Gene: Ube2q2 (ubiquitin-conjugating enzyme E2Q family member 2)
Rattus norvegicus
Symbol:
Ube2q2
Name:
ubiquitin-conjugating enzyme E2Q family member 2
Description:
ENCODES a protein that exhibits ubiquitin-protein ligase activity (ortholog); INVOLVED IN protein K48-linked ubiquitination (ortholog); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; (-)-epigallocatechin 3-gallate (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
LOC363065_predicted; RGD1307680; RGD1307680_predicted; similar to RIKEN cDNA 3010021M21 (predicted); Ube2q2_predicted; ubiquitin-conjugating enzyme E2 Q2; ubiquitin-conjugating enzyme E2Q (putative) 2; ubiquitin-conjugating enzyme E2Q (putative) 2 (predicted); ubiquitin-conjugating enzyme E2Q family member 2
Orthologs:
Homo sapiens : UBE2Q2
(ubiquitin-conjugating enzyme E2Q family member 2)
HGNC
Ube2q2
(ubiquitin-conjugating enzyme E2Q (putative) 2)
MGI
Allele / Splice:
Ube2q2em3Mcwi
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 8 q24 NCBI RGSC Genome Assembly v5.0 8 58,292,790 - 58,349,722 + NCBI RGSC Genome Assembly v3.4 8 58,688,257 - 58,749,088 + NCBI Rat Celera Assembly 8 55,003,555 - 55,063,447 + NCBI Genome Assembly 3.1 8 58,649,776 - 58,767,495 + NCBI
Model
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1605308 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of UBE2Q2 mRNA CTD PMID:22079256 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO 6480464 Tetrachlorodibenzodioxin affects the expression of UBE2Q2 mRNA CTD PMID:21570461 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:1605308 6480464 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UBE2Q2 mRNA CTD PMID:23146750 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of UBE2Q2 mRNA CTD PMID:19162173 7,9-dihydro-1H-purine-2,6,8(3H)-trione affects abundance ISO RGD:1605308 6480464 UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 aflatoxin B1 affects expression ISO RGD:1605308 6480464 Aflatoxin B1 affects the expression of UBE2Q2 protein CTD PMID:20106945 benzo[a]pyrene decreases expression ISO 6480464 Benzo(a)pyrene results in decreased expression of UBE2Q2 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO 6480464 Benzo(a)pyrene results in increased expression of UBE2Q2 mRNA CTD PMID:22228805 fenofibrate increases expression ISO 6480464 Fenofibrate results in increased expression of UBE2Q2 mRNA CTD PMID:21318169 fenofibrate multiple interactions ISO 6480464 PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE2Q2 mRNA] CTD PMID:21318169 pirinixic acid multiple interactions ISO RGD:1605308 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UBE2Q2 mRNA CTD PMID:19710929 quercetin decreases expression ISO RGD:1605308 6480464 Quercetin results in decreased expression of UBE2Q2 mRNA CTD PMID:21632981 uric acid affects abundance ISO RGD:1605308 6480464 UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486
Gene Ontology Annotations
71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat 2313086 Bss60 Bone structure and strength QTL 60 4.1 .0001 Bone structure 8 53049279 86628010 Rat 4889938 Bss89 Bone structure and strength QTL 89 3.8 Bone structure 8 53049279 86628010 Rat 5684973 Bss100 Bone structure and strength QTL 100 4.7 Bone structure tibial area 8 53049279 86628010 Rat 2303570 Gluco48 Glucose level QTL 48 2 Glucose level post-restraint 8 53621297 98621297 Rat 1358912 Bw51 Body weight QTL 51 2.95 Body weight 8 54364071 112242906 Rat 2293697 Bmd39 Bone mineral density QTL 39 Bone mineral density 8 57109012 103548876 Rat 1582243 Bw66 Body weight QTL 66 3.4 .0048 Body weight 8 57308572 89558994 Rat 1582254 Kidm31 Kidney mass QTL 31 Kidney mass 8 57308572 89558994 Rat 631664 Hcar3 Hepatocarcinoma resistance QTL 3 2.9 .0005 Liver tumor resistance nodule volume 8 57308572 103684785 Rat 1300150 Cm3 Cardiac mass QTL 3 3.97 Cardiac mass salt-loaded 8 57308742 58692901 Rat 1300177 Cm2 Cardiac mass QTL 2 3.65 Cardiac mass salt-loaded 8 58135371 104697495 Rat 2301402 Bp316 Blood pressure QTL 316 .005 Blood pressure mean arterial 8 58548876 103548876 Rat
Gene Ontology Annotations
