Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) - Rat Genome Database

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Gene: Cyp8b1 (cytochrome P450 family 8 subfamily B member 1) Rattus norvegicus
Analyze
Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
RGD ID: 71016
Description: Enables sterol 12-alpha-hydroxylase activity. Involved in response to cholesterol and response to nutrient levels. Predicted to be located in endoplasmic reticulum membrane. Biomarker of extrahepatic cholestasis. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1,3,7,9-tetramethyluric acid; 1-(3-(trifluoromethyl)phenyl)piperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; cytochrome P450, family 8, subfamily b, polypeptide 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,455,622 - 130,457,592 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8130,442,503 - 130,457,689 (-)EnsemblGRCr8
mRatBN7.28121,578,123 - 121,580,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8121,557,062 - 121,580,166 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8127,169,678 - 127,171,641 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,368,752 - 125,370,715 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,198,141 - 123,200,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8131,311,613 - 131,313,576 (-)NCBI
Lyon_Normotensive8133,413,341 - 133,415,304 (-)NCBI
Lyon_Hypertensive8131,899,990 - 131,901,953 (-)NCBI
F344_StmMcwi8123,306,796 - 123,308,759 (-)NCBI
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8120,702,850 - 120,704,820 (-)NCBICelera
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
acadesine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
allocholic acid  (ISO)
allopurinol  (ISO)
AM-251  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
atrazine  (EXP,ISO)
Augmentin  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bromuconazole  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cefalotin  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP)
cholic acid  (ISO)
choline  (ISO)
chrysene  (ISO)
chrysophanol  (EXP)
ciguatoxin CTX1B  (ISO)
clavulanic acid  (ISO)
clofibrate  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
Diosbulbin B  (ISO)
disodium selenite  (ISO)
elemental selenium  (ISO)
emodin  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fipronil  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
ginsenoside Re  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
hexadecanoic acid  (ISO)
imipenem hydrate  (ISO)
indometacin  (EXP)
kojic acid  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
malathion  (ISO)
melatonin  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methoxsalen  (EXP)
metronidazole  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
physcion  (EXP)
Picroside ii  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
ritodrine  (ISO)
ritonavir  (EXP,ISO)
rotenone  (EXP)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
tebuconazole  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thyroxine  (EXP)
toluene  (EXP)
triadimefon  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
xylazine  (EXP)
Yangonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, etal., Br J Nutr. 2014 Nov 28;112(10):1592-600. doi: 10.1017/S0007114514002517. Epub 2014 Sep 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B). Ishida H, etal., J Biochem (Tokyo) 1999 Jul;126(1):19-25.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1). Yang Y, etal., Biochem Biophys Res Commun 2004 Aug 6;320(4):1204-10.
15. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:29028359  


Genomics

Comparative Map Data
Cyp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,455,622 - 130,457,592 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8130,442,503 - 130,457,689 (-)EnsemblGRCr8
mRatBN7.28121,578,123 - 121,580,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8121,557,062 - 121,580,166 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8127,169,678 - 127,171,641 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,368,752 - 125,370,715 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,198,141 - 123,200,111 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8131,311,613 - 131,313,576 (-)NCBI
Lyon_Normotensive8133,413,341 - 133,415,304 (-)NCBI
Lyon_Hypertensive8131,899,990 - 131,901,953 (-)NCBI
F344_StmMcwi8123,306,796 - 123,308,759 (-)NCBI
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8120,702,850 - 120,704,820 (-)NCBICelera
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Cytogenetic Map8q32NCBI
CYP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38342,872,192 - 42,875,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl342,855,944 - 42,875,920 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37342,913,684 - 42,917,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,888,688 - 42,892,637 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34342,888,687 - 42,892,637NCBI
Celera342,851,598 - 42,855,548 (-)NCBICelera
Cytogenetic Map3p22.1NCBI
HuRef342,956,837 - 42,960,786 (-)NCBIHuRef
CHM1_1342,863,684 - 42,867,633 (-)NCBICHM1_1
T2T-CHM13v2.0342,887,769 - 42,891,456 (-)NCBIT2T-CHM13v2.0
Cyp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,743,422 - 121,745,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9121,743,422 - 121,745,371 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBIMGSCv36mm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.73NCBI
LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542027,988,067 - 27,990,637 (+)NCBIChiLan1.0ChiLan1.0
CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2242,832,717 - 42,836,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1342,837,479 - 42,841,169 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0342,775,679 - 42,779,440 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1343,838,315 - 43,842,260 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl343,824,423 - 43,842,716 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CYP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12311,965,685 - 11,968,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2311,967,341 - 11,968,846 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2311,939,545 - 11,942,820 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02312,255,398 - 12,258,673 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2312,257,054 - 12,258,559 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12312,057,378 - 12,060,653 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02312,199,554 - 12,202,829 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02312,202,997 - 12,206,280 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cyp8b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1219,914,375 - 19,916,713 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024405118199,911,411 - 199,913,713 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366952,263,868 - 2,265,373 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366952,263,868 - 2,265,373 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1326,330,233 - 26,331,738 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP8B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12296,987,219 - 96,990,895 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666041162,874,321 - 162,895,194 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1224,323,840 - 4,326,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl224,324,396 - 4,325,901 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
LOC116907995
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18113,075,343 - 113,077,363 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026355
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
133 93 402 327 1068 940 1092 8 853 106 851 43 2661 620 71 1022 5 839 349 248 18 16

Sequence


Ensembl Acc Id: ENSRNOT00000026355   ⟹   ENSRNOP00000026355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8130,442,503 - 130,457,689 (-)Ensembl
mRatBN7.2 Ensembl8121,557,062 - 121,580,166 (-)Ensembl
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102157   ⟹   ENSRNOP00000082229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8121,563,558 - 121,580,166 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113425   ⟹   ENSRNOP00000094493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8121,563,558 - 121,580,166 (-)Ensembl
RefSeq Acc Id: NM_031241   ⟹   NP_112520
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,455,622 - 130,457,592 (-)NCBI
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Dahl_SR_JrHsd8131,311,613 - 131,313,576 (-)NCBI
Lyon_Normotensive8133,413,341 - 133,415,304 (-)NCBI
Lyon_Hypertensive8131,899,990 - 131,901,953 (-)NCBI
F344_StmMcwi8123,306,796 - 123,308,759 (-)NCBI
Rnor_6.08130,548,418 - 130,550,388 (-)NCBI
Rnor_5.08129,723,896 - 129,725,866 (-)NCBI
RGSC_v3.48127,018,908 - 127,020,878 (+)RGD
Celera8120,702,850 - 120,704,820 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112520 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA76602 (Get FASTA)   NCBI Sequence Viewer  
  BAA82169 (Get FASTA)   NCBI Sequence Viewer  
  EDL76812 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026355.3
RefSeq Acc Id: NP_112520   ⟸   NM_031241
- Peptide Label: precursor
- UniProtKB: Q9WVT5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026355   ⟸   ENSRNOT00000026355
Ensembl Acc Id: ENSRNOP00000082229   ⟸   ENSRNOT00000102157
Ensembl Acc Id: ENSRNOP00000094493   ⟸   ENSRNOT00000113425

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8J2-F1-model_v2 AlphaFold G3V8J2 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696393
Promoter ID:EPDNEW_R6918
Type:initiation region
Name:Cyp8b1_1
Description:cytochrome P450 family 8 subfamily B member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08130,550,402 - 130,550,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71016 AgrOrtholog
BioCyc Gene G2FUF-28675 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000019481 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026355.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_CYP8B1 UniProtKB/TrEMBL
KEGG Report rno:81924 UniProtKB/TrEMBL
NCBI Gene 81924 ENTREZGENE
PANTHER PTHR24306 UniProtKB/TrEMBL
  PTHR24306:SF0 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp8b1 PhenoGen
PIRSF Cytochrome_CYP8B1 UniProtKB/TrEMBL
  Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019481 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt G3V8J2_RAT UniProtKB/TrEMBL
  Q9WVT5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-13 Cyp8b1  cytochrome P450 family 8 subfamily B member 1  Cyp8b1  cytochrome P450, family 8, subfamily b, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cyp8b1  cytochrome P450, family 8, subfamily b, polypeptide 1    cytochrome P450, 8b1, sterol 12 alpha-hydrolase  Name updated 1299863 APPROVED
2002-07-09 Cyp8b1  cytochrome P450, 8b1, sterol 12 alpha-hydrolase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA highly expressed in streptozotocin-induced diabetic rats 70706
gene_expression expressed specifically in liver 70706
gene_regulation mRNA induced by clofibrate, dexamethasone and thyroxin; decreased by insulin 70706