Gene: Lss (lanosterol synthase) Rattus norvegicus
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Symbol: Lss
Name: lanosterol synthase
Description: ENCODES a protein that exhibits lanosterol synthase activity; INVOLVED IN cholesterol biosynthetic process; sterol metabolic process; regulation of protein stability (ortholog); PARTICIPATES IN cholesterol biosynthetic pathway; alendronate pharmacodynamics pathway; cholesterol ester storage disease pathway; ASSOCIATED WITH Absence of Tibia with Polydactyly (ortholog); Acheiropodia (ortholog); acheiropody (ortholog); FOUND IN intracellular membrane-bounded organelle; lipid droplet (ortholog); membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2,3-epoxysqualene--lanosterol cyclase; 2,3-oxidosqualene: lanosterol cyclase; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); OSC; oxidosqualene--lanosterol cyclase
Orthologs:
Homo sapiens (human) : LSS (lanosterol synthase)  HGNC  AGR
Mus musculus (house mouse) : Lss (lanosterol synthase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Lss (lanosterol synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : LSS (lanosterol synthase)
Canis lupus familiaris (dog) : LSS (lanosterol synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lss (lanosterol synthase)
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Allele / Splice: Lssem2Mcwi  
Genetic Models: SS-Lssem2Mcwi
Is Marker For: Strains:   SCR/Sscr  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02012,844,522 - 12,870,474 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02015,337,114 - 15,338,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02015,000,298 - 15,027,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42012,507,575 - 12,534,612 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12012,507,801 - 12,534,839 (-)NCBI
Celera2013,590,952 - 13,616,816 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lss
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620955
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE