36  F-box protein 36  Fbxo36_predicted  F-box only protein 36 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Fbxo36_predicted  F-box only protein 36 (predicted)      Symbol and Name status set to approved 70820 APPROVED