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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HSD3B2 mRNA | CTD | PMID:12075121 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of HSD3B2 mRNA | CTD | PMID:12655037 | 1H-pyrazole | decreases expression | ISO | RGD:1318589 | 6480464 | pyrazole results in decreased expression of HSD3B2 mRNA | CTD | PMID:17945193 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1318589 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of HSD3B2 mRNA | CTD | PMID:16214954 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1318589 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HSD3B2 mRNA | CTD | PMID:21570461 | 2,6-dibromophenol | increases expression | ISO | RGD:1318588 | 6480464 | 2,6-dibromophenol results in increased expression of HSD3B2 mRNA | CTD | PMID:17447562 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:1318588 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HSD3B2 mRNA | CTD | PMID:16216300 | 3H-1,2-dithiole-3-thione | decreases expression | ISO | RGD:1318589 | 6480464 | 1,2-dithiol-3-thione results in decreased expression of HSD3B2 mRNA | CTD | PMID:15302862 | 4-nitro-m-cresol | multiple interactions | ISO | RGD:1318588 | 6480464 | [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein | CTD | PMID:18336853 | 8-bromo-3',5'-cyclic AMP | multiple interactions | ISO | RGD:1318588 | 6480464 | [4-nitro-3-cresol co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in decreased expression of HSD3B2 protein | CTD | PMID:18336853 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:1318588 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B2 mRNA | CTD | PMID:22079614 PMID:22546480 | 8-bromo-3',5'-cyclic AMP | multiple interactions | ISO | RGD:1318588 | 6480464 | Mitotane inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HSD3B2 mRNA] | CTD | PMID:22546480 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1318589 | 6480464 | Diethylhexyl Phthalate results in decreased expression of HSD3B2 mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:1318589 | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B2 mRNA] | CTD | PMID:19850644 | carbamazepine | decreases activity | ISO | RGD:1318588 | 6480464 | Carbamazepine results in decreased activity of HSD3B2 protein | CTD | PMID:15730543 | cinnamic acid | decreases activity | ISO | RGD:1318588 | 6480464 | cinnamic acid analog results in decreased activity of HSD3B2 protein | CTD | PMID:15072549 | clofibrate | multiple interactions | ISO | RGD:1318589 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of HSD3B2 mRNA; more ... | CTD | PMID:17585979 | diazoxide | decreases expression | ISO | RGD:1318589 | 6480464 | Isoproterenol results in decreased expression of HSD3B2 mRNA | CTD | PMID:21335049 | doxorubicin | decreases expression | ISO | RGD:1318589 | 6480464 | Doxorubicin results in decreased expression of HSD3B2 mRNA | CTD | PMID:15033991 | elemental selenium | increases expression | ISO | RGD:1318589 | 6480464 | Selenium results in increased expression of HSD3B2 mRNA; more ... | CTD | PMID:16170372 | ethanol | decreases expression | ISO | RGD:1318589 | 6480464 | Ethanol results in decreased expression of HSD3B2 mRNA | CTD | PMID:19167417 | gamma-hexachlorocyclohexane | multiple interactions | ISO | RGD:1318588 | 6480464 | Lindane inhibits the reaction [Forskolin results in increased expression of HSD3B2 mRNA] | CTD | PMID:17080404 | gamma-hexachlorocyclohexane | decreases expression | ISO | RGD:1318588 | 6480464 | Lindane results in decreased expression of HSD3B2 mRNA | CTD | PMID:17080404 | isoprenaline | decreases expression | ISO | RGD:1318589 | 6480464 | Isoproterenol results in decreased expression of HSD3B2 mRNA | CTD | PMID:21335049 | lamivudine | multiple interactions | ISO | RGD:1318589 | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA | CTD | PMID:18313992 | lamotrigine | decreases activity | ISO | RGD:1318588 | 6480464 | lamotrigine results in decreased activity of HSD3B2 protein | CTD | PMID:15730543 | paracetamol | multiple interactions | ISO | RGD:1318589 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of HSD3B2 mRNA; more ... | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:1318589 | 6480464 | Acetaminophen affects the expression of HSD3B2 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:1318589 | 6480464 | Acetaminophen results in decreased expression of HSD3B2 mRNA | CTD | PMID:11264010 | phenobarbital | multiple interactions | ISO | RGD:1318589 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of HSD3B2 mRNA] | CTD | PMID:19482888 | phenobarbital | decreases expression | ISO | RGD:1318589 | 6480464 | Phenobarbital results in decreased expression of HSD3B2 mRNA | CTD | PMID:19482888 PMID:23091169 | phenobarbital | decreases expression | ISO | RGD:1318589 | 6480464 | Phenobarbital results in decreased expression of HSD3B2 mRNA | CTD | PMID:19482888 | pioglitazone | decreases activity | ISO | RGD:1318588 | 6480464 | pioglitazone results in decreased activity of HSD3B2 protein | CTD | PMID:17138841 PMID:15072549 | pioglitazone | decreases activity | ISO | RGD:1318588 | 6480464 | pioglitazone results in decreased activity of HSD3B2 protein | CTD | PMID:15072549 PMID:17138841 | pioglitazone | decreases expression | ISO | RGD:1318588 | 6480464 | pioglitazone results in decreased expression of HSD3B2 mRNA | CTD | PMID:17138841 | pirinixic acid | multiple interactions | ISO | RGD:1318589 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of HSD3B2 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:15302862 more ... | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:18445702 more ... | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:20059764 more ... | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:20813756 more ... | pirinixic acid | multiple interactions | ISO | RGD:1318589 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of HSD3B2 mRNA] | CTD | PMID:20059764 | pirinixic acid | decreases expression | ISO | RGD:1318589 | 6480464 | pirinixic acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:15302862 more ... | propiconazole | decreases expression | ISO | RGD:1318589 | 6480464 | propiconazole results in decreased expression of HSD3B2 mRNA | CTD | PMID:21278054 PMID:19363144 | propiconazole | decreases expression | ISO | RGD:1318589 | 6480464 | propiconazole results in decreased expression of HSD3B2 mRNA | CTD | PMID:19363144 PMID:21278054 | rosiglitazone | decreases activity | ISO | RGD:1318588 | 6480464 | rosiglitazone results in decreased activity of HSD3B2 protein | CTD | PMID:15072549 | selenium atom | increases expression | ISO | RGD:1318589 | 6480464 | Selenium results in increased expression of HSD3B2 mRNA; more ... | CTD | PMID:16170372 | testosterone | increases expression | ISO | RGD:1318589 | 6480464 | Testosterone results in increased expression of HSD3B2 mRNA | CTD | PMID:21669218 | tetracycline | increases expression | ISO | RGD:1318589 | 6480464 | Tetracycline results in increased expression of HSD3B2 mRNA | CTD | PMID:16917069 | topiramate | decreases activity | ISO | RGD:1318588 | 6480464 | topiramate results in decreased activity of HSD3B2 protein | CTD | PMID:15730543 | tris(2-chloroethyl) phosphate | increases expression | ISO | RGD:1318588 | 6480464 | tris(chloroethyl)phosphate results in increased expression of HSD3B2 mRNA | CTD | PMID:22446829 | troglitazone | decreases activity | ISO | RGD:1318588 | 6480464 | troglitazone results in decreased activity of HSD3B2 protein | CTD | PMID:15072549 | valproic acid | decreases activity | ISO | RGD:1318588 | 6480464 | Valproic Acid results in decreased activity of HSD3B2 protein | CTD | PMID:15730543 | valproic acid | decreases expression | ISO | RGD:1318588 | 6480464 | Valproic Acid results in decreased expression of HSD3B2 mRNA | CTD | PMID:19566492 | vancomycin | increases expression | ISO | RGD:1318589 | 6480464 | Vancomycin results in increased expression of HSD3B2 mRNA | CTD | PMID:18930951 | zidovudine | multiple interactions | ISO | RGD:1318589 | 6480464 | [Zidovudine co-treated with Lamivudine] results in decreased expression of HSD3B2 mRNA | CTD | PMID:18313992 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Ovarian steroidogenesis | |
| Steroid hormone biosynthesis | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Ovarian steroidogenesis | |
| Steroid hormone biosynthesis | |
References - curated| 1. |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
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References - uncurated
RGD Disease Portals| Hsd3b2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Hsd3b2 (Rattus norvegicus) |
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| HSD3B2 (Homo sapiens) |
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| Hsd3b1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001007719 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHX01019003 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01019004 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086578 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474015 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DQ515797 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M38178 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001007719 | |||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | NP_001007720 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001007720 | (Get FASTA) |
| GenBank Protein | AAA63474 | (Get FASTA) |
| AAH86578 | (Get FASTA) | |
| ABF70960 | (Get FASTA) | |
| EDL85558 | (Get FASTA) | |
| P22071 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000042884 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000053018 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000056172 | UniProtKB/TrEMBL |
| Entrez Gene | 360348 | ENTREZGENE |
| Gene3D-CATH | NAD(P)-bd | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000019454 | UniProtKB/Swiss-Prot |
| IMAGE_CLONE | IMAGE:7306702 | IMAGE-MGC_LOAD |
| InterPro | 3Beta_OHSteriod_DH/Estase | UniProtKB/Swiss-Prot |
| NAD(P)-bd_dom | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:360348 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:105549 | IMAGE-MGC_LOAD |
| Pfam | 3Beta_HSD | UniProtKB/Swiss-Prot |
| UniGene | Rn.128814 | ENTREZGENE |
| UniProt | 3BHS1_RAT | UniProtKB/Swiss-Prot |
| F1LNS3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-11-02 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-12-18 | Hsd3b1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Hsd3b1_predicted | hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted) | Symbol and Name updated to reflect Human and Mouse nomenclature | 10779 | APPROVED |
| 2005-01-12 | Hsd3b1_predicted | hydroxysteroid dehydrogenase-1, delta<5>-3-beta (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Hsd3b2 | |
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Entrez Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308676 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




