Masp1 (MBL associated serine protease 1) - Rat Genome Database

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Gene: Masp1 (MBL associated serine protease 1) Rattus norvegicus
Analyze
Symbol: Masp1
Name: MBL associated serine protease 1
RGD ID: 620213
Description: Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway; negative regulation of complement activation; and zymogen activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement factor MASP-3; complement-activating component of Ra-reactive factor; LOC100910195; mannan-binding lectin serine peptidase 1; mannan-binding lectin serine protease 1; mannan-binding lectin serine protease 2-like; mannose-binding lectin-associated serine protease 1; mannose-binding protein associated serine protease-1; mannose-binding protein-associated serine protease; MASP-1; Masp1/3; Masp3; ra-reactive factor serine protease p100; raRF; serine protease 5; serine protease MASP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,839,081 - 90,909,922 (+)NCBIGRCr8
mRatBN7.21177,334,794 - 77,405,271 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,085,686 - 86,155,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,719,505 - 78,789,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,799,974 - 77,870,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,736,424 - 80,806,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,736,576 - 80,803,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01179,928,629 - 79,998,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,532,504 - 79,602,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,590,092 - 79,660,344 (+)NCBI
Celera1176,211,586 - 76,281,374 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fragrance  (ISO)
furan  (EXP)
genistein  (ISO)
graphite  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
metam  (ISO)
methimazole  (EXP)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
oxycodone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. Chen CB and Wallis R, J Biol Chem. 2004 Jun 18;279(25):26058-65. Epub 2004 Apr 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo. Knittel T, etal., Lab Invest 1997 Sep;77(3):221-30.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene. Stover CM, etal., Genes Immun 2003 Jul;4(5):374-84.
13. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations. Wallis R and Dodd RB, J Biol Chem 2000 Oct 6;275(40):30962-9.
Additional References at PubMed
PMID:10946292   PMID:11485744   PMID:11527969   PMID:12421953   PMID:12477932   PMID:12538697   PMID:17182967   PMID:18424734   PMID:18596036   PMID:22078562   PMID:28111019  


Genomics

Comparative Map Data
Masp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,839,081 - 90,909,922 (+)NCBIGRCr8
mRatBN7.21177,334,794 - 77,405,271 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,085,686 - 86,155,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01178,719,505 - 78,789,732 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,799,974 - 77,870,072 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01180,736,424 - 80,806,278 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1180,736,576 - 80,803,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01179,928,629 - 79,998,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,532,504 - 79,602,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,590,092 - 79,660,344 (+)NCBI
Celera1176,211,586 - 76,281,374 (+)NCBICelera
Cytogenetic Map11q23NCBI
MASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383187,217,282 - 187,291,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3187,217,282 - 187,291,980 (-)EnsemblGRCh38hg38GRCh38
GRCh373186,935,070 - 187,009,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,418,632 - 188,492,446 (-)NCBINCBI36Build 36hg18NCBI36
Build 343188,434,575 - 188,492,172NCBI
Celera3185,365,700 - 185,441,644 (-)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3184,338,300 - 184,414,290 (-)NCBIHuRef
CHM1_13186,897,245 - 186,973,187 (-)NCBICHM1_1
T2T-CHM13v2.03190,034,704 - 190,109,174 (-)NCBIT2T-CHM13v2.0
Masp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391623,261,778 - 23,340,127 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1623,268,167 - 23,339,565 (-)EnsemblGRCm39 Ensembl
GRCm381623,451,785 - 23,521,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,449,417 - 23,520,815 (-)EnsemblGRCm38mm10GRCm38
MGSCv371623,451,858 - 23,520,663 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,364,751 - 23,435,937 (-)NCBIMGSCv36mm8
Celera1624,010,198 - 24,079,173 (-)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1614.23NCBI
Masp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542020,540,016 - 20,605,854 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542020,540,266 - 20,605,830 (+)NCBIChiLan1.0ChiLan1.0
MASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22185,088,774 - 185,161,617 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13185,093,829 - 185,165,993 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03184,241,611 - 184,317,272 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,707,784 - 192,782,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,707,784 - 192,782,196 (-)Ensemblpanpan1.1panPan2
MASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13419,689,426 - 19,750,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,691,630 - 19,750,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,782,100 - 23,843,357 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,609,256 - 19,670,494 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,611,470 - 19,670,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,638,187 - 19,699,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,632,188 - 19,693,442 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,871,376 - 19,932,651 (-)NCBIUU_Cfam_GSD_1.0
Masp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602116,712,588 - 116,779,787 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365782,804,460 - 2,869,582 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365782,804,460 - 2,857,731 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13124,955,030 - 125,054,463 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,938,469 - 125,028,440 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,301,366 - 134,391,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MASP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11581,488,306 - 81,563,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,488,099 - 81,563,679 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604154,981,423 - 55,054,231 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Masp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473069,568,915 - 69,632,470 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,569,046 - 69,632,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Masp1
469 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:116
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000002507, ENSRNOT00000002512, ENSRNOT00000047678
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
RH129005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,385,537 - 77,385,748 (+)MAPPERmRatBN7.2
Rnor_6.01180,787,133 - 80,787,343NCBIRnor6.0
Rnor_5.01179,947,894 - 79,948,104UniSTSRnor5.0
RGSC_v3.41179,582,971 - 79,583,181UniSTSRGSC3.4
Celera1176,262,055 - 76,262,265UniSTS
RH 3.4 Map11641.9UniSTS
Cytogenetic Map11q23UniSTS
RH140729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,373,960 - 77,374,172 (+)MAPPERmRatBN7.2
Rnor_6.01180,775,556 - 80,775,767NCBIRnor6.0
Rnor_5.01179,959,470 - 79,959,681UniSTSRnor5.0
RGSC_v3.41179,571,394 - 79,571,605UniSTSRGSC3.4
Celera1176,250,478 - 76,250,689UniSTS
RH 3.4 Map11638.0UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 44 41 41 8 11 66 4 12 5 8
Low 3 6 13 19 8 31 29 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002507   ⟹   ENSRNOP00000002507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,340,870 - 77,402,974 (+)Ensembl
Rnor_6.0 Ensembl1180,742,467 - 80,803,382 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047678   ⟹   ENSRNOP00000044812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,335,067 - 77,374,247 (+)Ensembl
Rnor_6.0 Ensembl1180,736,576 - 80,775,847 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094154   ⟹   ENSRNOP00000079792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,334,859 - 77,402,974 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111260   ⟹   ENSRNOP00000078578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,334,935 - 77,385,759 (+)Ensembl
RefSeq Acc Id: NM_022257   ⟹   NP_071593
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,722 - 90,909,922 (+)NCBI
mRatBN7.21177,335,069 - 77,405,271 (+)NCBI
Rnor_6.01180,736,666 - 80,806,278 (+)NCBI
Rnor_5.01179,928,629 - 79,998,787 (-)NCBI
RGSC_v3.41179,532,504 - 79,602,755 (+)RGD
Celera1176,211,586 - 76,281,374 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248526   ⟹   XP_006248588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,081 - 90,890,415 (+)NCBI
mRatBN7.21177,334,794 - 77,386,379 (+)NCBI
Rnor_6.01180,736,424 - 80,787,359 (+)NCBI
Rnor_5.01179,928,629 - 79,998,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768804   ⟹   XP_008767026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,839,111 - 90,878,914 (+)NCBI
mRatBN7.21177,334,839 - 77,374,263 (+)NCBI
Rnor_6.01180,736,430 - 80,775,858 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_071593   ⟸   NM_022257
- Peptide Label: precursor
- UniProtKB: Q8CHN8 (UniProtKB/Swiss-Prot),   Q8CG41 (UniProtKB/Swiss-Prot),   Q5U365 (UniProtKB/Swiss-Prot),   O09020 (UniProtKB/Swiss-Prot),   Q9JJS9 (UniProtKB/Swiss-Prot),   A0A0H2UHA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248588   ⟸   XM_006248526
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZL57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767026   ⟸   XM_008768804
- Peptide Label: isoform X2
- UniProtKB: A6JS17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044812   ⟸   ENSRNOT00000047678
RefSeq Acc Id: ENSRNOP00000002507   ⟸   ENSRNOT00000002507
RefSeq Acc Id: ENSRNOP00000079792   ⟸   ENSRNOT00000094154
RefSeq Acc Id: ENSRNOP00000078578   ⟸   ENSRNOT00000111260
Protein Domains
CUB   EGF-like   Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHN8-F1-model_v2 AlphaFold Q8CHN8 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698242
Promoter ID:EPDNEW_R8767
Type:initiation region
Name:Masp1_1
Description:mannan-binding lectin serine peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01180,736,699 - 80,736,759EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620213 AgrOrtholog
BioCyc Gene G2FUF-20871 BioCyc
Ensembl Genes ENSRNOG00000001827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004619 UniProtKB/Swiss-Prot
  ENSRNOG00060013056 UniProtKB/Swiss-Prot
  ENSRNOG00065003514 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002507.8 UniProtKB/TrEMBL
  ENSRNOT00000047678.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094154 ENTREZGENE
  ENSRNOT00000094154.1 UniProtKB/Swiss-Prot
  ENSRNOT00000111260.1 UniProtKB/TrEMBL
  ENSRNOT00055007350 UniProtKB/Swiss-Prot
  ENSRNOT00060022314 UniProtKB/Swiss-Prot
  ENSRNOT00065005045 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191018 IMAGE-MGC_LOAD
InterPro CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64023 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93068 IMAGE-MGC_LOAD
NCBI Gene 64023 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANNAN-BINDING LECTIN SERINE PROTEASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Masp1 PhenoGen
PIRSF C1r_C1s_MASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001827 RatGTEx
  ENSRNOG00055004619 RatGTEx
  ENSRNOG00060013056 RatGTEx
  ENSRNOG00065003514 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZL57 ENTREZGENE, UniProtKB/TrEMBL
  A6JS17 ENTREZGENE, UniProtKB/TrEMBL
  MASP1_RAT UniProtKB/Swiss-Prot
  O09020 ENTREZGENE
  Q5U365 ENTREZGENE
  Q8CG41 ENTREZGENE
  Q8CHN8 ENTREZGENE
  Q8CIR7_RAT UniProtKB/TrEMBL
  Q9JJS9 ENTREZGENE
UniProt Secondary O09020 UniProtKB/Swiss-Prot
  Q5U365 UniProtKB/Swiss-Prot
  Q8CG41 UniProtKB/Swiss-Prot
  Q9JJS9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-18 Masp1  MBL associated serine protease 1  Masp1  mannan-binding lectin serine peptidase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-13 Masp1  mannan-binding lectin serine peptidase 1  LOC100910195  mannan-binding lectin serine protease 2-like  Data merged from RGD:6499887 737654 PROVISIONAL
2012-07-05 LOC100910195  mannan-binding lectin serine protease 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Masp1  mannan-binding lectin serine peptidase 1    mannose-binding protein associated serine protease-1  Name updated 1299863 APPROVED
2002-08-07 Masp1  mannose-binding protein associated serine protease-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript serine proteases Masp1 and Masp3 are alternative splicing/processing products of a single gene 633273