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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71016 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp8b1 Name: cytochrome P450, family 8, subfamily b, polypeptide 1

Acc ID: CHEBI:28834 Term: deoxycholic acid Definition: A dihydroxy-5beta-cholanic acid that has formula C24H40O4. CasRN: 83-44-3 Chemical ID: MESH:D003840

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:732213	6480464	CTD	Deoxycholic Acid results in decreased expression of CYP8B1 mRNA	PMID:21914718
multiple interactions	ISO	RGD:732213	6480464	CTD	SLCO1A1 protein affects the susceptibility to [Deoxycholic Acid results in decreased expression of CYP8B1 mRNA]	PMID:21914718