Gene: Lep (leptin) Rattus norvegicus
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Symbol: Lep
Name: leptin
Description: ENCODES a protein that exhibits hormone activity; peptide hormone receptor binding; receptor binding; INVOLVED IN bone mineralization involved in bone maturation; cardiac muscle hypertrophy; cellular response to L-ascorbic acid; PARTICIPATES IN energy homeostasis pathway; leptin system pathway; hypoxia inducible factor pathway; ASSOCIATED WITH increased circulating cholesterol level; increased circulating triglyceride level; increased liver triglyceride level; ASSOCIATED WITH Alzheimer Disease; Alzheimer's disease; Body Weight Changes; FOUND IN extracellular space; cytoplasm (ortholog); INTERACTS WITH (+)-catechin; (R)-lipoic acid; (S)-nicotine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: OB; obese; obesity (murine homolog leptin); obesity factor
Orthologs:
Homo sapiens (human) : LEP (leptin)  HGNC  AGR
Mus musculus (house mouse) : Lep (leptin)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Lep (leptin)
Pan paniscus (bonobo/pygmy chimpanzee) : LEP (leptin)
Canis lupus familiaris (dog) : LEP (leptin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lep (leptin)
more info ...
Allele / Splice: Lepem5Mcwi   Lepm1Kyo   Lepem1Sage   Lepem1  
Genetic Models: SD-Lepem1 SD-Lepem1Sage F344-Lepm1Kyo SS-Lepem5Mcwi
Is Marker For: Strains:   F344-Lepm1Kyo   SD-Lepem1Narl  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0456,337,695 - 56,351,818 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0456,085,079 - 56,099,209 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4455,943,837 - 55,945,938 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1456,185,364 - 56,197,221 (+)NCBI
Celera452,770,132 - 52,784,148 (+)NCBI
Cytogenetic Map4q22NCBImapview
RH 3.4 Map4309.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lep
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 3000
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE