Gene: Comt (catechol-O-methyltransferase) Rattus norvegicus
Symbol: Comt
Name: catechol-O-methyltransferase
Description: ENCODES a protein that exhibits catechol O-methyltransferase activity; INVOLVED IN developmental process; estrogen metabolic process; female pregnancy; PARTICIPATES IN alkaptonuria disease pathway; disulfiram pharmacodynamics pathway; dopamine beta hydroxylase deficiency pathway; ASSOCIATED WITH abnormal dopamine level; ASSOCIATED WITH Brain Injuries; Catalepsy; Diabetes Mellitus, Experimental; FOUND IN axon; cell body; cytosol; INTERACTS WITH (-)-epigallocatechin 3-gallate; (3,4-dihydroxyphenyl)acetic acid; (R)-adrenaline
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: catechol O-methyltransferase; catecholamine-O-methyltransferase
Allele / Splice: Comtem1Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01186,715,981 - 86,735,630 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01189,809,853 - 89,829,568 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41184,561,591 - 84,581,713 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,617,363 - 84,622,260 (+)NCBI
Celera1181,345,121 - 81,364,705 (+)NCBI
Cytogenetic Map11q23NCBImapview
RH 3.4 Map11712.2RGD

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Comt
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 2379
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-09-13
Status: ACTIVE