Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,2',5,5'-tetrachlorobiphenyl | affects expression | ISO | RGD:732202 | 6480464 | 2,5,2',5'-tetrachlorobiphenyl affects the expression of ACADS mRNA | CTD | PMID:21703328 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | RGD:732202 | 6480464 | 2,5,2',5'-tetrachlorobiphenyl results in increased expression of ACADS mRNA | CTD | PMID:21703328 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ACADS mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732203 | 6480464 | Tetrachlorodibenzodioxin affects the expression of ACADS mRNA | CTD | PMID:21570461 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of ACADS mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:732203 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ACADS mRNA | CTD | PMID:20188158 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ACADS mRNA | CTD | PMID:16483693 | clofibrate | decreases expression | ISO | RGD:732203 | 6480464 | Clofibrate results in decreased expression of ACADS mRNA | CTD | PMID:17585979 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of ACADS protein | CTD | PMID:16470657 PMID:35720 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of ACADS protein | CTD | PMID:35720 PMID:16470657 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of ACADS mRNA | CTD | PMID:18670166 | clofibrate | increases expression | EXP | | 6480464 | Clofibrate results in increased expression of ACADS protein | CTD | PMID:16470657 | clofibrate | multiple interactions | ISO | RGD:732203 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ACADS mRNA; more ... | CTD | PMID:17585979 | copper(2+) sulfate | decreases expression | ISO | RGD:732202 | 6480464 | Copper Sulfate results in decreased expression of ACADS mRNA | CTD | PMID:19549813 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ACADS mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ACADS mRNA | CTD | PMID:17379624 PMID:21266533 | elemental selenium | multiple interactions | ISO | RGD:732202 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of ACADS mRNA | CTD | PMID:19244175 | elemental selenium | increases expression | ISO | RGD:732202 | 6480464 | Selenium results in increased expression of ACADS mRNA | CTD | PMID:19244175 | flutamide | affects expression | EXP | | 6480464 | Flutamide affects the expression of ACADS mRNA | CTD | PMID:21525395 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of ACADS protein | CTD | PMID:17311803 | furan | affects binding | EXP | | 6480464 | furan binds to ACADS protein | CTD | PMID:22240984 | hypochlorous acid | decreases expression | ISO | RGD:732203 | 6480464 | Hypochlorous Acid results in decreased expression of ACADS mRNA | CTD | PMID:19376150 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of ACADS mRNA | CTD | PMID:16393664 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of ACADS mRNA | CTD | PMID:22087261 | paracetamol | multiple interactions | ISO | RGD:732203 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of ACADS mRNA; more ... | CTD | PMID:17585979 | perfluorooctane-1-sulfonic acid | affects expression | ISO | RGD:732203 | 6480464 | perfluorooctane sulfonic acid affects the expression of ACADS mRNA | CTD | PMID:19429403 | perfluorooctanoic acid | affects expression | ISO | RGD:732203 | 6480464 | perfluorooctanoic acid affects the expression of ACADS mRNA | CTD | PMID:19429403 | phenobarbital | increases expression | ISO | RGD:732203 | 6480464 | Phenobarbital results in increased expression of ACADS mRNA | CTD | PMID:19270015 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ACADS mRNA | CTD | PMID:19162173 | pirinixic acid | increases expression | ISO | RGD:732203 | 6480464 | pirinixic acid results in increased expression of ACADS mRNA | CTD | PMID:16357043 more ... | pirinixic acid | increases expression | ISO | RGD:732203 | 6480464 | pirinixic acid results in increased expression of ACADS mRNA | CTD | PMID:18301758 more ... | pirinixic acid | increases expression | ISO | RGD:732203 | 6480464 | pirinixic acid results in increased expression of ACADS mRNA | CTD | PMID:17426115 more ... | pirinixic acid | increases expression | ISO | RGD:732203 | 6480464 | pirinixic acid results in increased expression of ACADS mRNA | CTD | PMID:16357043 more ... | propiconazole | decreases expression | ISO | RGD:732203 | 6480464 | propiconazole results in decreased expression of ACADS mRNA | CTD | PMID:21278054 | resveratrol | increases expression | ISO | RGD:732203 | 6480464 | resveratrol results in increased expression of ACADS mRNA | CTD | PMID:22610192 | rosiglitazone | increases expression | ISO | RGD:732203 | 6480464 | rosiglitazone results in increased expression of ACADS mRNA | CTD | PMID:15520860 | rosiglitazone | affects expression | ISO | RGD:732203 | 6480464 | rosiglitazone affects the expression of ACADS mRNA | CTD | PMID:22013433 | selenium atom | multiple interactions | ISO | RGD:732202 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of ACADS mRNA | CTD | PMID:19244175 | selenium atom | increases expression | ISO | RGD:732202 | 6480464 | Selenium results in increased expression of ACADS mRNA | CTD | PMID:19244175 | tert-butyl hydroperoxide | increases expression | ISO | RGD:732203 | 6480464 | tert-Butylhydroperoxide results in increased expression of ACADS mRNA | CTD | PMID:15003993 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of ACADS mRNA | CTD | PMID:12734012 | trans-resveratrol | increases expression | ISO | RGD:732203 | 6480464 | resveratrol results in increased expression of ACADS mRNA | CTD | PMID:22610192 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of ACADS mRNA | CTD | PMID:19448997 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of ACADS protein | CTD | PMID:21315101 | zinc atom | increases expression | ISO | RGD:732202 | 6480464 | Zinc results in increased expression of ACADS mRNA | CTD | PMID:15226459 | zinc sulfate | increases expression | ISO | RGD:732202 | 6480464 | Zinc Sulfate results in increased expression of ACADS mRNA | CTD | PMID:15226459 | zinc(0) | increases expression | ISO | RGD:732202 | 6480464 | Zinc results in increased expression of ACADS mRNA | CTD | PMID:15226459 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
| Fatty acid metabolism | |
| Metabolic pathways | |
| Valine, leucine and isoleucine degradation | |
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Butanoate metabolism |
| Fatty acid metabolism | |
| Metabolic pathways | |
| Valine, leucine and isoleucine degradation | |
References - curated| 1. |
Battaile KP, etal., Biochemistry. 1996 Dec 3;35(48):15356-63. |
| 2. |
Battaile KP, etal., J Biol Chem 2002 Apr 5;277(14):12200-7. |
| 3. |
Botham KM, etal., Biochim Biophys Acta. 2001 Dec 30;1534(2-3):96-109. |
| 4. |
Coulson A Vet Rec 1978 Oct 14;103(16):359. |
| 5. |
Dabrowski Z, etal., Pol Tyg Lek 1978 Jul 10;33(28):1093-5. |
| 6. |
Dakoji S, etal., Bioorg Med Chem. 1997 Dec;5(12):2157-64. |
| 7. |
Ghisla S and Thorpe C, Eur J Biochem. 2004 Feb;271(3):494-508. |
| 8. |
GOA data from the GO Consortium |
| 9. |
Ikeda Y, etal., J Biol Chem. 1985 Jan 25;260(2):1311-25. |
| 10. |
KEGG |
| 11. |
Kitayama K, etal., Eur J Pharmacol. 2006 Jul 1;540(1-3):121-30. Epub 2006 Apr 29. |
| 12. |
Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Nagao M, etal., J Biol Chem. 1993 Nov 15;268(32):24114-24. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Rexer BN and Ong DE, Biol Reprod 2002 Nov;67(5):1555-64. |
| 18. |
RGD automated data pipeline |
| 19. |
RGD automated import pipeline for gene-chemical interactions |
| 20. |
RGD Automated Pipelines |
| 21. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncurated| PubMed | 3813556 |
RGD Disease Portals| Acads has been annotated in the following RGD Disease Portals. |
|||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
![]() |
| ||||||
Comparative Map Data| Acads (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| ACADS (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Acads (Mus musculus) |
|
Position Markers| RH134326 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022512 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06072458 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06072459 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01072950 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01072951 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC072545 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473973 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ227562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| J05030 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022512 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071957 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_071957 | (Get FASTA) |
| GenBank Protein | AAA40669 | (Get FASTA) |
| AAH72545 | (Get FASTA) | |
| EDM13909 | (Get FASTA) | |
| EDM13910 | (Get FASTA) | |
| P15651 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001177 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000001556 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000001556 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 64304 | ENTREZGENE |
| Gene3D-CATH | Acyl_CoA_DH/ox_M | UniProtKB/Swiss-Prot |
| AcylCoA_DH/ox_N | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000001177 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20057 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7105799 | IMAGE-MGC_LOAD |
| InterPro | Acyl-CoA_DH_CS | UniProtKB/Swiss-Prot |
| Acyl-CoA_DH_N | UniProtKB/Swiss-Prot | |
| Acyl-CoA_Oxase/DH_1 | UniProtKB/Swiss-Prot | |
| Acyl-CoA_Oxase/DH_cen-dom | UniProtKB/Swiss-Prot | |
| AcylCo_DH/oxidase_C | UniProtKB/Swiss-Prot | |
| AcylCoA_DH/ox_N | UniProtKB/Swiss-Prot | |
| AcylCoA_DH/oxidase | UniProtKB/Swiss-Prot | |
| IPI | IPI00231359 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:64304 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:91690 | IMAGE-MGC_LOAD |
| Pfam | Acyl-CoA_dh_1 | UniProtKB/Swiss-Prot |
| Acyl-CoA_dh_M | UniProtKB/Swiss-Prot | |
| Acyl-CoA_dh_N | UniProtKB/Swiss-Prot | |
| PROSITE | ACYL_COA_DH_1 | UniProtKB/Swiss-Prot |
| ACYL_COA_DH_2 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | AcylCoA_dehyd_NM | UniProtKB/Swiss-Prot |
| AcylCoADH_C_like | UniProtKB/Swiss-Prot | |
| UniGene | Rn.1167 | ENTREZGENE |
| UniProt | ACADS_RAT | UniProtKB/Swiss-Prot |
| Q6IMX3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-07-28 | Acads | acyl-CoA dehydrogenase, C-2 to C-3 short chain | Acads | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-08-29 | Acads | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | Acads | acyl-Coenzyme A dehydrogenase, short chain | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-22 | Acads | acyl-Coenzyme A dehydrogenase, short chain | Acads | acetyl-Coenzyme A dehydrogenase, short chain | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-11-17 | Acads | acetyl-Coenzyme A dehydrogenase, short chain | acyl-coenzyme A dehydrogenase, short chain | Name updated | 10779 | APPROVED | |
| 2005-01-20 | Acads | acyl-coenzyme A dehydrogenase, short chain | short chain acyl-coenzyme A dehydrogenase | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Acads | short chain acyl-coenzyme A dehydrogenase | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_product | member of the acyl CoA dehydrogenase family | 631718 |
| More on Acads | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620514 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




