Ube3a (ubiquitin protein ligase E3A) - Rat Genome Database

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Gene: Ube3a (ubiquitin protein ligase E3A) Rattus norvegicus
Analyze
Symbol: Ube3a
Name: ubiquitin protein ligase E3A
RGD ID: 1306361
Description: Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; locomotory exploration behavior; and motor learning. Predicted to be located in nucleus. Predicted to be part of proteasome complex. Predicted to be active in cytosol and glutamatergic synapse. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aconitine; amphetamine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC103691124; LOC361585; ubiquitin-protein ligase E3A; uncharacterized LOC103691124
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Ube3aem1Jue  
Genetic Models: SD-Ube3aem1Jue
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81119,204,244 - 119,297,097 (+)NCBIGRCr8
mRatBN7.21110,070,260 - 110,161,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1110,070,480 - 110,157,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1115,450,417 - 115,541,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01123,923,035 - 124,013,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01117,171,279 - 117,262,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,586,901 - 116,678,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,587,815 - 116,679,973 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,745,283 - 117,834,011 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,729,142 - 110,816,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11110,807,819 - 110,893,065 (+)NCBI
Celera1104,203,680 - 104,290,036 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. Berg EL, etal., Transl Psychiatry. 2020 Jan 27;10(1):39. doi: 10.1038/s41398-020-0720-2.
2. Long-term abstinence from developmental cocaine exposure alters Arc/Arg3.1 modulation in the rat medial prefrontal cortex. Caffino L, etal., Neurotox Res. 2014 Oct;26(3):299-306. doi: 10.1007/s12640-014-9472-1. Epub 2014 May 9.
3. The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. Condon KH, etal., J Neurosci. 2013 Feb 27;33(9):3799-814. doi: 10.1523/JNEUROSCI.1930-11.2013.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Huang L, etal., Science 1999 Nov 12;286(5443):1321-6.
7. UBE3A/E6-AP mutations cause Angelman syndrome. Kishino T, etal., Nat Genet 1997 Jan;15(1):70-3.
8. The effects of oxidative stress on parkin and other E3 ligases. LaVoie MJ, etal., J Neurochem. 2007 Dec;103(6):2354-68. Epub 2007 Sep 19.
9. Towards a therapy for Angelman syndrome by targeting a long non-coding RNA. Meng L, etal., Nature. 2015 Feb 19;518(7539):409-12. doi: 10.1038/nature13975. Epub 2014 Dec 1.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. Silva-Santos S, etal., J Clin Invest. 2015 May;125(5):2069-76. doi: 10.1172/JCI80554. Epub 2015 Apr 13.
18. A coding-independent function of an alternative Ube3a transcript during neuronal development. Valluy J, etal., Nat Neurosci. 2015 May;18(5):666-73. doi: 10.1038/nn.3996. Epub 2015 Apr 13.
Additional References at PubMed
PMID:7708685   PMID:9182527   PMID:11756548   PMID:12890688   PMID:16254014   PMID:16772533   PMID:17108031   PMID:19182904   PMID:24105792   PMID:24728990   PMID:31505169   PMID:31625566  
PMID:31961493   PMID:34475199   PMID:37461021  


Genomics

Comparative Map Data
Ube3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81119,204,244 - 119,297,097 (+)NCBIGRCr8
mRatBN7.21110,070,260 - 110,161,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1110,070,480 - 110,157,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1115,450,417 - 115,541,305 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01123,923,035 - 124,013,927 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01117,171,279 - 117,262,170 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01116,586,901 - 116,678,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1116,587,815 - 116,679,973 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01117,745,283 - 117,834,011 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41110,729,142 - 110,816,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11110,807,819 - 110,893,065 (+)NCBI
Celera1104,203,680 - 104,290,036 (+)NCBICelera
Cytogenetic Map1q22NCBI
UBE3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381525,333,728 - 25,439,056 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1525,333,728 - 25,439,051 (-)EnsemblGRCh38hg38GRCh38
GRCh371525,578,875 - 25,684,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361523,133,489 - 23,235,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 341523,133,488 - 23,235,221NCBI
Celera153,744,415 - 3,845,932 (-)NCBICelera
Cytogenetic Map15q11.2NCBI
HuRef153,706,895 - 3,808,683 (-)NCBIHuRef
CHM1_11525,531,939 - 25,633,637 (-)NCBICHM1_1
T2T-CHM13v2.01523,070,379 - 23,175,682 (-)NCBIT2T-CHM13v2.0
Ube3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39758,871,891 - 58,960,585 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl758,878,498 - 58,961,284 (+)EnsemblGRCm39 Ensembl
GRCm38759,228,750 - 59,310,837 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl759,228,750 - 59,311,536 (+)EnsemblGRCm38mm10GRCm38
MGSCv37766,484,120 - 66,562,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36748,955,227 - 49,033,145 (+)NCBIMGSCv36mm8
MGSCv36759,096,619 - 59,174,596 (+)NCBIMGSCv36mm8
Cytogenetic Map7B5NCBI
cM Map733.95NCBI
Ube3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555333,733,148 - 3,821,577 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555333,733,148 - 3,828,353 (+)NCBIChiLan1.0ChiLan1.0
UBE3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2169,868,709 - 9,970,172 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11513,508,880 - 13,610,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,494,029 - 4,595,415 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11522,747,069 - 22,848,313 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1522,747,075 - 22,825,459 (-)Ensemblpanpan1.1panPan2
UBE3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,347,034 - 35,442,329 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl335,347,064 - 35,440,256 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,007,643 - 38,103,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0335,708,135 - 35,803,900 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl335,708,068 - 35,801,844 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1335,230,926 - 35,326,630 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0335,500,117 - 35,595,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,647,966 - 35,743,745 (+)NCBIUU_Cfam_GSD_1.0
Ube3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640123,339,609 - 123,442,282 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647141,187,612 - 41,283,517 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647141,187,665 - 41,290,345 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1141,887,227 - 141,995,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11141,887,179 - 142,001,595 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21157,783,503 - 157,881,397 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12656,638,936 - 56,738,555 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2656,666,162 - 56,736,737 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605439,545,194 - 39,648,255 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ube3a
212 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:180
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000021366
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847121834139Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat

Markers in Region
RH137614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21110,068,734 - 110,068,902 (+)MAPPERmRatBN7.2
Rnor_6.01116,586,070 - 116,586,237NCBIRnor6.0
Rnor_5.01117,744,482 - 117,744,649UniSTSRnor5.0
RGSC_v3.41110,727,397 - 110,727,564UniSTSRGSC3.4
Celera1104,201,935 - 104,202,102UniSTS
Cytogenetic Map1q22UniSTS
Ube3a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21110,153,395 - 110,154,672 (+)MAPPERmRatBN7.2
Rnor_6.01116,674,178 - 116,675,454NCBIRnor6.0
Rnor_5.01117,830,028 - 117,831,304UniSTSRnor5.0
RGSC_v3.41110,812,639 - 110,813,915UniSTSRGSC3.4
Celera1104,286,185 - 104,287,461UniSTS
Cytogenetic Map1q22UniSTS
Ube3a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21110,137,396 - 110,138,321 (+)MAPPERmRatBN7.2
Rnor_6.01116,658,015 - 116,658,939NCBIRnor6.0
Rnor_5.01117,813,865 - 117,814,789UniSTSRnor5.0
RGSC_v3.41110,796,641 - 110,797,565UniSTSRGSC3.4
Celera1104,270,221 - 104,271,145UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Ube3a is modified in the following models/strains:
SD-Ube3aem1Jue    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 40 24 19 24 8 10 74 34 41 11 8
Low 3 17 17 17 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021366   ⟹   ENSRNOP00000021366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1110,070,480 - 110,157,250 (+)Ensembl
Rnor_6.0 Ensembl1116,587,815 - 116,678,161 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083587   ⟹   ENSRNOP00000068717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1110,070,533 - 110,154,634 (+)Ensembl
Rnor_6.0 Ensembl1116,604,550 - 116,679,973 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108441   ⟹   ENSRNOP00000079079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1110,088,113 - 110,157,250 (+)Ensembl
RefSeq Acc Id: NM_001191837   ⟹   NP_001178766
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,148 - 119,297,097 (+)NCBI
mRatBN7.21110,070,480 - 110,161,434 (+)NCBI
Rnor_6.01116,587,815 - 116,678,161 (+)NCBI
Rnor_5.01117,745,283 - 117,834,011 (+)NCBI
Celera1104,203,680 - 104,290,036 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229310   ⟹   XP_006229372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,261 - 110,156,526 (+)NCBI
Rnor_6.01116,586,901 - 116,675,617 (+)NCBI
Rnor_5.01117,745,283 - 117,834,011 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229313   ⟹   XP_006229375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,541 - 119,297,033 (+)NCBI
mRatBN7.21110,070,262 - 110,156,526 (+)NCBI
Rnor_6.01116,586,901 - 116,675,617 (+)NCBI
Rnor_5.01117,745,283 - 117,834,011 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759399   ⟹   XP_008757621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,257,126 - 119,297,033 (+)NCBI
mRatBN7.21110,121,453 - 110,156,526 (+)NCBI
Rnor_6.01116,639,376 - 116,675,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759400   ⟹   XP_008757622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,261 - 110,156,526 (+)NCBI
Rnor_6.01116,586,901 - 116,675,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759401   ⟹   XP_008757623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,262 - 110,156,526 (+)NCBI
Rnor_6.01116,586,901 - 116,675,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589368   ⟹   XP_017444857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,787 - 119,297,033 (+)NCBI
mRatBN7.21110,071,114 - 110,156,526 (+)NCBI
Rnor_6.01116,588,330 - 116,675,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589369   ⟹   XP_017444858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,212,053 - 119,297,033 (+)NCBI
mRatBN7.21110,076,448 - 110,156,526 (+)NCBI
Rnor_6.01116,596,330 - 116,675,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082286   ⟹   XP_038938214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,260 - 110,161,675 (+)NCBI
RefSeq Acc Id: XM_063266837   ⟹   XP_063122907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,787 - 119,297,033 (+)NCBI
RefSeq Acc Id: XM_063266840   ⟹   XP_063122910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,787 - 119,297,033 (+)NCBI
RefSeq Acc Id: XM_063266841   ⟹   XP_063122911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,206,659 - 119,297,033 (+)NCBI
RefSeq Acc Id: XR_005487990
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,480 - 110,161,434 (+)NCBI
RefSeq Acc Id: XR_005488019
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81119,204,244 - 119,297,033 (+)NCBI
mRatBN7.21110,070,260 - 110,161,675 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178766   ⟸   NM_001191837
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL),   A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229372   ⟸   XM_006229310
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL),   A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229375   ⟸   XM_006229313
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757623   ⟸   XM_008759401
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757622   ⟸   XM_008759400
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757621   ⟸   XM_008759399
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZM14 (UniProtKB/TrEMBL),   A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444857   ⟸   XM_017589368
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL),   A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444858   ⟸   XM_017589369
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL),   A0A0G2JTH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021366   ⟸   ENSRNOT00000021366
RefSeq Acc Id: ENSRNOP00000068717   ⟸   ENSRNOT00000083587
RefSeq Acc Id: XP_038938214   ⟸   XM_039082286
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JTH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079079   ⟸   ENSRNOT00000108441
RefSeq Acc Id: XP_063122911   ⟸   XM_063266841
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122907   ⟸   XM_063266837
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122910   ⟸   XM_063266840
- Peptide Label: isoform X1
- UniProtKB: F1M7B8 (UniProtKB/TrEMBL)
Protein Domains
HECT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7B8-F1-model_v2 AlphaFold F1M7B8 1-868 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690088
Promoter ID:EPDNEW_R613
Type:multiple initiation site
Name:Ube3a_1
Description:ubiquitin protein ligase E3A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01116,587,874 - 116,587,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306361 AgrOrtholog
BioCyc Gene G2FUF-59422 BioCyc
Ensembl Genes ENSRNOG00000015734 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021366.8 UniProtKB/TrEMBL
  ENSRNOT00000083587.2 UniProtKB/TrEMBL
  ENSRNOT00000108441.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.130.10 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro AZUL UniProtKB/TrEMBL
  AZUL_sf UniProtKB/TrEMBL
  E3A/B/C-like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  Ubiquitin-protein_ligase_E6-AP UniProtKB/TrEMBL
KEGG Report rno:361585 UniProtKB/TrEMBL
NCBI Gene 361585 ENTREZGENE
PANTHER UBIQUITIN-PROTEIN LIGASE E3C UniProtKB/TrEMBL
  UBIQUITIN-PROTEIN LIGASE E3C UniProtKB/TrEMBL
Pfam AZUL UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
PhenoGen Ube3a PhenoGen
PIRSF Ubiquitin-protein_ligase_E6-AP UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015734 RatGTEx
SMART HECTc UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
UniProt A0A0G2JTH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM14 ENTREZGENE, UniProtKB/TrEMBL
  F1M7B8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ube3a  ubiquitin protein ligase E3A  LOC103691124  uncharacterized LOC103691124  Data merged from RGD:9088822 737654 PROVISIONAL
2014-08-25 LOC103691124  uncharacterized LOC103691124      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Ube3a  ubiquitin protein ligase E3A   Ube3a_predicted  ubiquitin protein ligase E3A (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ube3a_predicted  ubiquitin protein ligase E3A (predicted)      Symbol and Name status set to approved 70820 APPROVED